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Compare 27,196 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Palazzo Artemide - VRetreats
Palazzo Artemide - VRetreats

Charme Hotel Henry's House
Charme Hotel Henry's House

Borgo Pantano
Borgo Pantano

Hotel Livingston Siracusa
Hotel Livingston Siracusa

B&B Ninfeo Siracusa
B&B Ninfeo Siracusa

Il Giardino di Sicilia
Il Giardino di Sicilia
Great weekend hotel deals in Syracuse
Image gallery for Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Farmstays in Syracuse you'll enjoy

Agriturismo Terrauzza sul Mare
Agriturismo Terrauzza sul Mare
These apart-hotels in Syracuse may fit your trip

Aretusa Vacanze B&B
Aretusa Vacanze B&B
Check out hotels with a spa in Syracuse

Hotel Relax
Hotel Relax
Where to stay in Syracuse

Ortigia
The historic heart of Syracuse is dotted with churches and atmospheric piazzas, where visitors enjoy sweeping sea views while dining at gourmet restaurants.

Santa Lucia
Santa Lucia is noteworthy for its historic sites, and you can make a stop at top attractions like Porto Piccolo and Ionian Sea.
Grottasanta
Grottasanta is noteworthy for its historic sites, and you can make a stop at top attractions like Pista Ciclabile Siracusa and Ionian Sea.
Tiche
Gardens and restaurants are notable features of Tiche. You might consider a stop by Ionian Sea while you're exploring the neighborhood.
Acradina
You'll enjoy the churches and seaside views in Acradina. You might want to make time for a stop at Ionian Sea or Capuchin Quarry.
Learn more about Syracuse
Trip time! Discover the history, culture, and ruins in Syracuse.

More cheap stays in Syracuse
More cheap stays in Syracuse

Hotel Columbia
Stay near popular Syracuse attractions
Stay near popular Syracuse attractions
Recent reviews of Syracuse hotels
Recent reviews of Syracuse hotels

Palazzo Artemide - VRetreats
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Syracuse Neighborhoods
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