Southern Indiana Vacations
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Where to stay in Southern Indiana
Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
West Main Historic District
Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.
Madison Historic District
If you're spending some time in Madison Historic District, Historic District and Schofield House are top sights worth seeing.
Downtown Evansville
2 out of top 10 points of interest in this area
Dive into the cultural hub of Evansville, where you can catch a performance by the Evansville Philharmonic Orchestra at Victory Theatre or explore the Children's Museum of Evansville. Don't miss the LST-325 Museum and Ford Center nearby!
Portland
While visiting Portland, you might make a stop by sights like Portland Museum and Lannan Park Trailhead.
California
If you're spending some time in California, Ohio River Valley and Union Station are top sights worth seeing.
Find the Best Southern Indiana Vacation Packages
Southern Indiana Hotel Deals
Radisson Hotel Louisville North
505 Marriott Drive Clarksville IN
Fully refundable
NT$2,125
NT$2,402 total
Nov 10 - Nov 11
includes taxes & fees
Derby Hotel & Suites
505 K Marriot Dr Clarksville IN
Fully refundableReserve now, pay when you stay
NT$2,011
NT$2,273 total
Oct 20 - Oct 21
includes taxes & fees
7/10 Good! (261 reviews)
"It's on the backside of another motel. The bed was clean and it is outdated stuff but it was good for price. I'd say again."
Reviewed on 2026/10/9
Santas Lodge and Resort
91 W CHRISTMAS BLVD Santa Claus IN
Fully refundableReserve now, pay when you stay
NT$3,543
NT$3,968 total
Oct 11 - Oct 12
includes taxes & fees
8/10 Very Good! (455 reviews)
"Our girlfriend and I loved our stay. We aren’t going to be able to really have Christmas this year because of our baby being born so close so it was just what she needed. I also proposed on the property and she said yes!"
Reviewed on 2026/10/9
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Southern Indiana attractions
KFC Yum Center
8.8/10 (1,621 reviews)
This waterfront arena hosts Louisville's premier sporting events and world-class concerts with 22,000 seats. Arrive early to explore downtown's culinary scene before experiencing the vibrant atmosphere inside.
Photo by Indiana Office of Tourism Development
Holiday World and Splashin' Safari
9.4/10 (294 reviews)
Holiday World features themed holiday areas with thrilling coasters and water attractions. Enjoy complimentary soft drinks and sunscreen while experiencing the world's longest water coaster, Wildebeest.
Louisville Slugger Museum
9.2/10 (2,299 reviews)
Step inside the world's only Louisville Slugger factory where baseball history comes alive. Watch craftsmen transform raw wood into iconic bats, then hold the same models used by legends like Babe Ruth and Derek Jeter.
Whiskey Row
9.2/10 (11 reviews)
Find out about the history of Louisville when you spend time at Whiskey Row. Attend a sporting event or simply enjoy the lively bars while you're in the area.
Photo by Nura Mirzaliyeva
Fourth Street Live!
8.4/10 (2,560 reviews)
Louisville's premier entertainment district offers a vibrant mix of restaurants, bars, and live music venues. Savor diverse culinary experiences and dynamic nightlife in this pedestrian-friendly downtown hub.
Kentucky International Convention Center
8.4/10 (763 reviews)
Downtown Louisville's premier venue, KICC impresses with its modern glass design and light-filled spaces. Attend conventions, trade shows, and exhibitions in this state-of-the-art facility at the heart of the city.
Bally's Evansville Casino
8.0/10 (505 reviews)
Indiana's first casino offers scenic Ohio River views alongside a vibrant gaming experience. Enjoy upscale dining at Cavanaugh's while watching the river flow past your table.
Louisville Palace
8.2/10 (488 reviews)
You can get tickets for a performance at Louisville Palace on your trip to Louisville. Experience the area's acclaimed theater scene or attend a sporting event.
Frequently asked questions
How much does a Southern Indiana vacation package cost?
We make it simple to travel somewhere new, with Southern Indiana vacation packages starting from just . You'll have the flexibility to combine your preferred airlines, hotels and car rental. For the ultimate escape, why not add a few activities and tours to your itinerary?
How do I get a cheap travel package to Southern Indiana?
If you love bargains, combine your bookings into a Southern Indiana vacation package. Whether you're looking for flights, hotels, day tours or rental cars, you can book everything in one place. You'll have plenty of choice at your fingertips too. Expedia has over 550 airlines and 1,000,000 hotels around the globe to take your pick of. Fly with who you want, stay where you like and save a packet — now that's the ideal getaway!
Where should I stay in Southern Indiana?
Louisville is a fantastic place to explore. It draws in many travelers who come to see its top sights, like Churchill Downs and Muhammad Ali Center.
What are the top hotels in Southern Indiana?
When it comes to properties in Louisville, Galt House Hotel Trademark Collection by Wyndham and Radisson Hotel Louisville Jeffersonville are two fantastic options. If you're also spending time in Jeffersonville - Clarksville, Radisson Hotel Louisville Jeffersonville and JW Marriott Indianapolis look forward to welcoming you.
How far in advance should I book my Southern Indiana vacation?
It all depends on the airline, but you can normally browse through international airfares on Expedia up to a year in advance. While it's a good idea to book ahead of time, lucky travelers will sometimes score a cheaper seat only weeks before the date of departure.
What does an Expedia Southern Indiana travel package include?
With Expedia, you can select any combination of flights, car rentals and hotels to create your ideal Southern Indiana travel package. Once you've made your booking, you can add on all the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the greater the savings!
What should I know before booking a Southern Indiana travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fabulous discounts. Hotels aren't your only choice, though. Book with us and select from island resorts, rural cottages and everything in between!
Can I choose my airline with a Southern Indiana Expedia vacation package?
Expedia offers access to more than 550 partner airlines globally, so you certainly can. Simply select the carrier that suits you and create the perfect Southern Indiana trip.
If I'm not able to travel, can I cancel my Southern Indiana vacation package?
Yes, you can. We understand that even the best-laid plans can go awry, so we're here to help if you have to make changes to your Southern Indiana vacation package. You may be able to amend or cancel your itinerary at no cost if you've booked in the last 24 hours. Your hotel, airline or car rental company may impose a fee if your booking was made more than 24 hours ago. Have a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
