Southern Indiana Vacations

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Where to stay in Southern Indiana

Find the best Southern Indiana areas and neighborhoods for the activities you enjoy most. Learn more about Southern Indiana
Louisville Science Center featuring outdoor art

West Main Historic District

Boasting the largest collection of cast iron façades outside New York's SoHo district, this historic area features "Museum Row" with attractions like the Louisville Slugger Museum and Muhammad Ali Center.

Find hotels in West Main Historic District

Find the Best Southern Indiana Vacation Packages

Southern Indiana Hotel Deals

Radisson Hotel Louisville North

Radisson Hotel Louisville North

3 out of 5
505 Marriott Drive, Clarksville, IN
Fully refundable
The price is NT$1,771 per night from Sep 3 to Sep 4
NT$1,771
NT$2,001 total
Sep 3 - Sep 4
includes taxes & fees
6.8/10 (2,236 reviews)
"Chai and Kimberly up at the front are great people and treat you with the outmost respect and kindness. They are really helpful and quick to process your request. Been staying a couple nights and have not had a single issue. Super recommended."

Reviewed on 2025/8/1

Radisson Hotel Louisville North
Hyatt Place Evansville

Hyatt Place Evansville

3 out of 5
202 Se 2nd St, Evansville, IN
Fully refundableReserve now, pay when you stay
The price is NT$3,447 per night from Aug 9 to Aug 10
NT$3,447
NT$3,964 total
Aug 9 - Aug 10
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
"Clean up to date property, outstanding staff, premium breakfast, good selection of light meals balence of day/evening. Free onsight parking, good lighting in parking lot and safe. Exterior well cared for includes outdoor sitting areas."

Reviewed on 2025/8/1

Hyatt Place Evansville
Quality Inn & Suites

Quality Inn & Suites

2.5 out of 5
440 South Main St, Ferdinand, IN
Fully refundableReserve now, pay when you stay
The price is NT$2,499 per night from Sep 3 to Sep 4
NT$2,499
NT$2,799 total
Sep 3 - Sep 4
includes taxes & fees
7/10 Good! (590 reviews)
"Nice property, stayed when we went to Holiday World. Staff was great and helpful."

Reviewed on 2025/7/29

Quality Inn & Suites
See all 1,424 properties in Southern Indiana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Southern Indiana

Louisville Slugger Museum showing interior views

Louisville Slugger Museum

4.5/5(606 reviews)

Baseball is part of the American fabric. See where one important tool for this sport is produced in the factory that makes ball games possible.

Louisville Slugger Museum
Helped celebrate the Belle of Louisville's 100th birthday with a cruise up the Ohio River.

Louisville Waterfront Park

4.5/5(301 reviews)

After visiting Louisville Waterfront Park, make a plan to see the other sights and activities in Louisville. Stroll along the area's riverfront or experience its great live music.

Louisville Waterfront Park
Muhammad Ali Center featuring modern architecture and night scenes

Muhammad Ali Center

4.5/5(243 reviews)

One of the world’s greatest boxers continues providing inspiration beyond the world of sport. Understand this superstar by visiting this center honoring him.

Muhammad Ali Center

Frequently asked questions

How much does a Southern Indiana vacation package cost?
We make it simple to travel somewhere new, with Southern Indiana vacation packages starting from just . You'll have the flexibility to combine your preferred airlines, hotels and car rental. For the ultimate escape, why not add a few activities and tours to your itinerary?
How do I get a cheap travel package to Southern Indiana?
If you love bargains, combine your bookings into a Southern Indiana vacation package. Whether you're looking for flights, hotels, day tours or rental cars, you can book everything in one place. You'll have plenty of choice at your fingertips too. Expedia has over 550 airlines and 1,000,000 hotels around the globe to take your pick of. Fly with who you want, stay where you like and save a packet — now that's the ideal getaway!
Where should I stay in Southern Indiana?
Louisville is a fantastic place to explore. It draws in many travelers who come to see its top sights, like Churchill Downs and Muhammad Ali Center.
What are the top hotels in Southern Indiana?
When it comes to properties in Louisville, Galt House Hotel Trademark Collection by Wyndham and Radisson Hotel Louisville Jeffersonville are two fantastic options. If you're also spending time in Jeffersonville - Clarksville, Radisson Hotel Louisville Jeffersonville and JW Marriott Indianapolis look forward to welcoming you.
How far in advance should I book my Southern Indiana vacation?
It all depends on the airline, but you can normally browse through international airfares on Expedia up to a year in advance. While it's a good idea to book ahead of time, lucky travelers will sometimes score a cheaper seat only weeks before the date of departure.
What does an Expedia Southern Indiana travel package include?
With Expedia, you can select any combination of flights, car rentals and hotels to create your ideal Southern Indiana travel package. Once you've made your booking, you can add on all the fun stuff like sightseeing tours and activities. Remember — the more you bundle, the greater the savings!
What should I know before booking a Southern Indiana travel package?
You'll save plenty with an Expedia travel package. Combine your airfares, rental cars and hotels and land fabulous discounts. Hotels aren't your only choice, though. Book with us and select from island resorts, rural cottages and everything in between!
Can I choose my airline with a Southern Indiana Expedia vacation package?
Expedia offers access to more than 550 partner airlines globally, so you certainly can. Simply select the carrier that suits you and create the perfect Southern Indiana trip.
If I'm not able to travel, can I cancel my Southern Indiana vacation package?
Yes, you can. We understand that even the best-laid plans can go awry, so we're here to help if you have to make changes to your Southern Indiana vacation package. You may be able to amend or cancel your itinerary at no cost if you've booked in the last 24 hours. Your hotel, airline or car rental company may impose a fee if your booking was made more than 24 hours ago. Have a look at our Customer Service Portal for more information. Also, be sure to check your itinerary for the finer details on change fees.
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.