A modern glass building with a curved facade and a sign reading "The Kentucky Center".

Find Luxury Hotels in Southern Indiana

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Southern Indiana Luxury Hotels

Tonight
Aug 18 - Aug 19
Tomorrow
Aug 19 - Aug 20
This weekend
Aug 21 - Aug 23
Next weekend
Aug 28 - Aug 30

Our top choices for Southern Indiana luxury hotels

1. Hotel Distil, Autograph Collection

Hotel Distil, Autograph Collection
Downtown Louisville
NT$6,416
NT$7,549 total
includes taxes & fees
Sep 6 - Sep 7
Hotel Distil, Autograph Collection

2. The Grady

The Grady
Downtown Louisville
NT$5,156
NT$6,067 total
includes taxes & fees
Aug 30 - Aug 31
The Grady

3. The Brown Hotel

The Brown Hotel
Downtown Louisville
  • Elegantly designed spaces and refined comforts define this historic Louisville hotel offering a boutique feel in the city center.
NT$4,140
NT$4,871 total
includes taxes & fees
Aug 23 - Aug 24
The Brown Hotel

4. Omni Louisville Hotel

Omni Louisville Hotel
Downtown Louisville
NT$5,069
NT$5,964 total
includes taxes & fees
Aug 23 - Aug 24
Omni Louisville Hotel

5. Louisville Marriott Downtown

Louisville Marriott Downtown
Downtown Louisville
NT$5,449
NT$6,411 total
includes taxes & fees
Sep 4 - Sep 5
Louisville Marriott Downtown

6. 21c Museum Hotel Louisville

21c Museum Hotel Louisville
Downtown Louisville
  • Museum-infused luxury awaits at this hotel with spa, restaurant, and contemporary art steps from the river.
NT$4,844
NT$5,859 total
includes taxes & fees
Sep 7 - Sep 8
21c Museum Hotel Louisville

7. Hotel Bourré Bonne Louisville, Curio Collection by Hilton

Hotel Bourré Bonne Louisville, Curio Collection by Hilton
Downtown Louisville
NT$5,227
NT$6,150 total
includes taxes & fees
Aug 30 - Aug 31
Hotel Bourré Bonne Louisville, Curio Collection by Hilton

8. Seelbach Hilton Louisville Downtown

Seelbach Hilton Louisville Downtown
Downtown Louisville
  • Historic elegance meets modern luxury downtown, with pillowtop beds, designer toiletries, and 24-hour service.
NT$4,657
NT$5,480 total
includes taxes & fees
Aug 21 - Aug 22
Seelbach Hilton Louisville Downtown

9. Galt House Hotel Trademark Collection by Wyndham

Galt House Hotel Trademark Collection by Wyndham
Downtown Louisville
  • Upscale riverside hotel features panoramic views, spa services, and gourmet dining in downtown Louisville.
NT$4,553
NT$5,357 total
includes taxes & fees
Sep 2 - Sep 3
Galt House Hotel Trademark Collection by Wyndham

10. Hotel Genevieve part of JdV by Hyatt

Hotel Genevieve part of JdV by Hyatt
Downtown Louisville
NT$4,298
NT$5,057 total
includes taxes & fees
Aug 24 - Aug 25
Hotel Genevieve part of JdV by Hyatt
View all properties

Find out more about Southern Indiana

Southern Indianaand its attractions for luxury travelers

Southern Indiana offers a unique blend of luxury and adventure for travelers. Begin your exploration at the iconic French Lick Resort, renowned for its stunning architecture and world-class spa services, where guests can indulge in pampering treatments or enjoy a round of golf on its championship courses. Next, visit the beautiful Hoosier National Forest, where you can enjoy guided horseback riding adventures or tranquil nature hikes, all while basking in the serene landscapes that this region has to offer. For those with a taste for culture, the historic town of New Harmony presents a perfect blend of art and history, featuring galleries and the picturesque Roofless Church, ideal for an afternoon stroll. Don’t miss the opportunity to savor the local wine at the Turtle Run Winery, known for its breathtaking vineyard views and exquisite tastings. Lastly, a stay in the charming town of Bloomington allows you to experience vibrant dining options and bustling arts scenes, complemented by luxury hotels that provide attentive service and exceptional amenities, ensuring a comfortable and memorable stay.

Top Southern Indiana Hotel Reviews

Howard Johnson by Wyndham Evansville East

Howard Johnson by Wyndham Evansville East

10/10 Excellent
"Young lady at the front desk was incredibly helpful and kind. The room was incredibly clean, spacious + supplied. the pool was sparkling clean breakfast, had biscuits and sausage waffles and all the usual there. morning staff or smiling. helpful and kind. a wonderful well-run hotel"
T 1-night trip
Posted 3 hours ago
Howard Johnson by Wyndham Evansville East
Hampton Inn New Albany Louisville West

Hampton Inn New Albany Louisville West

10/10 Excellent
"Yes to all above very good "
Pearl 1-night trip
Posted 3 days ago
Hampton Inn New Albany Louisville West

Explore a world of travel with Expedia