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Find Luxury Hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri Luxury Hotels

Our top choices for Southeast Missouri luxury hotels

Lobby sitting area
The Riverview

The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (466)
"Place was nice and safe"
United States
ryan
The price is NT$3,003
NT$3,388 total
includes taxes & fees
Dec 14 - Dec 15
The Riverview
Daily cooked-to-order breakfast for a fee
River City Casino & Hotel

River City Casino & Hotel

River City Casino & Hotel
4.0 star property
St. Louis
9.0 out of 10, Wonderful, (1450)
"Awesome place to stay!!"
United States
Kaitlyn
The price is NT$2,744
NT$3,646 total
includes taxes & fees
Dec 15 - Dec 16
River City Casino & Hotel
Lobby
Hilton St. Louis Frontenac

Hilton St. Louis Frontenac

Hilton St. Louis Frontenac
4.0 star property
Frontenac
8.8 out of 10, Excellent, (1000)
"Clean room, felt like a mini apartment! The surrounding was beautiful. "
United States
Jane
The price is NT$4,066
NT$4,736 total
includes taxes & fees
Jan 4 - 2026/1/5
Hilton St. Louis Frontenac
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Clean room and spacious "
Belinda 1-night trip
Posted 2 days ago
Drury Inn & Suites Sikeston, MO

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