Photo by Bill Dillard
Find Luxury Hotels in Southeast Missouri, MO
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri Luxury Hotels
Our top choices for Southeast Missouri luxury hotels
9.4 out of 10, Exceptional, (511 reviews)
"The room was clean and I was able to check in a bit early."
Sara
The price is NT$3,046
NT$3,436 total
includes taxes & fees
Feb 24 - Feb 25
9.0 out of 10, Wonderful, (1,493 reviews)
"Clean and comfy great food "
Theresa A
The price is NT$3,036
NT$3,994 total
includes taxes & fees
Feb 24 - Feb 25
8.8 out of 10, Excellent, (1,002 reviews)
"Great staff"
irene
The price is NT$3,735
NT$4,351 total
includes taxes & fees
Mar 15 - Mar 16
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southeast Missouri Hotel Reviews
Motel 6 Poplar Bluff, MO
10/10 Excellent
Explore a world of travel with Expedia
- Hotels with Hot Tubs in Poplar Bluff
- Luxury Hotels in Farmington
- Marble Hill Hotels
- Farmington Hotels
- Park Hills Hotels
- Hotels near Taum Sauk Mountain State Park
- Hotels with a Pool in Bonne Terre
- Hotels near Elephant Rocks State Park
- Cottages in Wayne County
- Hotel Wedding Venues Hotels in Perryville
- Hotels near Millstream Gardens Conservation Area
- Pet-Friendly Hotels in Dexter
- Pet-Friendly Hotels in Poplar Bluff
- Resorts & Hotels with Spas in Perryville
- Hotels near St. James Catholic Church
- Bloomfield Hotels
- Pilot Knob Hotels
- Romantic Hotels in Poplar Bluff
- Hotels near Mo-Ark Regional Railroad Museum
- Hotels near Walnut Hollow Lake
- Fredericktown Hotels
- Casino Hotels in Farmington
- Belleview Hotels
- Hotel Wedding Venues Hotels in Southeast Missouri
- Black Hotels
- Hotels with an Indoor Pool in Poplar Bluff
- Hotels with a Pool in Fredericktown
- Hotels with Bars in Jackson
- Hotels near Big River
- Historic Hotels in Ste Genevieve
- Hotels with Bars in Farmington
- Casino Hotels in De Soto
- Van Buren Hotels
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Perryville Hotels
- Cheap Hotels in Poplar Bluff
- Hotels near Sand Creek Winery
- Hotels with an Indoor Pool in Bonne Terre
- Pet-Friendly Hotels in Perryville
- Hotel Wedding Venues Hotels in Farmington
- Hotels with an Indoor Pool in Jackson
- Hotels near Missouri's National Veterans Memorial
- Winery Hotels in Ste Genevieve
- Cheap Hotels in Farmington
- 3 Star Hotels in Doe Run
- Hotels near Johnson's Shut-ins State Park
- Hotels with smoking rooms in Farmington
- Romantic Hotels in Eminence
- Adults Only Resorts & in Southeast Missouri
- Bonne Terre Hotels
- Motels in Belleview
- Flights to Ironton
- Flights from New Offenburg
- Flights from Fredericktown
- Flights from Minneapolis (MSP) to Poplar Bluff (POF)
- Flights from Mountain Home (WMH) to Poplar Bluff (POF)
- Flights from Ada (ADT) to Poplar Bluff (POF)
- Flights from Friedheim
- Flights from St. Louis (SUS) to Poplar Bluff (POF)
- Flights from Southeast Missouri
- Flights to Southeast Missouri
- Flights from Belleview
- Flights from Murray (CEY) to Poplar Bluff (POF)
- Flights from Los Angeles (LAX) to Poplar Bluff (POF)
- Flights from Park Hills
- Flights from Branson (BKG) to Poplar Bluff (POF)
- Flights from Jasper (APT) to Poplar Bluff (POF)
- Flights to Fredericktown
- Flights from Black
- Visit Zalma
- Weingarten Vineyard
- Visit Jackson
- Visit Lesterville
- Visit Annapolis
- Visit Desloge
- Visit Belleview
- Taum Sauk Mountain State Park
- Twin Oaks Vineyard & Winery
- Johnson's Shut-ins State Park
- Visit Flat River
- National Shrine of Our Lady of the Miraculous Medal
- Visit Marble Hill
- Visit Farmington
- Visit Middle Brook
- Visit Ellington
- Visit Friedheim
- Visit Ironton
- Crown Valley Winery
- Visit Dutchtown
- Walnut Hollow Lake