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Our top choices for Santo Spirito hotels

SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (25 reviews)
"My husband and I enjoyed our stay here! Large rooms and bathrooms, wonderful location, and great staff! "
United States
Christina
The price is NT$5,068
NT$6,022 total
includes taxes & fees
Feb 22 - Feb 23
SPIRIT OF FLORENCE Boutique Rooms

Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (105 reviews)
"It was a great stay. The renovation style is very tasteful. "
Singapore
Maoying
The price is NT$4,904
NT$5,917 total
includes taxes & fees
Feb 23 - Feb 24
Oltrarno Splendid

AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (223 reviews)
"Wonderful room and everyone who worked at the hotel couldn’t be more helpful. Peaceful and calm, would thoroughly recommend."
United Kingdom
James
The price is NT$6,075
NT$7,205 total
includes taxes & fees
Feb 23 - Feb 24
AdAstra Suites

Hotel Palazzo Guadagni

Hotel Palazzo Guadagni
3.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (201 reviews)
"Absolutely amazing stay! Great location to all major attractions, great restaurants nearby, beautiful rooms, certain room has Duomo view, incredibly helpful staff! Definitely recommend it and we are planning to come back! "
United States
Ann
The price is NT$8,144
NT$9,406 total
includes taxes & fees
Feb 22 - Feb 23
Hotel Palazzo Guadagni

La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (173 reviews)
"The room was beautiful and clean, the staff was pleasant, breakfast was fantastic, 10/10"
United States
Dan
The price is NT$2,666
NT$3,380 total
includes taxes & fees
Feb 22 - Feb 23
La Fonderia Firenze

Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (621 reviews)
"Wonderful place, super clean, very nice staff and wonderful breakfast. Also great location for beautiful walks not too close to areas overcrowded by tourists!"
United States
Gianmaria
The price is NT$3,956
NT$4,874 total
includes taxes & fees
Feb 24 - Feb 25
Hotel Horto Convento

La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (234 reviews)
"Great location and great rooms"
United States
David
La Torre Del Cestello

Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (169 reviews)
"Great location and extremely charming!"
United States
Brook
The price is NT$6,234
NT$7,379 total
includes taxes & fees
Mar 19 - Mar 20
Ottantotto Firenze

Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
8.8 out of 10, Excellent, (140 reviews)
"Our stay was wonderful! Roxy was so welcoming and helpful! The room and view was beautiful as well! Great location with amazing food and sights nearby! "
United States
Jacqueline
Residenza D'Epoca Al Numero 8

Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1,083 reviews)
"Clean room, great staff, excellent location."
United States
Joseph
Palazzo Mannaioni Suites

Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca
Santo Spirito
9.4 out of 10, Exceptional, (46 reviews)
"Excellent place to stay!"
United States
Diane
The price is NT$3,494
NT$4,291 total
includes taxes & fees
Feb 18 - Feb 19
Palazzo D'Oltrarno - Residenza D'Epoca

Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (196 reviews)
"The room was clean a d comfortable, and the staff was very courteous and helpful. The location was also good with most attractions being a 30 to 40 minute walk or less."
United States
Roger
The price is NT$3,022
NT$3,772 total
includes taxes & fees
Feb 17 - Feb 18
Foresteria Valdese di Firenze - Casa per Ferie

Soggiorno Alessandra

Soggiorno Alessandra
Santo Spirito
8.6 out of 10, Excellent, (86 reviews)
"Alessandra is an amazing host, we had a perfect stay! The apartment is in excellent condition and very clean! "
United States
Elias
Soggiorno Alessandra

1900 Artevita

1900 Artevita
Santo Spirito
8.8 out of 10, Excellent, (178 reviews)
"Our stay here was wonderful! The host was so pleasant and the view from the terrace was beautiful. The location was in a great spot for enjoying the Florentine neighborhoods, and close to many of the restaurants recommended to us. We would stay here again in a heartbeat."
United States
Bianca
1900 Artevita

Luxury Petra San Frediano by Mmega

Luxury Petra San Frediano by Mmega
Santo Spirito
9.6 out of 10, Exceptional, (4 reviews)
"Very happy we booked here! It was such a pleasant place to stay!! Was happily surprised by a few things: The apartment is on the Piazza Carmine where there is a lovely old church Santa Maria del Carmine with the Brancacci Chapel. Also about a half block away and to left of the church steps there is a laundry mat, and just across the street from this a small grocery store, and a few more strides away a family bakery/kitchen where we got sandwiches, pastries and lasagna — lovely generational...
United States
Anita
The price is NT$8,536
NT$13,568 total
includes taxes & fees
Feb 22 - Feb 23
Luxury Petra San Frediano by Mmega

Hotel Firenze 2000

Hotel Firenze 2000
2.0 star property
Santo Spirito
7.2 out of 10, Good, (191 reviews)
"The staff was wonderful and very helpful; 24 hr service ! The room was very clean and breakfast was plentiful. Great location if you don’t mind a short walk to the historic town center ; would definitely recommend."
Canada
Josee
The price is NT$2,111
NT$2,658 total
includes taxes & fees
Feb 24 - Feb 25
Hotel Firenze 2000

Casa Santo Nome di Gesù

Casa Santo Nome di Gesù
Santo Spirito
8.8 out of 10, Excellent, (344 reviews)
"Really a nice place, like the room style and good for family stay!"
United States
Ning
Casa Santo Nome di Gesù

Home in Florence

Home in Florence
Santo Spirito
9.0 out of 10, Wonderful, (70 reviews)
"Perfect place, super friendly owners, really helpful. "
United Kingdom
Paul
The price is NT$2,686
NT$3,403 total
includes taxes & fees
Feb 17 - Feb 18
Home in Florence

Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103 reviews)
"Beautiful property and wonderful staff."
United States
Brad
The price is NT$12,001
NT$13,723 total
includes taxes & fees
Feb 17 - Feb 18
Torre di Bellosguardo

Appartamenti degli Artisti by Mmega

Appartamenti degli Artisti by Mmega
Santo Spirito
8.6 out of 10, Excellent, (29 reviews)
"We stayed here in November and had a wonderful experience. The location worked perfectly for my husband and I, close enough to the center to get everywhere easily, yet set in a quiet residential part of Florence where we could feel the local rhythm of the city. The staff who look after the house were all very easy to communicate with. The whole stay was smooth and comfortable. We truly enjoyed our time here!"
United States
Ray
The price is NT$2,490
NT$6,171 total
includes taxes & fees
Feb 17 - Feb 18
Appartamenti degli Artisti by Mmega
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Cathedral of Santa Maria del Fiore and Piazza del Duomo are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

San Giovanni

If you're spending some time in San Giovanni, Cathedral of Santa Maria del Fiore and Piazza della Repubblica are top sights worth seeing.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighborhood known for its beautiful river views. Be sure to check out Porta Romana and Piazza Santo Spirito as part of your Santo Spirito travel plans.
What's the best accommodation in Santo Spirito?
Based on Expedia customer reviews, Oltrarno Splendid is the highest ranked property in Santo Spirito. This B&B is a short 7-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and free WiFi. Other favorite options in the area include SPIRIT OF FLORENCE Boutique Rooms and Hotel Horto Convento.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 487 hotels and other accommodations in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals in Santo Spirito.
Where can I learn more about changing or cancelling my trip to Santo Spirito?
To find more details about updating your trip to Santo Spirito or cancelling it, head over to our customer service page.
What can I see and do in this Florence neighborhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighborhood, Porta Romana and Piazza Santo Spirito are some other places worth a visit. Favorite places to visit in the surrounding area include Piazza di Santa Maria Novella, Cathedral of Santa Maria del Fiore, and Piazza del Duomo. When you're sightseeing in Florence, Piazza del Carmine and Santa Maria della Carmine are also worth a stop.