Find hotels in Santa Ana, Antigua Guatemala

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Our top choices for Santa Ana hotels

Casa Buho B&B

Casa Buho B&B
3.0 star property
Santa Ana
9.2 out of 10, Wonderful, (52 reviews)
"Beautiful hotel with clean rooms and friendly staff. The only downsides are the distance to the center (a 30-minute walk) and the chickens and peacocks screaming early in the morning"
United States
Patrick
The price is NT$1,443
NT$1,761 total
includes taxes & fees
Jun 8 - Jun 9
Casa Buho B&B

Hostal Casa Buho

Hostal Casa Buho
3.0 star property
Santa Ana
8.8 out of 10, Excellent, (25 reviews)
"This place has two parts, the hotel and a hostel, I stayed in the private room of the hostel part, it wasn’t very good, but the whole place is very nice, like an oasis with a lot of plants, the hotel Part would be very nice."
United States
SUSAN
The price is NT$1,195
NT$1,458 total
includes taxes & fees
Jun 21 - Jun 22
Hostal Casa Buho

Castillo De Los Gigantes

Castillo De Los Gigantes
2.0 star property
Santa Ana
6.0 out of 10, (1 review)
"This property should be listed on Airbnb, it is not a hostel/hotel, it's more like a spare room in someone's home. There's nothing nearby. It was a saviour during semana santa, but otherwise not a particularly good place to stay. That being said the people were lovely, and the room was decent for the price."
American Samoa
Ella
The price is NT$418
NT$894 total
includes taxes & fees
Jun 8 - Jun 9
Castillo De Los Gigantes

La guarida del caudillo

La guarida del caudillo
1.0 star property
Santa Ana
The price is NT$874
NT$1,066 total
includes taxes & fees
Jun 8 - Jun 9
La guarida del caudillo

Ole España

Ole España
2.5 star property
20.8 km from Santa Ana
9.4 out of 10, Exceptional, (33 reviews)
"I liked the breakfast and clean area"
United States
Juan
The price is NT$1,143
NT$1,395 total
includes taxes & fees
Jun 8 - Jun 9
Ole España

Casa Aurora

Casa Aurora
3.0 star property
20.9 km from Santa Ana
8.8 out of 10, Excellent, (206 reviews)
"It was a really nice place enjoyed staying"
United States
Santos
The price is NT$1,736
NT$2,117 total
includes taxes & fees
Jun 15 - Jun 16
Casa Aurora

Le Suisse Spa

Le Suisse Spa
3.0 star property
6.8 km from Santa Ana
8.6 out of 10, Excellent, (31 reviews)
"I 100% recommend Le Suisse Spa. The facilities are first-class, the room was super clean, and the service was excellent. The staff made us feel very comfortable. We will definitely be coming back soon."
United States
David
The price is NT$3,166
NT$3,863 total
includes taxes & fees
Jun 8 - Jun 9
Le Suisse Spa

CASA DE LAS FLORES

CASA DE LAS FLORES
2.0 star property
24.7 km from Santa Ana
9.0 out of 10, Wonderful, (28 reviews)
"Beautiful place in the heart of guatemala city"
United States
Devin
The price is NT$929
NT$1,134 total
includes taxes & fees
Jun 8 - Jun 9
CASA DE LAS FLORES

Mestizo Cortijo

Mestizo Cortijo
3.0 star property
4.3 km from Santa Ana
8.8 out of 10, Excellent, (134 reviews)
"Beautiful property, spacious rooms, great views, amazing breakfast, friendly staff"
United States
Ligia
The price is NT$3,585
NT$4,374 total
includes taxes & fees
Jun 8 - Jun 9
Mestizo Cortijo

In & Out Hotel

In & Out Hotel
3.0 star property
20.9 km from Santa Ana
8.6 out of 10, Excellent, (871 reviews)
"We love staying atbthe In and Out, rooms have AC, very clean, great breakfast and a very reasonable price."
United States
Julian
The price is NT$1,566
NT$1,911 total
includes taxes & fees
Jun 8 - Jun 9
In & Out Hotel

Casa Carmel Bed and Breakfast

Casa Carmel Bed and Breakfast
3.0 star property
24.2 km from Santa Ana
9.6 out of 10, Exceptional, (133 reviews)
"Loved the breakfast! Great period house built in the 1930s, located in the historic district."
United States
Sudhir
The price is NT$1,940
NT$2,367 total
includes taxes & fees
Jun 8 - Jun 9
Casa Carmel Bed and Breakfast

Mariana's Petit Hotel

Mariana's Petit Hotel
3.0 star property
20.9 km from Santa Ana
9.2 out of 10, Wonderful, (194 reviews)
"Great owner"
United States
kurt
The price is NT$1,422
NT$1,735 total
includes taxes & fees
Jun 10 - Jun 11
Mariana's Petit Hotel

Dai Nonni Hotel

Dai Nonni Hotel
3.0 star property
22.4 km from Santa Ana
9.2 out of 10, Wonderful, (361 reviews)
"Excellent value"
United States
Tyler
The price is NT$2,021
NT$2,466 total
includes taxes & fees
Jun 8 - Jun 9
Dai Nonni Hotel

Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center
4.5 star property
20.1 km from Santa Ana
9.2 out of 10, Wonderful, (1,019 reviews)
"Great food, rooms are clean!!"
United States
Rossana
The price is NT$3,608
NT$4,402 total
includes taxes & fees
Jun 14 - Jun 15
Tikal Futura Hotel & Convention Center

Villas Santander

Villas Santander
3.0 star property
24.7 km from Santa Ana
7.4 out of 10, Good, (251 reviews)
"Parking is easy "
United States
Walter
The price is NT$982
NT$1,198 total
includes taxes & fees
Jun 8 - Jun 9
Villas Santander

EL TEJAR HOSTAL

EL TEJAR HOSTAL
3.0 star property
21 km from Santa Ana
8.0 out of 10, Very Good, (24 reviews)
"Very satisfying staying there the food was delicious travel with family parking was as it’s said I had trouble finding the place is gated and very secure ac was ok they also have rental car and they pick u up at the airport good to know I definitely going to book again on my next trip to Guatemala 04/08/2026"
United States
Yenmi
The price is NT$1,339
NT$1,634 total
includes taxes & fees
Jun 8 - Jun 9
EL TEJAR HOSTAL

L Aurora Inn

L Aurora Inn
3.0 star property
21 km from Santa Ana
9.0 out of 10, Wonderful, (154 reviews)
"The best hotel!"
United States
Krisia
The price is NT$1,860
NT$2,846 total
includes taxes & fees
Jun 22 - Jun 23
L Aurora Inn

Hotel Don Felipe Airport

Hotel Don Felipe Airport
2.0 star property
20.8 km from Santa Ana
8.4 out of 10, Very Good, (49 reviews)
"Had a great experience, staff was top notch, accommodating, and the lovely lady who works the evening shift deserves a huge raise!"
United States
Laura
The price is NT$1,047
NT$1,278 total
includes taxes & fees
Jun 8 - Jun 9
Hotel Don Felipe Airport

Inari Guatemala

Inari Guatemala
3.0 star property
20.8 km from Santa Ana
9.0 out of 10, Wonderful, (102 reviews)
"The breakfast was delicious "
United States
Shannon
The price is NT$1,463
NT$1,784 total
includes taxes & fees
Jun 9 - Jun 10
Inari Guatemala

Barceló Guatemala City

Barceló Guatemala City
4.5 star property
22.7 km from Santa Ana
9.2 out of 10, Wonderful, (3,338 reviews)
"Nice hotel and it is really close to the airport."
United States
Anonymous traveler
The price is NT$4,389
NT$5,354 total
includes taxes & fees
Jun 8 - Jun 9
Barceló Guatemala City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.

Top Santa Ana Hotel Reviews

Frequently asked questions

What's it like in Santa Ana?
Travelers to the Santa Ana neighborhood in Antigua Guatemala will be sure to enjoy their stay.
What's a favorite hotel to stay in Santa Ana?
Based on our traveler data, Casa Buho B&B is one of the top choices for your stay in Santa Ana. This hotel offers a restaurant and free parking.
How many hotels will I be able to find in Santa Ana?
If you're searching for places to stay in Antigua Guatemala, choose from one of Expedia's 14 hotels and other accommodations in Santa Ana.
If I need to cancel my hotel reservation in Santa Ana, will I receive a refund?
Yes! You'll find that most hotel bookings are fully refundable if you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a reservation that's non-refundable, you may still be able to cancel and receive a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then you can use the "fully refundable" filter to review the top deals on offer in Santa Ana.
Where can I learn more about changing or cancelling my trip to Santa Ana?
To find more details about updating your trip to Santa Ana or cancelling it, click here.
What are the top things to see and do in Santa Ana?
House of the Giants, Santa Clara Convent, and Jade Maya Factory and Museum are just a few of the places to visit in and around Santa Ana. While you're out sightseeing in Antigua Guatemala, be sure to visit other sights like Tanque La Unión or Museo del Hermano Pedro.