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Dec 22 - Dec 23
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Dec 23 - Dec 24
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Dec 26 - Dec 28
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Our top choices for Sant'Angelo hotels

Deluxe Apartment, City View | Living area | 25-inch flat-screen TV with digital channels
Palazzo Ottavia-Maison D'Art Collection

Palazzo Ottavia-Maison D'Art Collection

Palazzo Ottavia-Maison D'Art Collection
Sant'Angelo
10.0 out of 10, Exceptional, (4)
"Excellent location, safe, clean, quiet and walkable to tourist spots as well as transportation. "
United Kingdom
Natalie
The price is NT$4,784
NT$8,293 total
includes taxes & fees
Dec 24 - Dec 25
Palazzo Ottavia-Maison D'Art Collection
Daily buffet breakfast (EUR 10 per person)
Little Queen Suite

Little Queen Suite

Little Queen Suite
Sant'Angelo
9.2 out of 10, Wonderful, (332)
"Lovely staff, comfortable room, great location. "
United States
Stephanie
The price is NT$3,137
NT$3,895 total
includes taxes & fees
Dec 23 - Dec 24
Little Queen Suite
Deluxe Room, City View | In-room safe, desk, laptop workspace, blackout drapes
EFFE LUXURY ROOMS

EFFE LUXURY ROOMS

EFFE LUXURY ROOMS
Sant'Angelo
8.0 out of 10, Very Good, (4)
"Loved the location, the room & staff was really nice. "
United States
James
The price is NT$3,475
NT$4,340 total
includes taxes & fees
Jan 14 - 2026/1/15
EFFE LUXURY ROOMS
Property entrance
Reginella Suites

Reginella Suites

Reginella Suites
Sant'Angelo
8.6 out of 10, Excellent, (64)
"Great location very spacious room and quiet loved it!"
United States
Jessica
Reginella Suites
Deluxe Room | Minibar, in-room safe, soundproofing, free WiFi
Kame Hall

Kame Hall

Kame Hall
Sant'Angelo
9.4 out of 10, Exceptional, (107)
"Good location, cleanliness "
United States
irina
Kame Hall
Apartment, 2 Bedrooms | 2 bedrooms, individually decorated, individually furnished, desk
Portico - WR Apartments

Portico - WR Apartments

Portico - WR Apartments
Sant'Angelo
8.4 out of 10, Very Good, (8)
"Great apartment, great location-all round perfect stop over in Rome "
United Kingdom
Philip
Portico - WR Apartments
Outdoor spa tub
Relais Badoer

Relais Badoer

Relais Badoer
Sant'Angelo
9.2 out of 10, Wonderful, (95)
"The staff were very helpful! Location is great and the views were lovely. Our room had a terrace that made it feel special! Rooftop was also great."
United States
Hillary
The price is NT$4,011
NT$4,782 total
includes taxes & fees
Jan 11 - 2026/1/12
Relais Badoer
Superior Double Room, Non Smoking | Premium bedding, in-room safe, desk, iron/ironing board
History Suite

History Suite

History Suite
Sant'Angelo
9.0 out of 10, Wonderful, (29)
"Great location with all major attractions nearby if you don’t mind walking about 5 km each day. Centrally located between colosseum and St. Peter’s basilica, 2 major attraction. Morning breakfast served with care was a rarity and much appreciated. Be sure to tip amply to the Philippino server. "
United States
Sharad
The price is NT$4,110
NT$4,890 total
includes taxes & fees
Jan 12 - 2026/1/13
History Suite
Superior Double Room | Bathroom | Shower, free toiletries, towels
Residenza Costaguti

Residenza Costaguti

Residenza Costaguti
Sant'Angelo
6.4 out of 10, (7)
"We'll start with the good things - great location (especially for religious people, in the center of the Jewish ghetto) and very clean. But unfortunately its a very small room and small bathroom and it took time until someone answered and came over for check-in. There's no cellphone ot WhatsApp no. We had to wait outside the apartment for about an hour until we got them."
United States
Anonymous traveler
Residenza Costaguti
Property entrance
Lea Luxury Rooms

Lea Luxury Rooms

Lea Luxury Rooms
Sant'Angelo
9.2 out of 10, Wonderful, (137)
"Perfect for a stay in Rome."
Canada
Michele
Lea Luxury Rooms
Front of property
Residenza Gens Julia

Residenza Gens Julia

Residenza Gens Julia
Sant'Angelo
10.0 out of 10, Exceptional, (160)
"Good place to stay"
Canada
Meng
The price is NT$5,712
NT$6,652 total
includes taxes & fees
Jan 4 - 2026/1/5
Residenza Gens Julia
Rooftop terrace
Hosianum Palace

Hosianum Palace

Hosianum Palace
4.0 star property
Sant'Angelo
8.4 out of 10, Very Good, (647)
"Great location. "
United States
Samuel
Hosianum Palace
Executive Double Room | Premium bedding, minibar, in-room safe, blackout drapes
HT6 Boutique Hotel

HT6 Boutique Hotel

HT6 Boutique Hotel
4.0 star property
Sant'Angelo
9.4 out of 10, Exceptional, (394)
"Amazing stay wonderful staff and breakfast perfect Location"
United States
JESSICA
HT6 Boutique Hotel
2 bedrooms, individually decorated, individually furnished, desk
Reginella - WR Apartments

Reginella - WR Apartments

Reginella - WR Apartments
Sant'Angelo
Reginella - WR Apartments
Apartment | Private kitchen | Full-size fridge, microwave, oven, stovetop
Flatinrome Exclusive Historic Ghetto

Flatinrome Exclusive Historic Ghetto

Flatinrome Exclusive Historic Ghetto
Sant'Angelo
Flatinrome Exclusive Historic Ghetto
Front of property
Fly Decò Hotel

Fly Decò Hotel

Fly Decò Hotel
4.0 star property
24.5 km from Sant'Angelo
9.0 out of 10, Wonderful, (902)
"Beautiful breakfast, helpful, courteous staff, great location lovely beach views. "
United States
Coral
Fly Decò Hotel
Deluxe Triple Room | View from room
Hotel Manfredi Suite in Rome

Hotel Manfredi Suite in Rome

Hotel Manfredi Suite in Rome
3.0 star property
Campo Marzio, 1.6 km from Sant'Angelo
9.2 out of 10, Wonderful, (1001)
"Very friendly staff and helpful in helping us understanding the surrounding areas. Excellent location right smack in the Champs Elysees of Rome"
Singapore
A
Hotel Manfredi Suite in Rome
Exterior detail
A.Roma Lifestyle Hotel

A.Roma Lifestyle Hotel

A.Roma Lifestyle Hotel
4.0 star property
4.2 km from Sant'Angelo
9.2 out of 10, Wonderful, (1000)
"Great place to stay "
United States
Maria
The price is NT$6,209
NT$7,384 total
includes taxes & fees
Jan 3 - 2026/1/4
A.Roma Lifestyle Hotel
Daily buffet breakfast (EUR 13 per person)
Bettoja Hotel Mediterraneo

Bettoja Hotel Mediterraneo

Bettoja Hotel Mediterraneo
4.0 star property
Castro Pretorio, 1.9 km from Sant'Angelo
8.6 out of 10, Excellent, (1001)
"Great place "
United States
Sabah
Bettoja Hotel Mediterraneo
Terrace/patio
The Hoxton Rome

The Hoxton Rome

The Hoxton Rome
4.0 star property
3.3 km from Sant'Angelo
9.4 out of 10, Exceptional, (484)
"It's a beautiful property, the service is wonderful, and the food and drinks were great. While the hotel is a bit outside the city center, I like that it's in a relatively quiet neighborhood."
United States
Elizabeth
The price is NT$5,398
NT$6,492 total
includes taxes & fees
Jan 18 - 2026/1/19
The Hoxton Rome
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Sant'Angelo

Find the best Sant'Angelo areas and neighborhoods for the activities you enjoy most.
Via del Corso which includes heritage architecture, heritage elements and street scenes

Rome City Centre

Known for its fascinating museums, stunning cathedral, and stunning river views, there's plenty to explore in Rome City Centre. Top attractions like Trevi Fountain and Piazza Navona are major draws. Catch the metro at Venezia Tram Stop or Arenula-Cairoli Tram Station to see more of the city.

Rome Historic Centre showing a statue or sculpture, a fountain and a square or plaza

Rome Historic Centre

Enclosed by Aurelian Walls, this UNESCO-listed historic district boasts numerous museums, including the Capitoline Museums and Scuderie del Quirinale. Well-connected by public transport including the Roma Termini and Roma Ostiense stations which are nearby.

Trastevere showing street scenes as well as a couple

Trastevere

Narrow cobbled streets lined by ancient houses give this area a charming character. Enjoy lively pubs and restaurants at night, while being close to international academic institutions and the River Tiber.

Monti which includes heritage elements, heritage architecture and a ruin

Monti

Relax in wine bars and restaurants, take a walking tour and discover the famous Colosseum and other historic sites in one of Rome’s prominent districts.

Trevi which includes food and markets

Trevi

Art galleries, churches, and museums are just a few things travelers like about Trevi. Sights like Trevi Fountain and Piazza di Trevi are spots to explore, and you can get around the greater Rome area at Barberini Station.

Top Sant'Angelo Hotel Reviews

Trastevere Roma | UNA Esperienze

Trastevere Roma | UNA Esperienze

10/10 Excellent
"Amazing area! We looked for months on where to stay and this place was not in the location we were looking but so happy with our choice. It’s not overly touristy with great local vibe and day and night life. We were able to walk across the river every day for all the big atttractions. Hotel is clean, staff is accommodating. We would definitely return "
Kendall 9-night trip
Posted 2 days ago
Trastevere Roma | UNA Esperienze

Frequently asked questions

What is Sant'Angelo like?
Guests are sure to enjoy their time checking out all that Rome's Sant'Angelo neighborhood has to offer. Are you looking for Sant'Angelo travel tips? Be sure to check out Great Synagogue of Rome and Tiber Island while you're in the neighborhood.
What's a favorite place to stay in Sant'Angelo?
Based on Expedia customer reviews, Residenza Gens Julia is the highest ranked property in Sant'Angelo. This affittacamere is a short 6-minute walk from Pantheon, and it offers free WiFi and concierge services. Other top choices in the neighborhood include HT6 Boutique Hotel and Lea Luxury Rooms.
How many hotels should I expect to find in Sant'Angelo?
If you're searching for places to stay in Rome, Expedia has something to meet your needs with 101 Sant'Angelo hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in Sant'Angelo, will I receive a refund?
Yes! Most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, you might be able to still cancel and get a refund within a 24-hour period of booking. Add dates, click "Search", then you can use the "fully refundable" filter to get top deals in Sant'Angelo.
Where can I learn more about changing or cancelling my trip to Sant'Angelo?
To access more information about changing or cancelling your trip to Sant'Angelo, go to https://www.expedia.com/service/.
What is there to do in this Rome neighborhood?
Great Synagogue of Rome, Portico di Ottavia, and Theatre of Marcellus are landmarks that can't be missed during your stay in Sant'Angelo. You could also plan a visit to Tiber Island or Tiber River while you're in the neighborhood. Don't miss favorite places to visit in the surrounding area, such as Piazza Navona, Trevi Fountain, and Colosseum. Campo de' Fiori and Piazza di Spagna are also worth a visit when you're out sightseeing in Rome.