Photo by Leonardo De Leon

Find Resorts & Hotels with Spas in Otay Mesa West, CA

Start date: Check-in selected.
To Date
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Otay Mesa West Resorts & Hotels with Spas

Tonight
Sep 27 - Sep 28
Tomorrow
Sep 28 - Sep 29
Next weekend
Oct 3 - Oct 5
In two weeks
Oct 10 - Oct 12

Top Otay Mesa West Resorts & Hotels with Spas

Sycuan Casino Resort
Fitness studio

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1550)
"Great resort!"
Sycuan Casino Resort
Legacy Resort Hotel & Spa
Couples treatment rooms, body treatments, hot stone massages

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2893)
"Great stay overall"
The price is NT$4,784
NT$5,500 total
includes taxes & fees
Sep 30 - Oct 1
Legacy Resort Hotel & Spa
Loews Coronado Bay Resort
Couples treatment rooms, sauna, hot tub, steam room, body treatments

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1052)
"Loved this stay, will be back! "
The price is NT$6,074
NT$8,131 total
includes taxes & fees
Oct 26 - Oct 27
Loews Coronado Bay Resort
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3328)
"Good place to stay"
The price is NT$3,937
NT$4,339 total
includes taxes & fees
Sep 28 - Sep 29
Best Western Plus Marina Gateway Hotel
Best Western Plus Island Palms Hotel & Marina
Reception

Best Western Plus Island Palms Hotel & Marina

3.0 star property
8.8 out of 10, Excellent, (1574)
"Restaurant is amazing!"
The price is NT$4,346
NT$4,996 total
includes taxes & fees
Oct 28 - Oct 29
Best Western Plus Island Palms Hotel & Marina
Humphreys Half Moon Inn
Outdoor pool

Humphreys Half Moon Inn

3.5 star property
9.2 out of 10, Wonderful, (2552)
"Great front desk staff and beautiful grounds"
The price is NT$4,125
NT$5,352 total
includes taxes & fees
Oct 27 - Oct 28
Humphreys Half Moon Inn
Handlery Hotel
Premier Room, 1 King Bed | Premium bedding, in-room safe, desk, blackout drapes

Handlery Hotel

3.5 star property
8.2 out of 10, Very Good, (2116)
"Very nice stay"
Handlery Hotel
San Diego Mission Bay Resort
Spa

San Diego Mission Bay Resort

4.0 star property
8.4 out of 10, Very Good, (1312)
"Beautiful area"
The price is NT$6,684
NT$9,059 total
includes taxes & fees
Oct 26 - Oct 27
San Diego Mission Bay Resort
Pier South Resort, Autograph Collection by Marriott
Exterior

Pier South Resort, Autograph Collection by Marriott

4.0 star property
8.4 out of 10, Very Good, (1009)
"The staff was amazing in the hotel and the restaurants! We love this hotel to be able to sit on the balcony in the am and pm to listen to the waves and enjoy the ambiance! "
The price is NT$6,308
NT$7,887 total
includes taxes & fees
Oct 19 - Oct 20
Pier South Resort, Autograph Collection by Marriott
Hyatt Regency Mission Bay Spa and Marina
Exterior

Hyatt Regency Mission Bay Spa and Marina

4.0 star property
8.4 out of 10, Very Good, (1560)
"Clean rooms great view amazing pool and we loved the breakfast "
The price is NT$4,243
NT$6,488 total
includes taxes & fees
Sep 28 - Sep 29
Hyatt Regency Mission Bay Spa and Marina
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Otay Mesa West Hotel Reviews

Bay Club Hotel & Marina

Bay Club Hotel & Marina

10/10 Excellent
"Great calm place"
Ricardo 2-night trip
Posted 2 days ago
Bay Club Hotel & Marina

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Looking to vacation at a spa hotel in Otay Mesa West?
Book one of our wonderful spa hotels and treat yourself from the moment you arrive. Check out the cathedral in Otay Mesa West—your cultural tour starts here. Spa hotels are the perfect way to break away from your routine and add a layer of luxury to your holiday.
What's there to see and do in Otay Mesa West?
Experience all that Otay Mesa West has to offer when you visit San Diego Zoo, Mission Bay, and San Ysidro Border Crossing. If you have a little extra time during your trip, you might want to check out Hotel del Coronado and Petco Park.
What is a Otay Mesa West spa hotel?
Spa hotels in Otay Mesa West provide lodging and have an on-site spa offering services including couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.