Find Resorts & Hotels with Spas in Otay Mesa, CA

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Otay Mesa Resorts & Hotels with Spas

Tonight
Aug 24 - Aug 25
Tomorrow
Aug 25 - Aug 26
Next weekend
Aug 29 - Aug 31
In two weeks
Sep 5 - Sep 7

Top Otay Mesa Resorts & Hotels with Spas

Our top choices for Otay Mesa hotels with a spa

Sycuan Casino Resort
3 outdoor pools, cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1508)
"Love this place"
Sycuan Casino Resort
Best Western Plus Marina Gateway Hotel
Suite, 2 Queen Beds, Non Smoking, Refrigerator (with Sofabed) | Premium bedding, in-room safe, desk, laptop workspace

Best Western Plus Marina Gateway Hotel

3.5 star property
9.2 out of 10, Wonderful, (3232)
"Enjoyed my stay"
The price is NT$4,100
NT$4,518 total
includes taxes & fees
Sep 1 - Sep 2
Best Western Plus Marina Gateway Hotel
Loews Coronado Bay Resort
Exterior

Loews Coronado Bay Resort

4.0 star property
8.8 out of 10, Excellent, (1015)
"The staff is very friendly and the rooms very clean."
The price is NT$6,084
NT$8,144 total
includes taxes & fees
Sep 1 - Sep 2
Loews Coronado Bay Resort
Legacy Resort Hotel & Spa
Garden

Legacy Resort Hotel & Spa

4.0 star property
9.2 out of 10, Wonderful, (2870)
"Beautiful Hotel"
The price is NT$4,689
NT$5,390 total
includes taxes & fees
Sep 7 - Sep 8
Legacy Resort Hotel & Spa
San Diego Mission Bay Resort
Outdoor pool, open 9:00 AM to 9:00 PM, cabanas (surcharge)

San Diego Mission Bay Resort

4.0 star property
8.4 out of 10, Very Good, (1292)
"This was a beautiful resort and the staff was wonderful."
The price is NT$5,778
NT$8,020 total
includes taxes & fees
Sep 1 - Sep 2
San Diego Mission Bay Resort
Handlery Hotel
Outdoor pool, pool umbrellas, sun loungers

Handlery Hotel

3.5 star property
8.2 out of 10, Very Good, (1994)
"Great stay"
Handlery Hotel
Best Western Plus Island Palms Hotel & Marina
Reception

Best Western Plus Island Palms Hotel & Marina

3.0 star property
8.8 out of 10, Excellent, (1548)
"Great place to stay with "
The price is NT$4,476
NT$5,145 total
includes taxes & fees
Sep 21 - Sep 22
Best Western Plus Island Palms Hotel & Marina
Humphreys Half Moon Inn
Outdoor pool

Humphreys Half Moon Inn

3.5 star property
9.2 out of 10, Wonderful, (2488)
"Great place to stay!!"
The price is NT$4,861
NT$6,199 total
includes taxes & fees
Sep 1 - Sep 2
Humphreys Half Moon Inn
Gaylord Pacific Resort & Convention Center
3 outdoor pools

Gaylord Pacific Resort & Convention Center

4.0 star property
8.0 out of 10, Very Good, (106)
"Great experience for all our family, we enjoy the pools and common areas"
The price is NT$8,530
NT$11,302 total
includes taxes & fees
Aug 27 - Aug 28
Gaylord Pacific Resort & Convention Center
Pier South Resort, Autograph Collection by Marriott
Meeting facility

Pier South Resort, Autograph Collection by Marriott

4.0 star property
8.4 out of 10, Very Good, (1000)
"The happy hours here are amazing!"
The price is NT$6,211
NT$7,777 total
includes taxes & fees
Sep 1 - Sep 2
Pier South Resort, Autograph Collection by Marriott
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Otay Mesa Hotel Reviews

Hyatt Regency Mission Bay Spa and Marina

Hyatt Regency Mission Bay Spa and Marina

10/10 Excellent
"Great area family friendly "
daniel 1-night trip
Posted 13 hours ago
Hyatt Regency Mission Bay Spa and Marina