Find Business Hotels in Mission District, CA

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Mission District Business Hotels

Tonight
Dec 29 - Dec 30
Tomorrow
Dec 30 - Dec 31
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Our top choices for Mission District business-friendly hotels

Lobby sitting area
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf
4.0 star property
Fisherman's Wharf
9.0 out of 10, Wonderful, (7252)
"Great place to stay!"
United States
Isaiah
The price is NT$3,133
NT$4,983 total
includes taxes & fees
Jan 5 - 2026/1/6
Hotel Riu Plaza Fisherman's Wharf
Front of property - evening/night
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (2204)
"Great hotel "
United States
Tanya
The price is NT$3,583
NT$4,217 total
includes taxes & fees
Jan 5 - 2026/1/6
Hilton San Francisco Financial District
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (2835)
"Clean room, friendly staff and good location"
United States
Jose Eduardo
The price is NT$3,181
NT$3,744 total
includes taxes & fees
Jan 3 - 2026/1/4
Club Quarters Hotel in San Francisco
Free daily buffet breakfast
Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG

Holiday Inn Express and Suites Fisherman's Wharf by IHG
3.0 star property
Fisherman's Wharf
9.2 out of 10, Wonderful, (2241)
"Awesome place to stay"
United States
Mark Anthony
The price is NT$3,741
NT$5,346 total
includes taxes & fees
Jan 4 - 2026/1/5
Holiday Inn Express and Suites Fisherman's Wharf by IHG
Outdoor pool, open 9:00 AM to 7:00 PM, sun loungers
Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG
3.5 star property
Downtown San Francisco
9.0 out of 10, Wonderful, (5056)
"Nice stay. Hotel was clean, quiet and accessible. "
United States
Brandon
The price is NT$3,521
NT$4,144 total
includes taxes & fees
Jan 5 - 2026/1/6
Holiday Inn Golden Gateway by IHG
Egyptian cotton sheets, premium bedding, down comforters, pillowtop beds
Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf

Hotel Caza Fisherman's Wharf
4.0 star property
Fisherman's Wharf
9.0 out of 10, Wonderful, (3837)
"Excellent stay and great location! "
United States
CHRISTINE
The price is NT$3,981
NT$6,128 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Caza Fisherman's Wharf
Game room
Hotel Zephyr San Francisco

Hotel Zephyr San Francisco

Hotel Zephyr San Francisco
4.0 star property
Fisherman's Wharf
8.6 out of 10, Excellent, (2341)
"Great location"
United States
Deborah
The price is NT$3,948
NT$5,757 total
includes taxes & fees
Jan 27 - 2026/1/28
Hotel Zephyr San Francisco
Exterior
King George Hotel

King George Hotel

King George Hotel
3.0 star property
Union Square
8.6 out of 10, Excellent, (2101)
"Great place!"
United States
Troy
The price is NT$2,503
NT$3,418 total
includes taxes & fees
Jan 4 - 2026/1/5
King George Hotel
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
Union Square
9.4 out of 10, Exceptional, (3117)
"Clean room, helpful staff and great location to explore de city."
United States
Alan
The price is NT$2,381
NT$2,813 total
includes taxes & fees
Jan 4 - 2026/1/5
Chancellor Hotel on Union Square
Exterior
The Westin San Francisco Airport

The Westin San Francisco Airport

The Westin San Francisco Airport
4.0 star property
Millbrae
8.8 out of 10, Excellent, (2019)
"Comfortable room, welcome glass of wine, easy shuttle to and from airport, friendly staff."
United States
Carole
The price is NT$3,235
NT$4,639 total
includes taxes & fees
Dec 31 - 2026/1/1
The Westin San Francisco Airport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Mission District Hotel Reviews

Fairmont San Francisco

Fairmont San Francisco

10/10 Excellent
"It is a beautiful place to visit around the holidays, for he was a bit busy but still enjoyed our stay and the galleries inside, the Tonga Room, customer service was excellent and very kind From the lady checking us in to the valet , everyone was very helpful and cordial They make you feel like a VIP "
Cathya 1-night trip
Posted 17 hours ago
Fairmont San Francisco

Frequently asked questions

Why book your business-friendly hotel in Mission District with Expedia?
With conveniences like meeting rooms, 24-hour room service and on-site restaurants, our business-friendly accommodations come with all you'll need to close your big work deal — and then relax! Enter your travel dates and destination and we'll help you plan everything else.
How can I find cheap business-friendly hotels in Mission District?
When work takes you to Mission District, our "business friendly" filter will help you find the perfect hotel. From included breakfast and free WiFi to meeting rooms and work desks, they have the amenities you need to do your job. Another handy tip? Narrow your search by your budget and preferred star rating to view the cheapest stays.

Explore a world of travel with Expedia