Mission District Vacations

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Where to stay in Mission District

Find the best Mission District areas and neighborhoods for the activities you enjoy most. Learn more about Mission District
A marina with various boats docked, including a yellow and white boat named 'Golden Gate'.

Fisherman's Wharf

1 out of top 10 points of interest in this area

Discover Pier 39, Ghirardelli Square, and the San Francisco Maritime National Historical Park in this bustling tourist hotspot. Savor seafood at family-owned restaurants and explore the sea lion colony, while enjoying convenient cable car access.

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A cityscape with tall buildings, palm trees, and red double-decker buses.

Union Square

Major tourist destination in downtown San Francisco, Union Square boasts shopping, hotels, and theaters. Explore department stores, boutiques, and galleries, or catch a performance at various theaters. Enjoy the Dewey Monument and stunning views from nearby hotels. Easily accessible via cable car lines, buses, and subway systems.

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A trolley on a street with buildings and a clock tower.

Downtown San Francisco

3 out of top 10 points of interest in this area

Serving as San Francisco's central business district, this area boasts Northern California's two tallest buildings, the Salesforce Tower and Transamerica Pyramid. Explore shopping malls like the Embarcadero Center and enjoy parks such as Sue Biermann Park, all easily accessible via Muni bus and rail lines.

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A cityscape with modern skyscrapers, a central park with pathways, and a few people walking.

South of Market

From baseball games to top-notch art exhibits, find endless entertainment in one of San Francisco’s fastest-growing neighborhoods.

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A cityscape with a prominent skyscraper, a bridge, and a mix of modern and historic buildings.

Nob Hill

Luxury hotels, historic mansions, and Michelin-starred restaurants abound in this upscale area. Explore Union Square shopping district, Grace Cathedral, and the SF Masonic Auditorium for a taste of culture and history.

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Mission District Hotel Deals

Holiday Inn Golden Gateway by IHG

Holiday Inn Golden Gateway by IHG

1500 Van Ness Ave San Francisco CA
Fully refundableReserve now, pay when you stay
NT$4,616
NT$5,433 total
Sep 7 - Sep 8
includes taxes & fees
Holiday Inn Golden Gateway by IHG
Hotel Riu Plaza Fisherman's Wharf

Hotel Riu Plaza Fisherman's Wharf

2500 Mason St San Francisco CA
Fully refundableReserve now, pay when you stay
NT$4,649
NT$6,778 total
Aug 31 - Sep 1
includes taxes & fees
9/10 Wonderful! (7,653 reviews)
"We loved our stay. The hotel is clean and bright and comfortable. Breakfast buffet was amazing! It is situated an easy walk away from Fishermans Warf and the Pier. Travelling with kids, this made it easy. Parking is a bit expensive, but there are off site lots close by to choose from if preferred. ..."

Reviewed on 2026/8/29

Hotel Riu Plaza Fisherman's Wharf
Handlery Union Square Hotel

Handlery Union Square Hotel

351 Geary St San Francisco CA
Fully refundableReserve now, pay when you stay
NT$5,091
NT$5,991 total
Sep 20 - Sep 21
includes taxes & fees
Handlery Union Square Hotel
See all 4,415 properties in Mission District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mission District vacation package cost?
Our Mission District packages, which begin at just , are an awesome way to save big. Pick your favorite flights, hotels and rental cars to create a customized escape.
How do I get a cheap travel package to Mission District?
By bundling. Flights, rental cars and hotels — combine whatever you need into a Mission District vacation package to save a pile of cash. Score even more deals when you add extras such as sightseeing tours to your booking. But that's not the only impressive part. You have the freedom to customize your vacation your own way. We offer more than 550 partner airlines and 1,000,000 hotels worldwide, so that everyone has a chance to travel and live out those vacation dreams.
Where should I stay in Mission District?
A visit to Mission District isn't complete until you've seen Pier 39 and Alcatraz Island. Book a room close by for quick access to these popular attractions.
What are the top hotels in Mission District?
If it's your first time staying in Mission District, lock in a room at 1906 Mission or Charming And Cozy Dolores Park Condo By Redawning. Both will make you feel at home and are favorites among lots of travelers.
How far in advance should I book my Mission District vacation?
To bag rock-bottom prices, book ASAP. Airlines usually start selling tickets, along with some of the lowest fares, around 12 months ahead of time. Hotels, car rental and experiences should also be booked early so you can have the pick of the bunch. If you've decided on a last-minute getaway in Mission District, there are always lots of great deals to be had on Expedia. Book your escape today!
What does an Expedia Mission District travel package include?
It all boils down to what sort of getaway you want to have. Mission District vacation deals can include car rentals, hotels and flights. You can mix and match to create the travel package that fits your needs. You can also add on activities and experiences after you've booked to pick up even bigger discounts.
What should I know before booking a Mission District travel package?
Booking all the parts of your escape together is one of the best ways to save. Bundle your car rentals, airfares and hotels into a convenient package. But you're not restricted to hotels. Expedia has all types of properties, including vacation rentals like beachfront villas and serviced residences. You've got loads of choices!
Can I choose my airline with a Mission District Expedia vacation package?
With a vacation package, you're always in charge. Whether you want to fly to Mission District in first class or coach, simply select from the available airline options. Expedia has access to more than 550 airline partners around the world.
If I'm not able to travel, can I cancel my Mission District vacation package?
You sure can, and we're here to help. You may be able to cancel or change your Mission District vacation package for free if you booked in the last 24 hours. But you may incur a fee from your airline, hotel or car rental company if you booked more than 24 hours ago. If your travel plans unexpectedly change, visit our Customer Service Portal for more information.

Stay near popular Mission District attractions

A park with people sitting on the grass, a school building, and a cityscape in the background.

Mission Dolores Park

9.4/10 (3 reviews)
Mission Dolores Park is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Discover the beautiful sunsets and top-notch restaurants in this vibrant area.
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A colorful street with murals, potted plants, and a brick sidewalk.

Balmy Alley

Balmy Alley is just one of the places to see in San Francisco, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene and fascinating museums in this vibrant area.
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An interior of a church with arched ceilings, stained glass windows, and rows of pews.
Photo by Donny Campos

Mission San Francisco de Asís

Learn about the local history of San Francisco when you spend time at Mission San Francisco de Asís. Visit the notable monuments and shops in this vibrant area.
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San Francisco Public Library

After visiting San Francisco Public Library, make a plan to see the other sights and activities in San Francisco. Discover the entertainment choices and notable monuments in this vibrant area.
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Southern Exposure

You can spend time studying the exhibits at Southern Exposure during your travels in San Francisco. Take in the acclaimed theater scene and beautiful sunsets in this vibrant area.
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SF Armory

You can learn about the history of San Francisco when you stop by SF Armory. Experience the acclaimed art scene and fascinating museums in this vibrant area.
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The Great Northern

After visiting The Great Northern, make a plan to see the other sights and activities in San Francisco. You can enjoy the bars while in the area.
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Brick & Mortar Music Hall

You can enjoy a show at Brick & Mortar Music Hall during your trip to San Francisco. You can enjoy the bars while in the area.
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.