Photo by HTN

Find Resorts & Hotels with Spas in Greenville Downtown, SC

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Downtown Resorts & Hotels with Spas

Our top choices for Greenville Downtown hotels with a spa

Spa
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
4.0 star property
Greenville Downtown
9.6 out of 10, Exceptional, (418)
"Absolutely one of the best hotels to stay at. "
United States
stephen
The price is NT$8,949
NT$10,113 total
includes taxes & fees
Jan 4 - 2026/1/5
Grand Bohemian Lodge Greenville, Autograph Collection
Bar (on property)
Hotel Domestique

Hotel Domestique

Hotel Domestique
4.0 star property
Travelers Rest
9.6 out of 10, Exceptional, (30)
"Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away."
United States
Chuck
The price is NT$8,575
NT$9,433 total
includes taxes & fees
Jan 8 - 2026/1/9
Hotel Domestique
Couples treatment rooms, body treatments, body wraps, body scrubs
Hotel Hartness

Hotel Hartness

Hotel Hartness
4.0 star property
Greenville
9.8 out of 10, Exceptional, (624)
"Beautiful location, friendly staff"
United States
Andrew
The price is NT$4,719
NT$6,244 total
includes taxes & fees
Dec 15 - Dec 16
Hotel Hartness
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Greenville Downtown Hotel Reviews

The Westin Poinsett Greenville

The Westin Poinsett Greenville

10/10 Excellent
"Awesome place "
Dominick 1-night trip
Posted 5 days ago
The Westin Poinsett Greenville

Explore a world of travel with Expedia

Frequently asked questions

Looking to vacation at a spa hotel in Greenville Downtown?
Book one of our wonderful spa hotels and treat yourself from the moment you arrive. Travelers recommend the riverfront and gourmet restaurants in Greenville Downtown. Enjoy the live music and waterfalls during your vacation. Spa hotels are a great way to break out of your daily routine and add a layer of luxury to your vacation.
What is the best spa hotel in Greenville Downtown?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center, a bar, and a restaurant.
How many spa hotels are there in Greenville Downtown?
Among Expedia's 97 accommodation options in Greenville Downtown, there is 1 spa hotel.
What's there to see and do in Greenville Downtown?
Experience Greenville Downtown and visit The Peace Center, Bon Secours Wellness Arena, and The Children's Museum of the Upstate. If you have extra time while you're in the area, you might want to stop by Greenville Zoo and Fluor Field at the West End.
What is a Greenville Downtown spa hotel?
Spa hotels in Greenville Downtown have on-site spas which offer services including therapies and a selection of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.