A riverside walkway with cyclists, a bridge, and modern buildings.

Find Resorts & Hotels with Spas in Greenville, SC

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Greenville Resorts & Hotels with Spas

Tonight
Aug 18 - Aug 19
Tomorrow
Aug 19 - Aug 20
This weekend
Aug 21 - Aug 23
Next weekend
Aug 28 - Aug 30

Our top choices for Greenville hotels with a spa

Spa
2 bars/lounges
Exterior
2 bars/lounges

1. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
  • Escape to a Tudor retreat with a full-service spa and rooftop garden overlooking the scenic river in Greenville.
NT$11,144
NT$12,592 total
includes taxes & fees
Sep 8 - Sep 9
Grand Bohemian Lodge Greenville, Autograph Collection
Exterior
Terrace/patio
Superior Double Room, 2 Queen Beds | Premium bedding, in-room safe, desk, laptop workspace
Breakfast area

2. Hotel Hartness

Hotel Hartness
Greenville
  • Indulge in rejuvenating treatments at this upscale hotel with six couples spa rooms and scenic hiking trails for a peaceful escape.
NT$4,980
NT$6,678 total
includes taxes & fees
Sep 14 - Sep 15
Hotel Hartness
Courtyard
Seasonal outdoor pool
Interior detail
Lobby

3. Hotel Domestique

Hotel Domestique
Travelers Rest
  • Retreat to this mountain hotel with therapeutic massage treatments, sauna, and seasonal outdoor pool for deep relaxation.
NT$11,749
NT$12,923 total
includes taxes & fees
Aug 24 - Aug 25
Hotel Domestique
View from property
Cottage (Twin Poplar) | Soundproofing, WiFi (free), individually decorated
Exterior
Exterior

4. The Orchard Inn

The Orchard Inn
Saluda
  • Enjoy a couples massage or solo Swedish retreat in this peaceful bed & breakfast with gardens and a 24-hour gym.
NT$9,523
NT$10,452 total
includes taxes & fees
Aug 24 - Aug 25
The Orchard Inn
View all properties

Choose what matters most at spa hotels in Greenville

Pool
Hot tub
Breakfast included
4 stars
Gym

Top Greenville Hotel Reviews

Embassy Suites Greenville Golf Resort & Conference Center

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent
"Loved it. Always lovely and the staff are wonderful. Clean and great breakfast as usual."
Jennifer 1-night trip
Posted 1 hour ago
Embassy Suites Greenville Golf Resort & Conference Center

Frequently asked questions

Looking to vacation at a spa hotel in Greenville?
Treat yourself to some pampering and book a hotel with a spa. Travelers highly recommend Greenville for its array of shops and gourmet restaurants—your day tour starts here. Enjoy the live music and waterfalls during your vacation. Hotels with spas are a great way to take a break from your daily routine and add a layer of luxury to your weekend away.
What is the best spa hotel in Greenville?
Grand Bohemian Lodge Greenville, Autograph Collection is a top spa hotel featuring a 24-hour fitness center and a restaurant. Enjoy a massage at The Spa at Grand Bohemian. Another popular spa hotel in Greenville is Hotel Hartness.
How many spa hotels will I find in Greenville?
Among Expedia's 681 accommodation options in Greenville, there are 2 spa hotels.
What's there to see and do in Greenville?
Take in the sights and attractions that Greenville offers with a visit to The Peace Center, The Children's Museum of the Upstate, and Bon Secours Wellness Arena. If you have some spare time during your trip, you might want to check out Beattie House and Greenville Zoo.
What is a Greenville spa hotel?
Spa hotels in Greenville have full on-site spas and offer services like couples massages and a choice of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

Explore a world of travel with Expedia