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Compare 81 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Days Inn and Suites by Wyndham Sikeston
Desk, laptop workspace, blackout drapes, iron/ironing board

Days Inn and Suites by Wyndham Sikeston

2.0 star property
7.2 out of 10, Good, (1002)
"We were there to get a good nights sleep and we did."
The price is NT$2,159
NT$2,460 total
includes taxes & fees
Aug 4 - Aug 5
Days Inn and Suites by Wyndham Sikeston
Hampton Inn Sikeston
Exterior

Hampton Inn Sikeston

2.5 star property
8.8 out of 10, Excellent, (369)
"Great location and clean room. Plenty of food and shopping nearby."
The price is NT$3,175
NT$3,595 total
includes taxes & fees
Aug 23 - Aug 24
Hampton Inn Sikeston
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

2.5 star property
8.6 out of 10, Excellent, (419)
"Thank you to the courteous staff. Great night's rest after a really long day of travel"
The price is NT$3,357
NT$3,801 total
includes taxes & fees
Sep 1 - Sep 2
Holiday Inn Express & Suites Sikeston Southwest by IHG
Best Western Plus Sikeston
Free daily full breakfast

Best Western Plus Sikeston

2.5 star property
8.4 out of 10, Very Good, (1003)
"We enjoyed our stay and the breakfast was good!"
The price is NT$2,633
NT$3,001 total
includes taxes & fees
Aug 10 - Aug 11
Best Western Plus Sikeston
Super 8 by Wyndham Sikeston/Miner Area
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout drapes, free WiFi

Super 8 by Wyndham Sikeston/Miner Area

2.0 star property
6.6 out of 10, (545)
"I enjoyed our stay"
The price is NT$1,987
NT$2,265 total
includes taxes & fees
Aug 10 - Aug 11
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Charleston/Sikeston East MO
Front of property - evening/night

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
6.6 out of 10, (577)
"Located very close to the expanse of corn fields, quiet, clean rooms, everything is neat, the bathroom is also very clean. Friendly receptionist."
The price is NT$1,803
NT$2,001 total
includes taxes & fees
Aug 3 - Aug 4
Super 8 by Wyndham Charleston/Sikeston East MO
Pear Tree Inn Sikeston
Lobby

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1003)
"Great place to stay with kids "
The price is NT$2,390
NT$2,748 total
includes taxes & fees
Aug 10 - Aug 11
Pear Tree Inn Sikeston
Comfort Inn & Suites Sikeston I-55
Exterior

Comfort Inn & Suites Sikeston I-55

2.5 star property
8.4 out of 10, Very Good, (271)
"The facility was very nice. "
The price is NT$2,824
NT$3,218 total
includes taxes & fees
Aug 3 - Aug 4
Comfort Inn & Suites Sikeston I-55
Sleep Inn at Discovery Park of America
Lobby

Sleep Inn at Discovery Park of America

2.5 star property
9.0 out of 10, Wonderful, (253)
"Staff was very friendly and the manager managed to go out of her way to help me get the room I actually paid for. Thanks Sleep In Staff."
The price is NT$2,768
NT$3,287 total
includes taxes & fees
Aug 22 - Aug 23
Sleep Inn at Discovery Park of America
Hospitality House Union City I 69 / US 51
Seasonal outdoor pool

Hospitality House Union City I 69 / US 51

2.5 star property
7.0 out of 10, Good, (317)
"Excellent experience from check-in to check-out. The room was spotless, well-stocked with essentials, and surprisingly quiet. Front desk staft were courteous and etficient. Great value and location-highly recommend for travelers seeking a comfortable and affordable stop."
The price is NT$1,631
NT$1,937 total
includes taxes & fees
Aug 31 - Sep 1
Hospitality House Union City I 69 / US 51
Drury Inn & Suites Sikeston, MO
Property amenity

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Will stay again"
The price is NT$2,689
NT$3,091 total
includes taxes & fees
Aug 17 - Aug 18
Drury Inn & Suites Sikeston, MO
Country Yard Inn and Suite
1 bedroom, iron/ironing board, free WiFi, bed sheets

Country Yard Inn and Suite

2.0 star property
7.0 out of 10, Good, (100)
"Dead bugs all over in the room, bed was uncomfortable, bath was dirty, stains on ceiling"
The price is NT$1,937
NT$2,305 total
includes taxes & fees
Aug 3 - Aug 4
Country Yard Inn and Suite
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Hallway

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
8.4 out of 10, Very Good, (666)
"Property is always clean, rooms are nice."
The price is NT$2,106
NT$2,401 total
includes taxes & fees
Aug 3 - Aug 4
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Quality Inn Cairo I-57
Lobby

Quality Inn Cairo I-57

2.5 star property
6.6 out of 10, (263)
"The hotel is in need of some serious upkeep and cleaning. It is in fairly poor condition, but it the only hotel in town."
The price is NT$2,174
NT$2,413 total
includes taxes & fees
Aug 10 - Aug 11
Quality Inn Cairo I-57
Quality Inn Union City US 51
Lobby

Quality Inn Union City US 51

2.5 star property
8.4 out of 10, Very Good, (459)
"Nice place. Everything went as should and no hidden fees. "
The price is NT$2,006
NT$2,383 total
includes taxes & fees
Aug 24 - Aug 25
Quality Inn Union City US 51
Country Hearth Inn & Suites Union City
Reception

Country Hearth Inn & Suites Union City

2.5 star property
8.8 out of 10, Excellent, (527)
"Property is old and very average. Clean w/comfortable beds. "
The price is NT$2,151
NT$2,554 total
includes taxes & fees
Aug 3 - Aug 4
Country Hearth Inn & Suites Union City
New Orleans Inn Portageville
Premier Room, 1 Bedroom, Non Smoking | 1 bedroom, desk, free WiFi, bed sheets

New Orleans Inn Portageville

2.5 star property
8.2 out of 10, Very Good, (676)
"Clean, comfortable and friendly staff"
New Orleans Inn Portageville
Holiday Inn Express & Suites Union City by IHG
Free daily buffet breakfast

Holiday Inn Express & Suites Union City by IHG

2.5 star property
9.2 out of 10, Wonderful, (283)
"This hotel was directly across from the Discovery Park of America. Definitely recommend staying there!"
The price is NT$3,436
NT$4,080 total
includes taxes & fees
Aug 22 - Aug 23
Holiday Inn Express & Suites Union City by IHG
Quality Inn Charleston - Sikeston
Desk, laptop workspace, blackout drapes, iron/ironing board

Quality Inn Charleston - Sikeston

2.5 star property
6.8 out of 10, (396)
"I consistently choose to stay there due to positive past encounters."
The price is NT$2,029
NT$2,252 total
includes taxes & fees
Aug 13 - Aug 14
Quality Inn Charleston - Sikeston
Travel Inn
Gazebo

Travel Inn

2.5 star property
5.6 out of 10, (106)
"Everything was great except for the wifi issue. They said there was wifi and gav3ca password but it didnt work. I called the front desk and was told they might havevto reset it. Not sure bc i never got to use it. "
Travel Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about East Prairie

Explore attractions like Big Oak Tree State Park and Mississippi River as you discover things to see and do in East Prairie.

See all hotels in East Prairie

Top East Prairie Hotel Reviews

Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

10/10 Excellent
"I consistently choose to stay there due to positive past encounters."
IMTIAZ 1-night trip
Posted 3 days ago
Quality Inn Charleston - Sikeston

Frequently asked questions

What's the best place for a stay in East Prairie?

Best Western Plus Sikeston, located 11.1 mi (17.9 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Drury Inn & Suites Sikeston, MO and Pear Tree Inn Sikeston. See all available top hotels, or vacation rentals in East Prairie.

If I need to cancel my hotel reservation in East Prairie, will I receive a refund?

Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel’s cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.

Where can I learn more about changing or cancelling my trip to East Prairie?

To access more information about rescheduling or cancelling your trip to East Prairie, click here.

What are some hotels with pools in East Prairie?

Best Western Plus Sikeston: Features free full breakfast, a pool, and free parking. Pear Tree Inn Sikeston and Drury Inn & Suites Sikeston, MO are a couple of other choices that offer an onsite pool. View all hotels with pools in East Prairie.

What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?

Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.

What's it like to stay in East Prairie?

Visitors are sure to enjoy all that East Prairie has to offer. There are 30 hotels and other accommodations in the surrounding area. Find out more about East Prairie.

What should I do while I'm visiting East Prairie?

The picturesque setting of Big Oak Tree State Park and Mississippi River exemplify the area's natural beauty. You'll also find Central Park and Sikeston Depot Museum in the area. Check out what more to see and do in Expedia's East Prairie guide.

What's the weather like in East Prairie?

The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.