Find Business Hotels in Downtown San Francisco, CA

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Check availability on Downtown San Francisco Business Hotels

Tonight
Dec 21 - Dec 22
Tomorrow
Dec 22 - Dec 23
Next weekend
Dec 26 - Dec 28
In two weeks
Jan 2 - Jan 4

Our top choices for Downtown San Francisco business-friendly hotels

Front of property - evening/night
Hilton San Francisco Financial District

Hilton San Francisco Financial District

Hilton San Francisco Financial District
4.0 star property
Downtown San Francisco
8.6 out of 10, Excellent, (2156)
"Great hotel "
United States
Tanya
The price is NT$3,531
NT$4,155 total
includes taxes & fees
Dec 23 - Dec 24
Hilton San Francisco Financial District
Lobby sitting area
Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square
3.5 star property
Union Square
9.4 out of 10, Exceptional, (3088)
"Great hotel, great location, super friendly all staff "
Mexico
Claudia
The price is NT$2,391
NT$2,824 total
includes taxes & fees
Dec 23 - Dec 24
Chancellor Hotel on Union Square
Terrace/patio
Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco

Club Quarters Hotel in San Francisco
4.0 star property
Downtown San Francisco
8.8 out of 10, Excellent, (2817)
"Clean and comfortable room, good staff, great location. "
United Kingdom
David
The price is NT$3,165
NT$3,725 total
includes taxes & fees
Dec 23 - Dec 24
Club Quarters Hotel in San Francisco
Exterior detail
Hilton San Francisco Union Square

Hilton San Francisco Union Square

Hilton San Francisco Union Square
4.0 star property
Union Square
8.4 out of 10, Very Good, (1129)
"Great stay, friendly staff, and clean room!"
United States
Maria
The price is NT$4,995
NT$7,179 total
includes taxes & fees
Jan 4 - 2026/1/5
Hilton San Francisco Union Square
Restaurant
Grand Hyatt San Francisco

Grand Hyatt San Francisco

Grand Hyatt San Francisco
4.0 star property
Union Square
8.8 out of 10, Excellent, (1005)
"Staff was friendly and helpful. Rooms were clean and dining on site was convenient. "
United States
Suzanne
The price is NT$4,513
NT$6,798 total
includes taxes & fees
Jan 4 - 2026/1/5
Grand Hyatt San Francisco
Room, 1 King Bed (High Floor) | City view
citizenM San Francisco Union Square

citizenM San Francisco Union Square

citizenM San Francisco Union Square
4.0 star property
Union Square
9.4 out of 10, Exceptional, (1429)
"Great service, great room!!"
United States
Arlindo
The price is NT$3,729
NT$4,389 total
includes taxes & fees
Jan 1 - 2026/1/2
citizenM San Francisco Union Square
Exterior
Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA

Hyatt Regency San Francisco Downtown SOMA
4.0 star property
Downtown San Francisco
9.4 out of 10, Exceptional, (1302)
"Very nice and view was incredible "
United States
Morgan
The price is NT$4,955
NT$7,091 total
includes taxes & fees
Jan 1 - 2026/1/2
Hyatt Regency San Francisco Downtown SOMA
Exterior
King George Hotel

King George Hotel

King George Hotel
3.0 star property
Union Square
8.6 out of 10, Excellent, (2108)
"Great place!"
United States
Troy
The price is NT$2,682
NT$3,630 total
includes taxes & fees
Dec 24 - Dec 25
King George Hotel
Exterior
The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square

The Westin St. Francis San Francisco on Union Square
4.5 star property
Union Square
8.8 out of 10, Excellent, (2419)
"Always a great place to stay "
United States
Susan
The price is NT$5,339
NT$7,595 total
includes taxes & fees
Dec 26 - Dec 27
The Westin St. Francis San Francisco on Union Square
Exterior
Hyatt Regency San Francisco

Hyatt Regency San Francisco

Hyatt Regency San Francisco
4.0 star property
Downtown San Francisco
9.2 out of 10, Wonderful, (2007)
"Excellent location, Clean rooms and beautiful interior "
United States
Balasasindran
The price is NT$5,369
NT$7,769 total
includes taxes & fees
Jan 16 - 2026/1/17
Hyatt Regency San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Downtown San Francisco Hotel Reviews

Chancellor Hotel on Union Square

Chancellor Hotel on Union Square

10/10 Excellent
"Wonderful location and staff. "
Kellie 1-night trip
Posted 8 hours ago
Chancellor Hotel on Union Square

Frequently asked questions

Why book your business-friendly hotel in Downtown San Francisco with Expedia?
At Expedia, our top task is to help you locate an excellent stay at the right price. From luxurious, corporate-friendly escapes to affordable hotels filled with conveniences, you'll have your next work trip arranged in a couple of clicks.
How can I find cheap business-friendly hotels in Downtown San Francisco?
When work takes you to Downtown San Francisco, our "business friendly" filter will help you find the perfect hotel. From fast WiFi to conference spaces and in-room desks, they have the amenities you need to do your job. You can also refine your search by your preferred star rating and budget to view the most affordable stays.

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