Find hotels in Defiance, MO from NT$2,253

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Defiance hotels

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
3.0 star property
Fenton
8.0 out of 10, Very Good, (1,127 reviews)
"We stayed for a concert. Room was clean and staff were friendly. We would stay again"
United States
Faith
The price is NT$2,834
NT$3,273 total
includes taxes & fees
Mar 19 - Mar 20
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Quality Inn Foristell

Quality Inn Foristell
2.5 star property
Foristell
8.2 out of 10, Very Good, (949 reviews)
"Clean rooms, pleasant staff."
United States
Karen
The price is NT$2,161
NT$2,440 total
includes taxes & fees
Mar 22 - Mar 23
Quality Inn Foristell

WoodSpring Suites St Peters-OFallon

WoodSpring Suites St Peters-OFallon
2.5 star property
St. Peters
9.0 out of 10, Wonderful, (49 reviews)
"Super clean , quiet place "
United States
Phoenix
The price is NT$2,826
NT$3,346 total
includes taxes & fees
Mar 19 - Mar 20
WoodSpring Suites St Peters-OFallon

Drury Inn & Suites Southwest St. Louis

Drury Inn & Suites Southwest St. Louis
3.0 star property
Valley Park
9.6 out of 10, Exceptional, (1,014 reviews)
"Clean room, great kickback and breakfast. "
United States
Emilia
The price is NT$3,653
NT$4,274 total
includes taxes & fees
Apr 3 - Apr 4
Drury Inn & Suites Southwest St. Louis

Best Western Plus Fenton

Best Western Plus Fenton
2.5 star property
Fenton
9.2 out of 10, Wonderful, (222 reviews)
"Friendly staff, clean room, quiet, nice amenities."
United States
Catherine
The price is NT$2,896
NT$3,344 total
includes taxes & fees
Mar 18 - Mar 19
Best Western Plus Fenton

Holiday Inn Express Warrenton by IHG

Holiday Inn Express Warrenton by IHG
2.5 star property
Warrenton
9.0 out of 10, Wonderful, (526 reviews)
"Staff were so nice"
United States
Jennifer
The price is NT$4,512
NT$5,153 total
includes taxes & fees
Mar 15 - Mar 16
Holiday Inn Express Warrenton by IHG

Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton
2.5 star property
Warrenton
7.4 out of 10, Good, (1,000 reviews)
"The front desk stuff were nice and welcoming. The room was clean and the breakfast was great. "
United States
Dan
The price is NT$2,880
NT$3,289 total
includes taxes & fees
Mar 16 - Mar 17
Baymont by Wyndham Warrenton

Wingate by Wyndham St. Louis/Fenton Route 66

Wingate by Wyndham St. Louis/Fenton Route 66
3.0 star property
Fenton
8.0 out of 10, Very Good, (1,152 reviews)
"Great location, comfy and clean rooms "
United States
Nestor
The price is NT$2,512
NT$2,901 total
includes taxes & fees
Mar 15 - Mar 16
Wingate by Wyndham St. Louis/Fenton Route 66

Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very Good, (1,000 reviews)
"Over all our stay was good. The room was a good size, we are thankful there was an ironing board and iron in the room. Good options at breakfast and the staff we encountered we are very pleasant. "
United States
Elizabeth
The price is NT$2,674
NT$3,073 total
includes taxes & fees
Apr 5 - Apr 6
Comfort Suites St Charles - St Louis

Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.0 out of 10, Very Good, (1,001 reviews)
"Hotel was clean. Located in a good area, would stay here again. "
United States
Christy
The price is NT$2,672
NT$3,071 total
includes taxes & fees
Mar 25 - Mar 26
Super 8 by Wyndham St Charles

Sleep Inn & Suites O'Fallon MO - Technology Drive

Sleep Inn & Suites O'Fallon MO - Technology Drive
2.5 star property
O'Fallon
9.0 out of 10, Wonderful, (1,004 reviews)
"The room was very clean and staff very helpful."
United States
Cheryl
The price is NT$2,488
NT$2,934 total
includes taxes & fees
Mar 18 - Mar 19
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hampton Inn St. Louis Wentzville

Hampton Inn St. Louis Wentzville
2.5 star property
Wentzville
9.0 out of 10, Wonderful, (667 reviews)
"The room was clean and staff were nice. "
United States
Rachel
The price is NT$3,787
NT$4,334 total
includes taxes & fees
Mar 22 - Mar 23
Hampton Inn St. Louis Wentzville

Best Western Plus Washington Hotel

Best Western Plus Washington Hotel
2.5 star property
Washington
9.2 out of 10, Wonderful, (664 reviews)
"Great stay and accommodations. The pool was very nice. "
United States
Shane
The price is NT$4,096
NT$4,663 total
includes taxes & fees
Mar 19 - Mar 20
Best Western Plus Washington Hotel

Drury Inn & Suites St. Louis St. Peters

Drury Inn & Suites St. Louis St. Peters
3.0 star property
St. Peters
9.4 out of 10, Exceptional, (1,000 reviews)
"Greatest stay ever "
United States
Eddie
The price is NT$3,493
NT$4,015 total
includes taxes & fees
Mar 22 - Mar 23
Drury Inn & Suites St. Louis St. Peters

Comfort Inn & Suites St. Louis - O'Fallon

Comfort Inn & Suites St. Louis - O'Fallon
2.5 star property
O'Fallon
7.6 out of 10, Good, (1,006 reviews)
"Good spot and great location to visit with family "
United States
Ernest
The price is NT$2,593
NT$3,059 total
includes taxes & fees
Mar 22 - Mar 23
Comfort Inn & Suites St. Louis - O'Fallon

Holiday Inn Express St. Louis West - O'Fallon by IHG

Holiday Inn Express St. Louis West - O'Fallon by IHG
2.5 star property
O'Fallon
8.6 out of 10, Excellent, (881 reviews)
"It was a wonderful stay for my girls and her birthday. She had a blast and the room was Lovely 😍🌹"
United States
Amanda
The price is NT$2,763
NT$3,258 total
includes taxes & fees
Mar 15 - Mar 16
Holiday Inn Express St. Louis West - O'Fallon by IHG

TownePlace Suites by Marriott Wentzville

TownePlace Suites by Marriott Wentzville
3.0 star property
Wentzville
9.4 out of 10, Exceptional, (50 reviews)
"Clean room and the suite was nice. "
United States
Elizabeth
The price is NT$4,639
NT$5,468 total
includes taxes & fees
Apr 3 - Apr 4
TownePlace Suites by Marriott Wentzville

The Wildwood Hotel

The Wildwood Hotel
3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1,623 reviews)
"Great space for a couple "
United States
John
The Wildwood Hotel

Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,001 reviews)
"Great hotel "
United States
John Christopher
The price is NT$4,575
NT$5,303 total
includes taxes & fees
Apr 3 - Apr 4
Drury Plaza Hotel St. Louis St. Charles

Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton
2.0 star property
Warrenton
7.4 out of 10, Good, (634 reviews)
"The parking was easy, the room was verry clean."
United States
Gary
The price is NT$1,727
NT$1,973 total
includes taxes & fees
Mar 23 - Mar 24
Super 8 by Wyndham Warrenton
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Hotels in Defiance with star-rating

Find out more about Defiance

Top reasons to visit Defiance

  • Scenic Hiking Trails: Defiance offers access to beautiful hiking trails, perfect for outdoor enthusiasts looking to explore nature.
  • Charming Downtown: Stroll through downtown Defiance, featuring local shops and eateries that showcase the town's unique atmosphere.
  • Family-Friendly Attractions: Enjoy a variety of urban parks and amusement parks that cater to families and children.
  • Romantic Getaways: Defiance is ideal for couples seeking a romantic escape surrounded by picturesque landscapes.
  • Diverse Accommodations: Find comfortable lodging options, including pet-friendly and family-friendly hotels to suit every traveler's needs.

Find great hotels near Defiance

Discover a range of comfortable accommodations in Defiance, Missouri, perfect for every type of traveler. Whether you're seeking a pet-friendly hotel, a family-friendly getaway, or a business travel option, you'll find various choices to suit your needs. Explore the top hotels and available options in the area, ensuring a memorable stay in this charming destination.

  • Sonesta ES Suites St. Louis - Chesterfield: Embrace a home-away-from-home experience at Sonesta ES Suites, a 3-star hotel that caters to pet lovers. Located 19.3km from Defiance, this accommodation offers a welcoming environment for guests traveling with furry friends. With amenities like a pet-friendly policy, including variable fees and restrictions, the hotel ensures that your pets are comfortable, too. Guests appreciate the spacious suites equipped with fully functional kitchens, perfect for longer stays or families. Enjoy complimentary breakfast and a cozy atmosphere that makes this hotel an ideal choice for both leisure and business travelers.
  • The Wildwood Hotel: Nestled amidst nature, The Wildwood Hotel is a 3.5-star lodging just 14.5km from Defiance, perfect for those seeking an outdoor adventure. This hotel features a nature-themed ambiance, making it an excellent choice for business travelers and ski enthusiasts alike. Guests can take advantage of nearby ski shuttles and lifts, ensuring easy access to winter activities. The Wildwood Hotel boasts modern amenities, including a fitness center and meeting spaces, all while offering a warm and inviting atmosphere that reflects its picturesque surroundings.
  • Hyatt Place St. Louis/Chesterfield: A family-friendly choice, Hyatt Place St. Louis/Chesterfield is a 3-star hotel located 19.3km from Defiance. This hotel combines comfort and convenience, featuring spacious rooms and a variety of amenities suitable for both families and business travelers. With services tailored for children and a pet-friendly policy, including variable fees, it ensures a stress-free stay for everyone. Guests can enjoy a complimentary breakfast and a 24/7 market for snacks, making it a well-rounded option for those traveling with loved ones or on work trips.

Where to stay in and around Defiance

Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes. Stroll through downtown Defiance, where you can enjoy local shops and eateries, or take a leisurely walk to soak in the charming atmosphere. Nearby cities provide family-friendly and adventurous experiences, making it an ideal destination for any traveler seeking relaxation and exploration. Whether you're enjoying a relaxing break or uncovering historical gems, Defiance has something special for everyone.

  • Chesterfield: Located 19.3km from Defiance, Chesterfield is a vibrant city known for its family-friendly atmosphere and entertainment options. With a steady flow of visitors year-round, peak seasons occur in April and from June to July. Here, you'll find an array of activities, including theaters, an arcade adventure zone, and live music concerts. Local landmarks such as a theme park and sports facility stadium provide ample opportunities for fun and excitement, making Chesterfield a great destination for both relaxation and adventure.
  • Saint Albans: Just 6.4km from Defiance, Saint Albans offers a charming escape with its focus on outdoor activities and romantic experiences. Visitors flock to this city primarily in April, July, and September, appreciating its recreational areas and amusement parks. Notable attractions include a convention center, urban parks, and a picturesque lake that invites leisurely strolls or picnics. The blend of entertainment and natural beauty makes Saint Albans an ideal spot for travelers seeking a peaceful yet engaging getaway.
  • Hamburg: Nestled within the area of Defiance, Hamburg is a quaint village that welcomes visitors looking for outdoor adventures and family-oriented activities. With travel peaks from June to August, Hamburg offers beautiful parks and water features that are perfect for picnicking, hiking, or simply enjoying nature. The urban parks provide a serene environment for families to unwind and explore, making Hamburg a delightful addition to your travel itinerary.

Things to do in and around Defiance

Defiance, Missouri, is perfect for an outdoor, romantic getaway filled with memorable experiences. Enjoy scenic trail access and explore various hiking trails in this charming area. With its recreational spaces, you can engage in a variety of outdoor activities that promise to make your stay unforgettable. Whether you're seeking adventure or relaxation, Defiance offers a delightful blend of nature and entertainment for all visitors.

Shopping

In Defiance, you can shop at the St. Louis Premium Outlets, just 11.3km away, offering a lively atmosphere with various brands. If you're up for a drive, check out the Taubman Prestige Outlets, located 16.1km away, or the Wentzville Flea Market, 20.9km away, for unique finds.

Recreation

Broemmelsiek Park offers a tranquil escape with scenic walking trails and peaceful picnic spots, perfect for relaxation. For a blend of music and entertainment, The Factory hosts lively concerts just 16.1km away. If you enjoy sports, Missouri Bluffs Golf Course provides a beautiful outdoor setting for golf, located 11.3km from Defiance.

Adventure

At Hidden Valley Ski Resort, 14.5km from Defiance, enjoy exhilarating skiing and snowboarding on well-groomed slopes perfect for all skill levels. Hurricane Harbor, located 16.1km away, offers thrilling water rides and family-friendly attractions for a day of splashing fun. Explore Matson Hill Park Trailhead for scenic hiking amidst nature's beauty.

Nightlife

Experience the vibrant nightlife in Defiance with a visit to Chesterfield Sports Fusion for exciting arcade adventures, or enjoy the cultural charm at the New Jewish Theatre. For family fun, bounce over to Sky Zone Indoor Trampoline Park, just a short drive away.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Defiance

To save money on your trip to Defiance, Missouri, consider visiting during the off-peak months from December to February, when prices are lower. Book your stay on a Monday for the best rates, as Saturday is typically the most expensive day. Use Expedia to find budget-friendly accommodations by sorting prices from lowest to highest and exploring package deals that combine flights, hotels, and activities for extra savings. Look for flexible booking options and special offers to enhance your travel experience while keeping costs down.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as budget, desired location, and the type of hotel you’re looking for. To find the most affordable prices and special offers, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservation in Defiance with your flights and activities through an Expedia package.

Find the best attractions in and around Defiance

Defiance, Missouri, offers a perfect blend of outdoor adventures and romantic getaways. Visitors can explore a variety of attractions, including urban parks, national state parks, and amusement parks, making it ideal for families and those seeking a city experience. Whether you're looking to enjoy nature or entertain the kids, Defiance has something for everyone to create memorable vacation moments.

  • Six Flags St. Louis: Located 16.1km from Defiance, this amusement park offers thrilling rides and family-friendly attractions. Experience the excitement of roller coasters, live entertainment, and seasonal events, making it a perfect destination for adventure seekers of all ages.
  • August A. Busch Memorial Conservation Area: Situated within Defiance, this beautiful preserve is ideal for families looking to explore nature. Enjoy scenic trails, wildlife watching, and various outdoor excursions, all in a friendly atmosphere that encourages connection with the environment.
  • Historic Daniel Boone Home and Heritage Center: Also located in Defiance, this historic house immerses visitors in the rich culture and history of the region. Explore the preserved home of the legendary frontiersman and enjoy guided tours that showcase local heritage.

Best time to go to Defiance

The best time to visit Defiance can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Defiance falls in July, when visitor numbers are moderately high and weather is mostly sunny with light rain. The coolest average temperature in Defiance falls in January, visitor numbers are moderately low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January31.6°F (-0.2°C)Light RainMostly CloudyModerately LowSlightly Low
February34.7°F (1.5°C)Light RainMostly SunnyAverageSlightly Low
March46.4°F (8.0°C)Light RainMostly SunnyAverageAverage
April55.9°F (13.3°C)Light RainMostly SunnyModerately HighAverage
May66.2°F (19.0°C)Light RainMostly SunnyAverageSlightly High
June75.9°F (24.4°C)Light RainMostly SunnyAverageSlightly High
July79.0°F (26.1°C)Light RainMostly SunnyModerately HighSlightly High
August77.2°F (25.1°C)Light RainMostly SunnyAverageAverage
September70.9°F (21.6°C)Light RainMostly SunnyModerately HighAverage
October58.5°F (14.7°C)Light RainMostly SunnyAverageAverage
November46.2°F (7.9°C)Light RainMostly SunnyModerately LowAverage
December37.6°F (3.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Defiance

Visiting Defiance, Missouri, is convenient with its proximity to major airports. St. Louis Lambert International Airport (STL) is located 37.0km away, offering several nearby hotels such as The Ritz-Carlton, St. Louis, and Ameristar Casino Resort and Spa, both 11.3km from the airport. Another option is the Royal Sonesta Chase Park Plaza, situated 14.5km away. Alternatively, Spirit of St. Louis Airport (SUS) is only 11.3km from Defiance, with great accommodations like The Ritz-Carlton Sarasota, 4.8km away, and DoubleTree by Hilton Hotel St. Louis - Chesterfield, 6.4km away, ensuring a comfortable stay while you explore the area.

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are The Wildwood Hotel and Ameristar Casino Resort and Spa. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station and Busch Stadium. In Defiance, there are 19 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at August A. Busch Memorial Conservation Area, Missouri River, and Matson Hill Park Trailhead. A couple of additional sights to add to your agenda are Chandler Hill Vineyards and Sugar Creek Winery. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

Explore a world of travel with Expedia