Find hotels in Defiance, MO from NT$2,113

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Compare 847 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3.0 star property
Fenton
8.0 out of 10, Very Good, (1030)
"Very friendly staff "
United States
Amber
The price is NT$2,669
NT$3,082 total
includes taxes & fees
Dec 14 - Dec 15
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

The Wildwood Hotel

3.5 star property
Wildwood
9.2 out of 10, Wonderful, (1599)
"The hotel was amazing from the staff to the rooms. Great location as well. Definitely recommend this place if traveling! "
United States
Brandi
The Wildwood Hotel

Best Western Plus St. Louis West-Westport

2.5 star property
Maryland Heights
8.0 out of 10, Very Good, (1033)
"The room was great and the bed was very comfortable "
United States
Joyce
The price is NT$3,100
NT$3,596 total
includes taxes & fees
Dec 18 - Dec 19
Best Western Plus St. Louis West-Westport

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"Room very clean, most of staff helpful"
United States
Ranata
The price is NT$2,618
NT$3,004 total
includes taxes & fees
Dec 18 - Dec 19
Baymont by Wyndham Warrenton

Sonesta ES Suites St. Louis - Chesterfield

3.0 star property
Chesterfield
8.0 out of 10, Very Good, (1033)
"Clean room,Friendly staff, Good location and Good Breakfast options"
United States
Micheal
The price is NT$2,906
NT$3,371 total
includes taxes & fees
Dec 18 - Dec 19
Sonesta ES Suites St. Louis - Chesterfield

AC Hotel by Marriott St. Louis Chesterfield

3.5 star property
Chesterfield
9.2 out of 10, Wonderful, (233)
"Newer hotel, very clean, up to date and in nice area. "
United States
Johnny
The price is NT$3,736
NT$4,334 total
includes taxes & fees
Dec 21 - Dec 22
AC Hotel by Marriott St. Louis Chesterfield

WoodSpring Suites St Peters-OFallon

2.5 star property
St. Peters
9.8 out of 10, Exceptional, (15)
"Very nice:) "
United States
Alicia
The price is NT$2,317
NT$2,664 total
includes taxes & fees
Dec 8 - Dec 9
WoodSpring Suites St Peters-OFallon

Holiday Inn Express St. Louis West - O'Fallon by IHG

2.5 star property
O'Fallon
8.6 out of 10, Excellent, (828)
"The staff was so friendly and helpful! The hotel was exceptionally clean. Breakfast was very good with lots of variety!"
United States
Millie
The price is NT$2,606
NT$3,073 total
includes taxes & fees
Dec 18 - Dec 19
Holiday Inn Express St. Louis West - O'Fallon by IHG

Sleep Inn & Suites O'Fallon MO - Technology Drive

2.5 star property
O'Fallon
8.8 out of 10, Excellent, (1001)
"Nice breakfast, friendly staff"
United States
Damon
The price is NT$2,706
NT$3,191 total
includes taxes & fees
Dec 31 - 2026/1/1
Sleep Inn & Suites O'Fallon MO - Technology Drive

Hampton Inn St. Charles St. Peters

2.5 star property
St. Charles
8.0 out of 10, Very Good, (1002)
"Room was very clean. Staff were nice."
United States
Susann
The price is NT$2,738
NT$3,147 total
includes taxes & fees
Dec 11 - Dec 12
Hampton Inn St. Charles St. Peters

Holiday Inn Express & Suites Wentzville St Louis West by IHG

2.5 star property
Wentzville
9.4 out of 10, Exceptional, (831)
"Good all around stay "
United States
Chad
The price is NT$3,232
NT$3,888 total
includes taxes & fees
Jan 2 - 2026/1/3
Holiday Inn Express & Suites Wentzville St Louis West by IHG

Drury Plaza Hotel St. Louis St. Charles

3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1002)
"Hotel was very clean."
United States
christine
The price is NT$3,610
NT$4,185 total
includes taxes & fees
Dec 7 - Dec 8
Drury Plaza Hotel St. Louis St. Charles

Days Inn by Wyndham St Peters/St Charles

2.0 star property
St. Peters
6.4 out of 10, (1000)
"Staff was very friendly. Room was kept clean."
United States
Sandra
The price is NT$1,890
NT$2,173 total
includes taxes & fees
Jan 1 - 2026/1/2
Days Inn by Wyndham St Peters/St Charles

Hollywood Casino & Hotel St. Louis

3.5 star property
Maryland Heights
8.4 out of 10, Very Good, (2219)
"Decent room. Well priced and centrally located for out soccer tournament we were in town for"
United States
Travis
The price is NT$2,417
NT$3,273 total
includes taxes & fees
Dec 15 - Dec 16
Hollywood Casino & Hotel St. Louis

Wingate by Wyndham St. Louis/Fenton Route 66

3.0 star property
Fenton
7.8 out of 10, Good, (1112)
"The young lady that checked us in was very friendly and helpful."
United States
Wenona
The price is NT$2,476
NT$2,859 total
includes taxes & fees
Dec 18 - Dec 19
Wingate by Wyndham St. Louis/Fenton Route 66

Best Western Plus Washington Hotel

2.5 star property
Washington
9.2 out of 10, Wonderful, (634)
"Would stay again. "
United States
Alisa
The price is NT$4,040
NT$4,599 total
includes taxes & fees
Dec 11 - Dec 12
Best Western Plus Washington Hotel

Super 8 by Wyndham Warrenton

2.0 star property
Warrenton
7.4 out of 10, Good, (619)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is NT$1,841
NT$2,113 total
includes taxes & fees
Dec 22 - Dec 23
Super 8 by Wyndham Warrenton

Hilton Garden Inn Chesterfield

3.0 star property
Chesterfield
8.2 out of 10, Very Good, (782)
"Just a really nice hotel tucked away from everything, but still close to get whereevre you need to go!"
United States
Roy
The price is NT$3,057
NT$3,557 total
includes taxes & fees
Jan 4 - 2026/1/5
Hilton Garden Inn Chesterfield

Americas Best Value Inn & Suites St. Louis, St. Charles Inn

2.5 star property
St. Charles
5.8 out of 10, (1015)
"Great location near the St. Charles Convention Center and historic Main Street. "
United States
Linda
The price is NT$1,868
NT$2,165 total
includes taxes & fees
Dec 7 - Dec 8
Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Super 8 by Wyndham Eureka/Six Flags Nearby

2.0 star property
Eureka
7.0 out of 10, Good, (1008)
"A much needed comfortable bed and hot shower, staff was lovely. "
United States
Rachel
The price is NT$1,934
NT$2,253 total
includes taxes & fees
Jan 1 - 2026/1/2
Super 8 by Wyndham Eureka/Six Flags Nearby
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Defiance attractions

Learn more about Defiance

Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.

A covered bridge at the Historic Daniel Boone Home Park in Defiance, Missouri

Top Defiance Hotel Reviews

More cheap stays in Defiance

Hotels in Defiance with star-rating

Find out more about Defiance

Top reasons to visit Defiance

  • Scenic Hiking Trails: Defiance offers access to beautiful hiking trails, perfect for outdoor enthusiasts looking to explore nature.
  • Charming Downtown: Stroll through downtown Defiance, featuring local shops and eateries that showcase the town's unique atmosphere.
  • Family-Friendly Attractions: Enjoy a variety of urban parks and amusement parks that cater to families and children.
  • Romantic Getaways: Defiance is ideal for couples seeking a romantic escape surrounded by picturesque landscapes.
  • Diverse Accommodations: Find comfortable lodging options, including pet-friendly and family-friendly hotels to suit every traveler's needs.

Find great hotels near Defiance

Discover a range of comfortable accommodations in Defiance, Missouri, perfect for every type of traveler. Whether you're seeking a pet-friendly hotel, a family-friendly getaway, or a business travel option, you'll find various choices to suit your needs. Explore the top hotels and available options in the area, ensuring a memorable stay in this charming destination.

  • Sonesta ES Suites St. Louis - Chesterfield: Embrace a home-away-from-home experience at Sonesta ES Suites, a 3-star hotel that caters to pet lovers. Located 19.3km from Defiance, this accommodation offers a welcoming environment for guests traveling with furry friends. With amenities like a pet-friendly policy, including variable fees and restrictions, the hotel ensures that your pets are comfortable, too. Guests appreciate the spacious suites equipped with fully functional kitchens, perfect for longer stays or families. Enjoy complimentary breakfast and a cozy atmosphere that makes this hotel an ideal choice for both leisure and business travelers.
  • The Wildwood Hotel: Nestled amidst nature, The Wildwood Hotel is a 3.5-star lodging just 14.5km from Defiance, perfect for those seeking an outdoor adventure. This hotel features a nature-themed ambiance, making it an excellent choice for business travelers and ski enthusiasts alike. Guests can take advantage of nearby ski shuttles and lifts, ensuring easy access to winter activities. The Wildwood Hotel boasts modern amenities, including a fitness center and meeting spaces, all while offering a warm and inviting atmosphere that reflects its picturesque surroundings.
  • Hyatt Place St. Louis/Chesterfield: A family-friendly choice, Hyatt Place St. Louis/Chesterfield is a 3-star hotel located 19.3km from Defiance. This hotel combines comfort and convenience, featuring spacious rooms and a variety of amenities suitable for both families and business travelers. With services tailored for children and a pet-friendly policy, including variable fees, it ensures a stress-free stay for everyone. Guests can enjoy a complimentary breakfast and a 24/7 market for snacks, making it a well-rounded option for those traveling with loved ones or on work trips.

Where to stay in and around Defiance

Defiance, Missouri, offers a delightful blend of outdoor adventures and romantic escapes. Stroll through downtown Defiance, where you can enjoy local shops and eateries, or take a leisurely walk to soak in the charming atmosphere. Nearby cities provide family-friendly and adventurous experiences, making it an ideal destination for any traveler seeking relaxation and exploration. Whether you're enjoying a relaxing break or uncovering historical gems, Defiance has something special for everyone.

  • Chesterfield: Located 19.3km from Defiance, Chesterfield is a vibrant city known for its family-friendly atmosphere and entertainment options. With a steady flow of visitors year-round, peak seasons occur in April and from June to July. Here, you'll find an array of activities, including theaters, an arcade adventure zone, and live music concerts. Local landmarks such as a theme park and sports facility stadium provide ample opportunities for fun and excitement, making Chesterfield a great destination for both relaxation and adventure.
  • Saint Albans: Just 6.4km from Defiance, Saint Albans offers a charming escape with its focus on outdoor activities and romantic experiences. Visitors flock to this city primarily in April, July, and September, appreciating its recreational areas and amusement parks. Notable attractions include a convention center, urban parks, and a picturesque lake that invites leisurely strolls or picnics. The blend of entertainment and natural beauty makes Saint Albans an ideal spot for travelers seeking a peaceful yet engaging getaway.
  • Hamburg: Nestled within the area of Defiance, Hamburg is a quaint village that welcomes visitors looking for outdoor adventures and family-oriented activities. With travel peaks from June to August, Hamburg offers beautiful parks and water features that are perfect for picnicking, hiking, or simply enjoying nature. The urban parks provide a serene environment for families to unwind and explore, making Hamburg a delightful addition to your travel itinerary.

Things to do in and around Defiance

Defiance, Missouri, is perfect for an outdoor, romantic getaway filled with memorable experiences. Enjoy scenic trail access and explore various hiking trails in this charming area. With its recreational spaces, you can engage in a variety of outdoor activities that promise to make your stay unforgettable. Whether you're seeking adventure or relaxation, Defiance offers a delightful blend of nature and entertainment for all visitors.

Shopping

In Defiance, you can shop at the St. Louis Premium Outlets, just 11.3km away, offering a lively atmosphere with various brands. If you're up for a drive, check out the Taubman Prestige Outlets, located 16.1km away, or the Wentzville Flea Market, 20.9km away, for unique finds.

Recreation

Broemmelsiek Park offers a tranquil escape with scenic walking trails and peaceful picnic spots, perfect for relaxation. For a blend of music and entertainment, The Factory hosts lively concerts just 16.1km away. If you enjoy sports, Missouri Bluffs Golf Course provides a beautiful outdoor setting for golf, located 11.3km from Defiance.

Adventure

At Hidden Valley Ski Resort, 14.5km from Defiance, enjoy exhilarating skiing and snowboarding on well-groomed slopes perfect for all skill levels. Hurricane Harbor, located 16.1km away, offers thrilling water rides and family-friendly attractions for a day of splashing fun. Explore Matson Hill Park Trailhead for scenic hiking amidst nature's beauty.

Nightlife

Experience the vibrant nightlife in Defiance with a visit to Chesterfield Sports Fusion for exciting arcade adventures, or enjoy the cultural charm at the New Jewish Theatre. For family fun, bounce over to Sky Zone Indoor Trampoline Park, just a short drive away.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Defiance

To save money on your trip to Defiance, Missouri, consider visiting during the off-peak months from December to February, when prices are lower. Book your stay on a Monday for the best rates, as Saturday is typically the most expensive day. Use Expedia to find budget-friendly accommodations by sorting prices from lowest to highest and exploring package deals that combine flights, hotels, and activities for extra savings. Look for flexible booking options and special offers to enhance your travel experience while keeping costs down.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Defiance are December to February, where the prices are slightly lower. This is in comparison to May to July, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Defiance is Monday. The most expensive day to stay in Defiance is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to customize your preferences, such as budget, desired location, and the type of hotel you’re looking for. To find the most affordable prices and special offers, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservation in Defiance with your flights and activities through an Expedia package.

Find the best attractions in and around Defiance

Defiance, Missouri, offers a perfect blend of outdoor adventures and romantic getaways. Visitors can explore a variety of attractions, including urban parks, national state parks, and amusement parks, making it ideal for families and those seeking a city experience. Whether you're looking to enjoy nature or entertain the kids, Defiance has something for everyone to create memorable vacation moments.

  • Six Flags St. Louis: Located 16.1km from Defiance, this amusement park offers thrilling rides and family-friendly attractions. Experience the excitement of roller coasters, live entertainment, and seasonal events, making it a perfect destination for adventure seekers of all ages.
  • August A. Busch Memorial Conservation Area: Situated within Defiance, this beautiful preserve is ideal for families looking to explore nature. Enjoy scenic trails, wildlife watching, and various outdoor excursions, all in a friendly atmosphere that encourages connection with the environment.
  • Historic Daniel Boone Home and Heritage Center: Also located in Defiance, this historic house immerses visitors in the rich culture and history of the region. Explore the preserved home of the legendary frontiersman and enjoy guided tours that showcase local heritage.

Best time to go to Defiance

The best time to visit Defiance can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Defiance falls in July, when visitor numbers are moderately high and weather is mostly sunny with light rain. The coolest average temperature in Defiance falls in January, visitor numbers are moderately low and weather is mostly cloudy with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January31.6°F (-0.2°C)Light RainMostly CloudyModerately LowSlightly Low
February34.7°F (1.5°C)Light RainMostly SunnyAverageSlightly Low
March46.4°F (8.0°C)Light RainMostly SunnyAverageAverage
April55.9°F (13.3°C)Light RainMostly SunnyModerately HighAverage
May66.2°F (19.0°C)Light RainMostly SunnyAverageSlightly High
June75.9°F (24.4°C)Light RainMostly SunnyAverageSlightly High
July79.0°F (26.1°C)Light RainMostly SunnyModerately HighSlightly High
August77.2°F (25.1°C)Light RainMostly SunnyAverageAverage
September70.9°F (21.6°C)Light RainMostly SunnyModerately HighAverage
October58.5°F (14.7°C)Light RainMostly SunnyAverageAverage
November46.2°F (7.9°C)Light RainMostly SunnyModerately LowAverage
December37.6°F (3.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Defiance

Visiting Defiance, Missouri, is convenient with its proximity to major airports. St. Louis Lambert International Airport (STL) is located 37.0km away, offering several nearby hotels such as The Ritz-Carlton, St. Louis, and Ameristar Casino Resort and Spa, both 11.3km from the airport. Another option is the Royal Sonesta Chase Park Plaza, situated 14.5km away. Alternatively, Spirit of St. Louis Airport (SUS) is only 11.3km from Defiance, with great accommodations like The Ritz-Carlton Sarasota, 4.8km away, and DoubleTree by Hilton Hotel St. Louis - Chesterfield, 6.4km away, ensuring a comfortable stay while you explore the area.

Frequently asked questions

What's the best place to stay in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, located 17.9 mi (28.8 km) from the heart of Defiance, is a top choice for your stay based on our traveler data. Other good choices for your stay in the area are Hollywood Casino & Hotel St. Louis and The Wildwood Hotel. See all available top hotels, or vacation rentals in Defiance.
If I need to cancel my hotel reservation in Defiance, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Defiance.
Where can I learn more about changing or cancelling my trip to Defiance?
For more information about changing or cancelling your trip to Defiance, head over to our customer service page.
Where is the best hotel to stay with easy access to August A. Busch Memorial Conservation Area?
Sleep Inn & Suites O'Fallon MO - Technology Drive is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and an indoor pool. It's located 2.6 mi (4.3 km) from August A. Busch Memorial Conservation Area. Other good options within a few miles include Hilton Garden Inn St. Louis/O'Fallon MO and Holiday Inn Express St. Louis West - O'Fallon, an IHG Hotel.
What about the best place to stay near Chandler Hill Vineyards?
One of the top choices for your stay is The Wildwood Hotel, located 10 mi (16.1 km) from Chandler Hill Vineyards, and this 3.5-star hotel offers free breakfast and an indoor pool.
What are some accommodations with pools in Defiance?
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham: Features an indoor pool, an outdoor pool, and buffet. The Wildwood Hotel and Ameristar Casino Resort and Spa are two additional hotels that offer an onsite pool. View all hotels with pools in Defiance.
What's the best place to stay near Lambert-St. Louis International Airport (STL)?
Marriott St. Louis Airport is a popular 3.5-star hotel featuring a restaurant and an outdoor pool. It's located a short 0.3 mi (0.5 km) from Lambert-St. Louis Intl. Airport. Other good choices within close proximity to the airport include Pear Tree Inn Airport - St. Louis - St. Ann, MO and Drury Inn & Suites St. Louis Airport.
What's it like to stay in Defiance?
Visitors can enjoy all that Defiance has to offer including the wineries and parks. Top sights in the area include St. Louis Union Station and Gateway Arch. In Defiance, there are 20 hotels and other accommodations to choose from. Find out more about Defiance.
What is there to see in Defiance?
Natural beauty is on display at Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area, and Missouri River. A couple of additional sights to add to your agenda are Yellow Farmhouse Winery and Chandler Hill Vineyards. Check out what more to see and do in Expedia's Defiance guide.
What's the seasonal weather like in Defiance?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.

Explore a world of travel with Expedia