Find hotels near Casa Santo Domingo Museum, Antigua Guatemala from NT$1,141

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 30 - Dec 31
Tomorrow
Dec 31 - Jan 1
This weekend
Jan 2 - Jan 4
Next weekend
Jan 9 - Jan 11

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Casa Santo Domingo Museum hotels

42-inch LED TV with cable channels, TV, computer monitors
Barbaras Boutique Hostel

Barbaras Boutique Hostel

Barbaras Boutique Hostel
2.0 star property
0.7 km from Casa Santo Domingo Museum
10.0 out of 10, Exceptional, (25)
"Clean room, super friendly staff"
United States
Doylesa
The price is NT$4,647
NT$6,134 total
includes taxes & fees
Jan 5 - 2026/1/6
Barbaras Boutique Hostel
Comfort Suite, 1 King Bed | Terrace/patio
Villa Las Mil Flores

Villa Las Mil Flores

Villa Las Mil Flores
4.0 star property
Historic Center, 0.6 km from Casa Santo Domingo Museum
10.0 out of 10, Exceptional, (83)
"the room is magical. the staff in flawlessly wonderful"
United States
VICTOR
The price is NT$10,605
NT$12,938 total
includes taxes & fees
Jan 5 - 2026/1/6
Villa Las Mil Flores
Rooftop terrace
Las Cruces Boutique Hotel

Las Cruces Boutique Hotel

Las Cruces Boutique Hotel
4.0 star property
Historic Center, 0.5 km from Casa Santo Domingo Museum
9.8 out of 10, Exceptional, (224)
"Great place!"
United States
Ragnar
The price is NT$7,851
NT$9,578 total
includes taxes & fees
Jan 7 - 2026/1/8
Las Cruces Boutique Hotel
Property grounds
Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique

Casa Santa Rosa Hotel Boutique
3.5 star property
Historic Center, 0.4 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (322)
"Best place to stay in Antigua!!"
United States
Maria
The price is NT$4,016
NT$4,900 total
includes taxes & fees
Jan 3 - 2026/1/4
Casa Santa Rosa Hotel Boutique
Three-Bedroom House | Private kitchen
Hotel Casa Bella

Hotel Casa Bella

Hotel Casa Bella
3.0 star property
Historic Center, 0.5 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (265)
"Ac was great "
United States
George
The price is NT$6,783
NT$8,276 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Casa Bella
Terrace/patio
Luna Maya Boutique Hotel

Luna Maya Boutique Hotel

Luna Maya Boutique Hotel
3.0 star property
0.4 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (22)
"Really nice experience. Room was clean and the staff was very friendly. Will go back again."
United States
Wilfredo
The price is NT$2,075
NT$2,532 total
includes taxes & fees
Jan 8 - 2026/1/9
Luna Maya Boutique Hotel
Garden
Casa Noble Hotel

Casa Noble Hotel

Casa Noble Hotel
3.0 star property
0.7 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (168)
"Staff very friendly, breakfeast was good"
United States
HUBER
Casa Noble Hotel
Fitness studio
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo
4.5 star property
Barrio de La Concepción, < 0.1 km from Casa Santo Domingo Museum
9.2 out of 10, Wonderful, (1019)
"All staff was very friendly and location was convenient "
Canada
Stefany
The price is NT$7,474
NT$9,502 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Museo Spa Casa Santo Domingo
Exterior
Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua

Hotel Posada de Don Rodrigo Antigua
3.5 star property
Historic Center, 0.7 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (660)
"Friendly staff, clean rooms the location was excellent. "
United States
Elias
The price is NT$5,511
NT$7,490 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Posada de Don Rodrigo Antigua
Egyptian cotton sheets, premium bedding, in-room safe, desk
El Convento Boutique Hotel

El Convento Boutique Hotel

El Convento Boutique Hotel
4.0 star property
Historic Center, 0.4 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (810)
"Hotel was in a good location. "
United States
Paige
The price is NT$6,783
NT$8,747 total
includes taxes & fees
Jan 15 - 2026/1/16
El Convento Boutique Hotel
Restaurant
Hotel Camino Real Antigua

Hotel Camino Real Antigua

Hotel Camino Real Antigua
4.0 star property
Historic Center, 1 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (1007)
"Amazing hotel with beautiful gardens, great rooms, helpful staff and the top breakfast in Antigua. "
United States
Audrey
The price is NT$6,438
NT$8,639 total
includes taxes & fees
Jan 4 - 2026/1/5
Hotel Camino Real Antigua
Exterior
All Suite El Marques de Antigua

All Suite El Marques de Antigua

All Suite El Marques de Antigua
3.5 star property
0.9 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (305)
"The staff was courteous and all amenities were in place. "
United States
Debra
All Suite El Marques de Antigua
Property amenity
Porta Hotel Antigua

Porta Hotel Antigua

Porta Hotel Antigua
4.5 star property
0.8 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (1004)
"Everything about this hotel was fantastic. The bed was so comfortable. "
United States
Raymond
The price is NT$5,550
NT$7,086 total
includes taxes & fees
Jan 5 - 2026/1/6
Porta Hotel Antigua
Terrace/patio
Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa

Los Pasos Boutique Hotel & Spa
4.5 star property
0.7 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (1005)
"Great stay "
United States
BETTE
The price is NT$5,178
NT$6,505 total
includes taxes & fees
Jan 5 - 2026/1/6
Los Pasos Boutique Hotel & Spa
Massage in accommodation
Hotel Casa Bansley

Hotel Casa Bansley

Hotel Casa Bansley
2.5 star property
1.3 km from Casa Santo Domingo Museum
9.8 out of 10, Exceptional, (47)
"Property is beautiful and staff are great"
United States
Michael
The price is NT$4,005
NT$4,886 total
includes taxes & fees
Jan 3 - 2026/1/4
Hotel Casa Bansley
Lounge
Good Hotel Antigua

Good Hotel Antigua

Good Hotel Antigua
4.0 star property
0.4 km from Casa Santo Domingo Museum
9.2 out of 10, Wonderful, (529)
"Very friendly staff and the room was as expected, clean and cozy. "
United States
Sayda
The price is NT$5,184
NT$6,325 total
includes taxes & fees
Jan 5 - 2026/1/6
Good Hotel Antigua
Banquet hall
Pensativo House Hotel

Pensativo House Hotel

Pensativo House Hotel
4.5 star property
0.9 km from Casa Santo Domingo Museum
9.4 out of 10, Exceptional, (392)
"Rooms were clean and bed and pillows were comfortable with good A/C. Staff was very helpful and were always ready to assist. Food was excellent. "
United States
Carlos Alvarez
Pensativo House Hotel
Building design
Hostal Antigueño - Hostel

Hostal Antigueño - Hostel

Hostal Antigueño - Hostel
2.0 star property
0.3 km from Casa Santo Domingo Museum
9.0 out of 10, Wonderful, (32)
"Great place, great people! Highly recommend!"
Canada
Cody
The price is NT$527
NT$1,141 total
includes taxes & fees
Jan 19 - 2026/1/20
Hostal Antigueño - Hostel
Exterior
Hotel Casa Anturio

Hotel Casa Anturio

Hotel Casa Anturio
3.0 star property
Historic Center, 0.9 km from Casa Santo Domingo Museum
9.2 out of 10, Wonderful, (51)
"My room was spotless, the staff are very friendly and welcoming. The food is fantastic I highly recommend Casa Antorio. I Will definitely return."
Australia
Rhys
The price is NT$1,681
NT$2,050 total
includes taxes & fees
Jan 12 - 2026/1/13
Hotel Casa Anturio
Fountain
La Villa Serena

La Villa Serena

La Villa Serena
3.0 star property
1.5 km from Casa Santo Domingo Museum
9.6 out of 10, Exceptional, (110)
"room was very pretty and bed was extremely comfortable. "
United States
clara
The price is NT$2,671
NT$3,259 total
includes taxes & fees
Jan 5 - 2026/1/6
La Villa Serena
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Casa Santo Domingo Museum Hotel Reviews

Hotel Camino Real Antigua

Hotel Camino Real Antigua

10/10 Excellent
"Large and comfortable room, helpful staff, beautiful hotel, walkable to the city center. Highly recommended. "
Allegra 1-night trip
Posted 5 days ago
Hotel Camino Real Antigua

Hotels near other Casa Santo Domingo Museum attractions

Iglesia y Convento de Santo Domingo

After visiting Iglesia y Convento de Santo Domingo, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's shops, or seek out its local tours.
See properties

Jade Maya Factory and Museum

4.5/5 (188 reviews)
During your trip to Antigua Guatemala, you can do some window-shopping at Jade Maya Factory and Museum. Discover the volcano viewpoints in this romantic area, or enjoy its local tours.
See properties

Frequently asked questions

What's the area like around Casa Santo Domingo Museum?
Casa Santo Domingo Museum is located in a historic area of Antigua Guatemala known for its major shopping area. If you're looking for a convenient place to stay, check out the 488 hotels and other accommodations you'll find within a mile.
Where is the best place to stay close to Casa Santo Domingo Museum?
Adjacent to Casa Santo Domingo Museum, Hotel Museo Spa Casa Santo Domingo is one of the top choices for your stay based on our traveler data, and this hotel offers a full-service spa and 2 restaurants. Other good choices close by include Porta Hotel Antigua and Hotel Camino Real Antigua.
How many hotels will I find near Casa Santo Domingo Museum?
Expedia has 488 hotels and other accommodations within a mile from Casa Santo Domingo Museum.
If I need to cancel the hotel reservation for my stay near Casa Santo Domingo Museum, will I receive a refund?
Yes! You'll find that most room reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you may still be able to cancel and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then filter by "fully refundable" to view top deals close to Casa Santo Domingo Museum.
Where can I learn more about changing or cancelling my trip in the area near Casa Santo Domingo Museum?
To access more information about changing or cancelling your stay near Casa Santo Domingo Museum, go to https://www.expedia.com/service/.
What can I see and do near Casa Santo Domingo Museum?
You might want to spend some time browsing the exhibits at Antigua Guatemala Colonial Art Museum, Jade Maya Factory and Museum, or Casa K'Ojom Museum of Mayan Music. Explore notable local landmarks like Las Capuchinas Convent, Santa Clara Convent, and Santa Catalina Arch. Spend some time exploring the natural beauty of Central Park, Tanque La Unión, and El Reposo Spa.