Downtown Clayton, MO
St. Louis
Visit Downtown Clayton
Popular places to visit
St. Louis Union Station
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's fascinating museums or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's great live music or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Enterprise Center
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.
Forest Park
Nature, history and cultural institutions come together in one of the United States’ largest urban parks, which buzzes with St. Louis’ dynamic community spirit.
Downtown Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
Room was clean and good size. Decor was a little dated but room did seem to have been recently renovated. Bathroom was updated and higher end with a digital shower. Several restaurants within walking distance. It is located in business district with a park about ten minute walk from the hotel.
Reviewed on 2026/4/9
The Ritz-Carlton, St. Louis
Excellent and the room service food was AMAZING. We are making this hotel our go to everytime we visit st. Louis
Reviewed on 2026/3/28
Le Méridien St. Louis Clayton
Parking went up to $35 night. Small, tight hotel Parking garage, but it was secure. Ice machine in floor Wasn’t working, bar area was nice.
Reviewed on 2026/4/3
AC Hotel St. Louis Clayton
Awesome!
Reviewed on 2026/4/8
Drury Plaza Hotel St. Louis at the Arch
Nice clean room
Reviewed on 2026/4/9
Pear Tree Inn St. Louis Near Union Station
TV lost signal for hours the 2 nights we stayed during the ncaa basketball tournament. Was not happy at all!
Reviewed on 2026/4/9
Check Downtown Clayton hotel availability
Other neighborhoods around Downtown Clayton
Clayton
Visitors often come to Clayton for its abundant dining options, but many stay to explore sights like Chapel of St. Timothy And St. Titus, Concordia Seminary and Shaw Park Tennis Center. Getting around the area on the metro is easy if you catch a ride at Clayton Station.
University City
Noted for its shopping and restaurants, there's plenty to explore in University City. Top attractions like Museum of Transportation and Heman Park Tennis Center are major draws, and you can hop on the metro at Forsyth Station or U City Big Bend Station to see more of the city.
Ladue
The restaurants and churches are a few reasons travelers visit Ladue. Though there aren't many top sights in the neighborhood, you can visit Saint Louis Galleria Mall and St. Louis Zoo, a few notable attractions nearby.
Dogtown
If you're looking for some top things to see and do in Dogtown and surrounding area, you can visit St. Louis Zoo and St. Louis Art Museum.
The Hill
If you're looking for some top things to see and do in The Hill and surrounding area, you can visit St. Louis Zoo and St. Louis Science Center.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
