Clayton, MO
St. Louis
Popular places to visit
Washington University in St. Louis
Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.
St. Louis Union Station
You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.
Busch Stadium
Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed theater scene or attend a baseball game.
Gateway Arch
Enjoy 360-degree views and learn about the history of St. Louis at this world-famous landmark.
Enterprise Center
Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's great live music or attend a baseball game.
St. Louis Zoo
In the middle of St. Louis, meet the exotic and endangered animals that live in meticulously recreated ecosystems from all over the world.
Clayton Hotel Deals
Clayton Plaza Hotel & Extended Stay
This is an older property, but very clean, comfortable, spacious and convenient to downtown Clayton. Parking was convenient and free on the weekend. Breakfast was better than average, with chef-made omelets and waffles.
Reviewed on 2026/3/11
The Ritz-Carlton, St. Louis
Le Méridien St. Louis Clayton
Pool was closed for the season so didn’t get to enjoy but had wonderful view from our room. Staff and hotel was clean. Room was a little small but nice.
Reviewed on 2026/3/5
Hampton Inn & Suites Clayton/St. Louis-Galleria Area
We've stayed in this hotel several times. The rooms are clean and comfortable, and we'll return here in the future when we travel to St. Louis.
Reviewed on 2026/3/9
Pear Tree Inn St. Louis Near Union Station
Everyone and everything was amazing!! Definitely would recommend and stay again.
Reviewed on 2026/3/11
21C Museum Hotel St Louis
Such a cool hotel I love the museum on the second floor so interesting and all the penguins food is great restaurants great everything just what a great stay very unique but very quiet very cozy love everything about it. Can’t wait to stay at the other ones.
Reviewed on 2026/3/11
Other neighborhoods around Clayton
University City
Noted for its shopping and restaurants, there's plenty to explore in University City. Top attractions like Museum of Transportation and Center of Creative Arts are major draws, and you can hop on the metro at Forsyth Station or U City Big Bend Station to see more of the city.
Dogtown
If you're looking for some top things to see and do in Dogtown and surrounding area, you can visit St. Louis Zoo and St. Louis Art Museum.
Ladue
The restaurants and churches are a few reasons travelers visit Ladue. Though there aren't many top sights in the neighborhood, you can visit Saint Louis Galleria Mall and St. Louis Art Museum, a few notable attractions nearby.
The Hill
If you're looking for some top things to see and do in The Hill and surrounding area, you can visit St. Louis Science Center and Missouri Botanical Gardens and Arboretum.
Southwest Garden
Though Southwest Garden might not have many top sights, you can venture to the surrounding area to see attractions like Missouri Botanical Gardens and Arboretum and St. Louis Science Center.
Central West End
Bordering Forest Park with free cultural institutions, this St. Louis neighborhood boasts a bustling commercial district along Euclid Avenue and the world's largest mosaic collection at the Cathedral Basilica of Saint Louis.
