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Our top choices for Southeast Missouri hotels

1. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (337 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is NT$4,017
NT$4,388 total
includes taxes & fees
Nov 9 - Nov 10
Shepherd Mountain Inn

2. Madison Inn Lodge

Madison Inn Lodge
2.5 star property
Fredericktown
7.6 out of 10, Good, (314 reviews)
"Nice and clean friendly staff"
United States
Bawan
The price is NT$2,836
NT$3,098 total
includes taxes & fees
Nov 4 - Nov 5
Madison Inn Lodge

3. Holiday Inn Express & Suites Farmington by IHG

Holiday Inn Express & Suites Farmington by IHG
2.5 star property
Farmington
8.6 out of 10, Excellent, (444 reviews)
"We stayed one night and it was great! Breakfast was delicious."
United States
January
The price is NT$3,716
NT$4,296 total
includes taxes & fees
Nov 15 - Nov 16
Holiday Inn Express & Suites Farmington by IHG

4. Hampton Inn & Suites By Hilton Festus

Hampton Inn & Suites By Hilton Festus
Festus
9.4 out of 10, Exceptional, (22 reviews)
"This was a wonderful hotel and had a wonderful stay. Room was clean and staff was wonderful."
United States
Misty
The price is NT$3,714
NT$4,247 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn & Suites By Hilton Festus

5. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very good, (690 reviews)
"Clean nice staff are great"
United States
Marisa
The price is NT$1,939
NT$2,217 total
includes taxes & fees
Nov 17 - Nov 18
Super 8 by Wyndham Farmington

6. Fort Davidson Hotel

Fort Davidson Hotel
2.5 star property
Ironton
9.2 out of 10, Wonderful, (190 reviews)
"Clean rooms , nice pool."
United States
richard
The price is NT$4,073
NT$4,449 total
includes taxes & fees
Nov 6 - Nov 7
Fort Davidson Hotel

7. Hampton Inn Farmington

Hampton Inn Farmington
2.5 star property
Farmington
8.8 out of 10, Excellent, (582 reviews)
"The staff were so friendly & housekeeping came in each day to take care of our room. The breakfast was one of the best we have had. We had a great stay. Thank you to the staff!"
United States
Charlie
The price is NT$3,270
NT$3,739 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Farmington

8. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (975 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is NT$3,157
NT$3,567 total
includes taxes & fees
Nov 15 - Nov 16
Fairfield Inn & Suites by Marriott Poplar Bluff

9. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,002 reviews)
"Clean, great food, excellent staff."
United States
Dean
The price is NT$2,932
NT$3,313 total
includes taxes & fees
Nov 8 - Nov 9
Drury Inn & Suites Poplar Bluff

10. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,005 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
The price is NT$1,773
NT$2,027 total
includes taxes & fees
Nov 17 - Nov 18
Baymont Inn and Suites by Wyndham Farmington, MO

11. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
8.8 out of 10, Excellent, (700 reviews)
"Tucked away gem."
United States
christopher
The price is NT$3,296
NT$3,769 total
includes taxes & fees
Dec 3 - Dec 4
Crown Pointe Lodge, BW Signature Collection

12. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (117 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is NT$3,426
NT$3,729 total
includes taxes & fees
Nov 15 - Nov 16
EC Reed's Mercantile and Hotel

13. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (644 reviews)
"Excellent stay , couldn't believe the property was 10 years old , it looks like it was just built , great place , highly recommend ."
United States
allan p.
The price is NT$3,291
NT$3,767 total
includes taxes & fees
Nov 22 - Nov 23
Holiday Inn Express & Suites Perryville by IHG

14. Super 8 by Wyndham Perryville

Super 8 by Wyndham Perryville
2.0 star property
Perryville
8.6 out of 10, Excellent, (1,004 reviews)
"Nice room, friendly staff."
United States
Matthew
The price is NT$2,243
NT$2,568 total
includes taxes & fees
Nov 29 - Nov 30
Super 8 by Wyndham Perryville

15. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is NT$3,292
NT$3,744 total
includes taxes & fees
Nov 15 - Nov 16
Fairfield Inn & Suites by Marriott Sikeston

16. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,003 reviews)
"Everything was great about the stay!"
United States
Denise
The price is NT$2,963
NT$3,318 total
includes taxes & fees
Nov 15 - Nov 16
Hampton Inn Poplar Bluff

17. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (890 reviews)
"Breakfast was good."
United States
J
The price is NT$2,603
NT$2,818 total
includes taxes & fees
Nov 22 - Nov 23
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

18. La Quinta Inn & Suites by Wyndham Festus - St. Louis South

La Quinta Inn & Suites by Wyndham Festus - St. Louis South
3.0 star property
Festus
7.8 out of 10, Good, (1,004 reviews)
"it's nice to see familiar faces's. Daniella, the tiny girl with the great short hair and your breakfast server. Good luck and we'll be back. Thanks"
United States
Vincent
The price is NT$2,742
NT$3,135 total
includes taxes & fees
Nov 17 - Nov 18
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

19. Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville
3.0 star property
Hayti
9.2 out of 10, Wonderful, (1,001 reviews)
"Food and drinks were very good."
United States
Philip
The price is NT$3,193
NT$3,639 total
includes taxes & fees
Nov 22 - Nov 23
Drury Inn & Suites Hayti Caruthersville

20. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,008 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is NT$3,258
NT$3,675 total
includes taxes & fees
Nov 10 - Nov 11
Drury Plaza Hotel Cape Girardeau Conference Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Vacation Rentals in Southeast Missouri

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Stay near popular Southeast Missouri attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from K Bridge Recreation Area to Lake Wappapello State Park.

A historical marker sign for the Frisco Depot, detailing its construction in 1928, architectural style, and historical significance.
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Southeast Missouri is perfect for outdoor enthusiasts, featuring scenic parks and recreational activities that invite exploration.
  • Cultural Experiences: Engage with local culture through campus tours, breweries, and historic civic buildings that reflect the region’s heritage.
  • Charming Neighborhoods: Stroll through friendly neighborhoods that offer a welcoming atmosphere and a taste of local life.
  • Family-Friendly Activities: The area provides a variety of activities suitable for families, making it an ideal vacation spot.
  • Warm Hospitality: Enjoy the warmth of Southern hospitality in a range of charming hotels and lodges.

Find great hotels near Southeast Missouri

Discover a range of charming hotels in Southeast Missouri, perfect for business travelers, adventure seekers, and couples looking for a romantic getaway. Whether you’re searching for the closest accommodations or the best-reviewed options, you’ll find a variety of lodges and hotels that cater to your needs. Embrace the warmth of Southern hospitality and make your stay in Southeast Missouri a memorable one.

  • Madison Inn Lodge: A welcoming motel ideal for business travelers and pet owners alike, Madison Inn Lodge is located 25.7km from Southeast Missouri. This property offers a practical and comfortable stay with amenities tailored for those traveling with pets. Guests appreciate the pet-friendly policy, which includes restrictions to ensure a pleasant environment for all. The lodge features essential amenities designed for business needs, making it a great choice for corporate travelers seeking convenience and comfort.
  • Shepherd Mountain Inn: Positioned 33.8km from Southeast Missouri, Shepherd Mountain Inn stands as a solid choice for business travelers. This hotel combines a professional atmosphere with essential amenities, ensuring a smooth and productive stay. Guests often note the hotel's commitment to providing a comfortable environment, making it suitable for those on work trips or visiting the area for business events. Its strategic location also allows easy access to local attractions, enhancing the overall experience.
  • Alpaca Farm Stay: Located 12.9km from Southeast Missouri, Alpaca Farm Stay offers a unique and adventurous escape for families and couples. This lodge invites guests to immerse themselves in a delightful rural setting, featuring adventure sports options like kayaking, mountain climbing, and fishing nearby. Families will enjoy the shared playground for children, while couples can take advantage of romantic packages. With stunning lake and mountain views available, this property ensures a memorable getaway filled with excitement and relaxation.

Where to stay near Southeast Missouri

In Southeast Missouri, visitors can enjoy a blend of outdoor adventures and picturesque scenery perfect for families. Enjoy leisurely strolls through charming neighborhoods, where friendly locals create a welcoming atmosphere. This region is known for its scenic retreats and recreational activities, making it an ideal vacation spot. With convenient locations and vibrant community vibes, Southeast Missouri promises a delightful experience for all travelers looking to unwind and explore.

  • Central Fredericktown: Nestled about 16.1km from Southeast Missouri, Central Fredericktown is a charming village that attracts visitors year-round, with peak seasons occurring from June to August. This quaint area is ideal for families seeking outdoor adventures and city-themed experiences. Notable activities include exploring the local recreational areas, shopping at the mall center, and visiting the history museum. The village is home to lovely parks and urban greenspaces, providing ample opportunities for relaxation and enjoyment. Central Fredericktown offers a delightful mix of history and recreation that makes it a perfect stop for tourists.
  • Annapolis: Located approximately 22.5km away from Southeast Missouri, Annapolis is a vibrant city known for its stunning scenery and adventurous spirit. The city sees a steady stream of visitors throughout the year, peaking in June, July, and September. Travelers flock to Annapolis for its outdoor activities and picturesque landscapes, including national state parks and rivers. With recreational areas and an arena entertainment facility, there’s no shortage of fun and excitement. Whether you’re hiking through scenic trails or enjoying a day by the water, Annapolis promises an unforgettable experience for all types of adventurers.
  • Des Arc: Situated around 17.7km from Southeast Missouri, Des Arc is a lively city that experiences seasonal fluctuations in visitor numbers, with the summer months from June to August being the most popular. Known for its outdoor activities and natural beauty, Des Arc is a haven for adventure seekers. Visitors can enjoy recreational areas, a water park, and an arena entertainment facility. The nearby national state park, lake, and river provide the perfect backdrop for a day of exploration and relaxation. Des Arc is an excellent destination for those looking to immerse themselves in nature while enjoying a variety of fun-filled activities.

Things to do near Southeast Missouri

Southeast Missouri offers a wealth of outdoor adventures and scenic beauty, perfect for a memorable vacation. Engage in campus tours, outdoor activities, and sports tournaments, or explore local breweries on guided tours. Educational experiences abound, making it an excellent destination for those seeking both fun and learning. With recreational areas and entertainment facilities, there's something for everyone to enjoy in this vibrant region.

Shopping

For a unique shopping experience, visit Red's Flea Market, located 41.8km from Southeast Missouri, offering a variety of local goods. For a more traditional mall experience, check out the Farmington Mineral Area Shopping Center, 48.3km away, featuring entertainment and family-friendly shops.

Recreation

Crane Lake Recreation Area offers a serene environment perfect for relaxation and wellness activities, surrounded by nature's beauty. Silver Mine Recreation Area provides a tranquil setting for rejuvenation, while Arcadia Valley Golf Club combines outdoor sports with stunning landscapes, making it ideal for both leisure and recreation.

Adventure

At Shepherd Mountain Bike Park and Hiking Trails, located 33.8km from Southeast Missouri, enjoy exhilarating mountain biking and scenic hiking. The trails offer a thrilling adventure amidst picturesque landscapes, perfect for outdoor enthusiasts seeking both excitement and natural beauty.

Nightlife

In Southeast Missouri, Cape Girardeau's Riverfront offers vibrant bars and live music, while Sikeston's popular casinos provide exciting gaming and entertainment options. Enjoy the lively atmosphere, delicious local cuisine, and friendly crowds at these nightlife hotspots, perfect for an unforgettable evening out.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

To save money on your trip to Southeast Missouri, consider visiting between November and January when accommodation prices are lower. Tuesdays are the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to find hotel deals by filtering options to suit your budget and preferences, including eco-certified hotels. Additionally, booking a package that combines flights and hotel stays can yield significant savings. Make sure to compare room rates to secure the best deal available for your accommodation.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to refine your preferences, such as your budget, desired location, and preferred type of accommodation. For instance, selecting the Eco-certified option will showcase sustainable and environmentally friendly hotels that are currently available. If you're looking for the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by booking an Expedia package that combines your hotel accommodations in Southeast Missouri with your flights and activities.

Find the best attractions near Southeast Missouri

Southeast Missouri offers a fantastic getaway for outdoor enthusiasts and culture seekers alike. Visitors can explore scenic urban parks, national state parks, and historic civic government buildings. The area is perfect for those looking to connect with nature and experience local culture. Additionally, travelers can check out nearby attractions and visit Southeast Missouri State University for a taste of local education and community life.

  • Walnut Hollow Lake: Experience the serene beauty of Walnut Hollow Lake, located 20.9km from Southeast Missouri. This picturesque lake offers a charming beach, perfect for romantic getaways or family outings amidst stunning scenery.
  • K Bridge Recreation Area: Just 27.4km away, K Bridge Recreation Area is an urban park that caters to families and city dwellers alike. Enjoy outdoor activities surrounded by lush landscapes, making it an ideal spot for a fun-filled day with loved ones.
  • Millstream Gardens Conservation Area: Situated 24.1km from the city, this reserve offers a blend of adventure and relaxation. With its welcoming atmosphere, Millstream Gardens is perfect for families, and you can explore its historical significance while enjoying nature.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are slightly high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4000000000000004°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.700000000000003°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.200000000000003°C)Light RainMostly SunnySlightly HighAverage
August77.2°F (25.1°C)Light RainMostly SunnySlightly HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1000000000000005°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

Traveling to Southeast Missouri can be conveniently done by flying into one of its major airports. St. Louis Lambert International Airport (STL) is located 154.5km away, with nearby hotel options like The Ritz-Carlton and Ameristar Casino Resort, both about 11.3km from the airport. Fort Leonard Wood Regional Airport (TBN) is also 154.5km away, featuring hotels such as Z Loft Extended Stay Hotel, 9.7km from the terminal. Alternatively, Marion Williamson County Regional Airport (MWA) is 133.6km away, offering accommodations like Drury Inn & Suites just 3.2km from the airport. Each airport provides various transportation services for easy access to local hotels.

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