Photo by Bill Dillard
Southeast Missouri 3 Stars Hotels
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southeast Missouri 3 Star Hotels
Our top choices for Southeast Missouri 3-star hotels
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference CenterCape Girardeau
9.6 out of 10, Exceptional, (1,000 reviews)
"Hotel was nice and staff was quite helpful!"
Linda
The price is NT$3,145
NT$3,549 total
includes taxes & fees
May 17 - May 18
9.6 out of 10, Exceptional, (1,001 reviews)
"Nice place to stay"
Lance
The price is NT$3,499
NT$4,023 total
includes taxes & fees
May 17 - May 18
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
La Quinta Inn & Suites by Wyndham Jackson/Cape GirardeauJackson
9.0 out of 10, Wonderful, (755 reviews)
"Property was easily accessible and very clean!!"
Denise
The price is NT$2,809
NT$3,040 total
includes taxes & fees
Apr 30 - May 1
9.4 out of 10, Exceptional, (1,012 reviews)
"Great food and friendly staff. "
Debra
The price is NT$3,342
NT$3,809 total
includes taxes & fees
May 4 - May 5
La Quinta Inn & Suites by Wyndham Festus - St. Louis South
La Quinta Inn & Suites by Wyndham Festus - St. Louis SouthFestus
8.0 out of 10, Very Good, (972 reviews)
"Staff was super nice! "
Youpeng
The price is NT$3,436
NT$3,930 total
includes taxes & fees
Apr 30 - May 1
Fairfield Inn & Suites by Marriott Cape Girardeau
Fairfield Inn & Suites by Marriott Cape GirardeauCape Girardeau
9.4 out of 10, Exceptional, (177 reviews)
"Nice room, good breakfast "
KENNETH
The price is NT$2,921
NT$3,295 total
includes taxes & fees
May 7 - May 8
8.8 out of 10, Excellent, (736 reviews)
"Wonderful restaurant and rooms "
Robert
The price is NT$2,806
NT$3,170 total
includes taxes & fees
May 23 - May 24
9.4 out of 10, Exceptional, (1,004 reviews)
"Clean room, friendly staff, great breakfast. "
jessica
The price is NT$2,963
NT$3,343 total
includes taxes & fees
May 10 - May 11
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 3-star hotels. See all 4-star hotels in Southeast Missouri.
The Riverview
777 Main St Cape Girardeau MO
The price is NT$4,171 per night from May 4 to May 5
NT$4,171
NT$4,706 total
May 4 - May 5
includes taxes & fees
9.4/10 Exceptional! (559 reviews)
Still don't see what you're looking for?
See all properties in Southeast Missouri.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Southeast Missouri
Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.
Photo by Bill Dillard
Open Photo by Bill Dillard
Top Southeast Missouri Hotel Reviews
Drury Inn & Suites Hayti Caruthersville
10/10 Excellent
Frequently asked questions
Explore a world of travel with Expedia
- Hotels with smoking rooms in Farmington
- Hotels near Sand Creek Winery
- 3 Star Hotels in Doe Run
- Resorts & Hotels with Spas in Perryville
- 3 Star Hotels in Oran
- Hotels near Millstream Gardens Conservation Area
- Romantic Hotels in Poplar Bluff
- Van Buren Hotels
- 3 Star Hotels in Doniphan
- Pilot Knob Hotels
- Pet-Friendly Hotels in Poplar Bluff
- Adults Only Resorts & in Southeast Missouri
- Hotels with a Pool in Bonne Terre
- Marble Hill Hotels
- Hotels near Elephant Rocks State Park
- Hotel Wedding Venues Hotels in Southeast Missouri
- Hotels with Hot Tubs in Poplar Bluff
- Hotels near National Shrine of Our Lady of the Miraculous Medal
- Cottages in Wayne County
- Hotels near Taum Sauk Mountain State Park
- Cheap Hotels in Farmington
- Belleview Hotels
- Luxury Hotels in Farmington
- Hotels with a Pool in Fredericktown
- Hotels with Bars in Farmington
- Perryville Hotels
- Park Hills Hotels
- Cheap Hotels in Poplar Bluff
- 4 Star Hotels in Cadet
- Hotels with an Indoor Pool in Jackson
- Motels in Belleview
- Farmington Hotels
- Hotel Wedding Venues Hotels in Perryville
- Bloomfield Hotels
- Hotels near Walnut Hollow Lake
- Bonne Terre Hotels
- Hotels with Bars in Jackson
- Hotels with an Indoor Pool in Bonne Terre
- 3 Star Hotels in Cadet
- Hotels near Mo-Ark Regional Railroad Museum
- Black Hotels
- Hotels with an Indoor Pool in Poplar Bluff
- Hotels near Johnson's Shut-ins State Park
- Pet-Friendly Hotels in Perryville
- Hotel Wedding Venues Hotels in Farmington
- Casino Hotels in Farmington
- Fredericktown Hotels
- Hotels near Big River
- Potosi Hotels
- Hotels near Missouri's National Veterans Memorial
- Flights from Southeast Missouri
- Flights from Black
- Flights from Mountain Home (WMH) to Poplar Bluff (POF)
- Flights from Jasper (APT) to Poplar Bluff (POF)
- Flights from Fredericktown
- Flights from Murray (CEY) to Poplar Bluff (POF)
- Flights from Park Hills
- Flights from Valles Mines
- Flights to Southeast Missouri
- Flights from St. Louis (SUS) to Poplar Bluff (POF)
- Flights from Ada (ADT) to Poplar Bluff (POF)
- Flights to Ironton
- Flights from Friedheim
- Flights from Belleview
- Flights from New Offenburg
- Flights from Minneapolis (MSP) to Poplar Bluff (POF)
- Flights to Fredericktown
- Flights from Los Angeles (LAX) to Poplar Bluff (POF)
- Flights from Branson (BKG) to Poplar Bluff (POF)
- Visit Friedheim
- Twin Oaks Vineyard & Winery
- Taum Sauk Mountain State Park
- Visit Middle Brook
- Visit Flat River
- Crown Valley Winery
- Visit Belleview
- Visit Marble Hill
- Visit Ironton
- Visit Dutchtown
- Visit Ellington
- Visit Farmington
- Visit Annapolis
- Johnson's Shut-ins State Park
- National Shrine of Our Lady of the Miraculous Medal
- Visit Lesterville
- Visit Desloge
- Weingarten Vineyard
- Visit Zalma
- Visit Jackson
- Walnut Hollow Lake