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Find Business Hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri Business Hotels

Our top choices for Southeast Missouri business-friendly hotels

Property amenity
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
"Clean room, great location and friendly staff"
United States
Mark
The price is NT$2,807
NT$3,227 total
includes taxes & fees
Dec 20 - Dec 21
Drury Inn & Suites Sikeston, MO
Lobby
Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1004)
"Great place and staff, very accommodating!"
United States
Megan
The price is NT$2,807
NT$3,167 total
includes taxes & fees
Dec 21 - Dec 22
Drury Plaza Hotel Cape Girardeau Conference Center
Front of property
Echo Bluff State Park

Echo Bluff State Park

Echo Bluff State Park
2.5 star property
Eminence
9.6 out of 10, Exceptional, (217)
"The cabin was beautiful, comfy, & private! The park was FANTASTIC for hiking & scenery! We hope to return and maybe bring family or friends. The staff were all friendly too! :)"
United States
Joanne
The price is NT$4,960
NT$5,244 total
includes taxes & fees
Dec 18 - Dec 19
Echo Bluff State Park
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (702)
"Amazing place"
United States
Mladen
The price is NT$3,151
NT$3,559 total
includes taxes & fees
Dec 21 - Dec 22
Holiday Inn Poplar Bluff by IHG
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (964)
"Nice room helpful staff. "
United States
Deborah
The price is NT$2,932
NT$3,312 total
includes taxes & fees
Dec 21 - Dec 22
Drury Inn & Suites Poplar Bluff
Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (855)
"Very clean, great check in"
United States
Teresa
The price is NT$3,244
NT$3,665 total
includes taxes & fees
Jan 16 - 2026/1/17
Fairfield Inn & Suites by Marriott Poplar Bluff
Exterior
Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (540)
"Clean room and pleasant staff"
United States
David
The price is NT$2,714
NT$3,107 total
includes taxes & fees
Dec 25 - Dec 26
Holiday Inn Express & Suites Perryville by IHG
Lobby
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (468)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is NT$3,619
NT$4,100 total
includes taxes & fees
Dec 25 - Dec 26
Courtyard by Marriott Cape Girardeau Downtown
Exterior
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is NT$1,731
NT$1,973 total
includes taxes & fees
Dec 21 - Dec 22
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Children's play area - outdoor
Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View

Honeysuckle Inn - Mountain View
3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is NT$2,976
NT$3,226 total
includes taxes & fees
Dec 17 - Dec 18
Honeysuckle Inn - Mountain View
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Top Southeast Missouri Hotel Reviews

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

10/10 Excellent
"The room was clean, comfortable, cozy. "
Deborah 1-night trip
Posted 3 days ago
Holiday Inn Poplar Bluff by IHG

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Frequently asked questions

How much do business-friendly hotels in Southeast Missouri cost?
Rates for business hotels in Southeast Missouri range between NT$1,973 and NT$5,244 per night. No matter your budget, Expedia is here to help you find the perfect place to get the job done. These prices were available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
What are the best business-friendly hotels in Southeast Missouri?
Southeast Missouri has multiple business-friendly hotels with a total average guest review rating of 9.1. Attending a work-related event in Cape Girardeau? Hampton Inn Cape Girardeau I 55 East is a 2.5-stars stay that comes highly recommended by corporate travelers and includes a dining venue and a terrace. Another excellent choice for a business trip is Drury Plaza Hotel Cape Girardeau Conference Center. Also in Cape Girardeau, it has a 3-stars rating and amenities such as a swimming pool and a restaurant.
How many business-friendly hotels are there in Southeast Missouri?
Southeast Missouri has 50 business-friendly hotels to pick from. Whether you're meeting with new clients or working remotely, these stays come with the services and amenities you need to be productive.
What are the best cheap business-friendly hotels in Southeast Missouri?
When you're on the road for work in Southeast Missouri, Expedia will help you find the ideal business-friendly hotel. Hampton Inn Cape Girardeau I 55 East is a budget pick in Cape Girardeau. A dining venue and a swimming pool are some of its many amenities. Seeking affordable stays in Sikeston? Pear Tree Inn Sikeston is recommended by many corporate travelers. It offers conveniences that make it easy to both work and play, such as a swimming pool and a spa tub. Business-friendly hotels in Southeast Missouri start at just NT$1,973 a night. You'll find tons of fabulous and free attractions wherever you're off to in Southeast Missouri. If you're meeting with clients in Cape Girardeau, try to make time in your schedule for Hunter Valley Winery. You can also see the sights without spending a penny in Sikeston. Sikeston Depot Museum is one of the most popular free things to do here. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply.
Are there any family-friendly hotels in Southeast Missouri that are also business friendly?
There sure are. Whether you're searching for a stay in Southeast Missouri with a conference room or a quiet space to work alone, con espacio para trabajar Expedia's got you sorted. Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau is a fantastic choice. This 3-stars business and family-friendly option comes with all the necessary conveniences, like complimentary breakfast and housekeeping services. Pear Tree Inn Cape Girardeau West is another option in Cape Girardeau where corporate travelers can get some work done with the family in tow. Complimentary breakfast and a laundry service are among the many amenities at this 2.5-stars hotel. When you've finished work, it's time to discover Cape Girardeau with the kids. Popular family-friendly attractions include Cape Splash Family Aquatic Center and Lazy L Safari Park.
Why book your business-friendly hotel in Southeast Missouri with Expedia?
Expedia is here to help you find an ideal business-friendly hotel when work takes you away from home. From meeting rooms and conference spaces to gyms and on-site restaurants, our stays have all the amenities you'll need to settle that big contract.
How can I find cheap business-friendly hotels in Southeast Missouri?
Select the "business friendly" filter, located under the "traveler experience" heading, to find cheap business-friendly hotels in Southeast Missouri. Then fine-tune your search by your per-night budget. Basing yourself outside the city center is another easy way to save.
What is there to do in Southeast Missouri near my business-friendly hotel?
The most important accessory for your Southeast Missouri work visit is an epic itinerary for your downtime! Isle Casino Cape Girardeau, Show Me Center and Riverfront Park are among the top sights if you're headed to Cape Girardeau. Sikeston is also home to terrific attractions, such as Sikeston Depot Museum, Central Park and The Book Bug.