Find hotels in Santo Spirito, Florence from NT$2,763

Start date: Check-in selected.
To Date
End date: Check-out

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
Dec 2 - Dec 3
Tomorrow
Dec 3 - Dec 4
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Filter by

Guest rating
Guest rating
Star rating

Discover 477 Santo Spirito hotels and places to stay, with room rates, reviews, and availability. Most hotels are fully refundable.

Lobby
Hotel Horto Convento

Hotel Horto Convento

4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (594)
"Excellent staff, so friendly and helpful. Lovely hotel in a great location. "
United Kingdom
Emma
The price is NT$3,705
NT$4,586 total
includes taxes & fees
Dec 21 - Dec 22
Hotel Horto Convento
Lobby
Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

Santo Spirito
8.8 out of 10, Excellent, (337)
"I always enjoy my stay here. Nicely located, pleasant breakfast, terrific courtyard, nicely priced. "
United States
Marcie
Casa Santo Nome di Gesù
Interior
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Santo Spirito
8.8 out of 10, Excellent, (192)
"The staff was very helpful and room was clean "
United States
Cinda
Foresteria Valdese di Firenze - Casa per Ferie
Interior detail
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1069)
"Perfect stay"
United States
Juan P
Palazzo Mannaioni Suites
Front of property
Hotel Firenze 2000

Hotel Firenze 2000

2.0 star property
Santo Spirito
7.2 out of 10, Good, (189)
"The staff was wonderful and very helpful; 24 hr service ! The room was very clean and breakfast was plentiful. Great location if you don’t mind a short walk to the historic town center ; would definitely recommend."
Canada
Josee
The price is NT$2,213
NT$2,763 total
includes taxes & fees
Dec 14 - Dec 15
Hotel Firenze 2000
Classic Suite, 1 King Bed | Premium bedding, down comforters, in-room safe, desk
La Torre Del Cestello

La Torre Del Cestello

Santo Spirito
9.0 out of 10, Wonderful, (227)
"Great location and great rooms"
United States
David
The price is NT$2,298
NT$3,039 total
includes taxes & fees
Dec 8 - Dec 9
La Torre Del Cestello
Royal Double Room | Minibar, in-room safe, soundproofing, free WiFi
Oltrarno Splendid

Oltrarno Splendid

Santo Spirito
10.0 out of 10, Exceptional, (96)
"It was Wonderful!!!"
United States
MARGARITA
The price is NT$5,303
NT$6,344 total
includes taxes & fees
Dec 15 - Dec 16
Oltrarno Splendid
Free daily buffet breakfast
La Fonderia Firenze

La Fonderia Firenze

Santo Spirito
9.6 out of 10, Exceptional, (172)
"Breakfast outside was lovely"
United States
Kenneth
The price is NT$3,250
NT$4,012 total
includes taxes & fees
Dec 4 - Dec 5
La Fonderia Firenze
Front of property
Palazzo D'Oltrarno - Residenza D'Epoca

Palazzo D'Oltrarno - Residenza D'Epoca

Santo Spirito
9.4 out of 10, Exceptional, (46)
"Excellent place to stay!"
United States
Diane
The price is NT$4,893
NT$5,821 total
includes taxes & fees
Jan 2 - 2026/1/3
Palazzo D'Oltrarno - Residenza D'Epoca
Premium Double Room, Annex Building (in the garden) | Down comforters, in-room safe, individually decorated, desk
AdAstra Suites

AdAstra Suites

Santo Spirito
9.8 out of 10, Exceptional, (221)
"Great Room - Lovely breakfast excellent strong Cappuccino and lovely yoghurts. Thanks see you soon. "
United Kingdom
Tim
The price is NT$5,641
NT$6,716 total
includes taxes & fees
Dec 4 - Dec 5
AdAstra Suites
Comfort Double Room, Private Bathroom, Courtyard View | Courtyard view
Drom Florence Rooms & Apartments

Drom Florence Rooms & Apartments

Santo Spirito
9.8 out of 10, Exceptional, (135)
"Ver clean and quiet, wonderful stay."
United States
kevin
Drom Florence Rooms & Apartments
Seasonal outdoor pool
Torre di Bellosguardo

Torre di Bellosguardo

4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103)
"Beautiful property and wonderful staff."
United States
Brad
The price is NT$11,710
NT$13,391 total
includes taxes & fees
Dec 15 - Dec 16
Torre di Bellosguardo
Lounge
Hotel Palazzo Guadagni

Hotel Palazzo Guadagni

3.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (200)
"Hotel Palazzo was stunning. I would definitely stay here again and I already can't wait to! The staff were so friendly and made you feel right at home. Everything was walking distance and the area was incredible!"
United States
Annyelis
The price is NT$5,867
NT$6,891 total
includes taxes & fees
Dec 17 - Dec 18
Hotel Palazzo Guadagni
Exterior detail
Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8

Santo Spirito
8.8 out of 10, Excellent, (138)
"Very nice place to stay. closed to good restaurantsand shopping. "
United States
JULIO
The price is NT$2,298
NT$3,039 total
includes taxes & fees
Dec 8 - Dec 9
Residenza D'Epoca Al Numero 8
Garden
Ottantotto Firenze

Ottantotto Firenze

Santo Spirito
9.6 out of 10, Exceptional, (169)
"Fabulous hotel , breakfast was amazing , great location "
United Kingdom
SAMANTHA
The price is NT$6,749
NT$7,935 total
includes taxes & fees
Dec 18 - Dec 19
Ottantotto Firenze
Comfort Double Room | In-room safe, desk, free WiFi
L'Antica Porta Boutique B&B

L'Antica Porta Boutique B&B

Santo Spirito
9.0 out of 10, Wonderful, (19)
"Clean and comfy room | Easy transportation | Safe"
United States
Gabriel
The price is NT$3,492
NT$4,279 total
includes taxes & fees
Dec 9 - Dec 10
L'Antica Porta Boutique B&B
Reception
Hostel Santa Monaca

Hostel Santa Monaca

Santo Spirito
8.0 out of 10, Very Good, (60)
"I found it easy to move around and walked everywhere. Staff super friendly. Ten people in one room was a bit much, but overall comfortable. Thank you.!"
Canada
Alma
Hostel Santa Monaca
22-inch flat-screen TV with digital channels, TV
1900 Artevita

1900 Artevita

Santo Spirito
8.8 out of 10, Excellent, (176)
"This property is great and the manager is very kind and helpful."
United States
Elizabeth
1900 Artevita
Front of property
Soderini Apartments by MMega

Soderini Apartments by MMega

Santo Spirito
9.6 out of 10, Exceptional, (7)
"Having laundry in the room was great! The location was nice. Easy to walk to tourist sites. Grocery store was almost next door. Gelato store was almost next door. All the bases were covered!"
Canada
Brett
The price is NT$2,086
NT$5,651 total
includes taxes & fees
Dec 3 - Dec 4
Soderini Apartments by MMega
Reception
Home in Florence

Home in Florence

Santo Spirito
9.0 out of 10, Wonderful, (70)
"Perfect place, super friendly owners, really helpful. "
United Kingdom
Paul
The price is NT$2,507
NT$3,196 total
includes taxes & fees
Dec 9 - Dec 10
Home in Florence
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito
Arcetri showing a bridge and a river or creek

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo featuring heritage architecture and street scenes as well as a small group of people

Duomo

Via de' Calzaiuoli and Giotto's Campanile are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

Santa Maria Novella which includes heritage architecture, a church or cathedral and street scenes

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. The New Florence Opera House is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Uffizi Gallery which includes street scenes as well as a large group of people

San Giovanni

If you're spending some time in San Giovanni, Piazza della Repubblica and Via de' Calzaiuoli are top sights worth seeing.

Piazza Santa Croce showing a city and street scenes

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Hotel Horto Convento

Hotel Horto Convento

10/10 Excellent
"Staff were super lovely, we were greeted by a very enthusiastic and full of character Giovanni who made us feel welcome. The place is very well kept, breakfast had a surprisingly wider variety of food for a continental breakfast, and is in a nice quiet part of Florence that is still accessible to the city centre. There are also some roaming cats around that became joyful to spot throughout our stay - thoroughly recommend this hotel!"
Jeff 4-night trip
Posted 10 days ago
Hotel Horto Convento

Explore a world of travel with Expedia

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighborhood known for its beautiful river views. Be sure to check out Porta Romana and Piazza Santo Spirito as part of your Santo Spirito travel plans.
What's the best accommodation in Santo Spirito?
Based on Expedia customer reviews, Oltrarno Splendid is the highest ranked property in Santo Spirito. This B&B is a short 7-minute walk from Piazza di Santa Maria Novella, and it offers free breakfast and free WiFi. Other favorite options in the area include AdAstra Suites and SPIRIT OF FLORENCE Boutique Rooms.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 474 hotels and other accommodations in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals in Santo Spirito.
Where can I learn more about changing or cancelling my trip to Santo Spirito?
To find more details about updating your trip to Santo Spirito or cancelling it, head over to our customer service page.
What can I see and do in this Florence neighborhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighborhood, Porta Romana and Piazza Santo Spirito are some other places worth a visit. A few places to visit in the area around Santo Spirito include Piazza del Carmine, Santa Maria della Carmine, and Brancacci Chapel. When you're sightseeing in Florence, Il Nabucco di Matteo Gabellini and Teatro Comunale Florence are also worth a stop.