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Check prices for these dates

This weekend
May 22 - May 24
Next weekend
May 29 - May 31

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Our top choices for Santo Spirito hotels

Suite | Room amenity

Torre di Bellosguardo

Torre di Bellosguardo
4.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (103 reviews)
"Beautiful property and wonderful staff."
United States
Brad
The price is NT$17,919
NT$20,225 total
includes taxes & fees
May 28 - May 29
Torre di Bellosguardo
Lobby

Hotel Horto Convento

Hotel Horto Convento
4.0 star property
Santo Spirito
9.8 out of 10, Exceptional, (660 reviews)
"Amazing stay! Beautiful property! The spa is a wonderful amenity."
United States
Mina
The price is NT$10,763
NT$12,353 total
includes taxes & fees
Jun 22 - Jun 23
Hotel Horto Convento
Royal Double Room | Minibar, in-room safe, soundproofing, free WiFi

Oltrarno Splendid

Oltrarno Splendid
Santo Spirito
10.0 out of 10, Exceptional, (117 reviews)
"Fabulous place to stay"
United Kingdom
Kenneth
The price is NT$12,889
NT$14,692 total
includes taxes & fees
Jun 21 - Jun 22
Oltrarno Splendid
Apartment | 5 bedrooms, laptop workspace, iron/ironing board, free WiFi

Mamo Florence - Ardiglione Apartment

Mamo Florence - Ardiglione Apartment
Santo Spirito
8.0 out of 10, Very Good, (2 reviews)
"Located on quiet street that was within walking distance to shops, restaurants and santo spirito plaza. Great size apartment for large group. "
United States
PATRICIA
The price is NT$11,704
NT$20,677 total
includes taxes & fees
Jun 2 - Jun 3
Mamo Florence - Ardiglione Apartment
Suite | Egyptian cotton sheets, premium bedding, in-room safe, desk

Palazzo Mannaioni Suites

Palazzo Mannaioni Suites
4.0 star property
Santo Spirito
9.2 out of 10, Wonderful, (1,115 reviews)
"The management waswarm and welcoming and helped assist us with restaurants, travel and sightseeing."
United States
Janet
The price is NT$9,494
NT$10,957 total
includes taxes & fees
Jun 1 - Jun 2
Palazzo Mannaioni Suites
Panoramic Double Room, 1 Bedroom, Air conditioning, City View | Hypo-allergenic bedding, minibar, blackout drapes, soundproofing

SPIRIT OF FLORENCE Boutique Rooms

SPIRIT OF FLORENCE Boutique Rooms
Santo Spirito
10.0 out of 10, Exceptional, (25 reviews)
"Easy check in and very helpful and polite "
United States
Remi
The price is NT$11,386
NT$12,966 total
includes taxes & fees
Jun 7 - Jun 8
SPIRIT OF FLORENCE Boutique Rooms
Living area

Da mamma Grazia in Oltrarno by MMega

Da mamma Grazia in Oltrarno by MMega
Santo Spirito
The price is NT$240,350
NT$268,497 total
includes taxes & fees
Jun 5 - Jun 6
Da mamma Grazia in Oltrarno by MMega
Lobby sitting area

AdAstra Suites

AdAstra Suites
Santo Spirito
9.8 out of 10, Exceptional, (228 reviews)
"Great breakfast! Helpful staff! Very private and quiet. "
United States
howard
The price is NT$13,853
NT$15,753 total
includes taxes & fees
Jun 15 - Jun 16
AdAstra Suites
Front of property

Hotel Firenze 2000

Hotel Firenze 2000
2.0 star property
Santo Spirito
7.2 out of 10, Good, (195 reviews)
"The staff was very nice!"
Canada
Sergiu
The price is NT$3,867
NT$4,584 total
includes taxes & fees
May 24 - May 25
Hotel Firenze 2000
Double Room, Garden View | Pillowtop beds, minibar, in-room safe, desk

La Fonderia Firenze

La Fonderia Firenze
Santo Spirito
9.6 out of 10, Exceptional, (180 reviews)
"A charming place well situated to explore, a bit of a reprieve from the very busy area. Joan was very attentive and helpful, and offered a good breakfast that set us up well for the day. Very clean."
Canada
Hilary
The price is NT$5,940
NT$6,975 total
includes taxes & fees
Jun 10 - Jun 11
La Fonderia Firenze
Superior Double Room, 1 King Bed | Premium bedding, down comforters, in-room safe, desk

La Torre Del Cestello

La Torre Del Cestello
Santo Spirito
9.0 out of 10, Wonderful, (256 reviews)
"It was in a great location, we had an excellent view from our room."
United States
Tonya
The price is NT$7,451
NT$8,710 total
includes taxes & fees
Jun 9 - Jun 10
La Torre Del Cestello
Comfort Apartment, City View | Living area | Flat-screen TV

Lotus San Frediano by MMega

Lotus San Frediano by MMega
Santo Spirito
The price is NT$267,055
NT$297,874 total
includes taxes & fees
Jun 3 - Jun 4
Lotus San Frediano by MMega
Fireplace

Ottantotto Firenze

Ottantotto Firenze
Santo Spirito
9.6 out of 10, Exceptional, (171 reviews)
"Great location and extremely charming!"
United States
Brook
The price is NT$10,392
NT$11,945 total
includes taxes & fees
Jun 10 - Jun 11
Ottantotto Firenze
Apartment | Dining room

Mamo Florence - Brancacci Apartment

Mamo Florence - Brancacci Apartment
Santo Spirito
The price is NT$6,976
NT$11,796 total
includes taxes & fees
May 25 - May 26
Mamo Florence - Brancacci Apartment
Property entrance

Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie
Santo Spirito
8.8 out of 10, Excellent, (212 reviews)
"Great stay"
United States
Eric
The price is NT$3,930
NT$4,765 total
includes taxes & fees
May 26 - May 27
Foresteria Valdese di Firenze - Casa per Ferie
Rooftop terrace

Hotel Palazzo Guadagni

Hotel Palazzo Guadagni
3.0 star property
Santo Spirito
9.0 out of 10, Wonderful, (207 reviews)
"The staff are exceptional-all of them. They helped us with tickets and brought me tea and cookies one night when I was sick. The breakfast staff is so personable, kind, and attentive. The cleaning staff are impeccably efficient and energetic and have a wonderful sense of humor. We see the same people every year and they remember us. Thank you all!"
Canada
Mary Anne
The price is NT$12,584
NT$14,283 total
includes taxes & fees
May 27 - May 28
Hotel Palazzo Guadagni
Front of property

Oltrarno Classic by MMega

Oltrarno Classic by MMega
Santo Spirito
The price is NT$2,729
NT$6,756 total
includes taxes & fees
Jun 10 - Jun 11
Oltrarno Classic by MMega
Property entrance

Residenza D'Epoca Al Numero 8

Residenza D'Epoca Al Numero 8
Santo Spirito
9.0 out of 10, Wonderful, (156 reviews)
"Excellent place"
United States
Laura Patricia
The price is NT$7,451
NT$8,710 total
includes taxes & fees
Jun 7 - Jun 8
Residenza D'Epoca Al Numero 8
Apartment, 1 Bedroom | Private kitchenette | Full-size fridge, microwave, stovetop, dishwasher

Mamo Florence - Boheme Apartment

Mamo Florence - Boheme Apartment
Santo Spirito
The price is NT$3,581
NT$7,501 total
includes taxes & fees
Jun 21 - Jun 22
Mamo Florence - Boheme Apartment
Classic Apartment | Living area | Flat-screen TV

Le Volte by Mmega

Le Volte by Mmega
Santo Spirito
The price is NT$3,695
NT$7,442 total
includes taxes & fees
Jun 1 - Jun 2
Le Volte by Mmega
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Santo Spirito

Find the best Santo Spirito areas and neighborhoods for the activities you enjoy most. Learn more about Santo Spirito
Learn more about Santo Spirito

Historic Centre of Florence

Lose yourself in the Renaissance charm of Florence’s old town, where masterpieces by Brunelleschi and Giotto line up alongside cafés, gelato shops and trattorias.

Duomo

Uffizi Gallery and Via de' Calzaiuoli are just a few worthwhile attractions to visit in Duomo. Travelers also love the fascinating museums, stunning cathedral, and popular shops.

San Giovanni

If you're spending some time in San Giovanni, Uffizi Gallery and Cathedral of Santa Maria del Fiore are top sights worth seeing.

Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. Piazza di Santa Maria Novella is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

Santa Croce

Travelers come to Santa Croce for its interesting museums, and you can see top attractions like Basilica of Santa Croce and Piazza Santa Croce while you're in town.

Top Santo Spirito Hotel Reviews

Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

10/10 Excellent
"They staff were incredibly helpful and welcoming. They gave good recommendations. The location was impeccable with a wine window less than a block away. Good gelato not far away and a fun bar around the corner Spirituum Spirits Bar had excellent espresso martinis. I would skip Braceria as the other food outside the steak was mid. But the hotel itself is beautiful and has a lift but still some stairs in the event you need a fully accessible hotel. The terrace views were great and it was a large space."
Hannah 3-night trip
Posted 11 hours ago
Palazzo Mannaioni Suites

Frequently asked questions

What is Santo Spirito like?
Santo Spirito is a trendy neighborhood known for its beautiful river views. Be sure to check out Piazza Santo Spirito and Santo Spirito Basilica as part of your Santo Spirito travel plans.
What's the best accommodation in Santo Spirito?
Based on our traveler data, Hotel Horto Convento is one of the top choices for your stay in Santo Spirito. This hotel is a short 13-minute walk from Pitti Palace, and it offers free breakfast and a bar. Other good options for your stay in the neighborhood include Palazzo Mannaioni Suites and La Torre Del Cestello.
How many hotels can I expect to find in the Santo Spirito area?
Expedia has 501 hotels and other accommodations in Santo Spirito to choose from, making this an ideal home base for exploring the greater Florence area.
If I need to cancel my hotel reservation in Santo Spirito, will I receive a refund?
Yes, the majority of hotel reservations are refundable provided that you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Enter dates in and click on "Search", then you can filter by "fully refundable" to get the best deals in Santo Spirito.
Where can I learn more about changing or cancelling my trip to Santo Spirito?
To find more details about updating your trip to Santo Spirito or cancelling it, head over to our customer service page.
What can I see and do in this Florence neighborhood?
Spend some time exploring the natural setting of Santo Spirito with a visit to Arno River and Torrigiani Garden. As you're discovering the neighborhood, Piazza Santo Spirito and Santo Spirito Basilica are some other places worth a visit. A few places to visit in the area around Santo Spirito include Uffizi Gallery, Piazza del Carmine, and Santa Maria della Carmine. When you're sightseeing in Florence, Brancacci Chapel and Il Nabucco di Matteo Gabellini are also worth a stop.