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Our top choices for San Francisco hotels

Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica
4.0 star property
San Francisco
9.6 out of 10, Exceptional, (1127)
"The room was clean and the location was great."
United States
Wendy
The price is NT$3,081
NT$3,389 total
includes taxes & fees
Jan 12 - 2026/1/13
Ramada Plaza by Wyndham Panama Punta Pacifica

Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel
3.5 star property
San Francisco
9.4 out of 10, Exceptional, (2141)
"Great location of the hotel with a lovely breakfast and friendly staff"
United States
fouad
The price is NT$3,393
NT$3,733 total
includes taxes & fees
Jan 16 - 2026/1/17
Plaza Paitilla Inn Hotel

Courtyard by Marriott Panama Multiplaza Mall

Courtyard by Marriott Panama Multiplaza Mall
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1001)
"Staff was very helpful. Great location."
United States
John
The price is NT$2,912
NT$3,204 total
includes taxes & fees
Jan 24 - 2026/1/25
Courtyard by Marriott Panama Multiplaza Mall

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (1000)
"I loved my stay! "
United States
Jenniffer Gonzalez De La
The price is NT$4,933
NT$5,426 total
includes taxes & fees
Jan 13 - 2026/1/14
Las Americas Golden Tower Panama

Decapolis Hotel Panama City

Decapolis Hotel Panama City
4.0 star property
San Francisco
8.6 out of 10, Excellent, (1464)
"Excellent stay. Wonderful staff, good location and excellent breakfast"
United States
Michael
The price is NT$4,421
NT$4,864 total
includes taxes & fees
Jan 3 - 2026/1/4
Decapolis Hotel Panama City

Megapolis Hotel Panamá

Megapolis Hotel Panamá
4.5 star property
San Francisco
8.4 out of 10, Very Good, (1312)
"Clean convenient beautiful hotel. "
United States
Daniel
The price is NT$8,342
NT$9,177 total
includes taxes & fees
Jan 2 - 2026/1/3
Megapolis Hotel Panamá

Sheraton Grand Panama

Sheraton Grand Panama
4.0 star property
San Francisco
8.6 out of 10, Excellent, (996)
"Was amazing food was delicious and stay was great "
United States
Amanda
The price is NT$4,217
NT$4,638 total
includes taxes & fees
Jan 9 - 2026/1/10
Sheraton Grand Panama

Aloft Panama

Aloft Panama
3.5 star property
San Francisco
8.8 out of 10, Excellent, (896)
"Great staff..warm and welcoming...enjoyed our stay!"
United States
Alystra Marissa Arjoon
The price is NT$3,734
NT$4,108 total
includes taxes & fees
Jan 16 - 2026/1/17
Aloft Panama

JW Marriott Panama

JW Marriott Panama
5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1002)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is NT$10,345
NT$11,379 total
includes taxes & fees
Jan 3 - 2026/1/4
JW Marriott Panama

Residence Inn by Marriott Panama City

Residence Inn by Marriott Panama City
4.0 star property
San Francisco
9.0 out of 10, Wonderful, (543)
"It's location is close to everything. "
United States
Sharon
The price is NT$5,051
NT$5,556 total
includes taxes & fees
Jan 10 - 2026/1/11
Residence Inn by Marriott Panama City

Dovle Residences by HMS-Preferred Member

Dovle Residences by HMS-Preferred Member
3.0 star property
San Francisco
The price is NT$6,082
NT$6,691 total
includes taxes & fees
Jan 2 - 2026/1/3
Dovle Residences by HMS-Preferred Member

San Francisco by Wynwood House

San Francisco by Wynwood House
3.0 star property
San Francisco
9.2 out of 10, Wonderful, (56)
"Clean and walkable location"
United States
Tamera
The price is NT$3,792
NT$4,957 total
includes taxes & fees
Jan 15 - 2026/1/16
San Francisco by Wynwood House

Boutique Apartments Atlapa

Boutique Apartments Atlapa
3.0 star property
San Francisco
8.0 out of 10, Very Good, (28)
"I had an excellent stay here ! It was a very amazing the host is an amazing person thank you for making My stay great❤️"
United States
Shamia
Boutique Apartments Atlapa

Casa Orquídea

Casa Orquídea
2.0 star property
San Francisco
8.0 out of 10, Very Good, (5)
"For me was very convenient "
United States
Natalia
The price is NT$1,844
NT$2,029 total
includes taxes & fees
Jan 5 - 2026/1/6
Casa Orquídea

Wanders Panama by Boutique Apartments

Wanders Panama by Boutique Apartments
4.0 star property
San Francisco
10.0 out of 10, Exceptional, (1)
"I will go again thank you so much"
United States
GISY ITZEL
The price is NT$5,174
NT$10,499 total
includes taxes & fees
Jan 5 - 2026/1/6
Wanders Panama by Boutique Apartments

Living 73 Panamá by Boutique Apartments

Living 73 Panamá by Boutique Apartments
3.0 star property
San Francisco
The price is NT$1,203
NT$5,934 total
includes taxes & fees
Jan 10 - 2026/1/11
Living 73 Panamá by Boutique Apartments

Stylish 2BR Apt Near the Park Omar

Stylish 2BR Apt Near the Park Omar
2.0 star property
San Francisco
The price is NT$6,398
NT$8,117 total
includes taxes & fees
Jan 9 - 2026/1/10
Stylish 2BR Apt Near the Park Omar

Wanders & Yoo

Wanders & Yoo
4.0 star property
San Francisco
8.0 out of 10, Very Good, (11)
"Cool and modern condos, great location and views."
United States
Jorge
The price is NT$9,169
NT$10,086 total
includes taxes & fees
Jan 3 - 2026/1/4
Wanders & Yoo

w Bright 1BR w Private Balcony in San Francisco

w Bright 1BR w Private Balcony in San Francisco
2.0 star property
San Francisco
The price is NT$3,464
NT$4,744 total
includes taxes & fees
Jan 18 - 2026/1/19
w Bright 1BR w Private Balcony in San Francisco

Spacious 2BR w Terrace Lounge

Spacious 2BR w Terrace Lounge
2.0 star property
San Francisco
Spacious 2BR w Terrace Lounge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area.

Bella Vista

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Crown Casino. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip.

San Felipe

If you're spending some time in San Felipe, Interoceanic Canal Museum and National Theater are top sights worth seeing.

Punta Paitilla

Travelers come to Punta Paitilla for its abundant dining options, and you can see top attractions like Avenida Balboa and Multicentro Panama while you're in town.

Top San Francisco Hotel Reviews

Find out more about San Francisco

Top reasons to visit San Francisco

  • Vibrant Nightlife: San Francisco boasts a lively nightlife scene, with numerous bars, clubs, and entertainment venues to enjoy.
  • Stunning Ocean Views: Experience breathtaking ocean views while exploring the city's picturesque parks and waterfront areas.
  • Cultural Attractions: Discover the rich history and culture through landmarks like the historic Santa Maria and various urban parks.
  • Diverse Accommodations: Choose from a wide range of lodging options, from luxury hotels to budget-friendly hostels.
  • Family-Friendly Activities: Enjoy numerous activities perfect for families, including parks, shopping, and local events.

Find great hotels near San Francisco

San Francisco offers a diverse selection of accommodations, from luxurious hotels to budget-friendly hostels, catering to all types of travelers. Whether you're seeking a business-focused hotel or a family-friendly atmosphere, you'll discover top-rated options that highlight the city's unique charm. Explore the best hotels in San Francisco for a memorable stay, ensuring your visit to Panama City is both comfortable and enjoyable.

  • Hotel Riu Plaza Panama: This 4-star hotel is a haven for adventure seekers and business travelers alike, located just 1.6km from San Francisco. Hotel Riu Plaza Panama offers a unique blend of natural exploration and modern amenities, making it an ideal choice for those looking to combine work and play. Onsite and nearby, guests can indulge in a variety of adventure sports and recreational activities. With spacious rooms, a fitness center, and a refreshing pool, it promises a rejuvenating stay while being well-equipped for all your business needs.
  • Novotel Panama City: Perfect for families and business travelers, this 4-star hotel is also situated 1.6km from San Francisco. Novotel Panama City stands out with its family-friendly amenities, including a complimentary children’s club, cribs, window guards, and a shared playground. The hotel offers a welcoming environment for guests of all ages, ensuring that families can enjoy their vacation without worries. With contemporary rooms and a dedicated business center, it caters to both leisure and corporate needs seamlessly.
  • Plaza Paitilla Inn Hotel: This charming 3.5-star hotel is just 1.6km from San Francisco and is perfect for romantic getaways and business trips. Plaza Paitilla Inn Hotel features exclusive romance packages that create a dreamy atmosphere for couples. Enjoy a delightful meal through limited hours of room service, or relax together at the spa and pool area with amenities like pool umbrellas and body treatments. The intimate setting and attentive service make it a wonderful choice for those seeking both relaxation and a touch of romance during their stay.

Where to stay near San Francisco

San Francisco offers a vibrant mix of city life and relaxation, making it perfect for family or business-themed vacations. Explore the nearby Panama City for a unique cultural experience, or enjoy a weekend getaway in downtown San Rafael. Whether you're looking for luxury accommodations or budget-friendly options, you'll find friendly locals and rich history around every corner. Don't miss the charming San Francisco apartments for a cozy stay amidst the bustling atmosphere.

  • Panama City: As the vibrant capital of Panama, Panama City offers a rich blend of modernity and history. Nestled along the Pacific coast, this bustling metropolis attracts travelers year-round, especially in January, July, and September. Visitors flock to the city for family outings, city explorations, and business ventures. You’ll find a plethora of shopping centers, malls, and local markets to indulge in retail therapy. The nearby attractions, such as beautiful beaches and lush parks, provide ample opportunities for relaxation and outdoor activities, making Panama City a dynamic destination for all types of travelers.
  • Punta Paitilla: Approximately 1.6km from San Francisco, Punta Paitilla is a picturesque neighborhood known for its upscale living and stunning waterfront views. This area sees a steady flow of visitors throughout the year, with peak seasons in April, July, and September. Travelers come here for family-friendly experiences and outdoor adventures. The neighborhood is home to numerous shopping areas, including contemporary malls and local boutiques. Additionally, the nearby urban parks and tourist precincts offer perfect spots for leisurely walks and family picnics, ensuring a memorable visit.
  • Bella Vista: Located just 1.6km away from San Francisco, Bella Vista is a lively neighborhood that seamlessly blends urban charm with local culture. This area attracts visitors year-round, particularly from February to March and in December. Bella Vista is popular for family outings, city exploration, and business events. With various shopping centers and local markets at your disposal, you can enjoy a delightful shopping spree. The neighborhood’s parks and bustling streets provide an inviting atmosphere for leisurely strolls and delightful dining experiences, making Bella Vista a must-visit during your stay.

Things to do in and around San Francisco

San Francisco offers a variety of activities perfect for city-themed vacations, family trips, or business meetings. Visitors can enjoy shopping at various malls and centers, while also taking in beautiful ocean views. Don't miss out on the vibrant nightlife and relaxing picnic areas, ensuring a memorable stay during your visit to Panama City, Panamá Province.

Shopping

In San Francisco, you can shop at Multiplaza Pacific Mall and Multicentro Panama, both offering a mix of entertainment and family-friendly vibes. For a larger selection, visit Pacific Center, located 1.6km away, featuring various shops and dining options to enhance your shopping experience.

Recreation

In San Francisco, immerse yourself in the vibrant atmosphere at Estadio Rommel Fernandez, Estadio Nacional Rod Carew, and Maracana Stadium, each offering exhilarating sports experiences just 6.4km away. Enjoy the energetic vibes and participate in various recreational activities that promote both wellness and excitement.

Adventure

Embark on an exhilarating hike at Honeycreeper Ridge Trail, located 37.0km from San Francisco, where stunning scenery and outdoor vibes await. For a thrilling experience, zip through the treetops at Gatun Eco Adventures, situated 46.7km away, offering an adrenaline-pumping ropes course in a beautiful natural setting.

Nightlife

In San Francisco, the National Theater and Anita Villalaz Theater, both 4.8km away, offer captivating performances in a romantic atmosphere. Closer to the city, Theater Circle, just 1.6km away, provides a vibrant cultural experience, perfect for an exciting night out.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for San Francisco

To save money on your trip to San Francisco, consider visiting between September and November for lower accommodation prices. Tuesdays typically offer the best hotel rates, while Saturdays are the priciest. Use Expedia to find budget-friendly options by filtering prices from lowest to highest and consider bundling your hotel, flights, and activities for additional savings. Take advantage of free attractions like the Golden Gate Park and Pier 39, and utilize public transport, such as Muni and BART, for affordable travel around the city.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around San Francisco are September to November, where the prices are slightly lower. This is in comparison to January and March to April, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around San Francisco is Tuesday. The most expensive day to stay around San Francisco is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to customize your options by setting your budget, choosing your desired location, and selecting the type of hotel that suits you best. To find the most affordable prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel stay in San Francisco with your flights and activities through an Expedia package deal.

Find the best attractions near San Francisco

San Francisco is a vibrant destination ideal for city-themed vacations, family trips, and business travel. Visitors can explore a variety of attractions, including urban parks, lively streets, and event venues that showcase the city's culture and outdoor charm. Don't miss the chance to visit the historic Santa Maria, adding a unique touch to your experience in this captivating city.

  • Cinta Costera: This vibrant urban park stretches along the waterfront, offering stunning views of the Bay and city skyline. Perfect for families, it features walking paths, playgrounds, and green spaces, making it a great spot for relaxation and outdoor activities.
  • Avenida Balboa: As one of the main thoroughfares of Panama City, Avenida Balboa is lined with high-rise buildings and restaurants. Stroll along this bustling street to experience the energetic city vibe, with beautiful views of the ocean and the nearby parks.
  • Panama Viejo: Step back in time at this historic site, the remnants of the first Spanish settlement on the Pacific coast. Explore the fascinating ruins and learn about the rich cultural history that shaped Panama, providing a unique glimpse into its past.

Best time to go to San Francisco

The best time to visit San Francisco is dependent on what kind of holiday you are seeking. April is its hottest month on average. At this time, visitor numbers are average and weather is mostly sunny with light rain. November is its coolest month on average. At this time, visitor numbers are average and weather is mostly cloudy with frequent rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.8°F (26.0°C)No RainMostly SunnyAverageSlightly High
February79.2°F (26.2°C)No RainMostly SunnySlightly HighAverage
March79.7°F (26.5°C)No RainMostly SunnyAverageSlightly High
April80.4°F (26.9°C)Light RainMostly SunnyAverageSlightly High
May80.2°F (26.8°C)Frequent RainMostly CloudySlightly LowAverage
June79.9°F (26.6°C)Frequent RainMostly CloudyAverageAverage
July79.3°F (26.3°C)Frequent RainMostly CloudySlightly HighAverage
August79.2°F (26.2°C)Frequent RainMostly CloudyAverageAverage
September79.3°F (26.3°C)Frequent RainMostly CloudySlightly HighSlightly Low
October78.6°F (25.9°C)Frequent RainMostly CloudySlightly LowSlightly Low
November78.3°F (25.7°C)Frequent RainMostly CloudyAverageSlightly Low
December78.6°F (25.9°C)Light RainMostly CloudySlightly LowAverage

The nearest major airports for your trip to San Francisco

Traveling to San Francisco can be done via three major airports in Panama City. Tocumen International Airport (PTY) is 16.1km away and has nearby hotels like The Santa Maria, a Luxury Collection Hotel, and JW Marriott Panama. Marcos A. Gelabert International Airport (PAC) is closer at 6.4km, with excellent hotel options such as Waldorf Astoria Panama and Sofitel Legend Casco Viejo, offering various transportation services. Lastly, Balboa Airport (BLB) is 12.9km away, with top-tier hotels like Hilton Panama and Bristol Panama, providing convenient access to transportation shuttles. Each airport is easily reachable from these luxurious accommodations, ensuring a smooth travel experience.

Frequently asked questions

What is San Francisco like?
San Francisco is a welcoming neighborhood that travelers like for its restaurants. Be sure to check out Multiplaza Pacific Mall and Calle 50 as part of your San Francisco travel plans.
Where is the best hotel for a stay in San Francisco?
Based on Expedia customer reviews, Ramada Plaza by Wyndham Panama Punta Pacifica is the highest ranked property in San Francisco. This hotel is a short 4-minute walk from Multiplaza Pacific Mall, and it offers free breakfast and a restaurant. Other top choices in the neighborhood include Plaza Paitilla Inn Hotel and Residence Inn by Marriott Panama City.
How many hotels will I find in San Francisco?
If you're searching for places to stay in Panama City, Expedia has something to meet your needs with 263 San Francisco hotels and other accommodations to choose from.
If I need to cancel my hotel reservation in San Francisco, will I receive a refund?
Yes! Most room reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and receive a refund within a 24-hour period of booking. Add dates, click "Search", then use the "fully refundable" filter to get top deals in San Francisco.
Where can I learn more about changing or cancelling my trip to San Francisco?
For additional details about updating your trip to San Francisco or cancelling it, head over to our customer service page.
What is there to do in this Panama City neighborhood?
While you're in San Francisco, a shopping trip to Multiplaza Pacific Mall, Avenida Balboa, or Pacific Center, might be the perfect place to find that souvenir you've been looking for. Calle 50 and Panama Canal Murals are some other stops to visit in the neighborhood. A few places to visit in the area around San Francisco include Colonial Religious Art Museum, Bingo 90, and Soho City Center. When you're sightseeing in Panama City, National Shrine of the Heart of Mary and Panama Viejo Museum are also worth a stop.