Panama City Vacations
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to NT$5,067 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Where to stay in Panama City
Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
Casco Viejo
4.5/5(178 area reviews)
Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Find the Best Panama City Vacation Packages
Panama City Hotel Deals
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is NT$4,418 per night from Mar 8 to Mar 9
NT$4,418
NT$4,860 total
Mar 8 - Mar 9
includes taxes & fees
9/10 Wonderful! (5,027 reviews)
Spotless. Awesome hotel. Food delicious
Reviewed on 2026/2/27
Hotel El Panama by Faranda Grand, a member of Radisson Individuals
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is NT$3,373 per night from Mar 31 to Apr 1
NT$3,373
NT$3,711 total
Mar 31 - Apr 1
includes taxes & fees
7.8/10 Good! (1,002 reviews)
Yes greet staff jefeth in front desk, good food, good pool
Reviewed on 2026/2/25
Sheraton Grand Panama
Via Israel And 77th Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is NT$4,189 per night from Mar 8 to Mar 9
NT$4,189
NT$4,607 total
Mar 8 - Mar 9
includes taxes & fees
8.6/10 Excellent! (1,002 reviews)
Nice staff and everything was great.
Reviewed on 2026/2/27
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Discover the most popular places to visit in Panama City
Miraflores Locks
4.5/5(783 reviews)
Learn about the local history of Ancon with a stop at Miraflores Locks. Visit the shops and casinos in this vibrant area.
Amador Convention Center
4/5(2 reviews)
Learn about the events happening at Amador Convention Center during your trip to Ancon. While in this walkable area, you can savor the top-notch restaurants.
Explore a world of travel with Expedia
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.
