San Francisco Vacations

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Where to stay in San Francisco

Find the best San Francisco areas and neighborhoods for the activities you enjoy most. Learn more about San Francisco
My favourite store in Casco Viejo by far! It sells #colorful Kuna handmade products and the owner of the gallery is a very kind lady, who even allowed me to visit her place outside working hours. #LikeALocal

Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Interoceanic Canal Museum or Museum of History Panama while you're exploring the area.

Find hotels in Casco Viejo

San Francisco Hotel Deals

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
Av. Balboa con Calle 53 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is NT$4,824 per night from Feb 9 to Feb 10
NT$4,824
NT$5,306 total
Feb 9 - Feb 10
includes taxes & fees
8.8/10 Excellent! (1,004 reviews)
Good place to stay for medical services as Paitilla Medical Center, Paitilla Hospital and Royal Center Medical Offices are all within 5 minutes walking. Sushi restaurant on the entry level is excellent.

Reviewed on 2026/1/18

Las Americas Golden Tower Panama
Plaza Paitilla Inn Hotel

Plaza Paitilla Inn Hotel

3.5 out of 5
Italy Avenue, Punta Paitilla Panama City Panama
The price is NT$3,407 per night from Jan 24 to Jan 25
NT$3,407
NT$3,747 total
Jan 24 - Jan 25
includes taxes & fees
9.2/10 Wonderful! (2,154 reviews)
Everything was top notch. Breakfast was 1st class. Huge variety.

Reviewed on 2026/1/19

Plaza Paitilla Inn Hotel
Ramada Plaza by Wyndham Panama Punta Pacifica

Ramada Plaza by Wyndham Panama Punta Pacifica

4 out of 5
Via Israel y Calle 71, San Francisco Panama City Panama
Fully refundableReserve now, pay when you stay
The price is NT$3,487 per night from Feb 2 to Feb 3
NT$3,487
NT$3,836 total
Feb 2 - Feb 3
includes taxes & fees
9.4/10 Exceptional! (1,145 reviews)
We enjoyed the pool area, the free buffet style for breakfast with very attentive staff, parking was accessible and service at the front desk by Rafael & Carlos made our stay easy and enjoyable.

Reviewed on 2026/1/17

Ramada Plaza by Wyndham Panama Punta Pacifica
See all 1,701 properties in San Francisco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a San Francisco vacation package cost?
Much less than you might think — from a low , in fact! By bundling hotels, flights and car rentals into a custom-built vacation package, your San Francisco escape is only clicks away.
How do I get a cheap travel package to San Francisco?
Lock in flights that suit your schedule, add a hotel to your booking and watch how much you save with a San Francisco vacation package. It's that easy! From flights and hotels to rental cars and activities, Expedia makes traveling on the cheap easy. And with more than 550 partner airlines and 1,000,000 hotel options around the globe to pick from, you'll never be short of choice.
Where should I stay in San Francisco?
Make sightseeing easy by staying near San Francisco's main attractions. Miraflores Locks and Metropolitan Cathedral of Panama are two which top many visitors' bucket lists.
What are the top hotels in San Francisco?
If this will be your first visit to San Francisco, secure a room at Sublime Apartment City Center. Ph Boutique Quartier Atlapa or New Cozy Apartment Ocean View. Quartier Del Mar. Both hotels will make you feel at home and are popular options with lots of travelers.
How far in advance should I book my San Francisco vacation?
It can be hard to know when is the ideal time to book your trip to San Francisco. But typically the earlier you book, the lower the prices. Sometimes, you can reserve your flights and hotels up to a year prior to your departure date. If you're eager to escape on a last-minute getaway, no need to fret! There are unbeatable deals announced on Expedia every day.
What does an Expedia San Francisco travel package include?
That mostly depends on you. You can choose from a range of San Francisco packages, such as a hotel, rental car and flight. You can also book a hotel and a flight, or a flight and a rental car. Once you've made your booking, you can add the fun stuff like experiences and tours. Whatever your ideal San Francisco vacation looks like, you're sure to save!
What should I know before booking a San Francisco travel package?
So many places to go, so many things to see and do. With a travel package, you'll be able to afford more of them. Bundle your hotels, flights and rental cars and land big savings.
Can I choose my airline with a San Francisco Expedia vacation package?
Yes, definitely. Expedia has more than 550 airline partners to choose from worldwide. With such a huge range of choice, finding the ideal carrier to whisk you off to San Francisco won't be difficult.
If I'm not able to travel, can I cancel my San Francisco vacation package?
Your situation can change in a flash, so yes, you can. You may be able to amend or cancel your San Francisco vacation package for free if you've booked in the last 24 hours. For older bookings, you can still make changes, but your car rental company, airline or hotel may charge a fee. Need more information? Look up our Customer Service Portal. We'll help make sure your trip goes off without a hitch.

Discover the most popular places to visit in San Francisco

Panama

Miraflores Locks

Learn about the local history of Ancon with a stop at Miraflores Locks. Visit the casinos and shops in this vibrant area.

Miraflores Locks

Amador Convention Center

Learn about the events happening at Amador Convention Center during your trip to Ancon. While in this walkable area, you can savor the top-notch restaurants.

Amador Convention Center
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.