Find hotels in East Prairie, MO from NT$1,995

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1003)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.

"Clean room, great location and friendly staff"
United States
Mark
The price is NT$2,838
NT$3,263 total
includes taxes & fees
Dec 25 - Dec 26
Drury Inn & Suites Sikeston, MO

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1003)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.

"Easy parking , quiet and comfortable bed , we’ll stop again on our way back "
United States
joseph
The price is NT$2,198
NT$2,505 total
includes taxes & fees
Dec 24 - Dec 25
Best Western Plus Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (719)
Enjoy tranquil accommodations at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.

"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is NT$1,750
NT$1,995 total
includes taxes & fees
Dec 21 - Dec 22
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (548)
Discover convenience at this friendly Union City motel, where free breakfast and parking enhance every stay. Explore County Market Place and Reelfoot Shopping Center nearby. Guests consistently praise the clean rooms and helpful staff.

"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is NT$2,271
NT$2,696 total
includes taxes & fees
Dec 21 - Dec 22
Country Hearth Inn & Suites Union City

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.

"Staff was great! Room was nice. "
United States
Lana
The price is NT$1,959
NT$2,173 total
includes taxes & fees
Dec 21 - Dec 22
Super 8 by Wyndham Charleston/Sikeston East MO

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (318)
Located in Union City, this hotel offers convenient access to Discovery Park of America. Enjoy free breakfast, WiFi, and parking. Jump into the indoor pool or get active in the 24-hour fitness center, making your Tennessee adventure complete.

"Wonderful breakfast, awesome room"
United States
Kimberly
The price is NT$2,386
NT$2,833 total
includes taxes & fees
Jan 11 - 2026/1/12
Sleep Inn at Discovery Park of America

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
Escape to this serene retreat with both indoor and outdoor pools for year-round enjoyment. The fitness center keeps your routine intact while complimentary breakfast energizes your day exploring nearby Central Park and Sikeston Depot Museum.

"Everything was clean, staff was friendly "
United States
Matthew
The price is NT$2,365
NT$2,719 total
includes taxes & fees
Dec 24 - Dec 25
Pear Tree Inn Sikeston

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (164)
Located near County Market Place and Reelfoot Shopping Center, this welcoming hotel offers a free breakfast and convenient parking. Take a morning swim in the indoor pool after enjoying the complimentary meal. The helpful staff earns consistent praise from guests.

"Clean room, nice breakfast"
United States
STUART
The price is NT$3,078
NT$3,655 total
includes taxes & fees
Dec 26 - Dec 27
Hampton Inn Union City

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (728)
This welcoming motel offers clean rooms praised by guests, plus convenient amenities including free WiFi and parking. The 24-hour front desk ensures assistance anytime during your stay in charming Portageville.

"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."
United States
Roger
New Orleans Inn Portageville

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
Experience comfort in the entertainment district of Union City at this welcoming hotel. Start your day with free breakfast before exploring nearby Discovery Park of America. After sightseeing, unwind in the indoor pool or maintain your routine at the 24-hour fitness center.

"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is NT$2,996
NT$3,558 total
includes taxes & fees
Jan 2 - 2026/1/3
Holiday Inn Express & Suites Union City by IHG

Travel Inn

Travel Inn
2.5 star property
Marston
6.0 out of 10, (116)
This welcoming Marston hotel offers complimentary on-the-go breakfast to start your day right. Take advantage of free WiFi to stay connected and enjoy the convenience of complimentary self parking during your countryside stay.

"Had a great time loved it "
United States
Shyianne
The price is NT$1,356
NT$1,549 total
includes taxes & fees
Dec 21 - Dec 22
Travel Inn

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (459)
"Nice and quiet but there were bugs in the room the fridge didn't keep things cold and the A/C didn't keep the room cool. Great place if you're a fisherman."
United States
Carla
The price is NT$2,199
NT$2,523 total
includes taxes & fees
Dec 21 - Dec 22
Reelfoot Lake Inn

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (104)
Discover relaxation at this Charleston motel offering complimentary WiFi and parking. The onsite health club provides fitness options after exploring local attractions. Cape Girardeau Municipal Airport is just a 43-minute drive away.

"Middle of nowhere hotel was ok"
United States
David
The price is NT$1,908
NT$2,117 total
includes taxes & fees
Dec 21 - Dec 22
Eagle Inn Charleston

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (487)
Unwind at this Union City hotel offering a seasonal outdoor pool and hot tub for relaxation. Just a short distance from County Market Place and Reelfoot Shopping Center, guests enjoy free breakfast, WiFi, and parking.

"The staff I interacted with were pleasant and helpful. Initially they had me in a 2nd floor room, but accommodated my asking for a first floor due to problems I was having with my knee and back. The bed was comfortable and overall the room was nice except for the bathroom shower, it had mold growing in it. Breakfast the next morning was ok."
United States
Rose
The price is NT$2,118
NT$2,515 total
includes taxes & fees
Jan 4 - 2026/1/5
Quality Inn Union City US 51

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
This hotel in Marston offers complimentary perks including daily full breakfast served between 6:00 AM and 9:00 AM, WiFi, and self parking. Conveniently located for travelers exploring the area.

"Great hotel, great staff"
United States
Dmitry
The price is NT$1,818
NT$2,077 total
includes taxes & fees
Dec 22 - Dec 23
Super 8 By Wyndham Marston

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (40)
This business-friendly hotel offers an indoor pool, restaurant, and complimentary breakfast. Located near Sikeston Depot Museum, guests enjoy free WiFi and parking while exploring local attractions.

"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is NT$3,186
NT$3,607 total
includes taxes & fees
Dec 26 - Dec 27
Fairfield Inn & Suites by Marriott Sikeston

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
Start your day with complimentary full breakfast before exploring nearby attractions. This hotel provides free WiFi and parking, making it an ideal base for visiting Fort Defiance State Park and Ballard Wildlife Management Area.

"Break fast was excellent "
United States
Uma
The price is NT$2,307
NT$2,560 total
includes taxes & fees
Jan 17 - 2026/1/18
Quality Inn Cairo I-57

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (446)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness center. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.

"Friendly staff clean rooms "
United States
Christopher
The price is NT$3,078
NT$3,485 total
includes taxes & fees
Dec 28 - Dec 29
Hampton Inn Sikeston

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (120)
This Sikeston motel offers a convenient base for exploring nearby Central Park and Sikeston Depot Museum. Enjoy thoughtful amenities like free WiFi and parking alongside 24-hour front desk service for assistance anytime.

"Great spot en route home from Mississippi. Staff put me in a room that ended up being in a quiet section of the hotel. Great sleep."
United States
Andrew
The price is NT$1,686
NT$2,005 total
includes taxes & fees
Dec 21 - Dec 22
Country Yard Inn and Suite

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
Discover comfort at this Sikeston hotel with an indoor pool and fitness center. Enjoy complimentary breakfast, WiFi, and parking while exploring nearby Central Park and Sikeston Depot Museum. Guests consistently praise the helpful staff and immaculate rooms.

"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is NT$2,933
NT$3,321 total
includes taxes & fees
Jan 11 - 2026/1/12
Holiday Inn Express & Suites Sikeston Southwest by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Hotels in East Prairie with star-rating

Find out more about East Prairie

Top reasons to visit East Prairie

  • Outdoor Adventures: East Prairie offers scenic trails and recreational areas perfect for hiking, skiing, and family picnics.
  • Cultural Experiences: Immerse yourself in local history at museums and enjoy events at various conference venues.
  • Charming Accommodations: A range of comfortable lodging options are available, catering to families, pets, and business travelers.
  • Nearby Attractions: Explore nearby national parks and shopping opportunities just a short drive away.
  • Welcoming Atmosphere: Friendly locals enhance your travel experience, making for lasting memories.

Find great hotels near East Prairie

Discover a variety of comfortable accommodations in East Prairie, Missouri, perfect for every type of traveler. Whether you're seeking pet-friendly options for a family vacation or convenient lodging for business trips, you'll find a range of hotels and motels to suit your needs. Explore the best hotels in East Prairie, complete with helpful amenities and positive reviews to ensure a memorable stay in this charming town.

  • Days Inn and Suites by Wyndham Sikeston: This hotel is an ideal choice for travelers seeking a blend of comfort and convenience, especially those on business trips or traveling with pets. Located 17.7km from East Prairie, this property welcomes furry friends and features a pet-friendly policy, allowing dogs and cats. Guests appreciate the essential amenities such as complimentary breakfast and free Wi-Fi, ensuring a hassle-free stay. The warm and inviting atmosphere makes it a great home base for exploring the nearby attractions while enjoying the comforts of home.
  • Drury Inn & Suites Sikeston, MO: Known for its family-friendly environment, this 3-star hotel is also LGBTQIA welcoming, making it a standout option for diverse travelers. Situated 17.7km from East Prairie, Drury Inn offers exceptional amenities for children, including free cribs, and a range of pet-friendly options. Guests can indulge in complimentary hot breakfast and evening snacks, enhancing the overall experience. The welcoming atmosphere, combined with a focus on community and comfort, makes this hotel a top choice for families and friends looking to enjoy a memorable stay.
  • Pear Tree Inn Sikeston: This charming hotel, located 17.7km from East Prairie, caters to business travelers and families alike, with a welcoming stance toward LGBTQIA guests. Pear Tree Inn offers a cozy ambiance, complete with family-friendly amenities such as free cribs for younger guests. The property’s commitment to excellent service and comfort makes it an appealing choice for those traveling for work or leisure. With its convenient location and thoughtful features, guests can unwind after a day of exploring or meetings, making it a perfect retreat.

Where to stay near East Prairie

Discover the charm of East Prairie, Missouri, where outdoor enthusiasts and relaxation seekers unite. Explore the nearby open spaces, perfect for family-friendly excursions or a romantic picnic. Just a short drive from downtown Sikeston, you'll find delightful shopping opportunities and a warm, welcoming atmosphere. Don't miss the chance to unwind in this scenic region, where friendly locals enhance your travel experience and create lasting memories.

  • Sikeston: Located 20.9km from East Prairie, Sikeston offers a blend of outdoor adventure and family-friendly activities. Visitors can enjoy the local recreational areas, perfect for picnics and outdoor games. The city’s shopping centers provide great opportunities for retail therapy, while the nearby lake and event conference venues serve as popular attractions. Sikeston is ideal for those seeking a romantic getaway or a fun family vacation, particularly during the summer months when the weather is perfect for exploration.
  • Anniston: Just 8.0km away from East Prairie, Anniston is a charming city that caters to families and outdoor enthusiasts alike. With its urban parks and stadium, there's plenty of space for relaxation and recreational activities. The shopping centers and malls make it a convenient spot for those looking to indulge in some retail therapy. Anniston’s appeal lies in its blend of city life and green spaces, making it a delightful stop for travelers looking for a balanced experience.
  • Charleston: Situated 16.1km from East Prairie, Charleston is a city known for its stunning scenery and adventurous spirit. The nearby national state park and historic sites offer a fascinating glimpse into the area’s past while providing ample opportunities for hiking and outdoor activities. With recreational areas and shopping centers, Charleston is perfect for visitors looking to explore both nature and local culture. Its vibrant atmosphere and seasonal events make it an exciting destination throughout the year.

Things to do near East Prairie

East Prairie, Missouri, is perfect for outdoor and romantic getaways, offering a blend of scenic beauty and recreational activities. Visitors can explore the area's trails, enjoy skiing, and relax in the local recreational areas. For those interested in prairie tourism, East Prairie also features several major attractions that showcase the region's natural charm and rich culture, making it an ideal destination for nature lovers and adventure seekers alike.

Shopping

In East Prairie, visit local shops for unique souvenirs and gifts. If you're up for a drive, check out County Market Place, located 49.9km away, where you can enjoy a vibrant atmosphere with family-friendly options and diverse shopping experiences.

Recreation

East Prairie offers peaceful retreats like the Wellness Center, where you can indulge in yoga classes and soothing massages. Explore the nearby Mississippi River for fishing, kayaking, and hiking trails, providing a perfect blend of relaxation and outdoor adventure in a picturesque setting.

Adventure

In East Prairie, explore the stunning landscapes at the nearby Mississippi River, perfect for kayaking and fishing. Experience the thrill of off-roading at local ATV trails, or hike through scenic routes in the nearby wetlands, where wildlife viewing is abundant and nature thrives.

Nightlife

In East Prairie, the nightlife scene is vibrant yet relaxed. A short drive to Union City Masquerade Theatre offers an enchanting mix of romance and culture, perfect for a memorable evening filled with live performances and entertainment that will leave you captivated.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for East Prairie

For a budget-friendly trip to East Prairie, visit during the cheapest months of December to February, and consider staying on Sundays for lower rates. Utilize Expedia to compare hotel prices, focusing on deals that combine accommodations with flights and activities. Look for hotels with business amenities if needed, and sort options from lowest to highest price to find the best deals. Free activities in the area can also help stretch your budget further, making your visit enjoyable without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in East Prairie are December to February, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in East Prairie is Sunday. The most expensive day to stay in East Prairie is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to narrow down your choices based on your budget, desired location, and preferred hotel type. To discover the most affordable options and special offers, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your East Prairie hotel reservation with your flights and activities through an Expedia package deal.

Find the best attractions near East Prairie

East Prairie, Missouri, offers a delightful blend of outdoor adventures, scenic views, and romantic getaways. Visitors can explore nearby national parks, immerse themselves in local history at museums, and attend events at conference venues. This charming town is perfect for those seeking cultural experiences while enjoying nature. Be sure to check out nearby attractions to enhance your visit and make the most of your time in this picturesque area.

  • Central Park: Located 20.9km from East Prairie, Central Park offers a vibrant urban atmosphere perfect for families. Enjoy leisurely strolls, picnics, and various outdoor activities amidst beautiful landscapes and city vibes.
  • Sikeston Depot Museum: This art museum, also 20.9km away, boasts a rich cultural experience. Explore exhibits that showcase local history, art, and the heritage of the area, providing a deeper understanding of the community's roots.
  • Columbus-Belmont State Park: Situated 24.1km from East Prairie, this national state park is a haven for outdoor enthusiasts. With stunning scenery and ample opportunities for adventure, visitors can hike, fish, and enjoy a variety of recreational activities surrounded by nature.

Best time to go to East Prairie

The best time to visit East Prairie is dependent on what kind of holiday you are seeking. July is its hottest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain. January is its coolest month on average. At this time, visitor numbers are moderately high and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January36.3°F (2.4°C)Light RainMostly SunnyModerately HighSlightly Low
February39.4°F (4.1°C)Light RainMostly SunnyAverageSlightly Low
March49.5°F (9.7°C)Light RainMostly SunnyAverageAverage
April58.5°F (14.7°C)Light RainMostly SunnyAverageSlightly High
May68.2°F (20.1°C)Light RainMostly SunnyAverageAverage
June77.0°F (25.0°C)Light RainMostly SunnyModerately HighSlightly High
July79.5°F (26.4°C)Light RainMostly SunnyModerately HighAverage
August77.5°F (25.3°C)Light RainMostly SunnyAverageSlightly High
September72.1°F (22.3°C)Light RainMostly SunnyAverageAverage
October60.8°F (16.0°C)Light RainMostly SunnyModerately LowAverage
November48.6°F (9.2°C)Light RainMostly SunnyModerately LowAverage
December41.2°F (5.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to East Prairie

For your trip to East Prairie, Missouri, you have a few airport options. Cape Girardeau Municipal Airport (CGI) is 51.5km away, with nearby hotels like the 3-star Drury Plaza Hotel Cape Girardeau Conference Center and Courtyard by Marriott, both 9.7km from the airport. Cairo Regional Airport (CIR) is closer at 33.8km, offering options such as the Quality Inn just 3.2km away. Lastly, Barkley Regional Airport (PAH) in Paducah, Kentucky, is 62.8km from East Prairie, with notable stays like The Respite Bed and Breakfast, situated 14.5km from the airport. Transportation services are available to connect you to these accommodations.

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Hampton Inn Sikeston and Sleep Inn at Discovery Park of America. See all available top hotels, or vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 33 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Mississippi River and Big Oak Tree State Park exemplify the area's natural beauty. You'll also find Central Park and River Ridge Winery in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.

Explore a world of travel with Expedia