Find hotels in Cairo, IL from NT$2,110

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Our top choices for Cairo hotels

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
"Break fast was excellent "
United States
Uma
The price is NT$2,229
NT$2,474 total
includes taxes & fees
Jan 17 - 2026/1/18
Quality Inn Cairo I-57

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (17)
"Quiet and convenient."
United States
Alma
La Center Motel

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (615)
"Staff was great! Room was nice. "
United States
Lana
The price is NT$1,952
NT$2,166 total
includes taxes & fees
Dec 30 - Dec 31
Super 8 by Wyndham Charleston/Sikeston East MO

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (105)
"Middle of nowhere hotel was ok"
United States
David
The price is NT$1,901
NT$2,110 total
includes taxes & fees
Dec 30 - Dec 31
Eagle Inn Charleston

Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah
3.0 star property
Cunningham
The price is NT$3,804
NT$9,115 total
includes taxes & fees
Dec 30 - Dec 31
Quiet Country Stay: Modern Home Near Paducah
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular Cairo attractions

Learn more about Cairo

At the confluence of the Mississippi and Ohio rivers, explore Cairo's historic Fort Defiance Park with its sweeping water views. History buffs shouldn't miss the Custom House Museum, where you can discover artifacts from this once-thriving river port town.

Cairo Ohio River Bridge traversing over the Ohio River at sunset

Top Cairo Hotel Reviews

More cheap stays in Cairo

Hotels in Cairo with star-rating

Find out more about Cairo

Top reasons to visit Cairo

  • Outdoor Adventures: Enjoy scenic parks and recreational areas along the Mississippi River, perfect for hiking and relaxation.
  • Rich History: Explore the city’s fascinating history and picturesque landscapes, showcasing its unique cultural heritage.
  • Riverboat Tours: Experience delightful riverboat tours that offer a unique perspective of the Mississippi River.
  • Local Shopping: Discover unique shops that reflect Cairo’s cultural heritage and local craftsmanship.
  • Diverse Accommodations: Choose from a variety of lodging options, including pet-friendly properties and cozy motels.

Find great hotels in and around Cairo

Cairo, Illinois, offers a variety of lodging options to cater to different traveler needs, including agritourism properties and motels. Whether you're seeking pet-friendly accommodations for a family getaway or a comfortable spot for business travel, you'll find plenty of choices. Explore the best hotels in Cairo, read reviews, and discover available options to make your vacation memorable.

  • Super 8 by Wyndham Charleston/Sikeston East MO: This charming motel provides a welcoming atmosphere for families and pet owners alike. Located a mere 16.1km from Cairo, it offers a range of child-friendly amenities, including complimentary cribs and the option to reserve one in advance. Super 8 emphasizes a family vacation vibe, allowing pets on the premises, making it an ideal choice for those traveling with furry companions. Guests appreciate the motel's practical services and comfortable accommodations, ensuring a pleasant stay for all members of the family.
  • Quality Inn Charleston - Sikeston: Situated 19.3km from Cairo, Quality Inn Charleston - Sikeston is tailored for business travelers while also catering to pet owners. This hotel combines convenience and comfort, featuring essential amenities for work and leisure. Pets are welcome, subject to certain restrictions, and service animals are accommodated without any fees. Guests can enjoy the hotel's business-friendly environment while still having the flexibility of bringing their pets along, making it a versatile choice for various travelers.
  • Quality Inn Cairo I-57: Located right in Cairo, Quality Inn Cairo I-57 is perfect for families and pet lovers. The hotel provides essential amenities for children, including free cribs and a first aid kit for peace of mind. With a pet-friendly policy that allows dogs and offers specific cleaning fees, it ensures that your furry friends are well accommodated. Guests enjoy the convenience of being close to local attractions while experiencing comfort and hospitality, making this hotel an excellent choice for a memorable stay.

Where to stay near Cairo

Cairo, Illinois, offers a charming blend of outdoor adventure and rich history. Explore the scenic banks of the Mississippi River, enjoy warm weather in local parks, and visit unique shops that reflect the area's cultural heritage. Nearby towns provide family-friendly activities and a business-friendly atmosphere, making it an ideal destination for all types of travelers. Discover the welcoming vibe of Cairo and its surroundings for a memorable vacation experience.

  • Wickliffe: Situated 9.7km from Cairo, Wickliffe is a charming city that offers a delightful mix of outdoor adventures and scenic beauty. Visitors are drawn here year-round, with peak travel times occurring in March to April and August. The area is perfect for those seeking recreational experiences, featuring lush national parks, serene lakes, and extensive forests. Golf enthusiasts can enjoy well-maintained courses, making Wickliffe a fantastic destination for both relaxation and exploration.
  • Mound City: Located 9.7km from Cairo, Mound City is another inviting destination for outdoor lovers and adventure seekers. Similar to Wickliffe, Mound City welcomes visitors throughout the year, with a notable increase in travelers during March, July, and October. The city boasts beautiful landscapes, ideal for hiking and enjoying nature. Golf courses and recreational areas enhance the experience, while nearby national parks and lakes provide opportunities for fishing, boating, and wildlife observation.
  • Wyatt: A charming city located 11.3km from Cairo, Wyatt is perfect for families and those looking for a city-themed getaway. The peak travel season runs from June to August, making it an ideal summer destination. Visitors can enjoy various outdoor activities, including adventures in urban parks and scenic lakes. With ample recreational areas available, Wyatt offers a family-friendly atmosphere where visitors can unwind and create lasting memories amidst the beauty of nature.

Things to do near Cairo

Cairo, Illinois, offers a charming escape for outdoor enthusiasts and couples alike. Enjoy recreational areas, scenic golf courses, and riverboat tours along the Mississippi River. Ideal for weekend getaways, you can explore local camping sites and indulge in various indoor activities. Whether you're looking to relax or seek adventure, Cairo provides a delightful blend of nature and recreation for a memorable vacation experience.

Shopping

In Cairo, you can enjoy shopping at local stores and boutiques for unique gifts and souvenirs. If you're up for a drive, visit the nearby West Park Plaza, 24.1km away, which features a range of shops and dining options for a more extensive shopping experience.

Recreation

At eDen Spa & Salon, located 45.1km from Cairo, indulge in rejuvenating body treatments surrounded by a serene atmosphere. Experience ultimate relaxation and wellness as skilled therapists cater to your needs, ensuring a refreshing escape from the daily grind.

Adventure

At Cape Splash Family Aquatic Center, 49.9km from Cairo, enjoy thrilling water slides and wave pools perfect for family fun. For hiking enthusiasts, Limekin Springs Trail Trailhead, 32.2km away, offers breathtaking scenery and outdoor adventure along scenic trails surrounded by nature.

Nightlife

Cairo, Illinois offers a unique nightlife with cozy bars and local music venues. Enjoy a drink at the lively Hometown Pizza & Pub or catch live performances at the Cairo Community Center. The friendly atmosphere makes for a memorable night out in this charming town.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Cairo

To save money during your visit to Cairo, Illinois, consider traveling between November and January for lower accommodation rates, with Tuesday being the cheapest day to book. Use Expedia's search tool to compare hotel prices and filter for eco-friendly options. For additional savings, bundle your hotel, flights, and activities in an Expedia package. Explore free attractions and utilize public transport to keep costs down. Remember that Saturdays are the most expensive days, so plan accordingly to maximize your budget.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Cairo are November to January, where the prices are slightly lower. This is in comparison to April to May and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Cairo is Tuesday. The most expensive day to stay in Cairo is Saturday.
  • Find cheap hotels on Expedia: Expedia’s search tool enables you to customize your journey by selecting your budget, preferred location, and additional criteria. You can easily arrange your search results from the lowest to highest prices, ensuring that the most affordable hotels appear at the top. Additionally, you can refine your choices by hotel type; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that are available for booking.
  • Consider bundling your trip: You can save money by combining your hotel stay in Cairo with your flights and activities through an Expedia package.

Find the best attractions in and around Cairo

Cairo, Illinois, is perfect for outdoor and romantic getaways, with attractions like national parks, nature reserves, and event venues. Visitors can immerse themselves in the local culture and scenery while enjoying various outdoor experiences. A must-visit is the city itself, where you can explore its rich history and picturesque landscapes, making it an ideal destination for those seeking a blend of adventure and relaxation.

  • Fort Defiance State Park: Immerse yourself in history at this historic fort located in Cairo. The park offers a blend of cultural vibes with scenic views of the confluence of the Mississippi and Ohio Rivers, making it a perfect spot for exploration and photography.
  • Ballard Wildlife Management Area: Just 8.0km from Cairo, this wildlife preserve is ideal for nature enthusiasts. With rich historical significance and budget-friendly access, you can enjoy birdwatching, hiking, and experiencing the local flora and fauna.
  • Columbus-Belmont State Park: Located 27.4km away, this national park features stunning scenery and outdoor adventures. Engage in hiking, picnicking, or fishing while taking in the breathtaking views of the rivers and surrounding nature.

Best time to go to Cairo

The best time to visit Cairo can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Cairo falls in July, when visitor numbers are average and weather is mostly sunny with light rain. The coolest average temperature in Cairo falls in January, visitor numbers are moderately low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January35.2°F (1.8°C)Light RainMostly SunnyModerately LowSlightly Low
February38.5°F (3.6°C)Light RainMostly SunnyModerately LowAverage
March48.7°F (9.3°C)Light RainMostly SunnyModerately HighAverage
April57.7°F (14.3°C)Light RainMostly SunnyModerately HighSlightly High
May67.5°F (19.7°C)Light RainMostly SunnyAverageSlightly High
June76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
July79.0°F (26.1°C)Light RainMostly SunnyAverageAverage
August77.2°F (25.1°C)Light RainMostly SunnyModerately HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October60.1°F (15.6°C)Light RainMostly SunnyAverageAverage
November47.8°F (8.8°C)Light RainMostly SunnyModerately LowSlightly Low
December40.6°F (4.8°C)Light RainMostly SunnyAverageSlightly Low

The nearest major airports for your trip to Cairo

Traveling to Cairo, Illinois, is convenient with several nearby airports. Marion, IL (MWA-Williamson County Regional) is 83.7km away, with hotel options like Drury Inn & Suites Marion, 3.2km from the airport, and Holiday Inn Carbondale-Conference Center, 12.9km away. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is closer at 41.8km, offering hotels such as Drury Plaza Hotel Cape Girardeau Conference Center and Courtyard by Marriott Cape Girardeau Downtown, both 9.7km from the airport. Finally, Cairo, IL (CIR-Cairo Regional) is only 8.0km away, with Quality Inn Cairo I-57 located 3.2km from the airport.

Frequently asked questions

Where is the best place for a stay in Cairo?
Based on our traveler data, Quality Inn Cairo I-57 is one of the top choices for your stay. This hotel offers free breakfast and free parking. Other good choices for your trip to the area are Super 8 by Wyndham Charleston/Sikeston East MO and Quality Inn Charleston - Sikeston. See all available top hotels, or vacation rentals in Cairo.
If I need to cancel my hotel reservation in Cairo, will I receive a refund?
Yes! Most hotel room reservations are refundable if you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If you booked a non-refundable reservation, you may still be able to cancel and receive a refund within 24 hours of your booking. Filter your search by fully refundable to find flexible hotel deals in Cairo.
Where can I learn more about changing or cancelling my trip to Cairo?
For more information about updating your trip to Cairo or cancelling it, head over to our customer service page.
Where is the best hotel to stay close to Fort Defiance?
Quality Inn Cairo I-57 is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and free parking. It's located 4.9 mi (7.8 km) from Fort Defiance. Other good options around the area include Victorian Splendor in So. Illinois: wallmanor.com and Eagle Inn Charleston.
What's the best hotel for staying near Barkley Regional Airport (PAH)?
Drury Inn & Suites Paducah is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and an indoor pool. It's located 4.7 mi (7.6 km) from Barkley Regional Airport. Other choices close to the airport include La Quinta Inn & Suites by Wyndham Paducah and Baymont by Wyndham Paducah.
What is staying in Cairo like?
Visitors can enjoy all that Cairo has to offer including the restaurants, entertainment choices, and riverfront. This city also attracts tourists with its small-town vibe. There are 25 hotels and other accommodations in the surrounding area. Find out more about Cairo.
What should I see while I'm in Cairo?
The picturesque setting of Mississippi River and Ohio River Valley exemplify the area's natural beauty. Additionally, you might want to add Fort Defiance State Park to your itinerary. Check out what more to see and do in Expedia's Cairo guide.
What's the seasonal weather like in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.

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