A large eye sculpture in a park surrounded by trees.

Northeast Missouri 4 Stars Hotels

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Northeast Missouri 4 Star Hotels

Tonight
Oct 23 - Oct 24
Tomorrow
Oct 24 - Oct 25
This weekend
Oct 23 - Oct 25
Next weekend
Oct 30 - Nov 1

Our top choices for Northeast Missouri 4-star hotels

A multi-story building with a symmetrical facade, large windows, and a central entrance with a canopy.
A reception area with a curved wooden desk, a laptop, and a chair. The wall has a sign reading "Locust Street Athletic and Swim Club."
A spacious lobby with multiple seating areas, a pool table, and artwork on the walls.
A reception desk with a wooden finish and the name "IDOL WOLF" on it.

1. 21C Museum Hotel St Louis

21C Museum Hotel St Louis
Downtown West
United States
A.R.
NT$4,658
NT$5,609 total
includes taxes & fees
Nov 15 - Nov 16
21C Museum Hotel St Louis
A spacious hotel lobby with multiple seating areas, a reception desk, and large windows offering a view of the cityscape.
A buffet with fruits, pastries, and beverages.
A modern bar area with a long counter, white bar stools, and a mix of bar and dining tables.
The Renaissance Hotel with a modern architectural design, featuring a prominent central entrance and a symmetrical facade.

2. Renaissance St. Louis Airport Hotel

Renaissance St. Louis Airport Hotel
Berkeley
United States
Cory
NT$3,619
NT$4,234 total
includes taxes & fees
Nov 20 - Nov 21
Renaissance St. Louis Airport Hotel
A modern lobby with a staircase, seating area, and wall-mounted artwork.
A rooftop restaurant with round tables, chairs, and a view of the city.
A modern lobby with a staircase, seating area, and an exit sign.
A hotel with a prominent sign reading "MOONRISE."

3. Moonrise Hotel

Moonrise Hotel
Delmar Loop
United States
Jessie
NT$5,227
NT$6,216 total
includes taxes & fees
Oct 27 - Oct 28
Moonrise Hotel
A modern outdoor lounge area with seating, a bar, and a view of a cityscape.
A modern bar area with a central fire feature, bar stools, and seating.
The exterior of the Clark & Bourbon hotel with a well-lit entrance, a marquee sign, and a landscaped planter area.
A restaurant with tables set for dining, a kitchen in the background, and hanging light fixtures.

4. Live by Loews - St.Louis

Live by Loews - St.Louis
Downtown St. Louis
United States
brandon
NT$4,507
NT$5,361 total
includes taxes & fees
Nov 15 - Nov 16
Live by Loews - St.Louis
A modern tavern with a large sign, glass doors, and indoor seating visible through the windows.
A grand lobby with a central chandelier, multiple levels, and rows of liquor bottles.
A bakery display case with various pastries and cakes.
A bar area with multiple seating arrangements, a stage, and a chandelier.

5. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
St. Charles
United States
Melissa
NT$5,182
NT$6,596 total
includes taxes & fees
Nov 16 - Nov 17
Ameristar Casino Resort and Spa
A hotel with a swimming pool, lounge chairs, and a courtyard with palm trees.
A bar area with a marble counter, bar stools, and a variety of liquor bottles.
An outdoor patio with a brick fireplace, wicker furniture, and a dining table set with food and drinks.
A restaurant with multiple dining tables and chairs, a bar area with shelves of bottles, and a large mirror above the bar.

6. The Royal Sonesta Chase Park Plaza St. Louis

The Royal Sonesta Chase Park Plaza St. Louis
Central West End
United States
Kristina
NT$4,362
NT$6,103 total
includes taxes & fees
Nov 22 - Nov 23
The Royal Sonesta Chase Park Plaza St. Louis
A rooftop pool area with multiple lounge chairs and umbrellas, surrounded by a modern building with large windows.
An outdoor seating area with modern furniture, a metal railing, and a view of surrounding buildings.
A bar area with a round table, ice-filled glasses, bottles of champagne, and decorative plants.
A long dining table set with candles, glassware, and white flowers, suggesting a formal dining experience.

7. Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton
Clayton
United States
Marsha
NT$4,934
NT$5,809 total
includes taxes & fees
Nov 1 - Nov 2
Le Méridien St. Louis Clayton
A modern hotel room with a large bed, a nightstand, a mirror, and a view of the city through arched windows.
A bar area with wooden paneling, a counter, and multiple stools.
A lobby with wooden paneling, a green wall, and two armchairs.
A modern restaurant interior with high tables, chairs, and a central bar area.

8. The Westin St. Louis

The Westin St. Louis
Downtown St. Louis
United States
Stacy
NT$4,268
NT$4,991 total
includes taxes & fees
Nov 15 - Nov 16
The Westin St. Louis
A modern hotel lobby with a bar area, seating arrangements, and decorative lighting.
A Marriott hotel with a large building, multiple flags, and a well-lit entrance area.
A modern lobby with seating areas, a reception desk, and a bar area.
A modern dining area with round tables, orange chairs, and a decorative wall with pottery.

9. Marriott St. Louis Airport

Marriott St. Louis Airport
Edmundson
United States
Richard
NT$4,641
NT$5,585 total
includes taxes & fees
Oct 30 - Oct 31
Marriott St. Louis Airport
A spacious lobby with a high ceiling, a central chandelier, and a patterned floor.
A long bar with multiple tables and chairs, wooden floors, and ornate chandeliers.
A spacious hotel lobby with a central seating area, multiple armchairs, and a bar.
A luxurious hotel lobby with a grand stage, elegant seating, and a large chandelier.

10. River City Casino & Hotel

River City Casino & Hotel
St. Louis
United States
jodi
NT$2,839
NT$3,805 total
includes taxes & fees
Nov 23 - Nov 24
River City Casino & Hotel
A multi-story hotel with a prominent 'Marriott' sign, featuring a classic architectural style with a red brick facade and large windows.
A spacious interior with a central staircase, large windows, and hanging chandeliers.
Lobby
A spacious lobby with a high ceiling, a bar area, multiple seating arrangements, and a large screen displaying a sports event.

11. Marriott St. Louis Grand

Marriott St. Louis Grand
Downtown St. Louis
United States
Leonor
NT$4,134
NT$4,916 total
includes taxes & fees
Nov 22 - Nov 23
Marriott St. Louis Grand
A grand lobby with a large chandelier, a bar area, and classical architecture.
A bar area with a central bar, multiple stools, and a chandelier.
A grand lobby with a bar area, chandeliers, and seating.
A grand lobby with a bar area, ornate chandeliers, and a staircase.

12. Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
Downtown St. Louis
United States
Anastasia
NT$3,515
NT$4,181 total
includes taxes & fees
Oct 25 - Oct 26
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel
An indoor swimming pool with clear glass walls, a tiled floor, and a 'Step Down' sign.
A lobby with a reception desk, seating area with sofas and ottomans, and a patterned rug.
A Drury Plaza Hotel with a large parking lot and multiple cars parked in front.
A spa bath with a sign indicating a capacity of 8 persons.

13. Drury Plaza Hotel St. Louis Brentwood

Drury Plaza Hotel St. Louis Brentwood
Brentwood
United States
angelia
NT$4,150
NT$4,929 total
includes taxes & fees
Nov 1 - Nov 2
Drury Plaza Hotel St. Louis Brentwood
A grand building with a fountain in front.
A cozy lounge area with leather sofas, a fireplace, and a bar counter.
A traditional building with a stone facade, large windows, and outdoor seating area with wicker furniture.
A modern building with a unique, curved roof structure.

14. The Cheshire

The Cheshire
Richmond Heights
United States
Matthew
NT$4,812
NT$5,714 total
includes taxes & fees
Nov 1 - Nov 2
The Cheshire
A multi-story hotel with a prominent corner location, large windows, and a well-lit facade.
A spacious lobby with striped chairs, a central coffee table, and large potted plants.
An indoor swimming pool area with lounge chairs, a small table, and potted plants.
A bar area with a long counter, multiple stools, and a television mounted on the wall.

15. Embassy Suites by Hilton St. Louis Downtown

Embassy Suites by Hilton St. Louis Downtown
Downtown St. Louis
United Kingdom
Luke
NT$3,707
NT$4,409 total
includes taxes & fees
Nov 23 - Nov 24
Embassy Suites by Hilton St. Louis Downtown
A rooftop terrace with outdoor seating, string lights, and a city skyline view.
A modern lounge area with a central cylindrical light fixture, white seating, and artwork on the walls.
A modern hotel room with a large window, a bathtub, and a unique eye-themed pillow.
A woman sitting on a green sofa in a modern lobby with a staircase and a large framed artwork on the wall.

16. Angad Arts Hotel St. Louis, Tapestry Collection by Hilton

Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
Grand Center
United States
Skylee
NT$3,364
NT$3,967 total
includes taxes & fees
Nov 22 - Nov 23
Angad Arts Hotel St. Louis, Tapestry Collection by Hilton
A modern hotel room with a large dining table, comfortable seating, a sofa, and a television.
A gym with various exercise machines, including treadmills and stationary bikes, arranged in rows.
A bar area with seating and a bar counter, large windows, and a high ceiling with exposed beams.
A hotel room with a bed, a sofa, a red ottoman, a nightstand, a lamp, and a view of a cityscape through large windows.

17. Hilton St. Louis at the Ballpark

Hilton St. Louis at the Ballpark
Downtown St. Louis
United States
kristen
NT$4,511
NT$5,364 total
includes taxes & fees
Nov 15 - Nov 16
Hilton St. Louis at the Ballpark
A spacious lobby with high ceilings, ornate columns, and a blue patterned carpet.
A spacious lobby with high arched ceilings, ornate columns, and a central fountain.
A restaurant with tables and chairs, large windows, and a view of the street.
A spacious lobby with a high arched ceiling, multiple seating areas, and a central decorative column.

18. St. Louis Union Station Hotel, Curio Collection by Hilton

St. Louis Union Station Hotel, Curio Collection by Hilton
Downtown West
United States
Donna
NT$5,311
NT$6,317 total
includes taxes & fees
Oct 31 - Nov 1
St. Louis Union Station Hotel, Curio Collection by Hilton
A spacious lobby with modern seating arrangements, a large chandelier, and a view of the cityscape through large windows.
A lobby with a clock, a sign for The Merchants' Laclede National Bank, and a security vault.
A couple exiting a building through ornate black gates.
A hotel room with two beds, a TV, a desk, and a chair.

19. Hilton Pennywell St. Louis at the Arch

Hilton Pennywell St. Louis at the Arch
Downtown St. Louis
United States
Mary
NT$3,569
NT$4,173 total
includes taxes & fees
Nov 15 - Nov 16
Hilton Pennywell St. Louis at the Arch
A modern hotel with a prominent DoubleTree by Hilton sign, a well-lit entrance, and a landscaped front yard.
A hotel room with a bed, a desk, a chair, a small table, a framed artwork, and a bathroom with a mirror and sink.
A modern interior with a wooden panel wall, a kitchen area, and a dining space with pendant lighting.
A modern kitchen with a marble countertop, red ceiling, and pendant lighting.

20. DoubleTree by Hilton St. Louis Airport

DoubleTree by Hilton St. Louis Airport
Woodson Terrace
United States
Kimberly
NT$3,071
NT$3,634 total
includes taxes & fees
Nov 22 - Nov 23
DoubleTree by Hilton St. Louis Airport
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 5-star hotels

Many 5-star hotels have the same amenities as 4-star hotels. See all 5-star hotels in Northeast Missouri.
The Ritz-Carlton, St. Louis

The Ritz-Carlton, St. Louis

100 Carondelet Plaza St. Louis MO
NT$18,775
NT$21,918 total
Nov 1 - Nov 2
includes taxes & fees
9.2/10 Wonderful! (586 reviews)
The Ritz-Carlton, St. Louis
Still don't see what you're looking for?
See all properties in Northeast Missouri.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Northeast Missouri

Great live music, sports teams, and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theaters.

See all hotels in Northeast Missouri
A large eye sculpture in a park surrounded by trees.
Photo by Andrew Hershfeld

Top Northeast Missouri Hotel Reviews

Live by Loews - St.Louis

Live by Loews - St.Louis

10/10 Excellent
"Great place to stay."
brandon 1-night trip
Posted 5 days ago
Live by Loews - St.Louis

Frequently asked questions

What are the best 4-star hotels in Northeast Missouri?
You can find a variety of 4-star hotels in Northeast Missouri, including in St. Louis. St. Louis Union Station Hotel, Curio Collection by Hilton is an Expedia customer favorite here that offers premium bedding and concierge services. Another place that rates highly with travelers is The Last Hotel. Concierge services and a pillowtop mattress help make it their preferred choice.
How much does it cost to stay in a 4-star hotel in Northeast Missouri?
We can help you quickly locate the ideal 4-star hotel for your trip to Northeast Missouri. Use our filter tool to fine-tune your search by things like amenities, budget and star rating and get access to unbeatable deals in a couple of clicks.
  • Search for the lowest price from NT$21,918
What's the difference between 5-star and 4-star hotels in Northeast Missouri?
Give yourself the luxury treatment during your Northeast Missouri escape by checking in to a 4-star hotel. As well as featuring upscale accommodations, these properties are typically filled with amenities like large beds, complimentary bathrobes and more. A 5-star hotel will go the extra mile to make your trip an even more indulgent and unforgettable one. 24-hour front desk, luxurious spas and world-class dining are only the start of the exclusive services and conveniences you'll likely be able to enjoy.

Explore a world of travel with Expedia