Photo by Kirsten

Plan, book, travel with confidence
Better together
Save up to NT$25,000 when you book a flight and hotel together*
Find the right fit
With over 300,000 hotels worldwide, it's easy to create a perfect package
Rest easy
Plan, book, and manage your trip all in one place

Top Pet-friendly Southern Minnesota Hotels

La Quinta Inn & Suites by Wyndham Rochester Mayo Clinic S

4353 Canal Pl SE Rochester MN

11 min drive from Mayo Clinic

Make it a pet-friendly trip and bring along your four-legged friend. Dogs are welcome (fees apply) at this suburban hotel.

7.4/10 Good! (1,066 reviews)

"We love the location of this hotel, right next to a movie theatre, Target, restaurants. The bed was comfortable, room was clean, breakfast was wonderful, staff was friendly and efficient. My only complaint is that we look forward to using the hot tubs while we are in hotels and the pool area had ..."

Reviewed on 2026/6/19

Med City Inn & Suites - Mayo Clinic Area

435 16th Ave Nw Rochester MN

26 min walk from Mayo Clinic

Dogs are welcome to join you (fees apply) for a pet-friendly getaway at this family-friendly, city-center motel.

8/10 Very Good! (1,001 reviews)

"Breakfast was subpar. No waffle mix, milk for cereal and pancake grill didn’t even work. Hallway was musty. Location was great for access to Mayo and a walking trail close by."

Reviewed on 2026/6/17

Spark by Hilton Rochester South

4165 Maine Ave SE Rochester MN

10 min drive from Mayo Clinic

Book a stay at this business-friendly hotel in Rochester. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the helpful staff in our reviews. ...

9.2/10 Wonderful! (507 reviews)

"The room was well priced and very clean We enjoyed our stay there even though it was only one night it was very comfortable and there were no issues"

Reviewed on 2026/6/18

See all 1,186 properties in Southern Minnesota

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.