A calm lake reflecting trees with autumn foliage, a clear sky, and a distant shoreline.

Find Resorts & Hotels with Spas in St. Charles, MO

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Check availability on St. Charles Resorts & Hotels with Spas

This weekend
Nov 6 - Nov 8
Next weekend
Nov 13 - Nov 15

Our top choices for St. Charles hotels with a spa

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

1. Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles
3.0 star property
St. Charles
9.6 out of 10, Exceptional, (1,004 reviews)
"Wonderful place to stay and great location!"
United States
Robert
The price is NT$4,726
NT$5,479 total
includes taxes & fees
Nov 15 - Nov 16
Drury Plaza Hotel St. Louis St. Charles
A brick building with a sign reading "Country Inn & Suites."

2. Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District
2.5 star property
St. Charles Historic District
9.4 out of 10, Exceptional, (1,110 reviews)
"Very convenient to downtown St Charles. As per previous visits this hotel is excellent for the price range of the rooms."
United States
Stewart
The price is NT$4,154
NT$4,774 total
includes taxes & fees
Nov 29 - Nov 30
Country Inn & Suites by Radisson, St. Charles Historic District
A modern hotel lobby with a seating area, a coffee station, and a large window providing natural light.

3. Hampton Inn & Suites St. Charles Old Town Area

Hampton Inn & Suites St. Charles Old Town Area
2.5 star property
St. Charles
9.2 out of 10, Wonderful, (755 reviews)
"Great stay!"
United States
Sara
The price is NT$3,850
NT$4,626 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn & Suites St. Charles Old Town Area
A modern spa with a curved reception desk, a large mirror, and a decorative water feature.

4. Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa
4.5 star property
St. Charles
8.6 out of 10, Excellent, (1,089 reviews)
"Great place"
United States
Samuel
The price is NT$5,190
NT$6,606 total
includes taxes & fees
Nov 16 - Nov 17
Ameristar Casino Resort and Spa
A hotel with a prominent 'Comfort Suites' sign, a covered entrance with columns, and a parking lot.

5. Comfort Suites St Charles - St Louis

Comfort Suites St Charles - St Louis
2.5 star property
St. Charles
8.4 out of 10, Very good, (1,000 reviews)
"Great stay."
United States
Bryan
The price is NT$2,994
NT$3,441 total
includes taxes & fees
Nov 22 - Nov 23
Comfort Suites St Charles - St Louis
A spacious living room with a large sectional sofa, a coffee table, and a fireplace. There is a television mounted on the wall and a chandelier hanging from the ceiling.

6. Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel
3.0 star property
St. Charles
8.2 out of 10, Very good, (1,002 reviews)
"Hotel was clean and staff were super friendly. Breakfast was good and coffee bar was excellent!"
United States
Steven
The price is NT$2,840
NT$3,292 total
includes taxes & fees
Nov 4 - Nov 5
Best Western Plus The Charles Hotel
Exterior

7. Candlewood Suites St Louis St Charles by IHG

Candlewood Suites St Louis St Charles by IHG
2.5 star property
St. Charles
7.6 out of 10, Good, (830 reviews)
"Only stayed for 6 hours after returning from a trip but the staff who checked me in was awesome and v3ry helpful!!!"
United States
Jeffrey
The price is NT$2,900
NT$3,333 total
includes taxes & fees
Nov 29 - Nov 30
Candlewood Suites St Louis St Charles by IHG
A spacious lobby with a reception desk, seating area, and a fireplace.

8. Americas Best Value Inn & Suites St. Louis, St. Charles Inn

Americas Best Value Inn & Suites St. Louis, St. Charles Inn
2.5 star property
St. Charles
5.6 out of 10, (1,003 reviews)
"Staff was extremely accommodating and helpful"
United States
ROSE
The price is NT$3,258
NT$3,777 total
includes taxes & fees
Nov 5 - Nov 6
Americas Best Value Inn & Suites St. Louis, St. Charles Inn
A living room with a brown leather sectional sofa, a glass coffee table, a wooden side table with drawers, a mirror, and a framed picture on the wall.

9. Super 8 by Wyndham St Charles

Super 8 by Wyndham St Charles
2.0 star property
St. Charles
8.2 out of 10, Very good, (1,002 reviews)
"Clean room, staff was polite and helpful!"
United States
Tammie
The price is NT$2,603
NT$2,992 total
includes taxes & fees
Nov 11 - Nov 12
Super 8 by Wyndham St Charles
A swimming pool area with red and white lounge chairs, a glass table, and a blue and yellow ceiling.

10. Hampton Inn St. Charles St. Peters

Hampton Inn St. Charles St. Peters
2.5 star property
St. Charles
8.2 out of 10, Very good, (1,008 reviews)
"Fantastic place to stay! The staff was amazing!"
United States
Catherine
The price is NT$3,569
NT$4,102 total
includes taxes & fees
Nov 22 - Nov 23
Hampton Inn St. Charles St. Peters
A Holiday Inn Express & Suites hotel with a covered entrance and a brick facade.

11. Holiday Inn Express Hotel and Suites St. Charles by IHG

Holiday Inn Express Hotel and Suites St. Charles by IHG
3.0 star property
St. Charles
8.2 out of 10, Very good, (771 reviews)
"As always with a Holiday Inn property, our room was clean and very comfortable. The staff was very friendly. Breakfast was good and served hot."
United States
sharon
The price is NT$3,649
NT$4,194 total
includes taxes & fees
Nov 27 - Nov 28
Holiday Inn Express Hotel and Suites St. Charles by IHG
A reception desk with a wooden counter, a computer, a telephone, and a small plant. There are three pendant lights above the desk.

12. Country Inn & Suites by Radisson, St. Peters, MO

Country Inn & Suites by Radisson, St. Peters, MO
2.5 star property
St. Charles
8.0 out of 10, Very good, (1,005 reviews)
"Great location. Friendly staff decent breakfast."
United States
Heather
The price is NT$2,787
NT$3,204 total
includes taxes & fees
Nov 29 - Nov 30
Country Inn & Suites by Radisson, St. Peters, MO
A hotel room with a bed, a bedside table, and a window with curtains.

13. Relax Inn Saint Charles

Relax Inn Saint Charles
2.0 star property
St. Charles
6.8 out of 10, (1,000 reviews)
"It was nice"
United States
Christoph
The price is NT$2,053
NT$2,359 total
includes taxes & fees
Nov 6 - Nov 7
Relax Inn Saint Charles
A modern living room with a sofa, armchair, and coffee table. A flat-screen TV is mounted on a stand, and a staircase is visible in the background.

14. Sleep Inn Saint Charles North

Sleep Inn Saint Charles North
2.5 star property
St. Charles
5.8 out of 10, (564 reviews)
"Great stay!"
United States
Christine
The price is NT$2,372
NT$2,726 total
includes taxes & fees
Nov 27 - Nov 28
Sleep Inn Saint Charles North
A multi-story hotel with a green facade, a prominent logo at the top, and a symmetrical window arrangement.

15. WoodSpring Suites St Louis St Charles

WoodSpring Suites St Louis St Charles
2.5 star property
St. Charles
5.6 out of 10, (308 reviews)
"Clean and staff was nice."
United States
Erica
The price is NT$2,769
NT$3,183 total
includes taxes & fees
Nov 4 - Nov 5
WoodSpring Suites St Louis St Charles
A hotel room with a large bed, a desk, and a television.

16. Home2 Suites by Hilton St. Charles St.Louis

Home2 Suites by Hilton St. Charles St.Louis
3.0 star property
St. Charles
The price is NT$3,714
NT$4,120 total
includes taxes & fees
Dec 1 - Dec 2
Home2 Suites by Hilton St. Charles St.Louis
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in St. Charles

Pool
Hot tub

Find out more about St. Charles

Top St. Charles attractions for a relaxing vacation

St. Charles, Missouri offers a delightful blend of relaxation and adventure for travelers seeking hotels with spas. Start your journey with a visit to the historic Main Street, lined with charming boutiques, restaurants, and art galleries, perfect for a leisurely stroll after a rejuvenating spa session. The nearby Frontier Park provides scenic river views and walking trails, ideal for unwinding and connecting with nature. Families can enjoy a day at the St. Charles City Parks, which feature playgrounds and picnic areas, making it a great spot for children to play while parents indulge in some pampering. For a unique experience, consider exploring the local wineries; many offer tastings and tours with tranquil surroundings that enhance your relaxation. After a day of activities, retreat to a spa hotel in the heart of the historic district, where you can enjoy top amenities and attentive service, ensuring you feel pampered throughout your stay.

Find the best hotels & resorts with spas in St. Charles

For those seeking relaxation and rejuvenation in St. Charles, Missouri, these top hotels offer exceptional spa amenities that promise a tranquil escape. Discover the perfect haven to unwind and pamper yourself during your stay.

Ameristar Casino Resort and Spa

  • Why it's great for tailored spa getaway: Ameristar Casino Resort and Spa stands out as a premier destination for travelers seeking a luxurious spa experience, an excellent guest review rating of 8.4. This resort features a full-service spa where guests can indulge in an array of treatments including body treatments, massages, and hydrotherapy sessions, ensuring a rejuvenating retreat right at their fingertips.
  • Other amenities: In addition to its spa offerings, the resort provides a wealth of amenities to enhance every guest's stay. Guests can enjoy the soothing ambiance of the hot tub, relax by the resort pool, or take advantage of fitness facilities open 24 hours. The hotel also features a poolside bar for refreshing drinks, onsite dining options, and concierge services to help plan the perfect getaway. With nearby winery tours and golf opportunities, guests have plenty of options to explore beyond the spa.
  • Nearby attractions: Ameristar Casino St. Charles - 0.01 miles, Historic Main Street - 0.68 miles, Lewis & Clark Boathouse and Nature Center - 0.71 miles

Top St. Charles Hotel Reviews

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

10/10 Excellent
"Whenever we are in St. Louis overnight this is our preferred hotel. Always clean, nice amenities, excellent location and a great breaakfast to get you get you up and going in the morning!"
Tamara 1-night trip
Posted 13 hours ago
Clayton Plaza Hotel & Extended Stay

Frequently asked questions

Looking for a spa hotel in St. Charles?
Book one of our lush spa hotels and pamper yourself from the moment you arrive. Travelers highly recommend the restaurants in St. Charles. Enjoy the historical sites and riverfront during your vacation. Hotels with spas are a great way to break away from your daily routine and add a layer of luxury to your vacation.
What is the best spa hotel in St. Charles?
Ameristar Casino Resort and Spa is a top luxury spa hotel featuring 6 restaurants, a casino, a 24-hour fitness center, and an outdoor pool. Treat yourself to a facial, body scrub, or hydrotherapy at Ara.
How many spa hotels will I find in St. Charles?
Among Expedia's 178 accommodation options in St. Charles, there is 1 spa hotel.
What's there to see and do in St. Charles?
Experience all that St. Charles has to offer when you visit Historic Main Street, Katy Trail, and Lewis & Clark Boathouse and Nature Center. If you have some spare time during your trip, you might want to check out St Charles Convention Center and Ameristar Casino St. Charles.
What is a St. Charles spa hotel?
Spa hotels in St. Charles provide lodging and have an on-site spa which offers services like couples massages as well as body treatments. Some also offer in-room treatments. Spa hotels are a must if you want to give yourself an extra treat while on vacation.

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