Santa Cruz

Travel Guide

San Lorenzo Cathedral showing a garden
Santa Cruz which includes a city
San Lorenzo Cathedral which includes heritage architecture and heritage elements
Santa Cruz which includes a city
San Lorenzo Cathedral
Experience Bolivia as the locals see it in the country’s busiest city, where the museums, public squares and churches give you a glimpse into their everyday lives.

Although Santa Cruz de la Sierra, more commonly known as Santa Cruz, is the most populous city in Bolivia, it is still relatively unknown by tourists. Sample an authentic Bolivian lifestyle in this busy city. Visit Santa Cruz’s churches and museums for an insight into the region’s history or simply soak up the atmosphere over a drink with the friendly locals.

Explore a city that started out in a totally different location. Santa Cruz was founded in 1561, but had to move west after several decades of fending off attacks. Visit the historic heart of the city in Plaza 24 de SeptiembreOpens in a new window, which is more than 400 years old, to relax with the locals, who are known as “cruceños.”

The most distinctive attraction in the city is San Lorenzo CathedralOpens in a new window, which is immediately recognizable for its red-brick frontage featuring two clock towers standing on either side of a pediment. The cathedral hosts the Museum of Sacred Art, with exhibits that display religious icons and Jesuit relics. Climb to the top of the clock tower for panoramic views of the city.

Wander around the Parque Arenal, a green space in the middle of the city. The park has a boating lagoon and the Museo Etnofolklorico (Santa Cruz Ethnographic Museum). Other museums in the city include the Guarani Museum, which examines the culture of the indigenous Guarani people, and the National History Museum.

Take children to the Zoological Gardens, where they can meet animals from around Bolivia. The zoo’s llamas and sloths are always popular with younger visitors.

Fly into the busiest airport in Bolivia, Viru Viru International Airport. Flights arrive here from destinations in both Bolivia and cities in North and South America. Some operators even fly here from cities in Europe, such as Madrid.

Santa Cruz de la Sierra is located in the lowlands of Bolivia in the east of the country, which means that rainfall is high during the summer months around January. Come during the high season, between May and October, for more dependable weather but higher prices.

Where to stay in Santa Cruz

Default Image

Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.

Hamacas
Ibis Santa Cruz DE LA Sierra

Ibis Santa Cruz DE LA Sierra

3 out of 5
AVENIDA CRISTOBAL DE MENDOZA Santa Cruz
The price is NT$1,188 per night from Dec 14 to Dec 15
NT$1,188
NT$1,188 total
Dec 14 - Dec 15
Book a stay at this business-friendly hotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff in our ...
9.4/10 Exceptional! (73 reviews)
everything was perfect 👌

Reviewed on 2025/11/27

Ibis Santa Cruz DE LA Sierra
Marriott Santa Cruz de la Sierra Hotel

Marriott Santa Cruz de la Sierra Hotel

5 out of 5
4to Anillo Entre Radial 23 Santa Cruz Santa Cruz
The price is NT$3,469 per night from Dec 19 to Dec 20
NT$3,469
NT$3,469 total
Dec 19 - Dec 20
Book a stay at this luxury hotel in Santa Cruz. Enjoy free parking, a full-service spa, and a rooftop terrace. Our guests praise the helpful staff in our reviews. ...
9/10 Wonderful! (211 reviews)
Muy bien exelente

Reviewed on 2025/12/9

Marriott Santa Cruz de la Sierra Hotel
Hotel Las Américas

Hotel Las Américas

3 out of 5
Calle 21 de Mayo esq, Seoane N 356 Santa Cruz Santa Cruz Department
The price is NT$1,199 per night from Dec 13 to Dec 14
NT$1,199
NT$1,199 total
Dec 13 - Dec 14
Stay at this hotel in Santa Cruz. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions La Recova Artisan Walk and Guarani Nandereko ...
6/10 (1 review)
Hotel mediano, ótima localização
O chuveiro foi impossível tomar um.banho de qualidade

Reviewed on 2025/7/29

Hotel Las Américas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Apart Hotel Premium Suites Santa Cruz

Apart Hotel Premium Suites Santa Cruz

3.5 out of 5
Calle Las Begonias Nro 45 Santa Cruz
Book a stay at this business-friendly apartment in Santa Cruz. Enjoy free WiFi, free parking, and room service. Popular attractions Patio Design LifeStyle Center ...
8.6/10 Excellent! (92 reviews)
Everything is perfect!!

Reviewed on 2025/10/29

Apart Hotel Premium Suites Santa Cruz
Premium Suites Deluxe Aparthotel Equipetrol

Premium Suites Deluxe Aparthotel Equipetrol

3.5 out of 5
Calle Las Azucenas No. 127 Santa Cruz Santa Cruz
Book a stay at this business-friendly aparthotel in Santa Cruz. Enjoy free WiFi, free parking, and breakfast (surcharge). Popular attractions Patio Design LifeStyle ...
8.8/10 Excellent! (81 reviews)
Great folks with there. Clean rooms.

Reviewed on 2025/8/29

Premium Suites Deluxe Aparthotel Equipetrol
Equipetrol Suites Apart Hotel

Equipetrol Suites Apart Hotel

2.5 out of 5
Equipetrol Santa Cruz Departamento de Santa Cruz
Book a stay at this business-friendly aparthotel in Santa Cruz. Enjoy free breakfast, free WiFi, and a 24-hour front desk. Popular attractions Cine Center and ...
8.6/10 Excellent! (8 reviews)
Voltarei
Hotel cumpre o que promete, limpeza, localização e funcionários atentos e amáveis.

Reviewed on 2025/8/9

Equipetrol Suites Apart Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Reviews of Santa Cruz

4.2
Top Destination
5 - Excellent
19
5 - Excellent 38%
4 - Good
23
4 - Good 46%
3 - Okay
7
3 - Okay 14%
2 - Disappointing
0
2 - Disappointing 0%
1 - Terrible
1
1 - Terrible 2%

4/5 - Good

Verified traveler

Very nice people

5/5 - Excellent

Verified traveler

I have family and friends in Santa Cruz

3/5 - Okay

Verified traveler

Most modern city in Bolivia with all big city traffic.

5/5 - Excellent

Verified traveler

A nice stopover for a couple of days, or base to explore the surrounding area. The real highlight of the area is Amboro National Park, and deserves extra time to relax, hike and explore. Santa Cruz city seems quite prosperous. People are friendly

4/5 - Good

Steven

People are nice. Leisure, food, etc. Is economical.

1/5 - Terrible

markleonard99@h

Wrong Santa Cruz!!