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Compare 292 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (345)
"Accommodating staff, comfortable rooms, wonderful pool"
Canada
Jay
The price is NT$3,976
NT$3,976 total
Dec 12 - Dec 13
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Ibis Santa Cruz DE LA Sierra

3.0 star property
Santa Cruz
9.6 out of 10, Exceptional, (72)
"Great Spot"
United States
Jose
The price is NT$1,195
NT$1,195 total
Dec 31 - 2026/1/1
Ibis Santa Cruz DE LA Sierra

Sun Hotel

3.5 star property
Santa Cruz
8.4 out of 10, Very Good, (329)
"Staff spoke English. Airport pickup beat any US hotel. Rooms nice. Restaurant was ok"
United States
Peter
The price is NT$2,814
NT$2,814 total
Dec 5 - Dec 6
Sun Hotel

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (253)
"Nice hotel "
United States
Narciso Lorenzo
The price is NT$2,004
NT$2,004 total
Jan 1 - 2026/1/2
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hotel Cortez

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (121)
"The staff and property are second to none! "
United States
Cynthia
The price is NT$3,306
NT$3,306 total
Dec 5 - Dec 6
Hotel Cortez

Camino Real Hotel

4.5 star property
Santa Cruz
8.8 out of 10, Excellent, (407)
"The parrots. Unique"
United States
Juan P
The price is NT$3,956
NT$3,956 total
Dec 25 - Dec 26
Camino Real Hotel

Marriott Santa Cruz de la Sierra Hotel

5.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (210)
"Great hotel, food and location albeit a little expensive "
United States
Reinaldo
The price is NT$3,482
NT$3,482 total
Jan 2 - 2026/1/3
Marriott Santa Cruz de la Sierra Hotel

HOTEL OSHO

3.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (33)
"Excellent"
United States
Neysa
HOTEL OSHO

Delfines Collection Hotel By Mercure

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (71)
"Clean comfortable rooms "
United States
mary
The price is NT$1,459
NT$1,459 total
Dec 12 - Dec 13
Delfines Collection Hotel By Mercure

Apart Hotel Premium Suites Santa Cruz

3.5 star property
Santa Cruz
8.6 out of 10, Excellent, (93)
"Come and go easily, intellectual and kind owners who are working hard to make the property improvements that will bring this hotel up to the next level. A family friendly environment with easy walking distance to everything you need. Bed was not the best, but I know they are upgrading so I appreciate the ongoing process. For a few nights stay, the deals are very fair prices. "
United States
Andrew
Apart Hotel Premium Suites Santa Cruz

Novotel Santa Cruz De La Sierra

5.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (103)
"Great location and very clean hotel. Will stay again soon."
United States
William
The price is NT$3,140
NT$3,140 total
Dec 18 - Dec 19
Novotel Santa Cruz De La Sierra

Hotel Las Américas

3.0 star property
Santa Cruz
6.0 out of 10, (1)
"O chuveiro foi impossível tomar um.banho de qualidade "
Brazil
Jean
The price is NT$1,204
NT$1,204 total
Dec 8 - Dec 9
Hotel Las Américas

Lido Hotel

3.0 star property
Santa Cruz
9.0 out of 10, Wonderful, (30)
"Very helpful and nice staff. Quiet location. near the central plaza. Great value "
United Kingdom
David
The price is NT$1,438
NT$1,438 total
Dec 5 - Dec 6
Lido Hotel

Chairú Eco Hotel

3.5 star property
Santa Cruz
9.6 out of 10, Exceptional, (45)
"Nice property. Would definitely stay there again and again. Only negative was on our last night there was a really noisy party next door that lasted until 2am. "
United States
Andrew
Chairú Eco Hotel

Premium Suites Deluxe Aparthotel Equipetrol

3.5 star property
Santa Cruz
9.0 out of 10, Wonderful, (80)
"Good price, great hotel!"
United States
James
The price is NT$1,221
NT$1,221 total
Jan 2 - 2026/1/3
Premium Suites Deluxe Aparthotel Equipetrol

TRYP by Wyndham Santa Cruz

4.0 star property
Santa Cruz
9.2 out of 10, Wonderful, (144)
"Nice stay with good service "
United States
Jianyuan
The price is NT$2,389
NT$2,389 total
Dec 31 - 2026/1/1
TRYP by Wyndham Santa Cruz

Hotel LP Santa Cruz Centro

3.0 star property
Santa Cruz
8.0 out of 10, Very Good, (280)
"Clean, friendly staff"
United States
Giovanna
Hotel LP Santa Cruz Centro

Hotel Arenal

3.5 star property
Santa Cruz
7.6 out of 10, Good, (59)
"Perfect hotel in a central location!"
United States
Max
The price is NT$2,067
NT$2,067 total
Jan 4 - 2026/1/5
Hotel Arenal

Swissôtel Santa Cruz De La Sierra

4.5 star property
Santa Cruz
9.2 out of 10, Wonderful, (81)
"Beautiful hotel"
Australia
Joanna
The price is NT$2,846
NT$2,846 total
Jan 1 - 2026/1/2
Swissôtel Santa Cruz De La Sierra

Hotel LP Equipetrol

3.5 star property
Santa Cruz
8.2 out of 10, Very Good, (201)
"Nice place to stay"
United States
Ricardo
Hotel LP Equipetrol
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Santa Cruz

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.

Stay near popular Santa Cruz attractions

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

Find out more about Santa Cruz

Top reasons to visit Santa Cruz

  • Vibrant City Life: Santa Cruz boasts a lively city center with bustling shopping centers, exciting nightlife, and a variety of entertainment options.
  • Cultural Richness: Visitors can explore stunning cathedrals, vibrant piazzas, and local landmarks that highlight the city’s cultural heritage.
  • Outdoor Adventures: Enjoy outdoor activities that showcase Santa Cruz's beautiful surroundings, including parks and recreational areas.
  • Delicious Local Cuisine: Savor a range of delicious meals at local restaurants, offering a taste of Bolivian flavors.
  • Comfortable Accommodations: A variety of motels and hotels cater to different needs, ensuring a comfortable stay for every traveler.

Find great hotels in Santa Cruz

Explore a variety of hotel accommodations in Santa Cruz, Bolivia, catering to every traveler's needs. Whether you're looking for a business-friendly hotel, a family-oriented stay, or a pet-friendly environment, you'll find excellent options here. With numerous hotels and hostels available, you can easily read reviews and discover the best places to stay for an unforgettable vacation experience in this vibrant city.

  • Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel: Nestled in the vibrant heart of Santa Cruz, Los Tajibos is a delightful retreat that seamlessly blends business and leisure. This 3.5-star hotel is particularly family-friendly, offering essential amenities for children, including a First Aid Kit. With spacious accommodations and a welcoming atmosphere, this hotel is perfect for travelers seeking a comfortable base for both work and play. Guests can enjoy the lush gardens, modern facilities, and exceptional service, making it an ideal choice for a memorable stay.
  • Hotel Cortez: Experience relaxation at Hotel Cortez, a refined 3.5-star hotel that caters to business travelers and wellness enthusiasts alike. This property features a full-service spa where guests can indulge in various treatments, including massages and access to a hot tub. With a focus on rejuvenation, the hotel also boasts a refreshing pool area and an inviting ambiance that promotes relaxation. Whether you're on a business trip or a spa-themed getaway, Hotel Cortez provides an excellent environment to unwind and recharge.
  • Buganvillas Hotel Suites & Spa: Buganvillas Hotel Suites & Spa stands out as a luxurious 4-star family-friendly accommodation in Santa Cruz. This hotel is designed to cater to families, featuring amenities such as a children’s pool and cribs available for a fee. The spacious suites offer a comfortable and home-like atmosphere, making it an excellent choice for family vacations. With a focus on both relaxation and fun, Buganvillas provides a well-rounded experience, ensuring that both parents and children enjoy their stay in this beautiful destination.

Where to stay near Santa Cruz

Santa Cruz, Bolivia, offers a vibrant blend of culture and excitement, making it an ideal destination for families and city-themed vacations. Explore the lively city center, where you'll find exciting venues and a bustling nightlife. Nearby neighborhoods like San Francisco and the West Coast provide unique experiences with friendly locals and picturesque surroundings. Whether you're seeking excursions or cultural immersion, Santa Cruz promises an unforgettable adventure for every traveler.

  • Montero: Located 49.9km from Santa Cruz, Montero is a lively city that attracts travelers year-round. The peak travel months are January and September to October, making it a great choice for family and business-themed experiences. Visitors will find an array of shopping options, including shopping centers and malls that cater to both locals and tourists alike. Montero's urban vibe, coupled with its convenient amenities, makes it an ideal spot for those looking to explore local culture while indulging in retail therapy.
  • La Guardia: Situated 20.9km from Santa Cruz, La Guardia is a charming city known for its outdoor and family-friendly atmosphere. With peak visitor numbers in September and December to January, this destination offers a refreshing escape for nature lovers. The local botanical garden is a must-visit, showcasing the region's diverse flora. Additionally, resorts in the area provide a perfect setting for relaxation and leisure, making La Guardia an excellent choice for families and nature enthusiasts seeking a delightful getaway.
  • Warnes: Just 30.6km from Santa Cruz, Warnes is another inviting city perfect for families and outdoor adventurers. Peak arrivals occur in September and from December to January, and visitors can enjoy the best of both worlds with its blend of urban and natural attractions. The city features shopping centers and malls, alongside resorts that cater to relaxation seekers. The nearby botanical garden serves as an enchanting backdrop for leisurely strolls, making Warnes a well-rounded destination for those looking to experience both city life and nature.

Things to do in Santa Cruz

Santa Cruz offers a vibrant mix of family-friendly and cultural activities perfect for tourists. Explore its bustling shopping centers and malls, enjoy live music, and savor delicious meals at local restaurants. Don't miss the chance to experience outdoor activities that showcase the city's beautiful surroundings. With a rich array of entertainment options, Santa Cruz promises a memorable vacation filled with unique experiences.

Shopping

For a vibrant shopping experience, visit Ventura Mall, which offers entertainment and family-friendly vibes. Don't miss La Recova Artisan Walk for local crafts. If you're up for a drive, check out Patio Design LifeStyle Center, known for its stylish atmosphere and diverse shopping options.

Recreation

At Ramon Tahuichi Aguilera Stadium in Santa Cruz, immerse yourself in the vibrant sports culture. Engage in recreational activities, watch thrilling matches, or take part in community fitness events, all while enjoying the energetic atmosphere that this iconic venue has to offer.

Adventure

Parque Nacional Amboró offers thrilling hiking trails through diverse ecosystems, where you can spot exotic wildlife and stunning waterfalls. For an adrenaline rush, try white-water rafting on the Río Pirai, navigating exciting rapids surrounded by breathtaking scenery. Experience the vibrant culture by exploring the lively markets and local cuisine.

Nightlife

Experience the vibrant nightlife in Santa Cruz by catching a film at Cine Center, where you can enjoy a mix of romance and family-friendly entertainment. For a taste of local culture, visit Casa Municipal de Cultura Raúl Otero Reiche, a theater showcasing captivating performances in a charming atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Santa Cruz

For a budget-friendly trip to Santa Cruz, consider visiting in January, June, or August when prices are lower. Saturdays are the cheapest days to stay, while Tuesdays are the priciest. Use Expedia to compare room rates and explore package deals that combine hotels, flights, and activities for added savings. Look for free activities around the city and take advantage of local public transportation for affordable travel. Sorting options by price can help you find the best deals tailored to your budget and preferences.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Santa Cruz are January, June and August, where the prices are slightly lower. This is in comparison to February, September and December, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Santa Cruz is Saturday. The most expensive day to stay in Santa Cruz is Tuesday.
  • Find cheap hotels on Expedia: Utilize Expedia's search tool to narrow down your options based on your budget, preferred location, and the type of hotel you’re looking for. To find the best prices and deals, simply sort the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Santa Cruz with your flights and activities through an Expedia package deal.

Find the best attractions in Santa Cruz

Santa Cruz, Bolivia, is perfect for city-themed, family, and cultural vacations. Explore its stunning cathedrals, vibrant piazzas, and local landmarks that cater to travelers seeking cultural and outdoor experiences. Don't miss the beautiful Santa Cruz beach for relaxation and fun. For accommodations, consider the various motels in the Santa Cruz area to ensure a comfortable stay during your visit.

  • Plaza 24 de Septiembre: This vibrant square is the heart of Santa Cruz, offering a blend of local culture and city vibes. It's an ideal spot to relax, enjoy street performances, and savor traditional Bolivian snacks from nearby vendors.
  • San Lorenzo Cathedral: A stunning example of colonial architecture, this cathedral showcases exquisite art and deep cultural significance. Visitors can admire its beautiful façade and tranquil atmosphere, perfect for reflection and appreciation of local history.
  • Lomas de Arena Regional Park: Experience the natural beauty of Santa Cruz in this unique desert-like environment, featuring sandy hills and diverse wildlife. It's a perfect getaway for sunbathing, hiking, and enjoying the warm weather.

Best time to go to Santa Cruz

The best time to visit Santa Cruz can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Santa Cruz falls in October, when visitor numbers are slightly low and weather is mostly sunny with light rain. The coolest average temperature in Santa Cruz falls in June, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January78.3°F (25.7°C)Light RainMostly SunnySlightly HighSlightly Low
February77.0°F (25.0°C)Light RainMostly CloudyAverageSlightly High
March76.5°F (24.7°C)Light RainMostly SunnyAverageAverage
April74.5°F (23.6°C)Light RainMostly SunnyAverageAverage
May70.2°F (21.2°C)Light RainMostly SunnySlightly LowAverage
June67.8°F (19.9°C)Light RainMostly SunnyAverageSlightly Low
July68.5°F (20.3°C)No RainMostly SunnySlightly HighAverage
August72.9°F (22.7°C)No RainSunnyAverageSlightly Low
September77.9°F (25.5°C)Light RainSunnySlightly HighSlightly High
October79.5°F (26.4°C)Light RainMostly SunnySlightly LowAverage
November79.3°F (26.3°C)Light RainMostly SunnyAverageAverage
December78.4°F (25.8°C)Light RainMostly SunnySlightly LowSlightly High

The nearest major airports for your trip to Santa Cruz

Traveling to Santa Cruz, Bolivia, is convenient with the main airport, Viru Viru International Airport (VVI), located 16.1km from the city. Nearby, you’ll find excellent 5-star accommodations such as the Marriott Santa Cruz de la Sierra and Radisson Hotel Santa Cruz, both situated 14.5km from the airport. The Novotel Santa Cruz De La Sierra is also a great option, located 17.7km away. These hotels offer easy access to the airport, ensuring a smooth transition for your travels. Whether you seek luxury or comfort, these options provide a perfect stay while exploring the vibrant city of Santa Cruz.

Frequently asked questions

What's the best place for a stay in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a favorite with Expedia customers. This hotel offers a restaurant and free parking. Reviews from our site also recommend Chairú Eco Hotel and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.
What's the top vacation rental that Santa Cruz has to offer?
Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. See all vacation rentals in Santa Cruz.
If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?
Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.
Where can I learn more about changing or cancelling my trip to Santa Cruz?
To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.
What's the best budget-friendly accommodation in Santa Cruz?
Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Residencial Ikandire II and Nomad Hostel. View all budget hotels in Santa Cruz.
What's the best accommodation for a family trip to Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Novotel Santa Cruz De La Sierra. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.
What is the top LGBTQ-friendly accommodation in Santa Cruz?
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.
What's the best pet-friendly hotel in Santa Cruz?
Ibis Santa Cruz DE LA Sierra is a top hotel for people traveling with their pets, and offers a restaurant and free WiFi for its human guests. Other good options for you and your pet's trip include HOTEL OSHO and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.
Where is the best place to stay close to Plaza 24 de Septiembre?
Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.
What about the best place to stay near Ventura Mall?
One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.
What's the best luxury accommodation in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Novotel Santa Cruz De La Sierra and Camino Real Hotel are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.
What are some accommodations with pools in Santa Cruz?
Sun Hotel is a top hotel with a children's pool, an outdoor pool, and free buffet breakfast. A couple of other options that offer an onsite pool include Yotau All Suites Hotel and Buganvillas Hotel Suites & Spa. View all hotels with pools in Santa Cruz.
What is the best spa hotel in Santa Cruz?
Marriott Santa Cruz de la Sierra Hotel is a top luxury spa hotel featuring a rooftop terrace, a fitness center, tennis courts, and a bar. Spend an afternoon at Hotel Spa where you'll find massage treatments. Other popular spa hotels in Santa Cruz include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Hotel Cortez. See all spa hotels in Santa Cruz.
What's the best hotel for staying near Viru Viru International Airport (VVI)?
Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.
How is it to stay in Santa Cruz?
Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 285 hotels and other accommodations to choose from. Find out more about Santa Cruz.
What should I do while I'm visiting Santa Cruz?
Cultural venues include Ethno-folkloric Museum, Cine Center, and Sacred Art Museum. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. Natural beauty is on display at Guembe Biocenter, Lomas de Arena Regional Park, and Arenal Park. Check out what more to see and do in Expedia's Santa Cruz guide.
How should I get around Santa Cruz?
To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.
What's the weather like in Santa Cruz?
The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.