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Compare 277 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Sun Hotel

3.5 star property
8.2 out of 10, Very Good, (313)
"Todo excelente "
Sun Hotel

Swissôtel Santa Cruz De La Sierra

4.5 star property
9.2 out of 10, Wonderful, (77)
"Beautiful hotel"
The price is NT$4,525
NT$4,525 total
Sep 15 - Sep 16
Swissôtel Santa Cruz De La Sierra

Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

3.5 star property
9.0 out of 10, Wonderful, (325)
"Always an amazing hotel "
The price is NT$4,005
NT$4,005 total
Oct 1 - Oct 2
Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel

Novotel Santa Cruz De La Sierra

5.0 star property
9.2 out of 10, Wonderful, (95)
"Nice hotel, modern, with pool, good restaurant. Would stay here again without no doubt. "
The price is NT$3,210
NT$3,210 total
Sep 15 - Sep 16
Novotel Santa Cruz De La Sierra

Hotel LP Santa Cruz Centro

3.0 star property
8.0 out of 10, Very Good, (280)
"Clean, friendly staff"
Hotel LP Santa Cruz Centro

Terranova Suites

3.5 star property
8.0 out of 10, Very Good, (90)
"The pictures of the property have to be from a decade ago. This place it is dirty and in poor shape. "
The price is NT$1,490
NT$1,490 total
Sep 2 - Sep 3
Terranova Suites

TRYP by Wyndham Santa Cruz

4.0 star property
9.2 out of 10, Wonderful, (131)
"Nice stay with good service "
The price is NT$3,332
NT$3,332 total
Sep 1 - Sep 2
TRYP by Wyndham Santa Cruz

Marriott Santa Cruz de la Sierra Hotel

5.0 star property
9.0 out of 10, Wonderful, (193)
"Great hotel, food and location albeit a little expensive "
The price is NT$3,155
NT$3,155 total
Sep 5 - Sep 6
Marriott Santa Cruz de la Sierra Hotel

Camino Real Hotel

4.5 star property
8.8 out of 10, Excellent, (398)
"Great Hotel, had a great time ."
The price is NT$4,378
NT$4,378 total
Sep 13 - Sep 14
Camino Real Hotel

Casa Vida

3.5 star property
9.0 out of 10, Wonderful, (2)
"buena recepción, el lugar es muy bueno un poco alejado de la ciudad, falta comodidad en algunos aspectos pero la casa es grande y espaciosa"
Casa Vida

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

4.5 star property
9.2 out of 10, Wonderful, (248)
"Nice hotel "
The price is NT$2,300
NT$2,300 total
Oct 1 - Oct 2
Hampton by Hilton Santa Cruz/Equipetrol, Bolivia

Hotel Cortez

3.5 star property
9.0 out of 10, Wonderful, (111)
"I love the pool and garden area and ALL of the staff are so friendly and helpful "
The price is NT$3,522
NT$3,522 total
Sep 5 - Sep 6
Hotel Cortez

Hotel BY Armonia SCZ

3.0 star property
8.4 out of 10, Very Good, (7)
Hotel BY Armonia SCZ

Alfonsina Hotel Boutique by Inboccaluppo

3.5 star property
9.4 out of 10, Exceptional, (38)
"Love it. Will stay again!!"
The price is NT$4,093
NT$4,093 total
Sep 1 - Sep 2
Alfonsina Hotel Boutique by Inboccaluppo

Casa Por Temporadas

2.0 star property
10.0 out of 10, Exceptional, (1)
"The front desk staff was amazing! We checked in during a rain storm and the hotel had been hit by lightning and their computers and they computers were out. The staff maintained their professionalism and got us in a room quickly. Thank you for your help "
The price is NT$2,904
NT$2,904 total
Sep 1 - Sep 2
Casa Por Temporadas

Posada Express Fast Check

3.0 star property
10.0 out of 10, Exceptional, (1)
The price is NT$963
NT$1,059 total
Sep 5 - Sep 6
Posada Express Fast Check

Cosmopolitano Hotel Boutique

3.5 star property
9.2 out of 10, Wonderful, (121)
"Top class and 5 Stars. Attentive , caring staff and wonderful food ! A great location, only 10 minutes from 24 Septiembre plaza. Thoroughly recommend."
Cosmopolitano Hotel Boutique

Chairú Eco Hotel

3.5 star property
9.4 out of 10, Exceptional, (39)
"Nice and clean hotel "
Chairú Eco Hotel

Premium Suites Deluxe Aparthotel Equipetrol

3.5 star property
9.0 out of 10, Wonderful, (74)
"Good price, great hotel!"
Premium Suites Deluxe Aparthotel Equipetrol

Lido Hotel

3.0 star property
9.0 out of 10, Wonderful, (24)
"Clean, with AC and both hot and cold water. "
The price is NT$1,392
NT$1,392 total
Sep 6 - Sep 7
Lido Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Where to stay in Santa Cruz

Find the best Santa Cruz areas and neighborhoods for the activities you enjoy most. Learn more about Santa Cruz
Learn more about Santa Cruz

Hamacas

While Hamacas isn't home to many top sights, Santa Cruz Zoo and Las Brisas Shopping Center are some notable places to visit nearby.

Learn more about Santa Cruz

Tropical energy pulses through Plaza 24 de Septiembre, where locals gather under palm trees and the Metropolitan Cathedral's twin towers stand watch. Biocentro Güembé offers rainforest trails with butterfly gardens, while the massive Ventura Mall provides air-conditioned shopping when afternoon temperatures climb.

San Lorenzo Cathedral showing a garden

Top Santa Cruz Hotel Reviews

More cheap stays in Santa Cruz

More cheap stays in Santa Cruz

Frequently asked questions

What's the best place for a stay in Santa Cruz?

Ibis Santa Cruz DE LA Sierra is a favorite with Expedia customers. This hotel offers a restaurant and free parking. Reviews from our site also recommend Alfonsina Hotel Boutique by Inboccaluppo and Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel as top options for your trip. See all available top hotels, or vacation rentals in Santa Cruz.

What's the top vacation rental that Santa Cruz has to offer?

Casa Vida: Visitors give good reviews to this Santa Cruz vacation home rental, which is located in a rural location and has an outdoor pool, a patio, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a full-sized fridge, a stovetop, and a microwave, so you can cook with friends or family. Kick off your shoes and enjoy yourself with a private yard and a selection of games. See all vacation rentals in Santa Cruz.

If I need to cancel my hotel reservation in Santa Cruz, will I receive a refund?

Yes! Most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which often is within 24-48 hours of your scheduled arrival. If your reservation is non-refundable, you might still have the option to cancel and get a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Santa Cruz.

Where can I learn more about changing or cancelling my trip to Santa Cruz?

To find more details about picking new dates or cancelling your trip to Santa Cruz, head over to our customer service page.

What's the best budget-friendly accommodation in Santa Cruz?

Based on our traveler reviews, residencial francia - Hostel is a top choice for a less expensive stay. Other choices for your budget-friendly stay include Nomad Hostel and Urubo Suite - Hostel. View all budget hotels in Santa Cruz.

What's the best accommodation for a family trip to Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a hotel with an outdoor pool and a restaurant, and it's a top choice on Expedia for families. Other choices for your stay with the kids include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Hampton by Hilton Santa Cruz/Equipetrol, Bolivia. Attractions like Santa Cruz Zoo and Play Land Amusement Park are also fun for kids of all ages. Find more child-friendly accommodations in Santa Cruz.

What is the top LGBTQ-friendly accommodation in Santa Cruz?

Hampton by Hilton Santa Cruz/Equipetrol, Bolivia is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Swissôtel Santa Cruz De La Sierra and Radisson Hotel Santa Cruz are other good choices for your trip. See all available hotels listed as LGBTQ-friendly in Santa Cruz.

What's the best pet-friendly hotel in Santa Cruz?

Ibis Santa Cruz DE LA Sierra is a top hotel for people traveling with their pets, and offers a restaurant and free WiFi for its human guests. Other good options for you and your pet's trip include Hotel LP Santa Cruz Centro and Hotel LP Equipetrol. See more pet-friendly hotel accommodations in Santa Cruz.

Where is the best place to stay close to Plaza 24 de Septiembre?

Adjacent to Plaza 24 de Septiembre, Nomad Hostel is one of the top choices for your stay based on our traveler data, and this property offers a restaurant and a bar. Other good options close by include Senses Centro and Cosmopolitano Hotel Boutique.

What about the best place to stay near Ventura Mall?

One of the top choices for your stay is Camino Real Hotel, located next to Ventura Mall, and this 4-star hotel offers 2 bars and a restaurant. Los Tajibos Hotel And Convention Center and Marriott Santa Cruz de la Sierra Hotel are two other good choices in the immediate area.

What's the best luxury accommodation in Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a luxury hotel with a full-service spa and a rooftop terrace, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Hampton by Hilton Santa Cruz/Equipetrol, Bolivia and Novotel Santa Cruz De La Sierra are other upscale choices for your vacation. Find more luxury hotels in Santa Cruz.

What are some accommodations with pools in Santa Cruz?

Sun Hotel is a top hotel with a children's pool, an outdoor pool, and free buffet breakfast. A couple of other options that offer an onsite pool include Buganvillas Hotel Suites & Spa and Yotau All Suites Hotel. View all hotels with pools in Santa Cruz.

What is the best spa hotel in Santa Cruz?

Marriott Santa Cruz de la Sierra Hotel is a top luxury spa hotel featuring a rooftop terrace, a fitness center, tennis courts, and a bar. Spend an afternoon at Hotel Spa where you’ll find massage treatments. Other popular spa hotels in Santa Cruz include Los Tajibos, Santa Cruz de la Sierra, a Tribute Portfolio Hotel and Camino Real Hotel. See all spa hotels in Santa Cruz.

What's the best hotel for staying near Viru Viru International Airport (VVI)?

Sun Hotel is a popular 3.5-star hotel featuring free breakfast and a restaurant. It's located a short 1.3 mi (2.1 km) from Viru Viru Intl. Airport.

How is it to stay in Santa Cruz?

Visitors to Santa Cruz are sure to enjoy the shopping. Tourists can also enjoy the city's cafes, zoo, and cathedral. In Santa Cruz, there are 271 hotels and other accommodations to choose from. Find out more about Santa Cruz.

What should I do while I'm visiting Santa Cruz?

Cultural venues include Cine Center, Sacred Art Museum, and Franco Aleman Cultural Center. Landmarks like San Lorenzo Cathedral, Plaza 24 de Septiembre, and Blacutt Square might be worth a visit. The picturesque setting of Guembe Biocenter and Lomas de Arena Regional Park exemplify the area's natural beauty. Check out what more to see and do in Expedia's Santa Cruz guide.

How should I get around Santa Cruz?

To see more of the larger area, ride aboard one of the trains from Santa Cruz de la Sierra Station. If you want to venture out around the area, you may want a rental car in Santa Cruz for your journey.

What's the weather like in Santa Cruz?

The hottest months are usually October and November with an average temp of 79°F, while the coldest months are June and July with an average of 70°F. Average annual precipitation for Santa Cruz is 48 inches.