Santa Ana

Antigua Guatemala

A white colonial church with ornate architecture and a large wooden door.


Santa Ana Hotel Deals

Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9 Guatemala City Guatemala
The price is NT$3,156 per night from Oct 25 to Oct 26
NT$3,156
NT$3,850 total
Oct 25 - Oct 26
includes taxes & fees
Book a stay at this luxury hotel in Guatemala City. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the breakfast and the pool in our ...
Barceló Guatemala City
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 out of 5
3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez
The price is NT$7,869 per night from Oct 20 to Oct 21
NT$7,869
NT$9,990 total
Oct 20 - Oct 21
includes taxes & fees
Book a stay at this luxury hotel in Antigua Guatemala. Enjoy free parking, a full-service spa, and 2 restaurants. Our guests praise the helpful staff and the ...
Hotel Museo Spa Casa Santo Domingo
Wyndham Garden Guatemala City

Wyndham Garden Guatemala City

4 out of 5
1a Avenida 12-46 Zona 10 Guatemala City Guatemala
The price is NT$3,007 per night from Nov 1 to Nov 2
NT$3,007
NT$3,669 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this business-friendly hotel in Guatemala City. Enjoy free breakfast, free WiFi, and room service. Our guests praise the breakfast and the helpful ...
9.2/10 Wonderful! (1,942 reviews)
"Es muy céntrico, la señora de la limpieza es excelente y digo que ella porque fue la que nos tocó todos los días (Amparo), súper detallista y cuidadosa. El destino es muy rico y variado El restaurante del hotel es delicioso Todo está limpio, cuidado, y de verdad que tiene lugares cerca muy ..."

Reviewed on 2026/10/13

Wyndham Garden Guatemala City
Adriatika Hotel & Residence

Adriatika Hotel & Residence

4.5 out of 5
4 av 20-44 Zona 14 Guatemala City Guatemala
The price is NT$3,495 per night from Oct 23 to Oct 24
NT$3,495
NT$4,264 total
Oct 23 - Oct 24
includes taxes & fees
Book a stay at this luxury hotel in Guatemala City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff and the clean ...
9.6/10 Exceptional! (1,001 reviews)
"Beautiful property, courteous staff…top tier hotel!"

Reviewed on 2026/10/11

Adriatika Hotel & Residence
Hotel Camino Real Antigua

Hotel Camino Real Antigua

4 out of 5
7a Calle Poniente 33B Antigua Guatemala Sacatepequez
The price is NT$6,034 per night from Oct 18 to Oct 19
NT$6,034
NT$8,159 total
Oct 18 - Oct 19
includes taxes & fees
Book a stay at this spa hotel in Antigua Guatemala. Enjoy free WiFi, free parking, and a full-service spa. Our guests praise the helpful staff and the property ...
9.6/10 Exceptional! (1,007 reviews)
"Everyone there were so friendly, helpful, polite. The hotel is beautiful, close to everything. I will come back to Antigua and stay again in Camino Real. Gorgeous. Good location, amazing 👏"

Reviewed on 2026/10/14

Hotel Camino Real Antigua
Hotel Biltmore Guatemala

Hotel Biltmore Guatemala

3.5 out of 5
15 Calle 0-31, Zona 10 Guatemala City Guatemala
The price is NT$2,837 per night from Nov 1 to Nov 2
NT$2,837
NT$3,461 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this business-friendly hotel in Guatemala City. Enjoy free WiFi, free parking, and breakfast (surcharge). Our guests praise the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
"Excellent place to stay! In the heart of a livley zone and within walking distance from restaurants and malls. And just a few minutes from even more things to do."

Reviewed on 2026/10/13

Hotel Biltmore Guatemala
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most.

Historic Center

While visiting Historic Center, you might make a stop by sights like Central Park and Santa Catalina Arch.

Barrio de La Concepción

While visiting Barrio de La Concepción, you might make a stop by sights like Casa Santo Domingo Museum and Jade Maya Factory and Museum.



Santa Ana