Santa Ana Vacations

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to NT$25,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Santa Ana Hotel Deals

Barceló Guatemala City

Barceló Guatemala City

4.5 out of 5
7 Avenida 15-45, Zona 9 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
The price is NT$3,950 per night from Jun 23 to Jun 24
NT$3,950
NT$4,819 total
Jun 23 - Jun 24
includes taxes & fees
9.2/10 Wonderful! (3,337 reviews)
"As always, my stay was excellent. The toilet was having some issues but the staff was very responsive when I reported it."

Reviewed on 2026/6/6

Barceló Guatemala City
Tikal Futura Hotel & Convention Center

Tikal Futura Hotel & Convention Center

4.5 out of 5
Calzada Roosevelt 22-43 Guatemala City Guatemala
Fully refundableReserve now, pay when you stay
The price is NT$3,608 per night from Jun 14 to Jun 15
NT$3,608
NT$4,402 total
Jun 14 - Jun 15
includes taxes & fees
9.2/10 Wonderful! (1,019 reviews)
"The room in general was clean, but the shower head was not working and was dirty , where the water is supposed to come out from. Good thing the shower hose did work ."

Reviewed on 2026/6/7

Tikal Futura Hotel & Convention Center
Hotel Museo Spa Casa Santo Domingo

Hotel Museo Spa Casa Santo Domingo

4.5 out of 5
3a Calle Oriente No 28 A Antigua Guatemala Sacatepequez
Fully refundableReserve now, pay when you stay
The price is NT$7,496 per night from Jun 8 to Jun 9
NT$7,496
NT$9,529 total
Jun 8 - Jun 9
includes taxes & fees
9.2/10 Wonderful! (1,064 reviews)
""I have been visiting this hotel for years, and it consistently exceeds my expectations. The level of customer service is truly remarkable—the staff goes out of their way to make you feel like family, remembering your preferences and ensuring a seamless stay. Excellent service, dining, clean rooms, ..."

Reviewed on 2026/6/6

Hotel Museo Spa Casa Santo Domingo
See all 1,253 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana vacation package cost?
You can pick up a vacation package to this destination on Expedia. However, how much your vacation to Santa Ana costs will depend on the season, hotel choice and length of stay.
What are the cheapest months to go to Santa Ana?
If you'd like to snag a cheap Santa Ana vacation package, consider visiting in June, September and October. You'll usually find better prices on accommodations and flights during these months — perfect for a budget-friendly break.
How many days is enough for Santa Ana?
Generally, a handful of days is enough to tick off the main attractions during your Santa Ana vacation. However, if you'd like to have time to relax or go on day trips, consider extending your itinerary.
How to find the best Santa Ana package deals?
Begin your search for a Santa Ana package deal by entering your destination and preferred trip dates under our "Packages" tab. Then apply some filters, like "Property type" and "Popular locations," to tailor the results to your exact style. You can also sort by "Package discount" and discover offers that come with unbeatable savings. If you don't find the ideal Santa Ana package deal straight away, just play around with your dates and search again. Remember that deals are only available for a limited time, so book early and get your Santa Ana adventure underway.
Is it cheaper to book a Santa Ana vacation as a package?
An Expedia vacation package could land you great savings when compared to arranging hotels and flights individually. Better still, you can customize your Santa Ana trip to fit your exact style. Choose your preferred flight time, select the hotel type and add a car rental. Browse our bundle deals and find out how much you can save.
When to book a vacation package to Santa Ana?
If you're considering a spontaneous Santa Ana trip, check out our last-minute deals that can be booked up to a week before you take off. Don't want to leave things to the last minute? You can score incredible deals on your flights and hotels by booking well in advance.
How to plan a trip to Santa Ana?

  1. Pick your travel dates: What you'd like to do in Santa Ana and your preferred season can help you decide when to travel.
  2. Work out your budget: Make sure you have enough money to cover everything from meals and transportation to flights and activities. Your hotel will probably be the largest expense during your trip to Santa Ana.
  3. Decide how long to go for: Now that you're more familiar with Santa Ana, you can work out the ideal length of your break. Create a rough plan and give yourself enough time to get through everything on your must-do list.
  4. Bundle your accommodations and airfare: After you've nailed down your trip dates and duration, book the perfect Santa Ana vacation package for you.

Discover the most popular places to visit in Santa Ana

Antigua, Guatemala

Antigua Guatemala Cathedral

4.5/5(427 reviews)

After visiting Antigua Guatemala Cathedral, make a plan to see the other sights and activities in Antigua Guatemala. Discover the area's volcano viewpoints, or seek out its local tours.

Antigua Guatemala Cathedral
Antigua, Guatemala, volcano

Central Park

4.5/5(503 reviews)

Enjoy the volcano viewpoints and explore Central Park, a lovely green space in Antigua Guatemala. Discover the area's shops, or seek out its local tours.

Central Park
The Santa Catalina arch and the main street of Antigua city at sunrise, Guatemala.

Santa Catalina Arch

4.5/5(453 reviews)

Find out about the history of Antigua Guatemala when you spend time at Santa Catalina Arch. Discover the volcano viewpoints and shops in this family-friendly area.

Santa Catalina Arch
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.