A sunset over a mountainous landscape with scattered clouds.

Find Resorts & Hotels with Spas in La Mesa, CA

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on La Mesa Resorts & Hotels with Spas

Tonight
Sep 28 - Sep 29
Tomorrow
Sep 29 - Sep 30
This weekend
Oct 2 - Oct 4
Next weekend
Oct 9 - Oct 11

Our top choices for La Mesa hotels with a spa

A hotel with a curved entrance, palm trees, and a parking lot.
A resort with a large swimming pool surrounded by lounge chairs and palm trees.
A bar area with wooden chairs and tables, a bar counter with various bottles, and a sign reading "BEACH BUMS CATER HERE".
A spacious lobby with a central round table, a reception desk, and a bar area.

1. Handlery Hotel

Handlery Hotel
Mission Valley
  • Surrender to spa treatments and poolside luxury at this hotel with massage rooms and a beautiful heated outdoor pool and hot tub.
NT$3,277
NT$3,767 total
includes taxes & fees
Sep 29 - Sep 30
Handlery Hotel
A hotel room with a large bed, a desk, a chair, a painting, and a view of the city.
A spacious lobby with a round table, blue benches, a large painting, and a view of the outdoors.
A hotel entrance with a covered walkway, palm trees, and a parking area.
A swimming pool with lounge chairs and umbrellas, surrounded by palm trees and greenery.

2. Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
National City
  • Indulge in bay-side spa services and hot tub relaxation at this tranquil hotel where pampering treatments meet scenic marina views.
NT$4,830
NT$5,323 total
includes taxes & fees
Oct 25 - Oct 26
Best Western Plus Marina Gateway Hotel
A modern bathroom with a shower, a towel rack, and a bench.
A pathway leading to a building labeled "LEGACY Hotel."
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.
A hotel room with a large bed, a wooden nightstand, a bench, a desk with a TV, and a chair.

3. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
Mission Valley
  • Indulge in a serene escape at this upscale hotel with a full-service spa, outdoor pool with free cabanas, and couples massage treatments.
NT$4,954
NT$5,694 total
includes taxes & fees
Sep 29 - Sep 30
Legacy Resort Hotel & Spa
A person sitting by a pool with a tiled floor and a marble wall.
A modern lounge area with leather seating, a central fire feature, and geometric patterned railings.
A modern lounge area with dark-toned seating, a central coffee table, and a stone accent wall.
A modern bar area with a long counter, multiple stools, and a variety of bottles on shelves.

4. Sycuan Casino Resort

Sycuan Casino Resort
El Cajon
  • Escape to a luxurious mountain retreat with 10 treatment rooms and outdoor pools, where hot stone massages and aromatherapy await.
NT$2,763
NT$3,420 total
includes taxes & fees
Oct 15 - Oct 16
Sycuan Casino Resort
A modern spa room with two massage tables, a decorative wall piece, and a large window offering a view of the landscape.
Gym
A modern hotel with a rooftop pool, multiple floors, and a view of mountains in the background.
A modern bar area with a checkered tile backsplash, bar stools, a central bar counter, and a decorative light fixture.

5. Jamul Casino Resort

Jamul Casino Resort
Jamul
NT$6,002
NT$6,617 total
includes taxes & fees
Sep 29 - Sep 30
Jamul Casino Resort
A couple standing in a lobby with a display of vases and plants.
A rooftop lounge area with outdoor seating, a pool, and umbrellas.
A modern bar area with a curved counter, multiple bar stools, and a large window offering a view of the cityscape.
An outdoor patio area with seating arrangements, including sofas, chairs, and round tables.

6. Omni San Diego Hotel at the Ballpark

Omni San Diego Hotel at the Ballpark
Downtown San Diego
  • Rooftop spa retreat delivers poolside massages and soothing therapies in the heart of downtown San Diego.
NT$8,200
NT$10,944 total
includes taxes & fees
Oct 5 - Oct 6
Omni San Diego Hotel at the Ballpark
A modern bathroom with two sinks, a large mirror, and green tiled walls.
A dining area with a long wooden table set for multiple guests, surrounded by dark blue chairs.
A hotel entrance with a modern building, a central illuminated sculpture, and a landscaped area with plants.
A large building with a central dome and a reflection in the water.

7. The Westin San Diego Gaslamp Quarter

The Westin San Diego Gaslamp Quarter
Downtown San Diego
  • Indulge in rejuvenating spa services and body treatments at this upscale San Diego hotel with a rooftop terrace and heated outdoor pool.
NT$6,319
NT$8,253 total
includes taxes & fees
Oct 25 - Oct 26
The Westin San Diego Gaslamp Quarter
A reception area with a wooden reception desk, a potted plant, and a sofa with cushions.
A luxurious lobby with a grand chandelier, plush blue sofas, and ornate decor.
A rooftop terrace with white sofas, a fountain, and potted plants.
A luxurious room with ornate chandeliers, a grand staircase, and plush seating.

8. Westgate Hotel

Westgate Hotel
Downtown San Diego
  • Rooftop spa retreat with hot tub, sauna, and steam room offers luxurious escape with views of San Diego's cityscape and harbor.
NT$5,687
NT$7,699 total
includes taxes & fees
Oct 25 - Oct 26
Westgate Hotel
A spa room with a bed, a small table with a tray, a wall-mounted plant wall, and a corridor with chairs and a potted plant.
An outdoor dining area with wicker furniture and potted plants.
A rooftop pool area with lounge chairs and a view of the building's brick facade.
A multi-story hotel with a prominent 'PENDR' sign, large windows, and a corner entrance.

9. Pendry San Diego

Pendry San Diego
Downtown San Diego
  • Rejuvenate at this luxury San Diego hotel featuring a full-service spa with massages and facials alongside a poolside retreat.
NT$9,368
NT$12,603 total
includes taxes & fees
Oct 18 - Oct 19
Pendry San Diego
A spacious lobby with high ceilings, a fireplace, and a variety of seating options including armchairs and sofas.
A covered walkway with red flowers, lanterns, and a fountain in the distance.
A marina with boats, a yacht, and a balcony with two chairs and a table.
A hotel with a Mediterranean architectural style, featuring a curved entrance, palm trees, and a well-lit driveway.

10. Kona Kai San Diego

Kona Kai San Diego
Point Loma
  • Pamper yourself at this waterfront retreat with 6 luxurious spa treatment rooms and beachside massages for a truly restorative getaway.
NT$6,072
NT$8,884 total
includes taxes & fees
Sep 30 - Oct 1
Kona Kai San Diego
View all properties

Choose what matters most at spa hotels in La Mesa

Pool
Breakfast included
Hot tub
4 stars
5 stars

Top La Mesa Hotel Reviews

The Sofia Hotel

The Sofia Hotel

10/10 Excellent
"This was a nice little hotel with very friendly and helpful staff. I would definitely stay there again."
Michael 4-night trip
Posted less than an hour ago
The Sofia Hotel
Sheraton San Diego Resort

Sheraton San Diego Resort

10/10 Excellent
"Staff not too well coming."
Amandeep 1-night trip
Posted 1 hour ago
Sheraton San Diego Resort
Wyndham San Diego Bayside

Wyndham San Diego Bayside

8/10 Good
"Not enough staffs at check in counter. Lots of flights crews stay at this hotel, when they arrive, they have priority to check in, check in counter staffs will jump out to serve them first. Lack of communication between check in staffs and luggage storage staffs. The hotel is old and outdated but well maintained. Great location by the bayside, easy access to maritime museum and USS Carrier, easy to get around down town, little Italy and etc. Stayed in bay view room with balcony, enjoyed the nice view. Spacious and comfortable room. Because of the drawbacks mentioned, only 4 stars were given."
Tze Chung 1-night trip
Posted 1 hour ago
Wyndham San Diego Bayside
The Dana on Mission Bay

The Dana on Mission Bay

10/10 Excellent
"The outside pool bar and hair tub with games, movies, great food and amazing drinks. It's paradise in"
Betsy 1-night trip
Posted 2 hours ago
The Dana on Mission Bay
Handlery Hotel

Handlery Hotel

10/10 Excellent
"Stay over the weekend with family . The rooms were clean but just a little too small . the only thing that we were bump about was the Saturday the pool was close for an accident which we didn’t really get to enjoy . But staff was great and the restaurant/bar they have was really convenient."
Leslie 2-night trip
Posted 3 hours ago
Handlery Hotel
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

10/10 Excellent
"Check in process was easy and the location is perfect to walk around and to visit the downtown area."
Jose 2-night trip
Posted 3 hours ago
Manchester Grand Hyatt San Diego
Days Inn by Wyndham San Diego Hotel Circle

Days Inn by Wyndham San Diego Hotel Circle

8/10 Good
"Clean rooms, nice to stay"
Chitty babu 2-night trip
Posted 3 hours ago
Days Inn by Wyndham San Diego Hotel Circle
California Suites Hotel

California Suites Hotel

10/10 Excellent
"Great place to stay!"
Leo 2-night trip
Posted 4 hours ago
California Suites Hotel
The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent
"Great for my very late check-in past midnight!"
Eric 1-night trip
Posted 4 hours ago
The Alcala Hotel Mission Valley/Seaworld

Frequently asked questions

Looking for a spa hotel in La Mesa?
Treat yourself to some pampering and book a hotel with a spa. Travelers recommend the gourmet restaurants in La Mesa. Be sure to enjoy the shopping during your stay. Hotels with spas are the perfect way to break away from your daily routine and add a layer of luxury to your vacation.
What's there to see and do in La Mesa?
Enjoy La Mesa with a stop at Mount Helix Park, San Diego Zoo, and Mission Bay. If you have extra time while you're in the area, you might want to stop by Petco Park and Port of San Diego.
What is a La Mesa spa hotel?
Spa hotels in La Mesa provide lodging and have an on-site spa which offers services such as facials and body treatments. Some also offer in-room treatments. Spa hotels are ideal if you are looking for some R&R during your vacation.

Explore a world of travel with Expedia