A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Find Luxury Hotels in Key Largo, FL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo Luxury Hotels

Tonight
Sep 12 - Sep 13
Tomorrow
Sep 13 - Sep 14
Next weekend
Sep 18 - Sep 20
In two weeks
Sep 25 - Sep 27

Our top choices for Key Largo luxury hotels

1. Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
Rock Harbor
  • Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
NT$8,069
NT$10,822 total
includes taxes & fees
Sep 30 - Oct 1
Playa Largo Resort & Spa, Autograph Collection

2. Reefhouse Resort & Marina

Reefhouse Resort & Marina
Key Largo
NT$6,909
NT$9,035 total
includes taxes & fees
Sep 13 - Sep 14
Reefhouse Resort & Marina

3. Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
Key Largo
  • Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
NT$7,499
NT$10,181 total
includes taxes & fees
Sep 30 - Oct 1
Baker's Cay Resort Key Largo, Curio Collection by Hilton

4. The Islands of Islamorada

The Islands of Islamorada
Matecumbe
NT$12,778
NT$16,370 total
includes taxes & fees
Sep 13 - Sep 14
The Islands of Islamorada

5. Find Peace - Tiny House in Japanese Garden

Find Peace - Tiny House in Japanese Garden
Homestead
Find Peace - Tiny House in Japanese Garden

6. Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
Islamorada
  • Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
NT$5,780
NT$8,810 total
includes taxes & fees
Sep 20 - Sep 21
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

7. Islander Resort

Islander Resort
Matecumbe
  • Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
NT$6,999
NT$10,004 total
includes taxes & fees
Sep 21 - Sep 22
Islander Resort

8. Cheeca Lodge & Spa

Cheeca Lodge & Spa
Matecumbe
  • Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
NT$4,701
NT$7,596 total
includes taxes & fees
Sep 15 - Sep 16
Cheeca Lodge & Spa

9. Amara Cay Resort

Amara Cay Resort
Matecumbe
  • Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
NT$4,877
NT$7,794 total
includes taxes & fees
Sep 15 - Sep 16
Amara Cay Resort
View all properties

Top Key Largo Hotel Reviews

Holiday Inn Key Largo by IHG

Holiday Inn Key Largo by IHG

10/10 Excellent
"everthing"
Frank 2-night trip
Posted 11 hours ago
Holiday Inn Key Largo by IHG
Gilbert's Resort

Gilbert's Resort

8/10 Good
"C"
Allison 1-night trip
Posted 17 hours ago
Gilbert's Resort
Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection

10/10 Excellent
"Super good resorts"
Danilo 2-night trip
Posted 18 hours ago
Playa Largo Resort & Spa, Autograph Collection
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

10/10 Excellent
"This is my new go-to place to stay in Key Largo! It's clean, quaint & a good location. The view at the dock at Sunset was stunning. We had two queens & a bathroom. Our room was right behind the check in building so it was convenient to us. There also seems to be a table & chairs outside each room, I didn't know that when I booked but I was able to have my morning tea outside. Another nice feature was the in-room fridge (which was super cold), the coffee maker & the microwave. This microwave was nice! It had a USB & 3-prong plug on the front of it & when it stops running it's locked & you have to push the unlock button. If you are traveling with kids, this is a wonderful safety feature! We walked down to the docks twice on our overnight stay. There are chairs on the beach & on the dock. There were plenty of local places to eat, but I recommend C&Cs Wood Fired Pizza for their happy hour from 4-6 pm. A pizza (6 slices) & a pitcher for $10! At the Cottages, the staff were super nice. Irina & the other lady at check in were so helpful. I even asked a grounds person a question & he was helpful too. I don't care about super fancy. I care about CLEAN, a great view & beautiful surrounding. It's all of this & more!"
Stacy 1-night trip
Posted 2 days ago
The Pelican Key Largo Cottages
Amoray Dive Resort

Amoray Dive Resort

10/10 Excellent
"This property was clean and the staff was very friendly. It is a cozy little get away in Key Largo with nice restaurants close by. Would definitely stay again."
P 2-night trip
Posted 10 days ago
Amoray Dive Resort

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
During your visit, you might want to enjoy the sunsets and boating which Key Largo is known for.
What's the best high-end place to stay in Key Largo?
Playa Largo Resort & Spa, Autograph Collection is a luxury resort with 3 restaurants and a full-service spa, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Reefhouse Resort & Marina.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Jimmy Johnson's Big Chill, Bluefin Rock Harbor Marina, and John Pennekamp Coral Reef State Park. If you have a little extra time during your trip, you might want to make a stop at MarineLab Undersea Laboratory and Caribbean Club Bar.

Explore a world of travel with Expedia