A beachside restaurant with white tables and chairs, palm trees, and a view of the sea.

Find Luxury Hotels in Key Largo, FL

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check availability on Key Largo Luxury Hotels

Our top choices for Key Largo luxury hotels

Playa Largo Resort & Spa, Autograph Collection

Playa Largo Resort & Spa, Autograph Collection
4.5 star property
Rock Harbor
9.0 out of 10, Wonderful, (1,005 reviews)
  • cleanliness
    Beachfront luxury awaits at this Key Largo resort with spa treatments and ocean views.
The price is NT$9,006
NT$11,911 total
includes taxes & fees
Aug 12 - Aug 13
Playa Largo Resort & Spa, Autograph Collection

Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton
4.0 star property
Key Largo
8.6 out of 10, Excellent, (1,150 reviews)
  • cleanliness
    Beach luxury reimagined at Key Largo resort with private sands, refreshing pools, and coastal dining.
The price is NT$8,889
NT$11,780 total
includes taxes & fees
Aug 16 - Aug 17
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Reefhouse Resort & Marina

Reefhouse Resort & Marina
4.5 star property
Key Largo
9.4 out of 10, Exceptional, (1,495 reviews)
The price is NT$7,069
NT$9,244 total
includes taxes & fees
Aug 2 - Aug 3
Reefhouse Resort & Marina

The Islands of Islamorada

The Islands of Islamorada
4.0 star property
Matecumbe
9.6 out of 10, Exceptional, (78 reviews)
The price is NT$16,181
NT$19,991 total
includes taxes & fees
Aug 9 - Aug 10
The Islands of Islamorada

Islander Resort

Islander Resort
4.0 star property
Matecumbe
9.4 out of 10, Exceptional, (1,079 reviews)
  • cleanliness
    Beachfront luxury awaits at Florida Keys haven with private shores, poolside bars, and lavish lanai rooms.
The price is NT$8,425
NT$11,657 total
includes taxes & fees
Aug 19 - Aug 20
Islander Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort
4.0 star property
Islamorada
9.0 out of 10, Wonderful, (235 reviews)
  • cleanliness
    Seaside elegance awaits at this Islamorada resort with 3 pools, diverse dining, and a marina.
The price is NT$6,688
NT$9,885 total
includes taxes & fees
Aug 18 - Aug 19
Three Waters Resort and Marina, Islamorada, a Tribute Portfolio Resort

Cheeca Lodge & Spa

Cheeca Lodge & Spa
5.0 star property
Matecumbe
9.2 out of 10, Wonderful, (1,348 reviews)
  • cleanliness
    Experience seaside opulence with private beach access, three outdoor pools, and oceanfront dining at this beachfront Matecumbe resort.
The price is NT$6,424
NT$9,587 total
includes taxes & fees
Aug 12 - Aug 13
Cheeca Lodge & Spa

Amara Cay Resort

Amara Cay Resort
4.0 star property
Matecumbe
8.8 out of 10, Excellent, (1,298 reviews)
  • cleanliness
    Florida Keys resort offers private beach paradise with upscale rooms, coastal activities, and luxurious relaxation.
The price is NT$6,079
NT$9,200 total
includes taxes & fees
Aug 5 - Aug 6
Amara Cay Resort

La Siesta Resort & Villas

La Siesta Resort & Villas
4.0 star property
Matecumbe
8.6 out of 10, Excellent, (1,001 reviews)
The price is NT$5,425
NT$8,464 total
includes taxes & fees
Aug 24 - Aug 25
La Siesta Resort & Villas
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Key Largo Hotel Reviews

Frequently asked questions

Are you searching for a great accommodation for your luxury trip to Key Largo?
Known for its sunsets and boating, Key Largo also has some interesting things to see and do including Everglades National Park, so you may want to take in the local sights during your visit.
What's the best high-end place to stay in Key Largo?
Reefhouse Resort & Marina is a luxury hotel with a private beach and 3 restaurants, and it's a popular choice for Expedia travelers looking for an elegant place to stay. Another upscale choice for your vacation is Playa Largo Resort & Spa, Autograph Collection.
When can I expect good weather in Key Largo?
Planning for the weather is an important factor for making your trip to Key Largo a success, especially when you're splurging. The hottest months are usually August and July with an average temp of 83°F, while the coldest months are January and February with an average of 72°F. Average annual precipitation for Key Largo is 44 inches.
What's there to see and do in Key Largo?
Take in some sights and attractions while you're in Key Largo by visiting Everglades National Park, Jimmy Johnson's Big Chill, and Jacob's Aquatic Center. If you have a little extra time during your trip, you might want to make a stop at Bluefin Rock Harbor Marina and John Pennekamp Coral Reef State Park.

Explore a world of travel with Expedia