Find Resorts & Hotels with Spas in Cairo, IL

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Check availability on Cairo Resorts & Hotels with Spas

Tonight
Dec 1 - Dec 2
Tomorrow
Dec 2 - Dec 3
This weekend
Dec 5 - Dec 7
Next weekend
Dec 12 - Dec 14

Top Cairo Resorts & Hotels with Spas

No exact matches found, but these alternatives could be just right

Recommended hotels in Cairo

Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

2.5 star property
Cairo
6.6 out of 10, (272)
"Break fast was excellent "
United States
Uma
The price is NT$2,260
NT$2,508 total
includes taxes & fees
Jan 2 - 2026/1/3
Quality Inn Cairo I-57
Front of property - evening/night
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2.0 star property
Charleston
6.6 out of 10, (611)
"Staff was great! Room was nice. "
United States
Lana
The price is NT$1,841
NT$2,043 total
includes taxes & fees
Dec 3 - Dec 4
Super 8 by Wyndham Charleston/Sikeston East MO
Desk, laptop workspace, blackout drapes, iron/ironing board
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

2.5 star property
Charleston
6.8 out of 10, (406)
"The staff was very friendly and accommodating "
United States
Arturo
The price is NT$2,062
NT$2,289 total
includes taxes & fees
Dec 8 - Dec 9
Quality Inn Charleston - Sikeston
House (2 Bedrooms) | Interior
Quiet Country Stay: Modern Home Near Paducah

Quiet Country Stay: Modern Home Near Paducah

3.0 star property
Cunningham
The price is NT$3,798
NT$9,102 total
includes taxes & fees
Dec 3 - Dec 4
Quiet Country Stay: Modern Home Near Paducah
Desk, iron/ironing board, free WiFi, alarm clocks
Eagle Inn Charleston

Eagle Inn Charleston

2.0 star property
Charleston
6.8 out of 10, (103)
"Middle of nowhere hotel was ok"
United States
David
The price is NT$1,899
NT$2,107 total
includes taxes & fees
Dec 3 - Dec 4
Eagle Inn Charleston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cairo Hotel Reviews

Eagle Inn Charleston

Eagle Inn Charleston

10/10 Excellent
"Furniture missing knobs. No chair!!??? No coffee!!?? No breakfast. Nice location. Nice staff!! "
Gregory 1-night trip
Posted 7 months ago
Eagle Inn Charleston

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Frequently asked questions

Looking for a spa hotel in Cairo?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the historical sites and restaurants in Cairo—your day trip starts here. Enjoy the opera and riverfront during your vacation. Hotels with spas are the perfect way to break out of your routine and add a layer of luxury to your vacation.
What's there to see and do in Cairo?
When you're in Cairo, enjoy exploring the sights and attractions here including Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have a little extra time during your trip, you might want to check out Ballard Wildlife Management Area and Columbus-Belmont State Park.
What is a Cairo spa hotel?
Spa hotels in Cairo provide lodging and have an on-site spa offering services including couples massages and beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.