Find Luxury Hotels in Cairo, IL

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Check availability on Cairo Luxury Hotels

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Recommended hotels in Cairo

Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
"Break fast was excellent "
United States
Uma
The price is NT$2,281
NT$2,532 total
includes taxes & fees
Jan 10 - 2026/1/11
Quality Inn Cairo I-57
Basic Double Room | Living area
La Center Motel

La Center Motel

La Center Motel
2.0 star property
La Center
7.8 out of 10, Good, (16)
"The place was very clean"
United States
Victoria
La Center Motel
Lobby
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston
2.5 star property
Charleston
6.8 out of 10, (406)
"The staff was very friendly and accommodating "
United States
Arturo
The price is NT$2,049
NT$2,274 total
includes taxes & fees
Dec 21 - Dec 22
Quality Inn Charleston - Sikeston
Room, 1 King Bed, Non Smoking | View from room
Eagle Inn Charleston

Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.8 out of 10, (103)
"Middle of nowhere hotel was ok"
United States
David
The price is NT$1,887
NT$2,094 total
includes taxes & fees
Dec 16 - Dec 17
Eagle Inn Charleston
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
"Staff was great! Room was nice. "
United States
Lana
The price is NT$1,937
NT$2,150 total
includes taxes & fees
Dec 16 - Dec 17
Super 8 by Wyndham Charleston/Sikeston East MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cairo Hotel Reviews

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Frequently asked questions

Are you searching for the perfect hotel for your luxury trip to Cairo?
Let Expedia help you arrange your flight to Cairo, IL (CIR-Cairo Regional) airport or Paducah, KY (PAH-Barkley Regional) airport, and then choose from some places to stay that will deliver the luxury you seek. Amenities are important when you plan a trip, so we make it easy to find what you need to make your stay special. If you want an upscale hotel with a spa, an indoor pool, or luxury bedding, Expedia can assist you in finding the best luxury hotel experience that Cairo has to offer. Cairo has some interesting things to see and do including Mississippi River and Ohio River Valley, so you might want to take in the local sights during your visit.
When can I expect good weather in Cairo?
Planning for the weather is an important factor for making your trip to Cairo a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.
What's there to see and do in Cairo?
Enjoy all that Cairo has to offer when you visit Mississippi River, Ohio River Valley, and Fort Defiance State Park. If you have spare time during your trip, you might want to make a stop at Ballard Wildlife Management Area and Columbus-Belmont State Park.