Find Family Hotels in Cairo, IL

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Check availability on Cairo Family Hotels

Our top choices for Cairo family-friendly hotels

Lobby
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (273)
"Break fast was excellent "
United States
Uma
The price is NT$2,281
NT$2,532 total
includes taxes & fees
Jan 10 - 2026/1/11
Quality Inn Cairo I-57
Lobby
Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston

Quality Inn Charleston - Sikeston
2.5 star property
Charleston
6.8 out of 10, (406)
"The staff was very friendly and accommodating "
United States
Arturo
The price is NT$2,049
NT$2,274 total
includes taxes & fees
Dec 22 - Dec 23
Quality Inn Charleston - Sikeston
Laptop workspace, blackout drapes, free cribs/infant beds, free WiFi
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (612)
"Staff was great! Room was nice. "
United States
Lana
The price is NT$1,937
NT$2,150 total
includes taxes & fees
Dec 16 - Dec 17
Super 8 by Wyndham Charleston/Sikeston East MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cairo Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent
"Thank you "
Carlos 10-night trip
Posted 1 month ago
Super 8 by Wyndham Charleston/Sikeston East MO

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Frequently asked questions

What's Cairo like for family-friendly vacations?
You might want to consider the historic destination of Cairo if you've been thinking about a trip for the whole family. The entertainment, restaurants, and libraries are just a few things that make this an attractive spot for a family vacation. Arrange a flight into Cairo, IL (CIR-Cairo Regional), which is the closest airport, or Paducah, KY (PAH-Barkley Regional), which is located 22.9 mi (36.8 km) from the city center.
What's the best hotel for a family vacation to Cairo?
Quality Inn Cairo I-57 is a hotel with free parking and free breakfast, and it's a top choice on Expedia for families.
When's the best time to book a family-friendly vacation in Cairo?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for Cairo is 61 inches.
What's there to see and do with your family in Cairo?
While you and the family are vacationing in Cairo, you might want to get outside and enjoy the great outdoors at spots such as Mississippi River, Ohio River Valley, and Shawnee National Forest. Make sure you have time to check out activities like Ohio River and Fort Defiance State Park.