Motel 6 Upstate South Carolina hotels
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Compare rooms and suites by Motel 6 in Upstate South Carolina with rates, reviews, and availability. Most hotels are fully refundable.

Motel 6 Greenville, SC
Greenville
5.0 out of 10, (672)
The price is NT$1,530
NT$1,744 total
includes taxes & fees
Nov 25 - Nov 26

Motel 6 Greenville, SC - I-85 Near Downtown
Greenville
6.8 out of 10, (317)
The price is NT$1,734
NT$1,908 total
includes taxes & fees
Nov 25 - Nov 26

Motel 6 Simpsonville, SC - Greenville
Simpsonville
7.4 out of 10, Good, (346)
The price is NT$1,951
NT$2,146 total
includes taxes & fees
Nov 19 - Nov 20

Motel 6 Spartanburg, Sc – Northwest / Business 85
Spartanburg
7.2 out of 10, Good, (70)
The price is NT$2,388
NT$2,651 total
includes taxes & fees
Nov 13 - Nov 14
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Upstate South Carolina Hotel Reviews

Best Western Plus Greenville I-385 Inn & Suites
10/10 Excellent
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Upstate South Carolina Hotels by Brand
Hotels in Upstate South Carolina Neighborhoods
- Greenville Downtown Hotels
- West End Hotels
- Green Avenue Hotels
- Payne-Logan Hotels
- Pettigru Street Historic District Hotels
- Hampton-Pinckney Historic District Hotels
- Woodside Cotton Mill Village Historic District Hotels
- Colonel Elias Earle Historic District Hotels
- Turtlehead Hotels
- Pine Ridge Point Hotels
Hotels near popular Upstate South Carolina Attractions
- Hotels near Clemson University
- Hotels near Lake Keowee
- Hotels near BMW Performance Center
- Hotels near Greenville Convention Center
- Hotels near Bon Secours Wellness Arena
- Hotels near Haywood Mall
- Hotels near Lake Jocassee
- Hotels near The Peace Center
- Hotels near Wofford College
- Hotels near Prisma Health Greenville Memorial Hospital
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