Find Resorts & Hotels with Spas in Southeast Missouri, MO

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Resorts & Hotels with Spas

Tonight
Jul 31 - Aug 1
Tomorrow
Aug 1 - Aug 2
This weekend
Aug 1 - Aug 3
Next weekend
Aug 8 - Aug 10

Top Southeast Missouri Resorts & Hotels with Spas

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Relax in the stylish lobby, featuring a fireplace, comfortable seating, and a large flat-screen TV.

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
"Great place to stay. "
The price is NT$3,061
NT$3,453 total
includes taxes & fees
Aug 17 - Aug 18
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Excellent staff, amenities, cleanliness, and free breakfast. Property is well lit and visible from windows. The property is near the highway so you do hear trucks and motor cyclists unfortunately, but I would stay again if passing through as it seemed much better than nearby options and hotels."
Luke 1-night trip
Posted 9 days ago
Drury Plaza Hotel Cape Girardeau Conference Center