Find Boutique Hotels in South Carolina Midlands, SC
- Change your mindBook hotels with free cancellation
- Be pickySearch almost a million properties worldwide
Check availability on South Carolina Midlands Boutique Hotels
Top South Carolina Midlands Boutique Hotels
No exact matches found, but these alternatives could be just right
Recommended hotels in South Carolina Midlands

Tru By Hilton Santee
Santee
9.2 out of 10, Wonderful, (630)
The price is NT$2,999
NT$3,329 total
includes taxes & fees
Jan 4 - 2026/1/5

Holiday Inn Express & Suites Latta by IHG
Latta
9.4 out of 10, Exceptional, (532)
The price is NT$3,780
NT$4,120 total
includes taxes & fees
Dec 17 - Dec 18

Baymont by Wyndham Santee
Santee
8.0 out of 10, Very Good, (1407)
The price is NT$2,343
NT$2,600 total
includes taxes & fees
Dec 10 - Dec 11

Comfort Inn & Suites Florence Center Area
Florence
9.2 out of 10, Wonderful, (1160)
The price is NT$3,160
NT$3,539 total
includes taxes & fees
Dec 28 - Dec 29

Howard Johnson by Wyndham Florence
Florence
8.8 out of 10, Excellent, (2486)
The price is NT$1,936
NT$2,169 total
includes taxes & fees
Dec 15 - Dec 16

Hampton Inn & Suites Florence-North-I-95
Florence
9.0 out of 10, Wonderful, (809)
The price is NT$3,293
NT$3,688 total
includes taxes & fees
Dec 16 - Dec 17

Fairfield Inn & Suites by Marriott Santee
Santee
9.8 out of 10, Exceptional, (1003)
The price is NT$3,780
NT$4,196 total
includes taxes & fees
Dec 15 - Dec 16

Inn on the Square, an Ascend Collection Hotel
Uptown Greenwood
9.2 out of 10, Wonderful, (708)
The price is NT$3,406
NT$3,781 total
includes taxes & fees
Jan 4 - 2026/1/5
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top South Carolina Midlands Hotel Reviews

Graduate by Hilton Columbia SC
10/10 Excellent
Explore a world of travel with Expedia
Find More Hotels near South Carolina Midlands
More Hotel Options in South Carolina Midlands
- Adults Only Resorts & Hotels in South Carolina Midlands
- Adventure Hotels in South Carolina Midlands
- Beach Hotels in South Carolina Midlands
- Business Hotels in South Carolina Midlands
- Casinos in South Carolina Midlands
- Cheap Hotels in South Carolina Midlands
- Family Hotels in South Carolina Midlands
- Golf Hotels in South Carolina Midlands
- Green Hotels in South Carolina Midlands
- Historic Hotels in South Carolina Midlands
- Hotel Wedding Venues in South Carolina Midlands
- Hotel with a Concierge in South Carolina Midlands
- Hotels with Bars in South Carolina Midlands
- Hotels with Early Check-in in South Carolina Midlands
- Hotels with Free Parking in South Carolina Midlands
- Hotels with Hot Tubs in South Carolina Midlands
- Hotels with WiFi in South Carolina Midlands
- Hotels with a Pool in South Carolina Midlands
- Hotels with an Indoor Pool in South Carolina Midlands
- Hotels with smoking rooms in South Carolina Midlands
- Luxury Hotels in South Carolina Midlands
- Pet-friendly Hotels in South Carolina Midlands
- Resorts & Hotels with Spas in South Carolina Midlands
- Romantic Hotels in South Carolina Midlands
- Shopping Hotels in South Carolina Midlands
More Accommodation Types in South Carolina Midlands
- Vacation Homes in South Carolina
- Condo Rentals in South Carolina
- Apartments in South Carolina
- Cottages in South Carolina
- Villas in South Carolina
- Motels in South Carolina
- Aparthotels in South Carolina
- B&B in South Carolina
- Resorts in South Carolina
- Guest Houses in South Carolina
- Condo Resorts in South Carolina
- Cabin Rentals in South Carolina
- Inns in South Carolina
- Town Houses in South Carolina
- Lodges in South Carolina
- Chalets in South Carolina
- Hostels in South Carolina
- Houseboats in South Carolina
- Country Houses in South Carolina
Hotels near popular South Carolina Midlands Attractions
- Hotels near Fort Jackson
- Hotels near University of South Carolina
- Hotels near Carowinds Theme Park
- Hotels near Riverbanks Zoo and Garden
- Hotels near Lake Murray
- Hotels near Colonial Life Arena
- Hotels near Williams Brice Stadium
- Hotels near Florence Civic Center
- Hotels near Township Auditorium
- Hotels near Darlington Raceway
South Carolina Midlands Hotels by Star Rating
Explore more hotels
- Tru By Hilton Columbia Greystone
- Park Inn by Radisson Florence, SC
- La Quinta Inn by Wyndham Columbia NE/Fort Jackson
- Comfort Inn & Suites Florence Center Area
- Springhill Suites by Marriott Columbia near Fort Jackson
- Courtyard by Marriott Columbia Northeast/Fort Jackson Area
- Hyatt Place Columbia/Harbison
- Holiday Inn Express & Suites Columbia-I-26 @ Harbison Blvd by IHG
- Country Inn & Suites by Radisson, Columbia, SC
- Courtyard by Marriott Columbia Downtown at USC
- Comfort Suites Columbia at Harbison
- Marriott Columbia
- Hyatt Place Columbia/Downtown/The Vista
- Tru By Hilton Santee
- Hyatt Place Florence Downtown
- Holiday Inn Columbia - Downtown by IHG
- Hampton Inn Columbia-I-26 Airport
- Baymont by Wyndham Santee
- Clarion Pointe Rock Hill Near University
- Spark by Hilton Rock Hill
More ways to book
Expedia's Latest Trends
Hotels
Flights
General
- Visit Bay Area
- Visit Cape Cod
- Visit Kauai
- Visit Upstate New York
- Visit Oregon Coast
- Visit North Central Texas
- Visit Southeast Florida
- Visit Hawaii Island
- Visit Fire Island
- Visit Puget Sound
- Visit Long Island
- Visit Napa Valley
- Visit Pumpkintown
- Visit Sonoma Valley
- Visit Oahu
- Visit Northeast Georgia
- Visit Nantucket Island
- Visit North Coast California
- Visit Catalina Island
- Visit Finger Lakes Region
- Visit Outer Banks
































