Santa Cruz Vacation Rentals

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Check prices for these dates

Tonight
Dec 10 - Dec 11
Tomorrow
Dec 11 - Dec 12
This weekend
Dec 12 - Dec 14
Next weekend
Dec 19 - Dec 21

Our top choices for Santa Cruz vacation rentals

Standard Double Suite | City view
UTOPIC Polanco by ULIV

UTOPIC Polanco by ULIV

UTOPIC Polanco by ULIV
4.5 star property
Miguel Hidalgo
9.0 out of 10, Wonderful, (725)
"We had a great stay. Area was safe to walk around, and hotel was near tourist attractions. "
United States
Guadalupe
UTOPIC Polanco by ULIV
Business center
Downtown Treasure Place

Downtown Treasure Place

Downtown Treasure Place
2.5 star property
Downtown Mexico City
8.8 out of 10, Excellent, (728)
"The staff was very kind, easy access, very good place to stay…"
United States
Iuren
The price is NT$1,351
NT$1,635 total
includes taxes & fees
Dec 18 - Dec 19
Downtown Treasure Place
Two-Bedroom Apartment with Huge Private Patio | Terrace/patio
ULIV Parque Lincoln

ULIV Parque Lincoln

ULIV Parque Lincoln
3.5 star property
Polanco
9.6 out of 10, Exceptional, (818)
"Staff was great , same as location!"
United States
Ilan
ULIV Parque Lincoln
Terrace/patio
Las Suites Campos Eliseos

Las Suites Campos Eliseos

Las Suites Campos Eliseos
4.0 star property
Polanco
9.2 out of 10, Wonderful, (1346)
"The staff was top notch"
United States
Alan
The price is NT$5,038
NT$6,020 total
includes taxes & fees
Jan 5 - 2026/1/6
Las Suites Campos Eliseos
Luxury Apartment, Balcony, City View | Dining room
Capitalia Antara Polanco

Capitalia Antara Polanco

Capitalia Antara Polanco
4.5 star property
Polanco
9.2 out of 10, Wonderful, (169)
"Super smooth. Great rooms!!"
United States
Javier
Capitalia Antara Polanco
Restaurant
Alteza Polanco

Alteza Polanco

Alteza Polanco
4.0 star property
Polanco
8.6 out of 10, Excellent, (634)
"Amazing service, excellent location"
United States
Zeila
Alteza Polanco
Hypo-allergenic bedding, in-room safe, individually decorated
Kukun Homero Polanco

Kukun Homero Polanco

Kukun Homero Polanco
4.0 star property
Polanco
9.4 out of 10, Exceptional, (206)
"Loved the view from the balcony and very friendly staff. "
United States
Claudia
The price is NT$3,663
NT$4,432 total
includes taxes & fees
Jan 8 - 2026/1/9
Kukun Homero Polanco
Hallway
Residence L´ Heritage Royal Colonial by BlueBay

Residence L´ Heritage Royal Colonial by BlueBay

Residence L´ Heritage Royal Colonial by BlueBay
3.0 star property
Polanco
7.8 out of 10, Good, (284)
"Very happy with the breakfast and room cleaning. "
United States
jerry
The price is NT$2,593
NT$3,099 total
includes taxes & fees
Jan 1 - 2026/1/2
Residence L´ Heritage Royal Colonial by BlueBay
Superior Apartment with Balcony | Premium bedding, individually decorated, individually furnished, desk
ULIV Antara

ULIV Antara

ULIV Antara
4.0 star property
Polanco
9.6 out of 10, Exceptional, (254)
"Great staff. Great location. Great condo."
Canada
Gregory
ULIV Antara
Rooftop terrace
ULIV Apartments Polanco

ULIV Apartments Polanco

ULIV Apartments Polanco
4.0 star property
Miguel Hidalgo
8.8 out of 10, Excellent, (298)
"Clean and friendly staff"
United States
Claudia
ULIV Apartments Polanco
Indoor spa tub
UTOPIC Platón by ULIV

UTOPIC Platón by ULIV

UTOPIC Platón by ULIV
5.0 star property
Polanco
9.4 out of 10, Exceptional, (124)
"Very clean and safe place."
United States
NIDIA DENICE
The price is NT$3,989
NT$4,767 total
includes taxes & fees
Dec 15 - Dec 16
UTOPIC Platón by ULIV
Superior Apartment, 1 Bedroom | Cribs/infant beds, free WiFi, bed sheets
Park Life Masaryk

Park Life Masaryk

Park Life Masaryk
3.0 star property
Polanco
9.0 out of 10, Wonderful, (511)
"Loved it will stay here again "
United States
Valerie
Park Life Masaryk
Deluxe Double Room, 1 King Bed | Premium bedding, down comforters, in-room safe, laptop workspace
Ana Polanco Apartments

Ana Polanco Apartments

Ana Polanco Apartments
3.5 star property
Polanco
9.8 out of 10, Exceptional, (186)
"It was an amazing place to stay doung business in Mex city!!!"
United States
ROSALBA
Ana Polanco Apartments
Rooftop terrace
Capitalia Aristoteles Polanco

Capitalia Aristoteles Polanco

Capitalia Aristoteles Polanco
4.0 star property
Polanco
9.2 out of 10, Wonderful, (112)
"Great location and a nice apartment "
United States
Luis F
The price is NT$4,771
NT$5,773 total
includes taxes & fees
Jan 6 - 2026/1/7
Capitalia Aristoteles Polanco
Terrace/patio
The Wild Oscar

The Wild Oscar

The Wild Oscar
4.0 star property
Polanco
9.6 out of 10, Exceptional, (483)
"Don't delay - book the Wild Óscar "
United States
Kasha
The Wild Oscar
City view
Casa Sócrates by Kukun

Casa Sócrates by Kukun

Casa Sócrates by Kukun
2.0 star property
Polanco
8.6 out of 10, Excellent, (146)
"Nice place and good location "
United States
ifeka
Casa Sócrates by Kukun
Front of property
Residence L'heritage Aristóteles 225 by Bluebay

Residence L'heritage Aristóteles 225 by Bluebay

Residence L'heritage Aristóteles 225 by Bluebay
3.0 star property
Polanco
7.4 out of 10, Good, (380)
"Excelente servico"
Mexico
José
The price is NT$2,637
NT$3,191 total
includes taxes & fees
Jan 1 - 2026/1/2
Residence L'heritage Aristóteles 225 by Bluebay
Exterior
ULIV Polanco

ULIV Polanco

ULIV Polanco
3.5 star property
Polanco
8.6 out of 10, Excellent, (106)
"Clean aparrnent. Very polite and helpful staff, especially Teresa"
United States
Galia
The price is NT$7,830
NT$9,357 total
includes taxes & fees
Dec 13 - Dec 14
ULIV Polanco
In-room safe, blackout drapes, free WiFi, bed sheets
Hotel Monaco

Hotel Monaco

Hotel Monaco
3.5 star property
Historic Center
8.0 out of 10, Very Good, (806)
"The staff was exceptionally helpful and kind. I don't think I've ever felt so welcome at a hotel! Our dog was also welcome, which was a relief. "
United States
Chris
The price is NT$1,629
NT$1,947 total
includes taxes & fees
Dec 15 - Dec 16
Hotel Monaco
Interior detail
Residence L'heritage Aristóteles 140 by Bluebay

Residence L'heritage Aristóteles 140 by Bluebay

Residence L'heritage Aristóteles 140 by Bluebay
3.5 star property
Polanco
7.4 out of 10, Good, (419)
"Excelente todo "
Mexico
Edith
The price is NT$1,735
NT$2,099 total
includes taxes & fees
Jan 1 - 2026/1/2
Residence L'heritage Aristóteles 140 by Bluebay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Santa Cruz Hotel Reviews

ULIV Parque Lincoln

ULIV Parque Lincoln

10/10 Excellent
"Great Location. Clean. Friendly staff "
Josefina Rangel 1-night trip
Posted 1 day ago
ULIV Parque Lincoln

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
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  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Are there vacation rentals in Santa Cruz?

Yes, you can find vacation rentals near popular points of interest in Santa Cruz, or you can go with a secluded option if you want a relaxing place to stay.

What’s there to see and do in Santa Cruz?

Explore the area and family-friendly sights such as Planetario Luis Enrique Erro, or get out into nature at a spot like Hacienda La Concepcion. Temple of San Francisco Javier and National Museum of the Viceroyalty are a couple of places you'll find in the larger area.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties you can book for a long or short time in Santa Cruz. Vacation rentals feature extras such as patios, hot tubs, and fire pits so you'll feel just like you're at home. If you're concerned about a clean environment, vacation rentals can provide a sense of seclusion away from public hotel elevators and busy front desks while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for family trips.