Default HTG hotel image

Santa Cruz Vacation Rentals

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
Nov 13 - Nov 15
In two months
Dec 25 - Dec 27
In three months
Jan 22 - Jan 24
In four months
Feb 19 - Feb 21

Our top choices for Santa Cruz vacation rentals

A modern hotel corridor with a glass wall displaying multilingual greetings, a staircase, and a clean, tiled floor.

1. A30 Plaza Acequia Suite Black Plus

A30 Plaza Acequia Suite Black Plus
4.0 star property
Cuautitlán Izcalli
10.0 out of 10, Exceptional, (1 review)
"Todo un ambiente acogedor"
Mexico
GENER KEINER
The price is NT$2,123
NT$3,177 total
includes taxes & fees
Oct 28 - Oct 29
A30 Plaza Acequia Suite Black Plus
Balcony

2. S09 PREMIUM SUITE Full Service WiFi

S09 PREMIUM SUITE Full Service WiFi
4.0 star property
Ciudad López Mateos
9.6 out of 10, Exceptional, (4 reviews)
"Excelente"
United States
Yulissa Rubi
The price is NT$1,824
NT$2,821 total
includes taxes & fees
Nov 25 - Nov 26
S09 PREMIUM SUITE Full Service WiFi
Living area

3. Lofts by Verticca San Francisco

Lofts by Verticca San Francisco
3.5 star property
Ojo de Agua
8.6 out of 10, Excellent, (46 reviews)
"Great staff, clean environment, rooms look and feel new, how ever the lack of AC and heating, the blinds only covered half of the window letting the day light in even if you didn’t needed, the hot water was extremely hot and impossible to regulate, the price is a bit high but not outrageous. Overall I will book them again!"
United States
Gerardo Gonzalez
The price is NT$1,829
NT$2,195 total
includes taxes & fees
Nov 2 - Nov 3
Lofts by Verticca San Francisco
A spacious lounge area with wooden flooring, several chairs, and tables. A reception desk is visible in the background.

4. A14 SUPER PREMIUM SUITE AT PLAZA ACEQUIA

A14 SUPER PREMIUM SUITE AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
9.4 out of 10, Exceptional, (8 reviews)
"Buena la estancia "
Mexico
Héctor
The price is NT$1,824
NT$2,821 total
includes taxes & fees
Oct 29 - Oct 30
A14 SUPER PREMIUM SUITE AT PLAZA ACEQUIA
A spacious lounge area with wooden flooring, several chairs, and tables. A reception desk is visible in the background.

5. A08 SUPER CITY SUITES AT PLAZA ACEQUIA

A08 SUPER CITY SUITES AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
8.0 out of 10, Very good, (4 reviews)
"No dejan dormir pasaron algunos huéspedes ablandó fuerte y caminando por los corredores y nadie les llamó la atención. Según parecía estaban borrachos"
United States
Mario
The price is NT$1,816
NT$2,808 total
includes taxes & fees
Nov 8 - Nov 9
A08 SUPER CITY SUITES AT PLAZA ACEQUIA
A spacious lounge area with wooden flooring, several chairs, and tables. A reception desk is visible in the background.

6. A25 Full Suite MiniDept at Plaza Acequia

A25 Full Suite MiniDept at Plaza Acequia
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (1 review)
The price is NT$1,676
NT$3,252 total
includes taxes & fees
Nov 25 - Nov 26
A25 Full Suite MiniDept at Plaza Acequia
A compact kitchen with a built-in microwave, a gas stove, and a dishwasher.

7. Moderna, Comoda Suite Palma en Tepotzotlán centro

Moderna, Comoda Suite Palma en Tepotzotlán centro
3.0 star property
Tepotzotlán
10.0 out of 10, Exceptional, (3 reviews)
"Friendly host who was very helpful in recommending things to do and places to eat. Located just a few blocks from the historical district. On your way there, you'll pass wonderful restaurants, coffee shops, gyms, and convient stores. This place is in a great location and having garage parking was a real plus. Absolutely a beautiful room and very clean. I was very impressed and highly recommend staying here."
United States
Nathan
The price is NT$2,044
NT$2,453 total
includes taxes & fees
Nov 9 - Nov 10
Moderna, Comoda Suite Palma en Tepotzotlán centro
Interior entrance

8. Moderna, Cómoda Suite Nube en Tepotzotlán centro

Moderna, Cómoda Suite Nube en Tepotzotlán centro
4.0 star property
Tepotzotlán
9.6 out of 10, Exceptional, (9 reviews)
"Increíble!! Una habitación pequeña pero perfecta, muy cómoda, muy linda, daban ganas de quedarse más tiempo! Muy recomendable. Vale totalmente la pena"
Mexico
Eduardo
The price is NT$1,704
NT$2,044 total
includes taxes & fees
Nov 16 - Nov 17
Moderna, Cómoda Suite Nube en Tepotzotlán centro
A modern hotel corridor with a glass wall displaying multilingual greetings, a staircase, and a clean, tiled floor.

9. A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (2 reviews)
"Lo único que me disgusta es que no hay agua caliente )): Pero sin duda iré todos los 12 de cada mes "
Mexico
Jeik
The price is NT$1,824
NT$2,821 total
includes taxes & fees
Nov 21 - Nov 22
A05 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
A spacious lounge area with wooden flooring, several chairs, and tables. A reception desk is visible in the background.

10. A07 SUPER CITY SUITES AT PLAZA ACEQUIA

A07 SUPER CITY SUITES AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (2 reviews)
"Buen lugar tranquilo "
Mexico
Valeria
The price is NT$1,886
NT$2,263 total
includes taxes & fees
Nov 2 - Nov 3
A07 SUPER CITY SUITES AT PLAZA ACEQUIA
A modern hotel corridor with a glass wall displaying multilingual greetings, a staircase, and a clean, tiled floor.

11. A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
9.4 out of 10, Exceptional, (3 reviews)
"Buenas instalaciones y ubicación para mis desplazamientos"
Mexico
ANGEL
The price is NT$1,824
NT$2,821 total
includes taxes & fees
Nov 3 - Nov 4
A04 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
A modern living room with a sofa, a glass coffee table, a dining table with chairs, a painting on the wall, and a ceiling light.

12. Lofts by Verticca Héroes

Lofts by Verticca Héroes
2.0 star property
Ojo de Agua
10.0 out of 10, Exceptional, (1 review)
The price is NT$2,005
NT$2,406 total
includes taxes & fees
Oct 28 - Oct 29
Lofts by Verticca Héroes
A palm tree in front of a building with arched windows and a brick facade.

13. cabañas en arcos del sitio

cabañas en arcos del sitio
3.0 star property
Nicolás Romero
The price is NT$3,932
NT$5,662 total
includes taxes & fees
Nov 22 - Nov 23
cabañas en arcos del sitio
A balcony with two chairs, a small table with a book and a cup, and a view of the cityscape.

14. S06 PREMIUM SUITE Full Service WiFi Kitc

S06 PREMIUM SUITE Full Service WiFi Kitc
4.0 star property
Ciudad López Mateos
9.8 out of 10, Exceptional, (6 reviews)
"Estuvo super bien nuestra estancia "
Mexico
Sophie
The price is NT$1,702
NT$2,672 total
includes taxes & fees
Nov 17 - Nov 18
S06 PREMIUM SUITE Full Service WiFi Kitc
A compact kitchen with a wooden cabinet, a sink, and a countertop. There are kitchen utensils and a coffee maker on the counter.

15. S02 FULL SUITE ITESM CEM WiFi Terraza

S02 FULL SUITE ITESM CEM WiFi Terraza
4.0 star property
Ciudad López Mateos
10.0 out of 10, Exceptional, (1 review)
"Muy limpio Agradable la señorita de limpieza"
Mexico
Mauricio
The price is NT$1,835
NT$2,202 total
includes taxes & fees
Nov 1 - Nov 2
S02 FULL SUITE ITESM CEM WiFi Terraza
A spacious lounge area with wooden flooring, several chairs, and tables. A reception desk is visible in the background.

16. A02 SUPER SUITE PREMIUM AT PLAZA ACEQUIA

A02 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
The price is NT$1,643
NT$2,586 total
includes taxes & fees
Nov 26 - Nov 27
A02 SUPER SUITE PREMIUM AT PLAZA ACEQUIA
A spacious indoor area with a high ceiling, metal beams, and a staircase. There are multiple seating areas with tables and chairs, and a variety of plants are visible.

17. Downtown Treasure Place

Downtown Treasure Place
2.5 star property
Cuauhtémoc
8.8 out of 10, Excellent, (924 reviews)
"staff was really nice and bathrooms really clean"
United States
Rishi
The price is NT$949
NT$1,135 total
includes taxes & fees
Oct 28 - Oct 29
Downtown Treasure Place
A modern bedroom with a large bed, a nightstand, a desk, and a view through large windows.

18. S10 PREMIUM SUITE Full Service WiFi

S10 PREMIUM SUITE Full Service WiFi
4.0 star property
Ciudad López Mateos
8.0 out of 10, Very good, (1 review)
"Habitacion limpia"
Mexico
Yolanda Sandoval
The price is NT$1,710
NT$2,684 total
includes taxes & fees
Nov 5 - Nov 6
S10 PREMIUM SUITE Full Service WiFi
A modern hotel corridor with a glass wall displaying multilingual greetings, a staircase, and a clean, tiled floor.

19. A13 SUPER CITY SUITE PLAZA ACEQUIA

A13 SUPER CITY SUITE PLAZA ACEQUIA
3.5 star property
Cuautitlan Izcalli
10.0 out of 10, Exceptional, (1 review)
"Buen servicio "
Mexico
Ruben
The price is NT$2,043
NT$3,063 total
includes taxes & fees
Nov 9 - Nov 10
A13 SUPER CITY SUITE PLAZA ACEQUIA
A rooftop terrace with a fire feature, seating, and a city view at dusk.

20. ULIV Polanco

ULIV Polanco
4.0 star property
Miguel Hidalgo
8.8 out of 10, Excellent, (506 reviews)
"Great place to stay!"
United States
Maria
The price is NT$5,200
NT$6,214 total
includes taxes & fees
Nov 21 - Nov 22
ULIV Polanco
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Santa Cruz Hotel Reviews

Hotel MX forum buenavista CDMX, Trademark by Wyndham

Hotel MX forum buenavista CDMX, Trademark by Wyndham

10/10 Excellent
"Diana es súper amable y resuelve problemas muy profesionalmente. Definitivamente regresaré"
Elvis 3-night trip
Posted 17 hours ago
Hotel MX forum buenavista CDMX, Trademark by Wyndham

Find out more about Santa Cruz

Search for holiday rentals in Santa Cruz on Expedia! You can easily find your home rentals, villas, holiday apartments in Santa Cruz using one of the methods below:

  • View our selection of featured holiday rentals in Santa Cruz
  • Use the map to find apartments and other holiday homes in the Santa Cruz neighbourhood you prefer
  • Enter your travel dates to view the best deals on holiday rentals in Santa Cruz while they last

Look no further and take a look at our great range of rental properties in Santa Cruz!

Frequently asked questions

Are there vacation rentals in Santa Cruz?

Yes, you can find vacation rentals near popular points of interest in Santa Cruz, or you can go with a secluded option if you want a relaxing place to stay.

What’s there to see and do in Santa Cruz?

Explore the area and family-friendly sights such as Parque Acuatico Vito Spa, or get out into nature at a spot like Hacienda La Concepcion. Temple of San Francisco Javier and National Museum of the Viceroyalty are a couple of places you'll find in the larger area.

What’s a vacation rental in Santa Cruz like?

Vacation rentals are private properties you can book for a long or short time in Santa Cruz. Vacation rentals feature extras such as patios, hot tubs, and fire pits so you'll feel just like you're at home. If you're concerned about a clean environment, vacation rentals can provide a sense of seclusion away from public hotel elevators and busy front desks while still allowing you the enjoyment of travel. You'll also have more space in a vacation rental than in a hotel, which is another reason why a vacation rental is a popular option for family trips.