Otay Mesa Vacations

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Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Otay Mesa
US Grant Hotel

Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(8,497 area reviews)

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Find hotels in Downtown San Diego

Otay Mesa Hotel Deals

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

2.5 out of 5
2296 Niels Bohr Ct, San Diego, CA
Fully refundable
The price is NT$4,095 per night from Aug 10 to Aug 11
NT$4,095
NT$4,658 total
Aug 10 - Aug 11
includes taxes & fees
7.8/10 Good! (1,412 reviews)
"Excellent staff service !"

Reviewed on 2025/7/21

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NT$3,747 per night from Aug 17 to Aug 18
NT$3,747
NT$4,307 total
Aug 17 - Aug 18
includes taxes & fees
8/10 Very Good! (1,891 reviews)
Birthday Celebration
"Check in was easy, Hotel is older but fairly well maintained, The Staff was friendly and helpful, at the front desk during check in one of the staff team (WHO WAS NOT HELPING US AT ALL) went into a back office and came out a few minutes later with a ballon saying "where is that little guy" That simple ..."

Reviewed on 2025/7/21

Handlery Hotel
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is NT$4,227 per night from Jul 28 to Jul 29
NT$4,227
NT$5,746 total
Jul 28 - Jul 29
includes taxes & fees
8.2/10 Very Good! (5,770 reviews)
"we really liked the property but wish when we checked in they did a better job of explaining food options near or at the hotel . we spent a lot of time looking n it’s all very expensive so some tips would have been ideal"

Reviewed on 2025/7/22

Wyndham San Diego Bayside
See all 4,638 properties in Otay Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does an Otay Mesa vacation package cost?
Starting from as low as , a vacation package is your ticket to cheaper travel. Create your own Otay Mesa escape by choosing from our wide range of hotels, airfares and rental cars.
How do I get a cheap travel package to Otay Mesa?
Our Otay Mesa vacation packages mean plenty of savings for the savvy wanderer. For the best deal, simply bundle your hotel, flights and extras (such as activities) into a neat and tidy package. But impressive bargains are only the start of your next amazing adventure. When you book with Expedia, you'll have more than 550 air carriers and 1,000,000 hotel options all over the world to pick from. No matter your budget or style, there's a package that's perfect for you.
Where should I stay in Otay Mesa?
A getaway to Otay Mesa wouldn't be complete without paying a visit to North Island Credit Union Amphitheatre, Aquatica and White Water Canyon. Spend your evenings close to these tourist attractions and make sightseeing simple.
What are the top hotels in Otay Mesa?
Book a stay at Holiday Inn Express Hotel & Suites San Diego Otay Mesa, an IHG Hotel. It's one of this neighborhood's most sought-after hotels. Another reputable option in Otay Mesa is Quality Suites San Diego Otay Mesa.
How far in advance should I book my Otay Mesa vacation?
Your best bet is to book early. Air carriers typically release flights around a year prior to departure, and this is an ideal opportunity to score some rock-bottom prices. Boss just told you to take your vacation time next month? That's alright! Expedia are never short on fantastic deals to send you on the getaway of your dreams, at a price you can afford.
What does an Expedia Otay Mesa travel package include?
It comes down to what you want. If you're traveling alone, you might decide to bundle flights and hotels. Bringing the entire family to Otay Mesa? A travel package that includes rental cars, flights and hotels might be a better fit. Expedia gives you the flexibility and freedom to tailor-make your travel package.
What should I know before booking an Otay Mesa travel package?
When you book your flights, hotels and car rentals together, you'll land terrific discounts. Whether you're organizing an island getaway in a villa or prefer to stay in a cozy apartment in the city, Expedia can help make it happen.
Can I choose my airline with an Otay Mesa Expedia vacation package?
You can, and with over 550 airlines to select from worldwide, you have loads of choice. Look through the available options and find out which airline best suits your needs and budget.
If I'm not able to travel, can I cancel my Otay Mesa vacation package?
Don't worry if you're rethinking your Otay Mesa vacation package — it's possible to change or amend your booking. And if you've booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We get that life can sometimes throw a spanner in the works, so make your way to our Customer Service Portal if that happens. When you're ready to make changes, we're ready to help.

Discover the most popular places to visit in Otay Mesa

San Diego Zoo featuring landscape views, zoo animals and a pond

San Diego Zoo

4.5/5(3,565 reviews)

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

4.5/5(1,297 reviews)

During your trip, find out what's happening at San Diego Convention Center, a top convention center in San Diego. Experience the area's fascinating museums and entertainment choices.

San Diego Convention Center
Petco Park

Petco Park

4.5/5(1,160 reviews)

Purchase a hot dog and watch the San Diego Padres, California’s southernmost Major League Baseball team, play on their home field.

Petco Park
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages.