Otay Mesa, CA

San Diego

A city skyline with high-rise buildings and a bridge over a body of water.
An aerial view of a densely populated city with a mix of residential and commercial buildings, surrounded by greenery and a clear sky.
A hillside town with a winding road, a bridge in the distance, and a river in the foreground.

Stay near popular Otay Mesa attractions

Cross Border Xpress

Cross Border Xpress is just one of the places to see in San Diego, so why not enjoy the other things to explore during your travels? Visit the shops in this family-friendly area, or simply enjoy its restaurants.
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Otay Mesa Hotel Deals

Best Western Seven Seas

Best Western Seven Seas

3 out of 5
411 Hotel Circle South San Diego CA
The price is NT$2,695 per night from Oct 4 to Oct 5
NT$2,695
NT$3,098 total
Oct 4 - Oct 5
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, free parking, and 2 hot tubs. Our guests praise the pool and the restaurant in our ...
8/10 Very Good! (3,950 reviews)
"My room was clean, and the grounds were well maintained. The staff was friendly and helpful."

Reviewed on 2026/10/1

Best Western Seven Seas
Paradise Point Resort & Spa

Paradise Point Resort & Spa

4 out of 5
1404 Vacation Rd San Diego CA
Fully refundableReserve now, pay when you stay
The price is NT$6,622 per night from Oct 31 to Nov 1
NT$6,622
NT$9,298 total
Oct 31 - Nov 1
includes taxes & fees
Book a stay at this beach resort in San Diego. Enjoy free WiFi, 5 outdoor pools, and a full-service spa. Our guests praise the pool and the helpful staff in ...
Paradise Point Resort & Spa
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive San Diego CA
The price is NT$4,847 per night from Oct 25 to Oct 26
NT$4,847
NT$6,728 total
Oct 25 - Oct 26
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 3 restaurants, and breakfast (surcharge). Our guests praise the pool and the restaurant ...
Wyndham San Diego Bayside
Handlery Hotel

Handlery Hotel

3.5 out of 5
950 Hotel Cir N San Diego CA
The price is NT$3,288 per night from Oct 5 to Oct 6
NT$3,288
NT$3,779 total
Oct 5 - Oct 6
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy free WiFi, 2 restaurants, and 2 bars/lounges. Our guests praise the pool and the helpful staff ...
8.4/10 Very Good! (2,980 reviews)
"I like staying here .I feel safe and I have restaurants close to hotel.Everything was great only a strong order of dust in restroom .I would stay here again"

Reviewed on 2026/10/1

Handlery Hotel
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl San Diego CA
The price is NT$7,295 per night from Oct 25 to Oct 26
NT$7,295
NT$10,194 total
Oct 25 - Oct 26
includes taxes & fees
Book a stay at this business-friendly hotel in San Diego. Enjoy 6 restaurants, 3 bars/lounges, and breakfast (surcharge). Our guests praise the pool and the ...
Manchester Grand Hyatt San Diego
Hard Rock Hotel San Diego

Hard Rock Hotel San Diego

4 out of 5
207 5th Ave San Diego CA
The price is NT$5,606 per night from Oct 9 to Oct 10
NT$5,606
NT$8,037 total
Oct 9 - Oct 10
includes taxes & fees
Stay at this hotel in San Diego. Enjoy free WiFi, 2 restaurants, and a nightclub. Our guests praise the helpful staff and the convenient parking in our reviews. ...
9/10 Wonderful! (4,468 reviews)
"Staff was very kind!"

Reviewed on 2026/10/1

Hard Rock Hotel San Diego
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.
A large stadium with the sign "Cobo Park" and palm trees around it.

Downtown San Diego

Petco Park and Port of San Diego are a few top attractions in Downtown San Diego. Hop around the city on the metro at Civic Center Station or Civic Center Station and check out the area's fantastic nightlife, fascinating museums, and beautiful waterfront views.

A pier at sunset with people sitting and standing, waves crashing below.

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Pacific Beach while you're exploring the area.

A coastal cityscape with a long sandy beach, a pier, and dense urban buildings.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

A theater marquee with ornate designs and the name "Gaslamp Quarter".

Gaslamp Quarter

Fantastic nightlife and popular shops are a few of the things travelers enjoy most about Gaslamp Quarter. A visit to Gaslamp Museum at the Davis-Horton House or Nova SD is also recommended, and you can jump aboard the metro at Gaslamp Quarter Station to get around town.

An aerial view of a coastal city with a marina, a large body of water, and a peninsula with buildings.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Ski Beach are top sights worth seeing.

Otay Mesa, CA