O Brien, FL

Travel Guide

A calm river with clear water, surrounded by dense trees and rocky banks.
A clear blue pond surrounded by dense forest.
A calm river surrounded by trees reflecting in the water.
A calm river with trees reflecting the sunlight.
A swampy area with a calm water body surrounded by various trees and vegetation.
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

3 out of 5
165NW CALI DRIVE Lake City FL
The price is NT$3,064 per night from Oct 25 to Oct 26
NT$3,064
NT$3,448 total
Oct 25 - Oct 26
includes taxes & fees
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
La Quinta Inn & Suite by Wyndham Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
The price is NT$3,372 per night from Nov 1 to Nov 2
NT$3,372
NT$3,794 total
Nov 1 - Nov 2
includes taxes & fees
Book a stay at this business-friendly hotel in Alachua. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,000 reviews)
"Clean room, super friendly and helpful staff, and great breakfast. Will stay again when back in the area!"

Reviewed on 2026/10/19

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Best Western Plus Lake City

Best Western Plus Lake City

2.5 out of 5
350 SW Florida Gateway Dr Lake City FL
The price is NT$2,598 per night from Nov 15 to Nov 16
NT$2,598
NT$2,922 total
Nov 15 - Nov 16
includes taxes & fees
Book a stay at this business-friendly hotel in Lake City. Enjoy free breakfast, free WiFi, and free parking. Our guests praise the breakfast and the helpful ...
9/10 Wonderful! (1,122 reviews)
"Nice staff great rooms"

Reviewed on 2026/10/21

Best Western Plus Lake City
See all 405 properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

2 out of 5
1699 NE Co Rd 337 High Springs FL
Stay at this cabin in High Springs. Enjoy free parking, patios, and climate control. Popular attractions Ginnie Spring and Ruth B. Kirby Gilchrist Blue Springs ...
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
See all properties in O Brien
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cities near O Brien

A clear, turquoise pool surrounded by wooden decks and dense forest.

Branford

A white heron standing in shallow water surrounded by green vegetation.

Fort White

A calm river surrounded by trees with Spanish moss, reflecting the clear blue sky.

Mayo

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