A calm river with clear water, surrounded by dense trees and rocky banks.

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Our top choices for O Brien hotels

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.
A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.
A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.

1. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
United States
Steven
NT$3,160
NT$3,556 total
includes taxes & fees
Oct 21 - Oct 22
La Quinta Inn & Suite by Wyndham Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel room with two beds, a desk, a TV, and a large window with curtains.
A hotel room with a sofa, a small table, a lamp, and artwork on the wall.
A hotel entrance with a covered walkway, palm trees, and a clear sky.

2. Best Western Plus Lake City

Best Western Plus Lake City
Lake City
United States
Melissa
NT$2,576
NT$2,898 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Plus Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
Exterior
A modern hotel lobby with a fireplace, seating areas, and a bar.
A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

3. Comfort Suites Lake City

Comfort Suites Lake City
Lake City
United States
Carma
NT$2,843
NT$3,198 total
includes taxes & fees
Oct 21 - Oct 22
Comfort Suites Lake City
An outdoor patio area with tables and chairs, surrounded by palm trees and a building with large windows.
A hotel room with a sofa, a desk with a computer, a TV, a mirror, and framed pictures on the wall.
Snack bar
Fitness facility

4. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
United States
James
NT$3,348
NT$3,767 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Lake City
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.
An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

5. Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
United States
Carlos
NT$3,120
NT$3,510 total
includes taxes & fees
Oct 25 - Oct 26
Tru by Hilton Lake City
An outdoor patio with a stone fire pit, grey cushioned seating, and wicker ottomans.
A modern hotel lobby with a reception desk, seating areas, and a large screen.
A modern kitchen with stainless steel appliances, a dishwasher, and a built-in oven.
A modern hotel room with a bed, a desk with a computer, a TV, and a lamp.

6. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
Lake City
United States
William
NT$3,495
NT$3,932 total
includes taxes & fees
Oct 18 - Oct 19
Home2 Suites by Hilton Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.
A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.
A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

7. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
United States
Pedro
NT$3,025
NT$3,403 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites Lake City
A multi-story hotel with a modern design, featuring a prominent entrance and a parking area.
A reception area with two wooden reception desks, a wall-mounted decorative piece, and a refrigerator stocked with beverages.
Lobby
A modern restaurant with round tables and yellow chairs, a bar area with a TV, and a menu display.

8. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
Lake City
United States
Angel
NT$3,734
NT$4,201 total
includes taxes & fees
Oct 25 - Oct 26
Courtyard By Marriott Lake City
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.
A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.
A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

9. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
United States
Sara
NT$2,144
NT$2,412 total
includes taxes & fees
Oct 18 - Oct 19
Americas Best Value Inn Lake City
A hotel room with a teal accent wall, a sofa, a desk with a chair, a small table, and two framed artworks.
A hotel room with a beige sofa, a small table with a book, a TV on a wooden cabinet, and a window with blinds.
A gym with treadmills, weight machines, and dumbbells.
A multi-story building with balconies and a sign indicating it is a Holiday Inn.

10. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
Lake City
United States
C.jeffery
NT$3,224
NT$3,627 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn & Suites Lake City by IHG
An outdoor patio area with wicker chairs, a round table, and a fire pit.
A modern interior with a central kitchen area, a seating area with a sofa and chairs, and a large window providing natural light.
A modern interior with a dark wood desk, a blue chair, a sofa, and a patterned rug.
A hotel room with a bed, a sofa, a small table, a wardrobe, and a kitchenette.

11. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
Lake City
United States
John
NT$4,118
NT$4,633 total
includes taxes & fees
Oct 18 - Oct 19
TownePlace Suites by Marriott Lake City
A modern restaurant with a central counter, red chairs, and a blue and white color scheme.
A hotel room with a bed, a desk with a coffee maker, a chair, and a lamp.
A hotel with a covered entrance, a sign indicating it is a Holiday Inn Express, and a well-maintained lawn area.
A conference room with a stone fireplace, a flat-screen TV, and two office chairs.

12. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
Live Oak
United States
Tammy
NT$3,666
NT$4,033 total
includes taxes & fees
Nov 8 - Nov 9
Holiday Inn Express & Suites Live Oak by IHG
A hotel room with a large bed, a desk with a computer, a television, and a window with curtains.
Lobby
A restaurant with a yellow accent wall, white tiled floor, and black and blue chairs.
A swimming pool with lounge chairs and umbrellas, surrounded by a brick building with balconies and palm trees.

13. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
Lake City
United States
Scott
NT$2,105
NT$2,368 total
includes taxes & fees
Oct 20 - Oct 21
Super 8 by Wyndham Lake City
A spacious lobby with a high ceiling, a large window, a dining area with green chairs, and a black door leading outside.
A hotel room with two beds, a desk, a chair, a painting on the wall, and a patterned carpet.
A hotel dining area with tables and chairs, a reception desk, and a kitchen in the background.
A reception area with a counter, a coffee machine, and a potted plant.

14. Quality Inn Lake City

Quality Inn Lake City
Lake City
United States
Justin
NT$2,489
NT$2,800 total
includes taxes & fees
Nov 2 - Nov 3
Quality Inn Lake City
A covered outdoor area with a paved walkway, benches, and potted plants.
A compact RV kitchen with wooden cabinets, a microwave, a stove, and a sink.
A grassy area with a picnic table, a car parked in front of a building with a sloped roof, and trees with hanging moss.
A compact kitchen with a blue refrigerator, a black coffee maker, a microwave, and a small black refrigerator.

15. Cindys Motel

Cindys Motel
Mayo
United States
Diane
NT$2,801
NT$3,027 total
includes taxes & fees
Oct 18 - Oct 19
Cindys Motel
A hotel room with two beds, a TV, a desk, and a painting of a sunset.
A swimming pool with lounge chairs, a small pool house, and a yellow multi-story building with balconies.
A hotel room with a large bed, a bedside table, a nightstand, a window, and a bathroom with a toilet and sink.
A reception area with a wooden counter, a clock, and a computer on a desk.

16. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
Lake City
Canada
Danny
NT$2,290
NT$2,576 total
includes taxes & fees
Oct 18 - Oct 19
Days Inn by Wyndham Lake City I-75
A modern kitchen with a large window, a flat-screen TV, and a coffee machine.
A hotel room with a bed, desk, chair, and sofa.
A hotel lobby with a dining area, a reception desk, and a view of the outside.
A reception area with a tiled counter, a computer, a sign reading 'Quality,' and two decorative vases.

17. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
White Springs
United States
Pennee
NT$2,148
NT$2,363 total
includes taxes & fees
Nov 11 - Nov 12
Quality Inn White Springs Suwanee
An aerial view of a campground with RVs, a swimming pool, and tennis courts.
A wooden cabin with a porch, a front door, and a small window.
A wooden cabin with a kitchen, a bathroom, and a loft bedroom.
A covered outdoor dining area with a table and chairs, large windows, and a view of greenery.

18. Suwannee River Rendezvous

Suwannee River Rendezvous
Mayo
United States
Beth
NT$2,873
NT$3,852 total
includes taxes & fees
Oct 26 - Oct 27
Suwannee River Rendezvous
A hotel reception area with a reception desk, seating area, and a view of the parking lot.
A compact room with a flat-screen TV on a wooden cabinet, a microwave on a small black stand, a chair, and a mirror with a light above it.
A reception area with a wooden floor, a reception desk, a seating area with chairs, and a view through the glass doors to the outside.
A dining area with wooden chairs and tables, a coffee machine, and a counter with various items.

19. Econo Lodge Live Oak

Econo Lodge Live Oak
Live Oak
United States
Alexia
NT$2,811
NT$3,092 total
includes taxes & fees
Nov 5 - Nov 6
Econo Lodge Live Oak
A reception area with a stone wall, a blue accent wall, a clock, and a window with a view of the parking lot.
A modern bedroom with a wooden headboard, two bedside lamps, a patterned bedspread, and a blue door.
A bathroom with a bathtub, a shower, and a toilet.
A bathroom with a towel rack, a shower curtain, and a toilet.

20. Regal Inn

Regal Inn
Lake City
United States
Samuel
NT$1,783
NT$2,005 total
includes taxes & fees
Oct 15 - Oct 16
Regal Inn
View all properties

Hotels recommended for families in O Brien

A La Quinta hotel with a modern facade, multiple windows, and a well-lit entrance.
A hotel room with a large bed, a sofa, a desk, and a wall with a geometric pattern.
A modern lobby with a large map mural, a wooden column, and a seating area with a yellow cushion.
A modern restaurant with a long counter, multiple seating options including red and yellow chairs, and a large window providing a view.

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
Lake City
NT$3,160
NT$3,556 total
includes taxes & fees
Oct 21 - Oct 22
La Quinta Inn & Suite by Wyndham Lake City
A hotel room with a gray sofa, a bed with white linens, a desk with a chair, and a window with blinds.
Exterior
A modern hotel lobby with a fireplace, seating areas, and a bar.
A modern living room with a sectional sofa, a round coffee table, a hanging chair, and a flat-screen TV on a glass stand.

Comfort Suites Lake City

Comfort Suites Lake City
Lake City
NT$2,843
NT$3,198 total
includes taxes & fees
Oct 21 - Oct 22
Comfort Suites Lake City
A spacious living area with a grey sofa, a coffee table, and a TV stand.
A hotel room with two beds, a desk, a TV, and a large window with curtains.
A hotel room with a sofa, a small table, a lamp, and artwork on the wall.
A hotel entrance with a covered walkway, palm trees, and a clear sky.

Best Western Plus Lake City

Best Western Plus Lake City
Lake City
NT$2,576
NT$2,898 total
includes taxes & fees
Nov 1 - Nov 2
Best Western Plus Lake City
An outdoor patio area with tables and chairs, surrounded by palm trees and a building with large windows.
A hotel room with a sofa, a desk with a computer, a TV, a mirror, and framed pictures on the wall.
Snack bar
Fitness facility

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
Lake City
NT$3,348
NT$3,767 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Lake City
A picnic table with a potted plant, located in a grassy area with a tree and a road in the background.
A living room with a black leather sofa, a wooden coffee table with a plant, and framed pictures on the wall.
A hotel room with two beds, a nightstand with a phone and remote, and a patterned curtain.
A hotel lobby with a reception desk, a clock, a plant, a water dispenser, and a coffee station.

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
Lake City
NT$2,144
NT$2,412 total
includes taxes & fees
Oct 18 - Oct 19
Americas Best Value Inn Lake City
An indoor swimming pool with clear water, surrounded by glass doors and windows, and a wooden deck area.
An outdoor patio area with a sectional sofa, chairs, a coffee table, and a fire pit.
A modern dining area with multiple tables and chairs, a kitchen in the background, and a 'Hello Fall' sign on the wall.
A modern living room with two green sofas, a white coffee table, and a flat-screen TV mounted on the wall.

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
Lake City
NT$3,025
NT$3,403 total
includes taxes & fees
Oct 25 - Oct 26
Fairfield Inn & Suites Lake City
A self-service beverage station with a variety of drinks, snacks, and a refrigerated section.
A modern hotel lobby with a central counter displaying snacks and beverages, two digital screens above the counter, and a seating area with a view of the lobby.
A modern interior with two red chairs and a small table, large windows, and hanging pendant lights.
An outdoor patio with a stone fire feature, blue cushioned seating, and a grill.

Tru by Hilton Lake City

Tru by Hilton Lake City
Lake City
NT$3,120
NT$3,510 total
includes taxes & fees
Oct 25 - Oct 26
Tru by Hilton Lake City
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Quality Inn Lake City

Quality Inn Lake City

10/10 Excellent
"Woman checking us in was great... property was clean, convenient, and quiet. Breakfast was good too.... Would stay here again."
Raphael 1-night trip
Posted 9 hours ago
Quality Inn Lake City
Best Western Plus Lake City

Best Western Plus Lake City

10/10 Excellent
"Property us always just what we need when in the area. Staff is always courteous and helpful. We are at this property a few times a year and never have an issue other than the pool. Its indoor but the area could be maintained better and the water is always freezing. We opt not to use thos amenity"
Christina 2-night trip
Posted 11 hours ago
Best Western Plus Lake City
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent
"Great place to stay for checking out the springs in the area"
Katie 2-night trip
Posted 14 hours ago
Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy
Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

8/10 Good
"Hotel is in need of major remodeling"
Tom 1-night trip
Posted 16 hours ago
Baymont by Wyndham Lake City I-75
Courtyard By Marriott Lake City

Courtyard By Marriott Lake City

10/10 Excellent
"Great experience, clean , pleasant decor. Quiet and comfortable!"
mary 1-night trip
Posted 1 day ago
Courtyard By Marriott Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

8/10 Good
"Room was clean- shampoo and conditioner were included. Beds were comfortable. Breakfast was also good. Better than most breakfast buffets I have been too. Friendly and helpful staff."
ELIZABETH 1-night trip
Posted 1 day ago
Tru by Hilton Lake City
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

10/10 Excellent
"Everything was great. Definitely going back"
Robert 1-night trip
Posted 2 days ago
La Quinta Inn & Suite by Wyndham Lake City
Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City

10/10 Excellent
"Very clean and the staff was very helpful . My children loved it here. The waffles were amazing."
Cindy 1-night trip
Posted 2 days ago
Hampton Inn & Suites Lake City
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent
"Staff was friendly and helpful. Breakfast was good."
Chenetta 2-night trip
Posted 3 days ago
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
NT$1,845
NT$2,076 total
Oct 18 - Oct 19
includes taxes & fees
5/10 (1,000 reviews)
Baymont by Wyndham Lake City I-75
Quality Inn Lake City

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL
NT$2,489
NT$2,800 total
Nov 2 - Nov 3
includes taxes & fees
8.2/10 Very Good! (1,004 reviews)
Quality Inn Lake City
Best Western Plus Lake City

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL
NT$2,576
NT$2,898 total
Nov 1 - Nov 2
includes taxes & fees
9/10 Wonderful! (1,116 reviews)
Best Western Plus Lake City
Comfort Suites Lake City

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL
NT$2,843
NT$3,198 total
Oct 21 - Oct 22
includes taxes & fees
Comfort Suites Lake City
Tru by Hilton Lake City

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL
NT$3,120
NT$3,510 total
Oct 25 - Oct 26
includes taxes & fees
Tru by Hilton Lake City
Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129 Live Oak FL
NT$3,666
NT$4,033 total
Nov 8 - Nov 9
includes taxes & fees
Holiday Inn Express & Suites Live Oak by IHG

Hotels in O Brien with star-rating

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Provides buffet, an indoor pool, and free self parking. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Best Western Plus Lake City are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

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