The Best Hotels Closest to James S. McDonnell Prologue Room in St. Louis for 2026

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Our top choices for James S. McDonnell Prologue Room hotels

A spacious lobby with a high ceiling, large windows, and a central seating area with sofas and chairs.

A spacious indoor area with a high ceiling and large windows, featuring multiple seating areas with sofas and chairs, and a visible outdoor view through the windows.

A spacious indoor area with multiple wooden tables and chairs, large windows, and a high ceiling with exposed beams.

A spacious lobby with modern seating, a reception desk, and large windows offering views of the parking area.

1. Pear Tree Inn St. Louis Airport

2.6 km from James S. McDonnell Prologue Room

Murphy

NT$2,916

NT$3,462 total

includes taxes & fees

Oct 25 - Oct 26

A modern hotel room with a dining area, wooden cabinets, a checkered floor, and a flat-screen TV.

A hotel room with a desk, chair, TV, and a framed picture on the wall.

A hotel room with two beds, a desk, a chair, and a large window with curtains.

A Wingate hotel with a covered entrance, outdoor seating, and a parking lot.

2. Wingate by Wyndham St. Louis Airport

2.5 km from James S. McDonnell Prologue Room

Rachal

NT$3,135

NT$3,691 total

includes taxes & fees

Nov 2 - Nov 3

A multi-level hotel lobby with seating areas, a reception desk, and large windows offering views.

A pool area with two hot tubs, seating, and a view of the outdoors.

A modern kitchen with a stainless steel range hood, a bar area with stools, and a large window providing a view of the outdoors.

A hotel room with a bed, two armchairs, a sofa, a small table, and a nightstand.

3. Drury Inn & Suites St. Louis Airport

2.1 km from James S. McDonnell Prologue Room

Ethan

NT$3,726

NT$4,409 total

includes taxes & fees

Oct 25 - Oct 26

A modern living room with a built-in fireplace, a large flat-screen TV, a unique hexagonal pendant light, and a patterned rug.

A modern lobby with blue seating, a reception desk, and large windows.

A modern dining area with a long table, multiple chairs, and a unique chandelier.

A multi-story hotel with a stone facade, a covered entrance, and a parking lot.

4. Hyatt Select St. Louis Airport

1.9 km from James S. McDonnell Prologue Room

Daisy

NT$3,564

NT$4,419 total

includes taxes & fees

Oct 26 - Oct 27

An indoor swimming pool with clear glass walls, blue lounge chairs, and a lifeguard stand.

A snack vending machine with various snack options.

A hotel lobby with a reception desk, seating area, and a view of the parking lot.

A dining area with tables and chairs, a blue sofa, and a patterned carpet.

5. Hampton Inn By Hilton St Louis Airport

2 km from James S. McDonnell Prologue Room

Judith

NT$3,696

NT$4,448 total

includes taxes & fees

Nov 19 - Nov 20

A breakfast buffet with labeled sections for fruit and cereal.

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large window with curtains.

A conference room with a long table, chairs, water bottles, a phone, and a notepad.

A coffee station with two coffee machines and a variety of coffee pods and cups.

6. Holiday Inn Express & Suites St Louis Airport by IHG

2 km from James S. McDonnell Prologue Room

Keneace

NT$3,953

NT$4,887 total

includes taxes & fees

Nov 1 - Nov 2

A buffet with fruits, pastries, and beverages.

The Renaissance Hotel with a modern architectural design, featuring a prominent central entrance and a symmetrical facade.

A modern bar area with a long counter, white bar stools, and a mix of bar and dining tables.

A modern living room with a flat-screen TV, comfortable seating, and decorative items on shelves.

7. Renaissance St. Louis Airport Hotel

2 km from James S. McDonnell Prologue Room

Anthony

NT$3,828

NT$4,479 total

includes taxes & fees

Nov 15 - Nov 16

A modern dining area with round tables, orange chairs, and a decorative wall with pottery.

A modern hotel lobby with a bar area, seating arrangements, and decorative lighting.

A Marriott hotel with a large building, multiple flags, and a well-lit entrance area.

A modern lobby with seating areas, a reception desk, and a bar area.

8. Marriott St. Louis Airport

2.4 km from James S. McDonnell Prologue Room

Sha

NT$4,620

NT$5,560 total

includes taxes & fees

Oct 30 - Oct 31

A modern interior with a wooden panel wall, a kitchen area, and a dining space with pendant lighting.

A modern hotel with a prominent DoubleTree by Hilton sign, a well-lit entrance, and a landscaped front yard.

A hotel room with a bed, a desk, a chair, a small table, a framed artwork, and a bathroom with a mirror and sink.

A modern kitchen with a marble countertop, red ceiling, and pendant lighting.

9. DoubleTree by Hilton St. Louis Airport

2.1 km from James S. McDonnell Prologue Room

AshLynn

NT$3,415

NT$4,041 total

includes taxes & fees

Nov 1 - Nov 2

A bar area with a long counter, multiple seating options, and a television screen displaying a program.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and large windows offering views of the outdoors.

A hotel lobby with a central seating area featuring sofas and tables, a large TV screen displaying a sports game, and a bar area with chairs and a counter.

A multi-story hotel with a prominent 'Hilton' sign, a parking area, and a covered walkway.

10. Hilton St. Louis Airport

1.9 km from James S. McDonnell Prologue Room

raymond

NT$4,143

NT$4,987 total

includes taxes & fees

Nov 19 - Nov 20

A hotel dining area with multiple tables and chairs, a sofa, and a large window with curtains.

A hotel room with two beds, a desk with a lamp, a television, and a painting on the wall.

A hotel with a beige facade, a clear sign reading "Quality Inn," and a parking lot with a red car.

A workspace with two desks, two computers, a clock, and a framed picture on the wall.

11. Quality Inn Florissant - St Louis

3.1 km from James S. McDonnell Prologue Room

Annalyn

NT$2,154

NT$2,565 total

includes taxes & fees

Nov 1 - Nov 2

A reception desk with a cityscape on the monitor, a blue-lit ceiling, and a sign for key drop-off.

A restaurant with tables and chairs, a coffee machine, and a refrigerator.

A modern hotel with a covered entrance, large windows, and a sign indicating a one-way street.

A hotel room with a large bed, two bedside tables, a TV, a desk, and a window with curtains.

12. Travelodge by Wyndham St. Louis

2.4 km from James S. McDonnell Prologue Room

Monica

NT$1,976

NT$2,340 total

includes taxes & fees

Nov 1 - Nov 2

A parking lot with multiple cars, a building with a green and beige facade, and a sign for Home Towne Studios.

A compact kitchenette with a sink, stove, microwave, and a white refrigerator.

A hotel entrance with a covered waiting area, a parking lot, and a building with multiple windows and a green exterior.

13. HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

2.9 km from James S. McDonnell Prologue Room

Kimberly

NT$1,983

NT$2,424 total

includes taxes & fees

Oct 22 - Oct 23

A hotel room with a large bed, bedside tables, a heater, and a view of the city.

A multi-story brick building with a central entrance, parking lot, and designated handicapped parking spaces.

A modern kitchen with dark cabinets, a white countertop, a stove, a microwave, and a sink.

A stairwell with a metal railing, a trash can, and a window with a view of trees.

14. Welcome Suites Hazelwood

3 km from James S. McDonnell Prologue Room

Fed

NT$2,430

NT$2,970 total

includes taxes & fees

Oct 20 - Oct 21

A hotel room with a bed, bedside table, lamp, TV, and a desk with a chair.

A spacious dining area with multiple tables and chairs, a kitchen area with dark cabinets, and a flat-screen TV mounted on the wall.

A reception area with a marble floor, a reception desk, and a sign that says "Quality."

A spacious lobby with a patterned tile floor, a staircase, and seating areas.

15. Quality Inn Saint Louis Airport

2 km from James S. McDonnell Prologue Room

Donald

NT$1,807

NT$2,247 total

includes taxes & fees

Nov 1 - Nov 2

A modern lobby with orange seating, a flat-screen TV, and a stone accent wall.

A hotel room with two beds, a headboard, bedside lamps, a clock, and a window with curtains.

A hotel pool area with a hot tub, lounge chairs, and a 'No Diving Allowed' sign.

A gym with treadmills, stationary bikes, and a weight machine.

16. Drury Plaza Hotel St. Louis St. Charles

12.8 km from James S. McDonnell Prologue Room

Robert

NT$4,698

NT$5,446 total

includes taxes & fees

Oct 25 - Oct 26

A restaurant with round tables and chairs, a bar area, and a patterned ceiling.

A Drury Plaza Hotel with a large parking lot and multiple cars parked in front.

A lobby with a reception desk, seating area with sofas and ottomans, and a patterned rug.

A spa bath with a sign indicating a capacity of 8 persons.

17. Drury Plaza Hotel St. Louis Brentwood

13.6 km from James S. McDonnell Prologue Room

angelia

NT$4,147

NT$4,925 total

includes taxes & fees

Nov 1 - Nov 2

An outdoor patio with a fire pit, seating, and a building in the background.

A modern bar area with a wooden counter, a beverage dispenser, and a menu board.

A Courtyard by Marriott hotel with a modern facade, multiple floors, and a well-lit entrance.

A modern hotel lobby with a bar area, a large dining table, and a seating area with chairs.

18. Courtyard by Marriott St. Louis Brentwood

13.5 km from James S. McDonnell Prologue Room

Anna

NT$3,828

NT$4,669 total

includes taxes & fees

Nov 1 - Nov 2

A courtyard with outdoor seating, a central fountain, and a view of a tower.

A spacious lobby with a bar area, seating arrangements, and a clock on the wall.

A hotel room with two beds, a desk, and a chair.

The exterior of the Charles F. Knight Center with a stone facade, large arched entrance, and a sign above the doors.

19. The Knight Center at Washington University

11.4 km from James S. McDonnell Prologue Room

Rosalyn

NT$4,685

NT$5,387 total

includes taxes & fees

Nov 19 - Nov 20

A brick building with a sign reading "Country Inn & Suites."

A modern kitchen with blue cabinetry, a central island with stools, pendant lighting, and a variety of kitchen appliances and utensils.

A spacious living room with a blue sofa, a white coffee table, and a striped armchair. There is a bookshelf filled with decorative items and a television on a wooden stand.

An indoor swimming pool with a tiled floor, a central window, and multiple chairs around the pool.

20. Country Inn & Suites by Radisson, St. Charles Historic District

12.5 km from James S. McDonnell Prologue Room

Stewart

NT$3,966

NT$4,558 total

includes taxes & fees

Nov 15 - Nov 16

View all properties

Compare popular hotels close to James S. McDonnell Prologue Room

Property	Property class	Guest rating
Pear Tree Inn St. Louis Airport	9.4 Exceptional 3,311 reviews	View
Wingate by Wyndham St. Louis Airport	9.2 Wonderful 1,709 reviews	View
Drury Inn & Suites St. Louis Airport	9.2 Wonderful 1,440 reviews	View
Hyatt Select St. Louis Airport	9.2 Wonderful 1,004 reviews	View
Hampton Inn By Hilton St Louis Airport	9.0 Wonderful 249 reviews	View

Top James S. McDonnell Prologue Room Hotel Reviews

Hampton Inn By Hilton St Louis Airport

10/10 Excellent

"Stayed here for 1 night, room was clean and comfortable"

Drury Inn & Suites St. Louis Airport

10/10 Excellent

"Very hospitable staff, The breakfast was good and the evening kickback snacks and drink was a great option as well. I will definitely stay here again in the future"

La Quinta Inn & Suites by Wyndham St. Louis Hazelwood/ North

10/10 Excellent

"Nice"

Quality Inn Florissant - St Louis

10/10 Excellent

"Friendly people"

Holiday Inn Express & Suites St Louis Airport by IHG

8/10 Good

"Clean room. Wonderful staff"

DoubleTree by Hilton St. Louis Airport

10/10 Excellent

"I will definitely book this hotel again!!!!"

Travelodge by Wyndham St. Louis

10/10 Excellent

"My second year staying here and it’s a great place for me based on the location (close to the airport), amenities (breakfast and laundry), transit (buses, Red line, and Enterprise and Uber extremely close by), and food choices nearby. The staff are really friendly and helpful, and the price of my room is very affordable and cheaper than most places in the area. I’ve never had a vehicle staying here but the free parking is always available with plenty of space when I’m here (August and October). My room was always quiet (107 and 115)."

Wingate by Wyndham St. Louis Airport

10/10 Excellent

"Clean, comfortable room that very close to the airport. Its also about a 3 minute walk across the parking lot to Bandana's which has amazing BBQ!! The hotel is also just down the street from The Parking Spot. Everything is very close and convenient"

Other attractions near James S. McDonnell Prologue Room

Blacks in Flight Mural

You can enjoy some culture when you stop by Blacks in Flight Mural in St. Louis. Experience the area's fascinating museums and acclaimed art scene.

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Payne-Gentry Historical House

7.0/10 (37 reviews)

Find out about the history of Bridgeton when you spend time at Payne-Gentry Historical House. Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Blanche M. Touhill Performing Arts Center

10.0/10 (2 reviews)

Enjoy an outing to Blanche M. Touhill Performing Arts Center during your stay in St. Louis. Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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Old St. Ferdinand Shrine

2.0/10 (1 review)

You can spend time exploring the galleries in Old St. Ferdinand Shrine in Florissant. Experience the great live music and acclaimed theater scene in this family-friendly area.

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St. Louis Mercantile Library

St. Louis Mercantile Library is just one of the places to see in Normandy, so why not enjoy the other things to explore during your travels? Attend a sporting event or simply enjoy the top-notch restaurants while you're in the area.

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St. Louis Car Museum

9.2/10 (5 reviews)

You can spend time exploring the galleries in St. Louis Car Museum during your travels in Overland. Experience the acclaimed theater scene and great live music in this family-friendly area.

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St. Louis Kaplan Feldman Holocaust Museum

6.0/10 (1 review)

You can spend time studying the exhibits at St. Louis Kaplan Feldman Holocaust Museum during your travels in St. Louis. Experience the great live music and acclaimed theater scene in this family-friendly area.

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New Jewish Theatre

6.0/10 (1 review)

You can make plans for a show at New Jewish Theatre during your trip to St. Louis. Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Frequently asked questions

What's the area like around James S. McDonnell Prologue Room?

James S. McDonnell Prologue Room is located in a welcoming area of St. Louis known for its array of dining options and sporting events. You'll find 116 hotels and other accommodations within a few miles for a convenient home base.

What's the best hotel to stay close to James S. McDonnell Prologue Room?

Renaissance St. Louis Airport Hotel is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and an indoor pool. It's located 1.2 mi (2 km) from James S. McDonnell Prologue Room. Other good choices within a few miles include Pear Tree Inn St. Louis Airport and Drury Inn & Suites St. Louis Airport.

How many hotels will I find near James S. McDonnell Prologue Room?

Expedia has 116 hotels and other accommodations a few miles from James S. McDonnell Prologue Room.

If I need to cancel the hotel reservation for my stay near James S. McDonnell Prologue Room, will I receive a refund?

Yes, most hotel reservations are fully refundable as long as you cancel prior to the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of your arrival date. If you booked a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the best options available near James S. McDonnell Prologue Room.

Where can I learn more about changing or cancelling my trip in the area near James S. McDonnell Prologue Room?

For more details about picking new dates or cancelling your stay near James S. McDonnell Prologue Room, go to https://www.expedia.com/service/.

What can I see and do near James S. McDonnell Prologue Room?

You'll want to browse the exhibits at Payne-Gentry Historical House and St. Louis Car Museum. Create some family memories at Par-Tee Recreation Center and Blanche M. Touhill Performing Arts Center. Old St. Ferdinand Shrine and St. Louis Mercantile Library are both worth a visit while you're checking out the area.

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James S. McDonnell Prologue Room

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Find hotels near James S. McDonnell Prologue Room, St. Louis from NT$2,247

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for James S. McDonnell Prologue Room hotels

1. Pear Tree Inn St. Louis Airport

2. Wingate by Wyndham St. Louis Airport

3. Drury Inn & Suites St. Louis Airport

4. Hyatt Select St. Louis Airport

5. Hampton Inn By Hilton St Louis Airport

6. Holiday Inn Express & Suites St Louis Airport by IHG

7. Renaissance St. Louis Airport Hotel

8. Marriott St. Louis Airport

9. DoubleTree by Hilton St. Louis Airport

10. Hilton St. Louis Airport

11. Quality Inn Florissant - St Louis

12. Travelodge by Wyndham St. Louis

13. HomeTowne Studios by Red Roof St. Louis - Airport/ N Lindbergh

14. Welcome Suites Hazelwood

15. Quality Inn Saint Louis Airport

16. Drury Plaza Hotel St. Louis St. Charles

17. Drury Plaza Hotel St. Louis Brentwood

18. Courtyard by Marriott St. Louis Brentwood

19. The Knight Center at Washington University

20. Country Inn & Suites by Radisson, St. Charles Historic District

Compare popular hotels close to James S. McDonnell Prologue Room

Top James S. McDonnell Prologue Room Hotel Reviews

Hampton Inn By Hilton St Louis Airport

Drury Inn & Suites St. Louis Airport

La Quinta Inn & Suites by Wyndham St. Louis Hazelwood/ North

Quality Inn Florissant - St Louis

Holiday Inn Express & Suites St Louis Airport by IHG

DoubleTree by Hilton St. Louis Airport

Travelodge by Wyndham St. Louis

Wingate by Wyndham St. Louis Airport

Other attractions near James S. McDonnell Prologue Room

Blacks in Flight Mural

Payne-Gentry Historical House

Blanche M. Touhill Performing Arts Center

Old St. Ferdinand Shrine

St. Louis Mercantile Library

St. Louis Car Museum

St. Louis Kaplan Feldman Holocaust Museum

New Jewish Theatre

Frequently asked questions

Explore a world of travel with Expedia