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Our top choices for East Cape Girardeau hotels

A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.
An indoor swimming pool with a clear view of the pool area, including the pool's edge, a set of stairs leading into the pool, and a few lounge chairs and tables around the pool.
A living room with a stone fireplace, a television mounted above it, and a large sofa with cushions.
A spacious hotel lobby with a high ceiling, a central seating area with sofas and chairs, a fireplace, and a television mounted on the wall.

1. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Cape Girardeau
United States
ELAINE
NT$3,159
NT$3,595 total
includes taxes & fees
Oct 29 - Oct 30
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.
A spacious lobby with a curved seating area, a reception desk, and a large window providing natural light.
An indoor swimming pool with clear blue water, surrounded by beige walls and large windows.
A spacious corridor with a high ceiling, recessed lighting, and a series of posters on the walls.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
Cape Girardeau
United States
Sandra
NT$3,178
NT$3,585 total
includes taxes & fees
Oct 5 - Oct 6
Drury Plaza Hotel Cape Girardeau Conference Center
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.
A modern outdoor seating area with a fire feature, a stone wall, and a view of the sunset.
A modern living room with a large sectional sofa, a flat-screen TV, and a view of the sea through large windows.
A modern bar area with a herringbone patterned wall, a long counter with bar stools, and a variety of bottles and glasses.

3. The Riverview

The Riverview
Cape Girardeau
United States
Alyssa
NT$3,632
NT$4,098 total
includes taxes & fees
Oct 5 - Oct 6
The Riverview
A spacious dining area with high ceilings, large windows, and modern lighting fixtures.
A gym with exercise equipment, a treadmill, and a wall-mounted TV.
An outdoor patio with stone walls, wicker furniture, and large windows.
A hotel room with a bed, a desk with a television, a chair, a suitcase, and a map on the wall.

4. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
Cape Girardeau
United States
Rebekah
NT$3,375
NT$3,807 total
includes taxes & fees
Oct 11 - Oct 12
Hampton Inn Cape Girardeau I 55 East
A spacious lobby with marble flooring, elegant seating, and a grand staircase.
A lobby with seating areas, a reception desk, and a bar.
A Courtyard by Marriott hotel with a modern brick facade, large windows, and a covered entrance area.
A spacious living room with a sofa set, a coffee table, and a dining area.

5. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
Cape Girardeau
United States
Kristin
NT$3,976
NT$4,505 total
includes taxes & fees
Oct 12 - Oct 13
Courtyard by Marriott Cape Girardeau Downtown
A hotel room with a large bed, two bedside lamps, a chair, and a wooden headboard.
A bowl of cereal with raisins and milk, a half orange, and a sandwich on a table with a yellow napkin.
A breakfast setting with waffles, scrambled eggs, toast, a glass of orange juice, and a white mug on a table with a green placemat.
A plate of mixed greens salad with cherry tomatoes and croutons, a bowl of baked pasta, and a glass of red wine on a wooden table.

6. Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau
Cape Girardeau
United States
Teresa
NT$2,892
NT$3,262 total
includes taxes & fees
Oct 5 - Oct 6
Drury Inn & Suites Cape Girardeau
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.
A Fairfield by Marriott hotel with a modern design, featuring a stone facade, multiple floors, and a well-lit entrance.
A modern living room with a sofa, a coffee table, and a dining area with chairs and a table.
A reception area with a wooden reception desk, a glass door leading to a storage room, and a decorative wall piece.

7. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
Cape Girardeau
United States
Carlos
NT$3,227
NT$3,641 total
includes taxes & fees
Oct 8 - Oct 9
Fairfield Inn & Suites by Marriott Cape Girardeau
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.
A reception desk with a large mural of a bridge, wooden reception area, and a potted plant.
An outdoor patio with tables and chairs, a stone wall, and large windows.
A hotel room with two beds, a nightstand, a lamp, and a chair.

8. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Jackson
United States
Elaine
NT$2,674
NT$2,894 total
includes taxes & fees
Oct 5 - Oct 6
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.
A Dear Tree Inn building with a covered entrance and a clear sky at dusk.
A modern dining area with wooden tables and chairs, a kitchen area with a tiled backsplash, and framed pictures on the wall.
A hotel room with two beds, a window with curtains, an air conditioning unit, and a lamp on a nightstand.

9. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
Cape Girardeau
United States
Elizabeth
NT$2,297
NT$2,591 total
includes taxes & fees
Oct 11 - Oct 12
Pear Tree Inn Cape Girardeau West
A modern retail area with a display of local items and snacks.
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.
An outdoor patio area with seating arrangements, including a sofa and chairs, and a table.
A hotel room with two beds, a desk, a chair, a TV, and a window with a view.

10. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
Cape Girardeau
United States
Shannon
NT$2,841
NT$3,233 total
includes taxes & fees
Oct 12 - Oct 13
Tru By Hilton Cape Girardeau
A spacious lobby with large windows, comfortable seating, and a modern ceiling design.
A hotel room with a bed, a dark sofa, an ottoman, a lamp, and artwork on the wall.
A room with large windows, two red upholstered chairs, a small table, and a potted plant.
A breakfast bar with coffee machines, a cereal dispenser, and a fruit display.

11. Comfort Suites Jackson-Cape Girardeau

Comfort Suites Jackson-Cape Girardeau
Jackson
United States
VICTORIA
NT$2,449
NT$2,650 total
includes taxes & fees
Oct 22 - Oct 23
Comfort Suites Jackson-Cape Girardeau
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.
A hotel patio with a gazebo, outdoor seating, and a view of the road.
An indoor swimming pool with tiled flooring, a seating area with chairs, and a staircase leading to a door.
A hotel entrance with a large tree, a well-maintained garden with various plants and flowers, and a parking lot.

12. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
Cape Girardeau
United States
Samuel
NT$2,712
NT$3,235 total
includes taxes & fees
Oct 11 - Oct 12
Candlewood Suites Cape Girardeau by IHG
A spacious living area with a high ceiling, a green accent wall, and a wooden balcony railing.
A restaurant with multiple tables and chairs, an exit sign, a television, and a counter with food items.
A hotel room with a flat-screen TV, a microwave, a sofa, a lamp, and a window with curtains.
A hotel room with a large bathtub, a bed with a wooden headboard, a nightstand with a lamp, and a painting of a building on the wall.

13. Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North
Cape Girardeau
United States
Danny
NT$1,911
NT$2,156 total
includes taxes & fees
Oct 11 - Oct 12
Quality Inn Cape Girardeau North
A hotel room with a bed, desk, chair, television, and two wall-mounted lamps.
A bathroom with a marble wall and a white bathtub.
A hotel room with a kitchenette, a bed, a dining table with chairs, a TV mounted on the wall, and a dresser.
A hotel room with a large bed, two bedside tables, a nightstand, a telephone, and two wall-mounted lamps.

14. Town House Inn Cape Giradreau

Town House Inn Cape Giradreau
Cape Girardeau
United States
Joshua
NT$2,225
NT$2,599 total
includes taxes & fees
Oct 1 - Oct 2
Town House Inn Cape Giradreau
A kitchen with dark wooden cabinets, a stainless steel refrigerator, a black stove, a microwave, and a sink.
A trophy labeled "Town House Inn" with "Cape Girardeau County, Missouri" and "2025" on it.
A bathroom with a granite countertop sink, a mirror, two hair dryers mounted on the wall, and a trash bin.
A hotel room with two beds, a wooden dresser, a bathroom with a shower, and a kitchen area.

15. Town House Inn

Town House Inn
Jackson
United States
Taylor
NT$2,265
NT$2,452 total
includes taxes & fees
Oct 12 - Oct 13
Town House Inn
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.
A restaurant with a brick wall, a flat-screen TV, and a bar area.
A hotel room with two beds, a brick wall, and a wooden headboard.
An indoor swimming pool with a wooden ceiling, lounge chairs, and a lifeguard chair.

16. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
Jackson
United States
Thomas
NT$2,744
NT$2,901 total
includes taxes & fees
Oct 25 - Oct 26
Drury Inn & Suites Jackson MO
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Top East Cape Girardeau Hotel Reviews

Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"One of the best hotels I have stayed in."
Steve 1-night trip
Posted 3 hours ago
Drury Inn & Suites Jackson MO
Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

10/10 Excellent
"Great place great breakfast great room staff was great"
Jim 1-night trip
Posted 3 hours ago
Quality Inn Cape Girardeau North
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

10/10 Excellent
"trodo estubo excelente gracias por sus servicios"
Julio 1-night trip
Posted 1 day ago
Candlewood Suites Cape Girardeau by IHG
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

10/10 Excellent
"Clean rooms. Nice breakfast. Very nice staff."
Teresa 1-night trip
Posted 2 days ago
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Upgraded to a 2 room suite. Rey nice room lots of storage. Would definitely stay here again."
Christy 2-night trip
Posted 2 days ago
Drury Inn & Suites Cape Girardeau
Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East

8/10 Good
"Liked the cleanliness of the room, and every time my family left or when returning to our room the staff said hello. What I didn’t like there were a lot of ants in the room where the especially by the TV and desks."
Valarie 2-night trip
Posted 3 days ago
Hampton Inn Cape Girardeau I 55 East
Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown

10/10 Excellent
"Very nice! Bed was comfortable and room had a very large bathroom and shower. Towels were thick and fluffy. Enjoyed having a bar downstairs with a fun friendly staff. Will stay there again when I’m coming through."
Sheila and keith 1-night trip
Posted 5 days ago
Courtyard by Marriott Cape Girardeau Downtown
Town House Inn Cape Giradreau

Town House Inn Cape Giradreau

8/10 Good
"The outside needed cleaning, but the room was very clean and well maintained."
Michael p 1-night trip
Posted 1 month ago
Town House Inn Cape Giradreau

More cheap stays in East Cape Girardeau

Quality Inn Cape Girardeau North

Quality Inn Cape Girardeau North

2011 North Kingshighway Cape Girardeau MO
NT$1,911
NT$2,156 total
Oct 11 - Oct 12
includes taxes & fees
7/10 Good! (801 reviews)
Quality Inn Cape Girardeau North
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

103 Cape West Pkwy Cape Girardeau MO
NT$2,297
NT$2,591 total
Oct 11 - Oct 12
includes taxes & fees
Pear Tree Inn Cape Girardeau West
Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau

2520 Veterans Memorial Dr Cape Girardeau MO
NT$2,841
NT$3,233 total
Oct 12 - Oct 13
includes taxes & fees
Tru By Hilton Cape Girardeau
Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

485 S Mount Auburn Rd Cape Girardeau MO
NT$2,712
NT$3,235 total
Oct 11 - Oct 12
includes taxes & fees
8/10 Very Good! (1,002 reviews)
Candlewood Suites Cape Girardeau by IHG
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

3253 William Street Cape Girardeau MO
NT$3,159
NT$3,595 total
Oct 29 - Oct 30
includes taxes & fees
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Hotel 7 Inn Anna

Hotel 7 Inn Anna

100 Richview Dr Anna IL
Get rates
6.6/10 (244 reviews)
Hotel 7 Inn Anna

Hotels in East Cape Girardeau with star-rating

Frequently asked questions

What's the best place to stay in East Cape Girardeau?
Located 4.6 mi (7.5 km) from the heart of East Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Center is a top choice for your stay based on our traveler data. Two other options for your trip to the area are Pear Tree Inn Cape Girardeau West and The Riverview. See all available top hotels, or vacation rentals in East Cape Girardeau.
If I need to cancel my hotel reservation in East Cape Girardeau, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might still have the option to cancel and be given a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in East Cape Girardeau.
Where can I learn more about changing or cancelling my trip to East Cape Girardeau?
For more details about changing or cancelling your trip to East Cape Girardeau, head over to our customer service page.
How is it staying in East Cape Girardeau?
Travelers to East Cape Girardeau will find plenty to explore and enjoy. There are 111 hotels and other accommodations in the surrounding area. Find out more about East Cape Girardeau.
What should I see while I'm in East Cape Girardeau?
Places to visit in the wider area include Century Casino & Hotel Cape Girardeau, Hunter Valley Winery, and eDen Spa & Salon. You'll also find Show Me Center and Cape Splash Family Aquatic Center in the area. Check out what more to see and do in Expedia's East Cape Girardeau guide.
What's the weather like in East Cape Girardeau?
The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for East Cape Girardeau is 59 inches.

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